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Oxidative DNA Damage Products and Diseases

Year 2012, Issue: 2, 40 - 57, 01.10.2012

Nazlı Ercan Ulvi Reha Fidancı

Abstract

The free radicals formed with many ways and antioxidant defence mechanism is in a balance within the organism. In cases when
the free radicals are not cleaned enough from the organism, it causes damage to the DNA and damage products are formed. These
damage products can lead to many metabolic diseases, to aging, to cancer and even modifications in the structure of DNA which is a
genetic material. 8-hydroxy-2’-deoxyguanosine (8-OHdG) is a damage product whose mutagenity is most known.

Keywords

DNA Diseases Oxidative Damage 8-OHdG

References

  • 1. Akira M, Ikeda T, Enomoto K et al (2000). Increased formation of oxidative DNA damage, 8-hydroxy-2’- deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett. 151: 87-95.
  • 2. Alam Z I, Jenner A, Daniel S E et al (1997). Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem. 69: 1196-1203.
  • 3. Beehler, BC, Przybyszewski, J, Box, HB, Kulesz-Martin, F (1992). Formation of 8- hydroxydeoxyguanosine within DNA of Mouse keratinocytes exposed in culture to UVB and H 2 O 2 . Carcinogenesis 13: 2003-2007.
  • 4. Bogdanov M B, Andreassen O A, Dedeoğlu A, Ferrante R J, Beal M F (2001). Increased oxidative damage to DNA in a transgenic Mouse model of Huntington’s disease. J Neurochem. 79: 1246-1249.
  • 5. Bogdanov M, Brown R H, Matson W et al (2000). Increased oxidative damage to DNA in ALS patients. Free Radical Bio Med. 7: 652-658.
  • 6. Breen A P, Murphy J A (1995). Reactions of oxyl radicals with DNA. Free Radical Bio Med. 8(6):1033-77.
  • 7. Chang C S, Chen W N, Lin H H, Wu C C, Wang C J (2004). Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor B expression and enhanced antiapoptosis- related proteins in Helicobacter pylori- infected non-cardiacgastric adenocarcinoma. World J Gastroentero. 10(15):2232-2240.
  • 8. Chuma M, Hige S, Nakanishi M et al (2008). 8-hydroxy-2’-deoxyguanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. J Gastroen Hepatol. 23: 1431-1436.
  • 9. Collier A C, Dandge S D, Woodrow J E, Pritsos C A (2005). Differences in DNA damage in non smoking men and women exposed to environmental tobacco smoke (ETS). Toxicol Lett. 158: 10-19.
  • Dandona P, Thusu K, Cook S et al (1996). Oxidative damage to DNA in diabetes mellitus. Lancet. 347 (8999):444-445.
  • Dinçer Y, Erzin Y, Himmetoğlu S, Güneş K N, Bal K, Akçay T (2007). Oxidative DNA damage and antioxidant activity in patients with inflamatory Bowel Disease. Digest Dis Sci. 52: 1639-1641.
  • Dirksen ML, Blakely WF, Holwitt E, Dizdaroğlu M (1988). Effect of DNA conformation on the hydroxyl radical- induced formation of 8,5’-cyclopurine 2’-deoxyribonucleoside rezidues in DNA. Int J Radiat Biol. 54(2): 195- 204.
  • Dizdaroğlu M, Holwitt E, Hagan M, Blakely W (1986). Formation of cytosine glycol and 5,6- dihydroxycytosine in deoxyribonucleic acid on treatment with osmiumtetroxide. Biochem. 235:531- 536.
  • Dizdaroğlu M (1991). Chemical determination of free radical-induced damage to DNA. Free Radical Bio Med. 10: 225-242.
  • Dizdaroğlu M (1992). Oxidative damage to DNA in mammalian chromatin. Mutat Res. 275:331-342.
  • Dizdaroğlu, M (1992). Measurement of radiation-induced damage to DNA at the molecular level. Int J Radiat Biol. 61(2): 175-183.
  • Dizdaroğlu M (1993). Quantative determination of oxidative base damge in DNA by stable isotope-dilution mass spectrometry. Febs Lett. 315(1):1-6.
  • Dizdaroğlu M, Laval J, Boiteux S (1993). Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine- derived lesions in DNA produced by radiation-generated free radicals. Biochem. 32(45):12105-12111.
  • Dizdaroğlu M, Bauche C, Rodriguez H, Laval J (2000). Novel substrates of Esherichia coli Nth protein and its kinetics for excision of modified bases from Dna damaged by free radicals. Biochem. 39: 5586-5592.
  • Dizdaroğlu, M (2005). Serbest Radikaller, DNA Hasarı, DNA onarımı ve Hastalıklarla ilişkisi. Kurs Kitabı.
  • 21. Dizdaroğlu M, Jaruga P, Birincioğlu M, Rodriguez H (2002). Free Radical- Induced Damaged to DNA: Mechanisms and measurement. Free Radical Bio Med. 32(11): 1102-1115.
  • 22. Dong QY, Cui Y, Chen L, Song J, Sun L (2008). Urinary 8- hydroxydeoxyguanosine levels in diabetic retinopathy patients. Eur J Ophthalmol. 18(1): 94-98.
  • 23. Ercan N, Fidancı U R (2012). Piyodermalı köpeklerde 8-hidroksi-2’- deoksiguanozin (8-OHdG) düzeyleri. Ank Üniv Vet Fak Derg. 59: 163-168.
  • 24. Evans M D, Dizdaroğlu M, Cooke M S (2004). Oxidative DNA damage and disease induction, repair and significance. Mutat Res. 567: 1-61.
  • 25. Fidancı U R, Turgay F, Zengin S, Kargın F, Çelik S, Taşdemir U (2001). Genotipin Ankara Keçilerinde antioksidatif Metabolizma Üzerine Etkisi. Turk J Vet Anim Sci. 25: 975- 981.
  • 26. Fujita S, Steenken S (1981). Pattern of OH radical addtion to uracil and methyl- and carboxyl-substitued uracils. Electron transfer of OH adducts with N,N,N’,N’-Tetramethyl- p-phenylenediamine and tetranitromethane. J Am Chem Soc. 103:2540-2545.
  • 27. Fraga C, Shigenaga M, Park J, Degan P, Ames B (1990). Oxidative damage to DNA during aging: 8-Hydroxy-2’- deoxyguanosine in rat organ DNA urine. Proc Nat Acad Sci. 87: 4533- 4537.
  • 28. Gencer M, Ceyla E, Aksoy A, Uzun K (2005). Oksidatif stres benign ve malign akciğer hastalıklarının ayırıcı tanısında belirteç olabilir mi? Akciğer arşivi 6: 89-92.
  • 29. Halliwell B (2000). Why and how should we measure oxidative DNA damage in nutritional studies? How far we come? Am J Clin Nutr. 72: 1082- 1087.
  • 30. Haliwell B (2007). Oxidative stres and cancer: have we moved forward? Biochem J. 401: 1-11.
  • 31. Hattori Y, Nishigori C, Tanaka T et al (1996). 8-hydroxy-2’-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol. 107(5):733-737.
  • 32. Hattori-Nakakuki, Y., Nisgiori, C., Okamato, K., Imamura, S., Hiai, H., Toyokuni, S. (1994). Formation of 8- hydroxy-2’-deoxyguanosine in epidermis of hairless mice exposed to near-UV. Biochem Biophys Res Commun. 201: 1132-1139.
  • 33. Heidarpour M, Soltani S, Mohri M, Khoshnegah J (2012). Canine visceral leishmaniasis: relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status. Parasitol Res.
  • 34. Heidarpour M, Mohri M, Borji H, Moghdass E (2012). Oxidative stress and trace elements in camel (Camelus dromedarius) with liver cystic echinococcosis. Vet Parasitol. 187(3- 4):459-63.
  • 35. Helbock HJ, Beckman KB, Shigenaga MK et al (1998). DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo- deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci. 95: 288-293.
  • 36. Herbert K A, Evans M D, Finnegan M et al (1996). A novel HPLC procedure fort he analysis of 8-oxoguanine in DNA. Free Radical Bio Med. 20(3): 467-473.
  • 37. Honda M, Yamada Y, Tomonaga M, Ichinose H, Kamihira S (2000). Correlation of urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders: a pilot study. Leukemia Res. 24: 461-468.
  • 38. Inoue T, Hayashi M, Takayanagi K, Morooka S (2003). Oxidative DNA damage is induced by chronic cigarette smoking but repaired by abstention. J Health Sci. 49(3):217-220.
  • 39. Ishizakai M, Yoshida K, Nishimoto N et al (2004). Urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG) in patients with chronic liver diseases. Rinsho Byori. 52(9):732-736.
  • 40. Jaruga P, Zastwany T H, Skokowski J, Dizdaroğlu M, Olinski R (1994). Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. Febs lett. 341: 59-64.
  • 41. Jaruga P, Rodriguez H, Dizdaroğlu M (2001). Measurement of 8-hydroxy-2’- deoxyadenosine in DNA by liquid chromatography/mass spectometry. Free Radical Bio Med. 31(3): 336-344.
  • 42. Kasai, H. (2002). Chemistry-based studies on oxidative DNA damage formation, repair and mutagenesis. Free Radical Bio Med. 33(4): 450-456.
  • 43. Keleş H, Fidan F, Ciğerci H, Küçükkurt İ, Karadaş E (2010). Increased DNA damage and oxidative stres in chickens with Natural Marek’ Disease. Vet Immunol Immunop. 133: 51-58.
  • 44. Koçyiğit A, Keleş H, Selek S ve ark (2005). Increased DNA damage and oxidative stres in patients with cutaneous leishmaniasis. Mutat Res. 585: 71-78.
  • 45. Koppele J M, Lucassen P J, Sakkee A N et al (1996). 8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer’s disease. Neurobiol aging. 17(6):819-826.
  • 46. Köken, T, Kahraman, A, Serteser, M, Gökçe, Ç. (2004). Hemodiyaliz ve oksidatif stres. Kocatepe Tıp Dergisi. 5: 9-13.
  • 47. Lin H, Jenner A, Ong C et al (2004). A high-throughput and sensitive methodology for the quantificaition of urinary 8-hydroxy-2’-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase exraction. Biochem. 380: 541-548.
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  • 49. Long D J, Matson W R, Juhl A R et al (2012). 8OHdG as a marker for huntington disease progression. Neurobiol Dis. 46: 625-634.
  • 50. Martinis B, Bianchi M (2002). Methodology for urinary 8-hydroxy-2’- deoxyguanosine analysis by HPLC with electrochemical detection. Pharmacol Res. 46(2): 129-131.
  • 51. Musarrat J, Arezina-Wilson J, Wani AA (1996). Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur J Cancer. 32A(7):1209-1214.
  • 52. Nagashima M, Tsuda H, Takenoshita S et al (1995). 8-hydroxydeoxyguanosine levels in DNA of human breastcancers are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method. Cancer lett. 90(2):157-162.
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Oksidatif DNA Hasar Ürünleri ve Hastalıklar

Year 2012, Issue: 2, 40 - 57, 01.10.2012

Nazlı Ercan Ulvi Reha Fidancı

Abstract

Organizmada, çeşitli yollarla oluşan serbest radikallerle antioksidan savunma sistemi denge halindedir. Bununla beraber serbest
radikallerin organizmadan yeterince temizlenemediği durumlarda DNA’da hasara yol açmakta ve hasar ürünleri şekillenmektedir.
Bu hasar ürünleri çeşitli metabolik hastalıklara, yaşlanmaya, kansere ve hatta genetik materyal olan DNA yapısındaki
modifikasyonlara neden olabilmektedir. Mutajenitesi en çok bilinmekte olan hasar ürünlerinden bir tanesi de 8-hidroksi-2’-
deoksiguanozin (8-OHdG)’dir.

Keywords

DNA Hastalıklar Oksidatif Hasar 8-OHdG

References

  • 1. Akira M, Ikeda T, Enomoto K et al (2000). Increased formation of oxidative DNA damage, 8-hydroxy-2’- deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett. 151: 87-95.
  • 2. Alam Z I, Jenner A, Daniel S E et al (1997). Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem. 69: 1196-1203.
  • 3. Beehler, BC, Przybyszewski, J, Box, HB, Kulesz-Martin, F (1992). Formation of 8- hydroxydeoxyguanosine within DNA of Mouse keratinocytes exposed in culture to UVB and H 2 O 2 . Carcinogenesis 13: 2003-2007.
  • 4. Bogdanov M B, Andreassen O A, Dedeoğlu A, Ferrante R J, Beal M F (2001). Increased oxidative damage to DNA in a transgenic Mouse model of Huntington’s disease. J Neurochem. 79: 1246-1249.
  • 5. Bogdanov M, Brown R H, Matson W et al (2000). Increased oxidative damage to DNA in ALS patients. Free Radical Bio Med. 7: 652-658.
  • 6. Breen A P, Murphy J A (1995). Reactions of oxyl radicals with DNA. Free Radical Bio Med. 8(6):1033-77.
  • 7. Chang C S, Chen W N, Lin H H, Wu C C, Wang C J (2004). Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor B expression and enhanced antiapoptosis- related proteins in Helicobacter pylori- infected non-cardiacgastric adenocarcinoma. World J Gastroentero. 10(15):2232-2240.
  • 8. Chuma M, Hige S, Nakanishi M et al (2008). 8-hydroxy-2’-deoxyguanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. J Gastroen Hepatol. 23: 1431-1436.
  • 9. Collier A C, Dandge S D, Woodrow J E, Pritsos C A (2005). Differences in DNA damage in non smoking men and women exposed to environmental tobacco smoke (ETS). Toxicol Lett. 158: 10-19.
  • Dandona P, Thusu K, Cook S et al (1996). Oxidative damage to DNA in diabetes mellitus. Lancet. 347 (8999):444-445.
  • Dinçer Y, Erzin Y, Himmetoğlu S, Güneş K N, Bal K, Akçay T (2007). Oxidative DNA damage and antioxidant activity in patients with inflamatory Bowel Disease. Digest Dis Sci. 52: 1639-1641.
  • Dirksen ML, Blakely WF, Holwitt E, Dizdaroğlu M (1988). Effect of DNA conformation on the hydroxyl radical- induced formation of 8,5’-cyclopurine 2’-deoxyribonucleoside rezidues in DNA. Int J Radiat Biol. 54(2): 195- 204.
  • Dizdaroğlu M, Holwitt E, Hagan M, Blakely W (1986). Formation of cytosine glycol and 5,6- dihydroxycytosine in deoxyribonucleic acid on treatment with osmiumtetroxide. Biochem. 235:531- 536.
  • Dizdaroğlu M (1991). Chemical determination of free radical-induced damage to DNA. Free Radical Bio Med. 10: 225-242.
  • Dizdaroğlu M (1992). Oxidative damage to DNA in mammalian chromatin. Mutat Res. 275:331-342.
  • Dizdaroğlu, M (1992). Measurement of radiation-induced damage to DNA at the molecular level. Int J Radiat Biol. 61(2): 175-183.
  • Dizdaroğlu M (1993). Quantative determination of oxidative base damge in DNA by stable isotope-dilution mass spectrometry. Febs Lett. 315(1):1-6.
  • Dizdaroğlu M, Laval J, Boiteux S (1993). Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine- derived lesions in DNA produced by radiation-generated free radicals. Biochem. 32(45):12105-12111.
  • Dizdaroğlu M, Bauche C, Rodriguez H, Laval J (2000). Novel substrates of Esherichia coli Nth protein and its kinetics for excision of modified bases from Dna damaged by free radicals. Biochem. 39: 5586-5592.
  • Dizdaroğlu, M (2005). Serbest Radikaller, DNA Hasarı, DNA onarımı ve Hastalıklarla ilişkisi. Kurs Kitabı.
  • 21. Dizdaroğlu M, Jaruga P, Birincioğlu M, Rodriguez H (2002). Free Radical- Induced Damaged to DNA: Mechanisms and measurement. Free Radical Bio Med. 32(11): 1102-1115.
  • 22. Dong QY, Cui Y, Chen L, Song J, Sun L (2008). Urinary 8- hydroxydeoxyguanosine levels in diabetic retinopathy patients. Eur J Ophthalmol. 18(1): 94-98.
  • 23. Ercan N, Fidancı U R (2012). Piyodermalı köpeklerde 8-hidroksi-2’- deoksiguanozin (8-OHdG) düzeyleri. Ank Üniv Vet Fak Derg. 59: 163-168.
  • 24. Evans M D, Dizdaroğlu M, Cooke M S (2004). Oxidative DNA damage and disease induction, repair and significance. Mutat Res. 567: 1-61.
  • 25. Fidancı U R, Turgay F, Zengin S, Kargın F, Çelik S, Taşdemir U (2001). Genotipin Ankara Keçilerinde antioksidatif Metabolizma Üzerine Etkisi. Turk J Vet Anim Sci. 25: 975- 981.
  • 26. Fujita S, Steenken S (1981). Pattern of OH radical addtion to uracil and methyl- and carboxyl-substitued uracils. Electron transfer of OH adducts with N,N,N’,N’-Tetramethyl- p-phenylenediamine and tetranitromethane. J Am Chem Soc. 103:2540-2545.
  • 27. Fraga C, Shigenaga M, Park J, Degan P, Ames B (1990). Oxidative damage to DNA during aging: 8-Hydroxy-2’- deoxyguanosine in rat organ DNA urine. Proc Nat Acad Sci. 87: 4533- 4537.
  • 28. Gencer M, Ceyla E, Aksoy A, Uzun K (2005). Oksidatif stres benign ve malign akciğer hastalıklarının ayırıcı tanısında belirteç olabilir mi? Akciğer arşivi 6: 89-92.
  • 29. Halliwell B (2000). Why and how should we measure oxidative DNA damage in nutritional studies? How far we come? Am J Clin Nutr. 72: 1082- 1087.
  • 30. Haliwell B (2007). Oxidative stres and cancer: have we moved forward? Biochem J. 401: 1-11.
  • 31. Hattori Y, Nishigori C, Tanaka T et al (1996). 8-hydroxy-2’-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol. 107(5):733-737.
  • 32. Hattori-Nakakuki, Y., Nisgiori, C., Okamato, K., Imamura, S., Hiai, H., Toyokuni, S. (1994). Formation of 8- hydroxy-2’-deoxyguanosine in epidermis of hairless mice exposed to near-UV. Biochem Biophys Res Commun. 201: 1132-1139.
  • 33. Heidarpour M, Soltani S, Mohri M, Khoshnegah J (2012). Canine visceral leishmaniasis: relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status. Parasitol Res.
  • 34. Heidarpour M, Mohri M, Borji H, Moghdass E (2012). Oxidative stress and trace elements in camel (Camelus dromedarius) with liver cystic echinococcosis. Vet Parasitol. 187(3- 4):459-63.
  • 35. Helbock HJ, Beckman KB, Shigenaga MK et al (1998). DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo- deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci. 95: 288-293.
  • 36. Herbert K A, Evans M D, Finnegan M et al (1996). A novel HPLC procedure fort he analysis of 8-oxoguanine in DNA. Free Radical Bio Med. 20(3): 467-473.
  • 37. Honda M, Yamada Y, Tomonaga M, Ichinose H, Kamihira S (2000). Correlation of urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders: a pilot study. Leukemia Res. 24: 461-468.
  • 38. Inoue T, Hayashi M, Takayanagi K, Morooka S (2003). Oxidative DNA damage is induced by chronic cigarette smoking but repaired by abstention. J Health Sci. 49(3):217-220.
  • 39. Ishizakai M, Yoshida K, Nishimoto N et al (2004). Urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG) in patients with chronic liver diseases. Rinsho Byori. 52(9):732-736.
  • 40. Jaruga P, Zastwany T H, Skokowski J, Dizdaroğlu M, Olinski R (1994). Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. Febs lett. 341: 59-64.
  • 41. Jaruga P, Rodriguez H, Dizdaroğlu M (2001). Measurement of 8-hydroxy-2’- deoxyadenosine in DNA by liquid chromatography/mass spectometry. Free Radical Bio Med. 31(3): 336-344.
  • 42. Kasai, H. (2002). Chemistry-based studies on oxidative DNA damage formation, repair and mutagenesis. Free Radical Bio Med. 33(4): 450-456.
  • 43. Keleş H, Fidan F, Ciğerci H, Küçükkurt İ, Karadaş E (2010). Increased DNA damage and oxidative stres in chickens with Natural Marek’ Disease. Vet Immunol Immunop. 133: 51-58.
  • 44. Koçyiğit A, Keleş H, Selek S ve ark (2005). Increased DNA damage and oxidative stres in patients with cutaneous leishmaniasis. Mutat Res. 585: 71-78.
  • 45. Koppele J M, Lucassen P J, Sakkee A N et al (1996). 8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer’s disease. Neurobiol aging. 17(6):819-826.
  • 46. Köken, T, Kahraman, A, Serteser, M, Gökçe, Ç. (2004). Hemodiyaliz ve oksidatif stres. Kocatepe Tıp Dergisi. 5: 9-13.
  • 47. Lin H, Jenner A, Ong C et al (2004). A high-throughput and sensitive methodology for the quantificaition of urinary 8-hydroxy-2’-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase exraction. Biochem. 380: 541-548.
  • 48. Loft S, Nielsen A, Jeding IB, Vistisen K, Poulsen HE (1993). 8- Hydoxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Env Health. 40(2-3): 391-404.
  • 49. Long D J, Matson W R, Juhl A R et al (2012). 8OHdG as a marker for huntington disease progression. Neurobiol Dis. 46: 625-634.
  • 50. Martinis B, Bianchi M (2002). Methodology for urinary 8-hydroxy-2’- deoxyguanosine analysis by HPLC with electrochemical detection. Pharmacol Res. 46(2): 129-131.
  • 51. Musarrat J, Arezina-Wilson J, Wani AA (1996). Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur J Cancer. 32A(7):1209-1214.
  • 52. Nagashima M, Tsuda H, Takenoshita S et al (1995). 8-hydroxydeoxyguanosine levels in DNA of human breastcancers are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method. Cancer lett. 90(2):157-162.
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There are 72 citations in total.

Details

Subjects Veterinary Surgery
Journal Section Review
Authors

Nazlı Ercan

Ulvi Reha Fidancı This is me

Publication Date October 1, 2012
Published in Issue Year 2012 Issue: 2

Cite

APA Ercan, N., & Fidancı, U. R. (2012). Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniversitesi Veteriner Fakültesi Dergisi(2), 40-57.
AMA Ercan N, Fidancı UR. Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniv Vet Fak Derg. October 2012;(2):40-57.
Chicago Ercan, Nazlı, and Ulvi Reha Fidancı. “Oksidatif DNA Hasar Ürünleri Ve Hastalıklar”. Dicle Üniversitesi Veteriner Fakültesi Dergisi, no. 2 (October 2012): 40-57.
EndNote Ercan N, Fidancı UR (October 1, 2012) Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniversitesi Veteriner Fakültesi Dergisi 2 40–57.
IEEE N. Ercan and U. R. Fidancı, “Oksidatif DNA Hasar Ürünleri ve Hastalıklar”, Dicle Üniv Vet Fak Derg, no. 2, pp. 40–57, October 2012.
ISNAD Ercan, Nazlı - Fidancı, Ulvi Reha. “Oksidatif DNA Hasar Ürünleri Ve Hastalıklar”. Dicle Üniversitesi Veteriner Fakültesi Dergisi 2 (October 2012), 40-57.
JAMA Ercan N, Fidancı UR. Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniv Vet Fak Derg. 2012;:40–57.
MLA Ercan, Nazlı and Ulvi Reha Fidancı. “Oksidatif DNA Hasar Ürünleri Ve Hastalıklar”. Dicle Üniversitesi Veteriner Fakültesi Dergisi, no. 2, 2012, pp. 40-57.
Vancouver Ercan N, Fidancı UR. Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniv Vet Fak Derg. 2012(2):40-57.

DANIŞMA KURULU
Prof. Dr. Abit AKTAŞ, İstanbul Üniversitesi-Cerrahpaşa
Prof. Dr. Yılmaz ARAL, Ankara Üniversitesi
Prof. Dr. Ali ARSLAN, Fırat Üniversitesi, Elazığ
Prof. Dr. M. Sedat BARAN, Dicle Üniversitesi, Diyarbakır
Prof. Dr. Cengiz CEYLAN, Balıkesir Üniversitesi
Prof. Dr. Ahmet ÇAKIR, Ankara Üniversitesi
Prof. Dr. Burhan ÇETİNKAYA, Fırat Üniversitesi, Elazığ
Prof. Dr. Ülker EREN, Adnan Menderes Üniversitesi, Aydın
Prof. Dr. Abdurrahman GÜL, Bingöl Üniversitesi
Prof. Dr. Hakki KARA, Cumhuriyet Üniversitesi, Sivas
Prof. Dr. Narin LİMAN, Erciyes Üniversitesi, Kayseri
Prof. Dr. Abdullah ÖZEN, Fırat Üniversitesi, Elazığ
Prof. Dr. Ayşe SERBEST, Uludağ Üniversitesi, Bursa
Prof. Dr. Kazım ŞAHİN, Fırat Üniversitesi, Elazığ
Prof. Dr. Tekin ŞAHİN, Siirt Üniversitesi
Prof. Dr. Nihat ŞINDAK, Siirt Üniversitesi
Prof. Dr. Muzaffer TAŞ, Namık Kemal Üniversitesi, Tekirdağ
Prof. Dr. Necati TİMURKAN Fırat Üniversitesi, Elazığ
Prof. Dr. Emine ÜNSALDI, Fırat Üniversitesi, Elazığ
Prof. Dr. Murat YILDIRIM, Kırıkkale Üniversitesi
Doç. Dr. M. Osman ATLI, Harran Üniversitesi, Şanlıurfa
Doç. Dr. Bülent ELİTOK, Afyon Kocatepe Üniversitesi
Doç. Dr. Serkan ERDOĞAN, Namık Kemal Üniversitesi, Tekirdağ
Dr. Öğr. Üyesi Zelal KARAKOÇ, Dicle Üniversitesi, Diyarbakır
Dr. Öğr. Üyesi Ersin UYSAL, Dicle Üniversitesi, Diyarbakır
*Not: Yayın ve Danışma Kurulu Üyeleri alfabetik sıraya göre dizilmiştir.