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Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri

Year 2023, Volume: 6 Issue: 1, 43 - 49, 27.12.2022

Hilal Er Pınar Gobel

https://doi.org/10.53493/avrasyasbd.1085272

Abstract

Polikistik over sendromu üreme çağındaki kadınlarda görülen, sıklığı gün geçtikçe artan endokrin bir hastalıktır. Tedavinin temelinde beslenme ve yaşam tarzı değişiklikleri yer almaktadır. Ancak optimal bir diyet tanımlanmamıştır. Berberin; insülin direnci, diyabet ve obezite gibi birçok hastalık üzerinde etkili biyoaktif bir bileşiktir. Bu bileşiğin polikistik over sendromu tedavisinde etkisini inceleyen birçok çalışma bulunmaktadır. Polikistik over sendromu tedavisinde berberin kullanımı güvenli ve umut verici olarak gözükmekle birlikte daha fazla sayıda çalışmaya ihtiyaç vardır.

Keywords

Polikistik over sendromu berberin beslenme

References

  • 1. Amini MR, Sheikhhossein F, Naghshi S, Djafari F, Askari M, Shahinfar H, Safabakhsh M, Jafari A, Shab-Bidar S. (2020). Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med, 49: 102337. doi: 10.1016/j.ctim.2020.102337.
  • 2. Asbaghi O, Ghanbari N, Shekari M, Reiner Ž, Amirani E, Hallajzadeh J, Mirsafaei L, Asemi Z. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN, 38: 43-49. doi: 10.1016/j.clnesp.2020.04.010.
  • 3. Aydos A, Öztemur Y, Gür-Dedeoğlu B. (2016). Polikistikover sendromu ve moleküler yaklaşımlar. Turk Hij Den Biyol Derg, 73 (1): 81-88.
  • 4. Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, Lizneva D, Natterson-Horowtiz B, Teede HJ, Yildiz BO. (2016). Polycystic ovary syndrome. Nat Rev Dis Primers, 11 (2): 16057. doi: 10.1038/nrdp.2016.57.
  • 5. Boyle JA, Cunningham J, O'Dea K, Dunbar T, Norman RJ. (2012). Prevalence of polycystic ovary syndrome in a sample of indigenous women in Darwin, Australia. Med J Aust, 196: 62-66.
  • 6. Faghfoori Z, Fazelian S, Shadnoush M, Goodarzi R. (2017). Nutritional management in women with polycystic ovary syndrome: a review study. Diabetes Metab. Syndr, 11 (1): 429–432. doi: 10.1016/j.dsx.2017.03.030.
  • 7. Gaba S, Saini A, Singh G, Monga V. (2021). An insight into the medicinal attributes of berberine derivatives: A review. Bioorganic & Medicinal Chemistry, 38: 116143.
  • 8. İleritürk M. Doğan T. Kandemir Ö. (2021). Investigation of the Effect of Berberine with Arginase Activity and Oxidant-Antioxidant Parameters on Bortezomib-Induced Spleen Injury in Rats. Kocatepe Vet J, 14 (1): 6-15.
  • 9. Kuang H, Duan Y, Li D, Xu Y, Ai W, Li W, Wang Y, Liu S, Li M, Liu X, Shao M. (2020) The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome. PLoS ONE, 15 (8): e0235404. doi: 10.1371/journal.pone.0235404.
  • 10. Lentscher JA, Decherney AH. (2021). Clinical Presentation and Diagnosis of Polycystic Ovarian Syndrome. Clin Obstet Gynecol, 64 (1): 3-11. doi: 10.1097/GRF.0000000000000563.
  • 11. Li Y, Kuang H, Shen W, Ma H, Zhang Y, Stener-Victorin E, Hung E, Ng Y, Liu J, Kuang H, Hou L, Wu X. (2013). Letrozole, berberine, or their combination for anovulatory infertility in women with polycystic ovary syndrome: study design of a double-blind randomised controlled trial. BMJ Open, 3 (11): e003934. doi: 10.1136/bmjopen-2013-003934.
  • 12. Li MF, Zhou XM, Li XL. (2018). The effect of berberine on polycystic ovary syndrome patients with insulin resistance (PCOS-IR): a meta-analysis and systematic review. Evid Based Complement Altern Med, 14: 2532935. doi: 10.1155/2018/2532935.
  • 13. Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ. (2019). Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev, 3 (3): CD007506. doi: 10.1002/14651858.CD007506.pub4.
  • 14. Marnani EH, Ghadiri-Anari A, Ramezani-Jolfaie N, Mohammadi M, Abdollahi N, Namayandeh SM, Mozaffari-Khosravi H, Salehi-Abargouei A, Nadjarzadeh A. (2020). Effect of fennel supplementation along with high-protein, low-carbohydrate weight-loss diet on insulin resistance and percentage of fat and muscle mass in overweight/obese women with polycystic ovary syndrome. Journal of Functional Foods, 67: 103848.
  • 15. Miao X, Cui W. (2022). Berberine alleviates LPS-induced apoptosis, oxidation, and skewed lineages during mouse preimplantation development. Biology of Reproduction, 1-11.
  • 16. Mirzaee F, Razmjouei P, Shahrahmani H, Vafisani F, Najaf Najafi M, Ghazanfarpour M. (2021). The effect and safety of Berberine on polycystic ovary syndrome: a systematic review. J Obstet Gynaecol, 41 (5): 684-689. doi: 10.1080/01443615.2020.1787964.
  • 17. Moran C, Tena G, Moran S, Ruiz P, Reyna R, Duque X. (2010). Prevalence of Polycystic Ovary Syndrome and Related Disorders in Mexican Women. Gynecol Obstet Invest, 69: 274-280. doi: 10.1159/000277640.
  • 18. Neag MA, Mocan A, Echeverría J, Pop RM, Bocsan CI, Crişan G, Buzoianu AD. (2018). Berberine: Botanical Occurrence, Traditional Uses, ExtractionMethods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Front Pharmacol, 9 (557): 1-30. doi: 10.3389/fphar.2018.00557.
  • 19. Noormohammadi M, Eslamian G, Malek S, Shoaibinobarian N, Mirmohammadali SN. (2021). The association between fertility diet score and polycystic ovary syndrome: A Case-Control study. Health Care Women Int, 2: 1-15.
  • 20. Rocca ML, Venturella R, Mocciaro R, DiCello A, Sacchinelli A, Russo V, Trapasso S, Zullo F, Morelli M. (2015). Polycystic ovary syndrome: chemical pharmacotherapy. Expert Opin Pharmacother, 16 (9): 1369-1393. doi: 10.1517/14656566.2015.1047344.
  • 21. Rodriguez Paris V, Solon-Biet SM, Senior AM, Edwards MC, Desai R, Tedla N, Cox MJ, Ledger WL, Gilchrist RB, Simpson SJ, Handelsman DJ, Walters KA. (2020). Defining the impact of dietary macronutrient balance on PCOS traits. Nat Commun, 11 (1): 5262. doi: 10.1038/s41467-020-19003-5.
  • 22. Rondanelli M, Infantino V, Riva A, Petrangolini G, Faliva MA, Peroni G, Naso M, Nichetti M, Spadaccini D, Gasparri C, Perna S. (2020). Polycystic ovary syndrome management: a review of the possibleamazing role of berberine. Arch Gynecol Obstet, 301 (1): 53-60. doi: 10.1007/s00404-020-05450-4.
  • 23. Shen HR, Xu X, Ye D, Li XL. (2021). Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites. Gynecol Obstet Invest, 86: 388-397. doi: 10.1159/000518040.
  • 24. Szczuko M, Kikut J, Szczuko U, Szydłowska I, Nawrocka-Rutkowska J, Ziętek M, Verbanac D, Saso L. (2021). Nutrition Strategyand Life Style in Polycystic Ovary Syndrome- Narrative Review. Nutrients, 13 (7): 2452. doi: 10.3390/nu13072452.
  • 25. Toscani MK, Mario FM, Radavelli-Bagatini S, Spritzer PM. (2011). Insulin resistance is not strictly associated with energy intake or dietary macronutrient composition in women with polycystic ovary syndrome. Nutrition Research, 31 (2): 97-103.
  • 26. Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. (2012). A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol, 166: 99–105. doi: 10.1530/EJE-11-0616.
  • 27. Williamson K, Gunn AJ, Johnson N, Milsom SR. (2001). The impact of ethnicity on the presentation of polycystic ovarian syndrome. Aust N Z J Obstet Gynaecol, 41: 202-206.
  • 28. Wu XK, Wang YY, Liu JP, Liang RN, Xue HY, Ma HX, Shao XG, Ng EH. (2016). Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome. Fertil Steril, 106 (3): 757–765.e1. doi: 10.1016/j.fertnstert.2016.05.022.
  • 29. Xie L, Zhang D, Ma H, He H, Xia Q, Shen W, Chang H, Deng Y, Wu Q, Cong J, Wang CC, Wu X. (2019). TheEffect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Reviewand Meta-Analysis of Randomized Control Trials. Evid Based Complement Alternat Med, 2019: (1-14). doi: 10.1155/2019/7918631.
  • 30. Yılmaz M, İsaoğlu Ü, Kadanalı S. (2009). Polikistik over sendromuna güncel yaklaşım. Haseki Tıp Bülteni. 47 (1): 1-5.
  • 31. Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H. (2012). Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum Reprod, 27 (10): 3067-3073. doi: 10.1093/humrep/des232.
  • 32. Yu J, Ding C, Hua Z, Jiang X, Wang C. (2021). Protective effects of berberine in a rat model of polycystic ovary syndrome mediated via the PI3K/AKT pathway. J Obstet Gynaecol Res, 47 (5): 1789-1803.
  • 33. Yurtdaş G, Akdevelioğlu Y. (2020). A New Approach to Polycystic Ovary Syndrome: The Gut Microbiota. J Am Coll Nutr, 39 (4): 371-382. doi: 10.1080/07315724.2019.1657515.
  • 34. Zhang F, Ma T, Cui P, Tamadon A, He S, Huo C, Yierfulati G, Xu X, Hu W, Li X, Shao LR, Guo H, Feng Y, Xu C. (2019). Diversity of the Gut Microbiota in Dihydrotestosterone-Induced PCOS Rats and the Pharmacologic Effects of Diane-35, Probiotics, and Berberine. Front Microbiol, 10: 175. doi: 10.3389/fmicb.2019.00175.
  • 35. Zhang N, Liu X, Zhuang L, Liu X, Zhao H, Shan Y, Liu Z, Li F, Wang Y, Fang J. (2020). Berberine decreases insülin resistance in a PCOS rats by improving GLUT4: Dual regulation of the PI3K/AKT and MAPK pathways. Regul Toxicol Pharmacol, 110: 104544.
  • 36. Zhang S, Zhou J, Gober HJ, Leung WT, Wang L. (2021). Effect and mechanism of berberine against polycystic ovary syndrome. Biomedicine & Pharmacotherapy, 138: 111468.
  • 37. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab, 93 (7): 2559-2565. doi: 10.1210/jc.2007-2404.

Year 2023, Volume: 6 Issue: 1, 43 - 49, 27.12.2022

Hilal Er Pınar Gobel

https://doi.org/10.53493/avrasyasbd.1085272

Abstract

References

  • 1. Amini MR, Sheikhhossein F, Naghshi S, Djafari F, Askari M, Shahinfar H, Safabakhsh M, Jafari A, Shab-Bidar S. (2020). Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med, 49: 102337. doi: 10.1016/j.ctim.2020.102337.
  • 2. Asbaghi O, Ghanbari N, Shekari M, Reiner Ž, Amirani E, Hallajzadeh J, Mirsafaei L, Asemi Z. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN, 38: 43-49. doi: 10.1016/j.clnesp.2020.04.010.
  • 3. Aydos A, Öztemur Y, Gür-Dedeoğlu B. (2016). Polikistikover sendromu ve moleküler yaklaşımlar. Turk Hij Den Biyol Derg, 73 (1): 81-88.
  • 4. Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, Lizneva D, Natterson-Horowtiz B, Teede HJ, Yildiz BO. (2016). Polycystic ovary syndrome. Nat Rev Dis Primers, 11 (2): 16057. doi: 10.1038/nrdp.2016.57.
  • 5. Boyle JA, Cunningham J, O'Dea K, Dunbar T, Norman RJ. (2012). Prevalence of polycystic ovary syndrome in a sample of indigenous women in Darwin, Australia. Med J Aust, 196: 62-66.
  • 6. Faghfoori Z, Fazelian S, Shadnoush M, Goodarzi R. (2017). Nutritional management in women with polycystic ovary syndrome: a review study. Diabetes Metab. Syndr, 11 (1): 429–432. doi: 10.1016/j.dsx.2017.03.030.
  • 7. Gaba S, Saini A, Singh G, Monga V. (2021). An insight into the medicinal attributes of berberine derivatives: A review. Bioorganic & Medicinal Chemistry, 38: 116143.
  • 8. İleritürk M. Doğan T. Kandemir Ö. (2021). Investigation of the Effect of Berberine with Arginase Activity and Oxidant-Antioxidant Parameters on Bortezomib-Induced Spleen Injury in Rats. Kocatepe Vet J, 14 (1): 6-15.
  • 9. Kuang H, Duan Y, Li D, Xu Y, Ai W, Li W, Wang Y, Liu S, Li M, Liu X, Shao M. (2020) The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome. PLoS ONE, 15 (8): e0235404. doi: 10.1371/journal.pone.0235404.
  • 10. Lentscher JA, Decherney AH. (2021). Clinical Presentation and Diagnosis of Polycystic Ovarian Syndrome. Clin Obstet Gynecol, 64 (1): 3-11. doi: 10.1097/GRF.0000000000000563.
  • 11. Li Y, Kuang H, Shen W, Ma H, Zhang Y, Stener-Victorin E, Hung E, Ng Y, Liu J, Kuang H, Hou L, Wu X. (2013). Letrozole, berberine, or their combination for anovulatory infertility in women with polycystic ovary syndrome: study design of a double-blind randomised controlled trial. BMJ Open, 3 (11): e003934. doi: 10.1136/bmjopen-2013-003934.
  • 12. Li MF, Zhou XM, Li XL. (2018). The effect of berberine on polycystic ovary syndrome patients with insulin resistance (PCOS-IR): a meta-analysis and systematic review. Evid Based Complement Altern Med, 14: 2532935. doi: 10.1155/2018/2532935.
  • 13. Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ. (2019). Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev, 3 (3): CD007506. doi: 10.1002/14651858.CD007506.pub4.
  • 14. Marnani EH, Ghadiri-Anari A, Ramezani-Jolfaie N, Mohammadi M, Abdollahi N, Namayandeh SM, Mozaffari-Khosravi H, Salehi-Abargouei A, Nadjarzadeh A. (2020). Effect of fennel supplementation along with high-protein, low-carbohydrate weight-loss diet on insulin resistance and percentage of fat and muscle mass in overweight/obese women with polycystic ovary syndrome. Journal of Functional Foods, 67: 103848.
  • 15. Miao X, Cui W. (2022). Berberine alleviates LPS-induced apoptosis, oxidation, and skewed lineages during mouse preimplantation development. Biology of Reproduction, 1-11.
  • 16. Mirzaee F, Razmjouei P, Shahrahmani H, Vafisani F, Najaf Najafi M, Ghazanfarpour M. (2021). The effect and safety of Berberine on polycystic ovary syndrome: a systematic review. J Obstet Gynaecol, 41 (5): 684-689. doi: 10.1080/01443615.2020.1787964.
  • 17. Moran C, Tena G, Moran S, Ruiz P, Reyna R, Duque X. (2010). Prevalence of Polycystic Ovary Syndrome and Related Disorders in Mexican Women. Gynecol Obstet Invest, 69: 274-280. doi: 10.1159/000277640.
  • 18. Neag MA, Mocan A, Echeverría J, Pop RM, Bocsan CI, Crişan G, Buzoianu AD. (2018). Berberine: Botanical Occurrence, Traditional Uses, ExtractionMethods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Front Pharmacol, 9 (557): 1-30. doi: 10.3389/fphar.2018.00557.
  • 19. Noormohammadi M, Eslamian G, Malek S, Shoaibinobarian N, Mirmohammadali SN. (2021). The association between fertility diet score and polycystic ovary syndrome: A Case-Control study. Health Care Women Int, 2: 1-15.
  • 20. Rocca ML, Venturella R, Mocciaro R, DiCello A, Sacchinelli A, Russo V, Trapasso S, Zullo F, Morelli M. (2015). Polycystic ovary syndrome: chemical pharmacotherapy. Expert Opin Pharmacother, 16 (9): 1369-1393. doi: 10.1517/14656566.2015.1047344.
  • 21. Rodriguez Paris V, Solon-Biet SM, Senior AM, Edwards MC, Desai R, Tedla N, Cox MJ, Ledger WL, Gilchrist RB, Simpson SJ, Handelsman DJ, Walters KA. (2020). Defining the impact of dietary macronutrient balance on PCOS traits. Nat Commun, 11 (1): 5262. doi: 10.1038/s41467-020-19003-5.
  • 22. Rondanelli M, Infantino V, Riva A, Petrangolini G, Faliva MA, Peroni G, Naso M, Nichetti M, Spadaccini D, Gasparri C, Perna S. (2020). Polycystic ovary syndrome management: a review of the possibleamazing role of berberine. Arch Gynecol Obstet, 301 (1): 53-60. doi: 10.1007/s00404-020-05450-4.
  • 23. Shen HR, Xu X, Ye D, Li XL. (2021). Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites. Gynecol Obstet Invest, 86: 388-397. doi: 10.1159/000518040.
  • 24. Szczuko M, Kikut J, Szczuko U, Szydłowska I, Nawrocka-Rutkowska J, Ziętek M, Verbanac D, Saso L. (2021). Nutrition Strategyand Life Style in Polycystic Ovary Syndrome- Narrative Review. Nutrients, 13 (7): 2452. doi: 10.3390/nu13072452.
  • 25. Toscani MK, Mario FM, Radavelli-Bagatini S, Spritzer PM. (2011). Insulin resistance is not strictly associated with energy intake or dietary macronutrient composition in women with polycystic ovary syndrome. Nutrition Research, 31 (2): 97-103.
  • 26. Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. (2012). A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol, 166: 99–105. doi: 10.1530/EJE-11-0616.
  • 27. Williamson K, Gunn AJ, Johnson N, Milsom SR. (2001). The impact of ethnicity on the presentation of polycystic ovarian syndrome. Aust N Z J Obstet Gynaecol, 41: 202-206.
  • 28. Wu XK, Wang YY, Liu JP, Liang RN, Xue HY, Ma HX, Shao XG, Ng EH. (2016). Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome. Fertil Steril, 106 (3): 757–765.e1. doi: 10.1016/j.fertnstert.2016.05.022.
  • 29. Xie L, Zhang D, Ma H, He H, Xia Q, Shen W, Chang H, Deng Y, Wu Q, Cong J, Wang CC, Wu X. (2019). TheEffect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Reviewand Meta-Analysis of Randomized Control Trials. Evid Based Complement Alternat Med, 2019: (1-14). doi: 10.1155/2019/7918631.
  • 30. Yılmaz M, İsaoğlu Ü, Kadanalı S. (2009). Polikistik over sendromuna güncel yaklaşım. Haseki Tıp Bülteni. 47 (1): 1-5.
  • 31. Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H. (2012). Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum Reprod, 27 (10): 3067-3073. doi: 10.1093/humrep/des232.
  • 32. Yu J, Ding C, Hua Z, Jiang X, Wang C. (2021). Protective effects of berberine in a rat model of polycystic ovary syndrome mediated via the PI3K/AKT pathway. J Obstet Gynaecol Res, 47 (5): 1789-1803.
  • 33. Yurtdaş G, Akdevelioğlu Y. (2020). A New Approach to Polycystic Ovary Syndrome: The Gut Microbiota. J Am Coll Nutr, 39 (4): 371-382. doi: 10.1080/07315724.2019.1657515.
  • 34. Zhang F, Ma T, Cui P, Tamadon A, He S, Huo C, Yierfulati G, Xu X, Hu W, Li X, Shao LR, Guo H, Feng Y, Xu C. (2019). Diversity of the Gut Microbiota in Dihydrotestosterone-Induced PCOS Rats and the Pharmacologic Effects of Diane-35, Probiotics, and Berberine. Front Microbiol, 10: 175. doi: 10.3389/fmicb.2019.00175.
  • 35. Zhang N, Liu X, Zhuang L, Liu X, Zhao H, Shan Y, Liu Z, Li F, Wang Y, Fang J. (2020). Berberine decreases insülin resistance in a PCOS rats by improving GLUT4: Dual regulation of the PI3K/AKT and MAPK pathways. Regul Toxicol Pharmacol, 110: 104544.
  • 36. Zhang S, Zhou J, Gober HJ, Leung WT, Wang L. (2021). Effect and mechanism of berberine against polycystic ovary syndrome. Biomedicine & Pharmacotherapy, 138: 111468.
  • 37. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab, 93 (7): 2559-2565. doi: 10.1210/jc.2007-2404.
There are 37 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Derlemeler
Authors

Hilal Er 0000-0002-0028-3042

Pınar Gobel 0000-0001-7152-1581

Publication Date December 27, 2022
Submission Date March 10, 2022
Published in Issue Year 2023 Volume: 6 Issue: 1

Cite

APA Er, H., & Gobel, P. (2022). Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri. Avrasya Sağlık Bilimleri Dergisi, 6(1), 43-49. https://doi.org/10.53493/avrasyasbd.1085272
AMA Er H, Gobel P. Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri. EurasianJHS. December 2022;6(1):43-49. doi:10.53493/avrasyasbd.1085272
Chicago Er, Hilal, and Pınar Gobel. “Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri”. Avrasya Sağlık Bilimleri Dergisi 6, no. 1 (December 2022): 43-49. https://doi.org/10.53493/avrasyasbd.1085272.
EndNote Er H, Gobel P (December 1, 2022) Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri. Avrasya Sağlık Bilimleri Dergisi 6 1 43–49.
IEEE H. Er and P. Gobel, “Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri”, EurasianJHS, vol. 6, no. 1, pp. 43–49, 2022, doi: 10.53493/avrasyasbd.1085272.
ISNAD Er, Hilal - Gobel, Pınar. “Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri”. Avrasya Sağlık Bilimleri Dergisi 6/1 (December 2022), 43-49. https://doi.org/10.53493/avrasyasbd.1085272.
JAMA Er H, Gobel P. Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri. EurasianJHS. 2022;6:43–49.
MLA Er, Hilal and Pınar Gobel. “Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri”. Avrasya Sağlık Bilimleri Dergisi, vol. 6, no. 1, 2022, pp. 43-49, doi:10.53493/avrasyasbd.1085272.
Vancouver Er H, Gobel P. Polikistik Over Sendromunun Beslenme Tedavisinde Berberinin Yeri. EurasianJHS. 2022;6(1):43-9.
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