Review

Retraction: The Relationship Between Propionic Acid and Autism Spectrum Disorder

Year 2023, Volume: 12 Issue: 3, 1464 - 1473, 26.09.2023

İbrahim Hakkı Çağıran Adviye Gülçin Sağdıçoğlu Celep

https://doi.org/10.37989/gumussagbil.1226210
This article was retracted on December 26, 2023. https://dergipark.org.tr/en/pub/gumussagbil/issue/81745/1376344

Abstract

Autism spectrum disorder (ASD) is a compound brain development disorder of uncertain etiology and pathophysiology. In addition to environmental factors, genetic factors also affect the pathophysiology of ASD. Propionic acid (PA), which is used as a food additive and drug, can affect the genetic processes of brain development through the modulation of molecular pathways. Propionic acid causes the formation of ASD by causing mTOR/Gskβ, cytokine imbalance and disruption of developmental molecular pathways in the prenatal and neonatal period. This review was made to investigate the possible effects of PA.

Keywords

Autism Animal model Food additive Propionic acid.

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Retraction: Propiyonik Asit ve Otizm Spektrum Bozukluğu İlişkisi

Year 2023, Volume: 12 Issue: 3, 1464 - 1473, 26.09.2023

İbrahim Hakkı Çağıran Adviye Gülçin Sağdıçoğlu Celep

https://doi.org/10.37989/gumussagbil.1226210
This article was retracted on December 26, 2023. https://dergipark.org.tr/en/pub/gumussagbil/issue/81745/1376344

Abstract

Otizm spektrum bozukluğu (OSB), etiyolojisi ve patofizyolojisi belirsiz olan bileşik bir beyin gelişimi bozukluğudur. OSB patofizyolojisinde çevresel faktörlerin yanında genetik faktörler de etki etmektedir. Gıda katkı maddesi ve ilaç olarak kullanılmakta olan propiyonik asit (PA) moleküler yolların modülasyonu yoluyla beyin gelişiminin genetik süreçlerini etkileyebilmektedir. Propiyonik asit, prenatal ve neonatal dönemde mTOR/Gskβ, sitokin dengesizliğine ve gelişimsel moleküler yollarının bozulmasına neden olarak OSB’nin oluşmasına neden olur. Bu derleme, PA’nın olası etkilerini araştırmak amacıyla yapılmıştır.

Keywords

Otizm Hayvan modeli Gıda katkı maddesi Propiyonik asit.

References

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  • 2. Simpson, R.L. (2005). “Evidence-Based Practices and Students With Autism Spectrum Disorders”. Focus on Autism and Other Developmental Disabilities, 20, 140-149. https://doi.org/10.1177/10883576050200030201
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Derlemeler
Authors

İbrahim Hakkı Çağıran 0000-0003-3125-1198

Adviye Gülçin Sağdıçoğlu Celep 0000-0002-4598-5814

Publication Date September 26, 2023
Published in Issue Year 2023 Volume: 12 Issue: 3
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