Research Article
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Year 2023, Volume: 6 Issue: 1, 46 - 59, 30.06.2023
https://doi.org/10.46876/ja.1298971

Abstract

References

  • Abou Khalil, N. S., Abou-Elhamd, A. S., Wasfy, S. I., El Mileegy, I. M., Hamed, M. Y., & Ageely, H. M. (2016). Antidiabetic and antioxidant impacts of desert date (Balanites aegyptiaca) and parsley (Petroselinum sativum) aqueous extracts: Lessons from experimental rats. J. Diabetes Res, 2016(ID 8408326), 1-10.
  • Abu-Zaiton, A. S. (2010). Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pak J Biol Sci, 13(2), 97-100.
  • Aebi, H. (1984). Catalase in vitro. In Methods in enzymology (Vol. 105, pp. 121-126): Elsevier.
  • Akhlaghi, F., Rajaei, Z., Hadjzadeh, M. A., İranshahi, M., & Mahdi, A. (2012). Antihyperglycemic effect of asafoetida (Ferula assafoetida Oleo-Gum-Resin) in streptozotocin-induced diabetic rats. World Applied Sci J, 17(2), 157-162.
  • Altındağ, F., Rağbetli, M. Ç., Özdek, U., Koyun, N., Alhalboosi, J. K. I., & Elasan, S. (2021). Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats. Food Chem Toxicol, 156, 112443.
  • Andrade-Cetto, A. (2011). Hypoglycemic effect of Smilax moranensis root on N5-STZ diabetic rats. Pharmacologyonline, 1, 111-115.
  • Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. J Agric Food Chem, 52(26), 7970-7981.
  • Arıtuluk, Z. C., Çankaya Tatlı, İ. İ., & Özkan Gençler, A. M. (2016). Antioxidant activity, total phenolic and flavonoid contents of some Tanacetum L. (Asteraceae) taxa growing in Turkey. J Pharm Sci, 41, 17-25.
  • Bazancir, N., & Meydan, I. (2022). Characterization of Zn nanoparticles of Platonus orientalis plant, investigation of DPPH radical extinquishing and antimicrobial activity. East J Med, 27(4), 615-619
  • Bhandari, R., Singh, M., Jindal, S., & Kaur, I. P. (2021). Toxicity studies of highly bioavailable isoniazid loaded solid lipid nanoparticles as per Organisation for Economic Co-operation and Development (OECD) guidelines. Eur J Pharm Biopharm, 160, 82-91.
  • Blois, M. S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181(4617), 1199.
  • Bulduk, B., Gokhan, O., Günbatar, N., Bulduk, M., Koçak, Y., Elasan. (2022). S. J. J. o. H. S., & Medicine. The effect of resveratrol on toxicity caused by cisplatin in rats with experimentally created diabetes by streptozotocin. 5(1), 124-130.
  • Cinar, A. S., Bakar-Ates, F., & Onder, A. (2020). Seseli petraeum M. Bieb.(Apiaceae) Significantly inhibited cellular growth of A549 lung cancer cells through G0/G1 cell cycle arrest. An Acad Bras Cienc, 92(4), 1-11.
  • Doğan, D., Meydan, I., & Kömüroğlu, A. U. (2022). Protective effect of silymarin and gallic acid against cisplatin-induced nephrotoxicity and hepatotoxicity. Int J Clin Pract, 2022.
  • Esmaeili, H., Esmailidehaj, M., Zarch, S. E., & Azizian, H. (2020). Role of the potassium channels in vasorelaxant effect of asafoetida essential oil. Avicenna J Phytomed, 10(4), 407.
  • Fadem, S. Z. (2022). Diabetes and Kidney Disease. In Staying Healthy with Kidney Disease (pp. 23-33): Springer.
  • Gao, H. X., Liang, H. Y., Chen, N., Shi, B., & Zeng, W. C. (2022). Potential of phenolic compounds in Ligustrum robustum (Rxob.) Blume as antioxidant and lipase inhibitors: Multi‐spectroscopic methods and molecular docking. J Food Sci, 87, 651-663.
  • Giribabu, N., Kumar, K. E., Rekha, S. S., Muniandy, S., & Salleh, N. (2014). Chlorophytum borivilianum root extract maintains near normal blood glucose, insulin and lipid profile levels and prevents oxidative stress in the pancreas of streptozotocin-induced adult male diabetic rats. Int J Med Sci, 11(11), 1172-1184.
  • Gomathi, D., Ravikumar, G., Kalaiselvi, M., Devaki, K., & Uma, C. (2013). Efficacy of Evolvulus alsinoides (L.) L. on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats. J Diabetes Metab Disord, 12(1), 39-44.
  • Jagtap, A., & Patil, P. (2010). Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats. Food Chem Toxicol, 48(8), 2030-2036.
  • Jain, P. K., Ravichandran, V., Sharma, S., & Agrawal, R. K. (2008). The antioxidant activity of some medicinal plants. Turk J Biol, 32(3), 197-202.
  • Jalili-Nik, M., Soukhtanloo, M., Javanshir, S., Yazdi, A. J., Esmaeilizadeh, M., Jafarian, A. H., & Ghorbani, A. (2019). Effects of ethanolic extract of Ferula gummosa oleo-resin in a rat model of streptozotocin-induced diabetes. Res Pharm Sci, 14(2), 138.
  • Kaval, U., & Tonçer, O. (2020). A Revıew on Antibacterial, Antifungal and Antiviral Activities of Plants Included in the Apiaceae Lindley Family. Batman University Journal of Life Sciences, 10(2), 163-182.
  • Krishnasamy, G., Muthusamy, K., Chellappan, D. R., & Subbiah, N. (2016). Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats. Pharm Biol, 54(9), 1716-1726.
  • Kumar, V., Jain, P., Rathore, K., & Ahmed, Z. (2016). Biological evaluation of Pupalia lappacea for antidiabetic, antiadipogenic, and hypolipidemic activity both in vitro and in vivo. Scientifica (Cairo), 2016, 1-10. doi:10.1155/2016/1062430
  • Lazzaroni, E., Nasr, M. B., Loretelli, C., Pastore, I., Plebani, L., Lunati, M. E., Montefusco, L. (2021). Anti-diabetic drugs and weight loss in patients with type 2 diabetes. Pharmacol Res, 171, 105782.
  • Lowry, O. H., Rosebrough, N. J., Farr, A. L., & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem, 193, 265-275.
  • Meydan, I., Burhan, H., Gür, T., Seçkin, H., Tanhaei, B., & Sen, F. (2022). Characterization of Rheum ribes with ZnO nanoparticle and its antidiabetic, antibacterial, DNA damage prevention and lipid peroxidation prevention activity of in vitro. Environ Res, 204, 112363.
  • Moreno, M. N., Isla, M., Sampietro, A. R., & Vattuone, M. A. (2000). Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. J Ethnopharmacol, 71(1), 109-114.
  • Noriega-Cisneros, R., Ortiz-Avila, O., Esquivel-Gutiérrez, E., Clemente-Guerrero, M., Manzo-Avalos, S., Salgado-Garciglia, R., Saavedra-Molina, A. (2012). Hypolipidemic activity of Eryngium carlinae on streptozotocin-induced diabetic rats. Biochem Res İnt, 2012(ID 603501), 1-5.
  • Olela, B., Mbaria, J., Wachira, T., & Moriasi, G. (2020). Acute oral toxicity and anti-inflammatory and analgesic effects of aqueous and methanolic stem bark extracts of piliostigma thonningii (schumach.). Evidence-Based Complementary Alternative Medicine, 2020, Article ID 5651390.
  • Özdek, U., Başbuğan, Y., Yıldırım, S., Fırat, M., & Değer, Y. (2018). Activity, acute and sub-acute toxicity and safety assesment of the hydroalcholic root extract of Diplotaenia turcica. Indian J Anim Res, 52(12), 1688-1694. doi:DOI: 10.18805/ijar.B-901
  • Özdek, U., Yıldırım, S., & Değer, Y. (2020). The effect of Diplotaenia turcica root extract in streptozotocin-induced diabetic rats. Turk J Biochem, 45(2), 1-10. doi:https://doi.org/10.1515/tjb-2018-0411.
  • Placer, Z. A., Cushman, L. L., & Johnson, B. C. (1966). Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem, 16(2), 359-364.
  • Rais, N., Ved, A., Ahmad, R., Parveen, K., Gautam, G. K., Bari, D. G., Singh, A. P. (2021). Model of Streptozotocin-Nicotinamide Induced Type 2 Diabetes: A Comparative Review. Current diabetes reviews.
  • Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 87(1), 4-14.
  • Shukla, R., Padhye, S., Modak, M., Ghaskadbi, S. S., & Bhonde, R. R. (2007). Bis (quercetinato) oxovanadium IV reverses metabolic changes in streptozotocin-induced diabetic mice. Rev Diabet Stud, 4(1), 33-43.
  • Singleton, V. L., Orthofer, R., & Lamuela-Raventós, R. M. (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. In Methods in enzymology (Vol. 299, pp. 152-178): Elsevier.
  • Şenol, K., & Ocak, E. (2018). Antimicrobial and antioxidant properties of sirmo (Allium vineale L.), mendi (Chaerophyllum macropodum Boiss.) and siyabo (Ferula rigidula DC.). Academic Food Journal, 43(2), 294-302.
  • Yanardağ, R., Bolkent, Ş., Tabakoğlu-Oğuz, A., & Özsoy-Saçan, Ö. (2003). Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biol Pharm Bul, 26(8), 1206-1210.
  • Yusufoglu, H., Soliman, G., Abdel-Rahman, R., Abdel-Kader, M., Ganaie, M., Bedir, E., Öztürk, B. (2015). Antihyperglycemic and antihyperlipidemic effects of Ferula duranii in experimental type 2 diabetic rats. Int J Pharmacol, 11(6), 532-541.

Effects of Ferula Rigidula plant extract on hyperglycemia, hyperlipidemia and pancreatic tissue oxidative stress in rats with experimental diabetes

Year 2023, Volume: 6 Issue: 1, 46 - 59, 30.06.2023
https://doi.org/10.46876/ja.1298971

Abstract

Ferula rigidula (FR) is one of the herbs used in traditional treatments. The aim of this study is to investigate the effects of this plant, which is used in traditional treatment, on insulin secretion, blood glucose level, lipid profile and some oxidative stress parameters in diabetes.In addition, studies on the total phenolic and flavonoid content of the plant extract, the determination of antioxidant activity by DPPH and CUPRAC method, and the lethal dose of FR were also performed. For the diabetes study, 49 male Wistar albino rats were used. Rats were divided into seven groups as control, diabetes, diabetes+ FR (250mg/kg), diabetes+ FR (500 mg/kg), diabetes+glibenclamide (5 mg/kg), FR (250 mg/kg), FR (500 mg/kg) group. According to the diabetes group, fasting blood glucose levels in the diabetes+FR 500 mg/kg group decreased. Cholesterol and HDL levels decreased in the diabetes+FR 250-500 mg/kg and diabetes+glibenclamide groups. MDA level decreased in diabetes+FR 250-500 mg/kg and diabetes+glibenclamide groups but it was determined that GSH level and CAT, GSH-Px, SOD enzyme activities increased. The positive effects of FR on some parameters that change in diabetes and examined in this study are explained.

References

  • Abou Khalil, N. S., Abou-Elhamd, A. S., Wasfy, S. I., El Mileegy, I. M., Hamed, M. Y., & Ageely, H. M. (2016). Antidiabetic and antioxidant impacts of desert date (Balanites aegyptiaca) and parsley (Petroselinum sativum) aqueous extracts: Lessons from experimental rats. J. Diabetes Res, 2016(ID 8408326), 1-10.
  • Abu-Zaiton, A. S. (2010). Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pak J Biol Sci, 13(2), 97-100.
  • Aebi, H. (1984). Catalase in vitro. In Methods in enzymology (Vol. 105, pp. 121-126): Elsevier.
  • Akhlaghi, F., Rajaei, Z., Hadjzadeh, M. A., İranshahi, M., & Mahdi, A. (2012). Antihyperglycemic effect of asafoetida (Ferula assafoetida Oleo-Gum-Resin) in streptozotocin-induced diabetic rats. World Applied Sci J, 17(2), 157-162.
  • Altındağ, F., Rağbetli, M. Ç., Özdek, U., Koyun, N., Alhalboosi, J. K. I., & Elasan, S. (2021). Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats. Food Chem Toxicol, 156, 112443.
  • Andrade-Cetto, A. (2011). Hypoglycemic effect of Smilax moranensis root on N5-STZ diabetic rats. Pharmacologyonline, 1, 111-115.
  • Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. J Agric Food Chem, 52(26), 7970-7981.
  • Arıtuluk, Z. C., Çankaya Tatlı, İ. İ., & Özkan Gençler, A. M. (2016). Antioxidant activity, total phenolic and flavonoid contents of some Tanacetum L. (Asteraceae) taxa growing in Turkey. J Pharm Sci, 41, 17-25.
  • Bazancir, N., & Meydan, I. (2022). Characterization of Zn nanoparticles of Platonus orientalis plant, investigation of DPPH radical extinquishing and antimicrobial activity. East J Med, 27(4), 615-619
  • Bhandari, R., Singh, M., Jindal, S., & Kaur, I. P. (2021). Toxicity studies of highly bioavailable isoniazid loaded solid lipid nanoparticles as per Organisation for Economic Co-operation and Development (OECD) guidelines. Eur J Pharm Biopharm, 160, 82-91.
  • Blois, M. S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181(4617), 1199.
  • Bulduk, B., Gokhan, O., Günbatar, N., Bulduk, M., Koçak, Y., Elasan. (2022). S. J. J. o. H. S., & Medicine. The effect of resveratrol on toxicity caused by cisplatin in rats with experimentally created diabetes by streptozotocin. 5(1), 124-130.
  • Cinar, A. S., Bakar-Ates, F., & Onder, A. (2020). Seseli petraeum M. Bieb.(Apiaceae) Significantly inhibited cellular growth of A549 lung cancer cells through G0/G1 cell cycle arrest. An Acad Bras Cienc, 92(4), 1-11.
  • Doğan, D., Meydan, I., & Kömüroğlu, A. U. (2022). Protective effect of silymarin and gallic acid against cisplatin-induced nephrotoxicity and hepatotoxicity. Int J Clin Pract, 2022.
  • Esmaeili, H., Esmailidehaj, M., Zarch, S. E., & Azizian, H. (2020). Role of the potassium channels in vasorelaxant effect of asafoetida essential oil. Avicenna J Phytomed, 10(4), 407.
  • Fadem, S. Z. (2022). Diabetes and Kidney Disease. In Staying Healthy with Kidney Disease (pp. 23-33): Springer.
  • Gao, H. X., Liang, H. Y., Chen, N., Shi, B., & Zeng, W. C. (2022). Potential of phenolic compounds in Ligustrum robustum (Rxob.) Blume as antioxidant and lipase inhibitors: Multi‐spectroscopic methods and molecular docking. J Food Sci, 87, 651-663.
  • Giribabu, N., Kumar, K. E., Rekha, S. S., Muniandy, S., & Salleh, N. (2014). Chlorophytum borivilianum root extract maintains near normal blood glucose, insulin and lipid profile levels and prevents oxidative stress in the pancreas of streptozotocin-induced adult male diabetic rats. Int J Med Sci, 11(11), 1172-1184.
  • Gomathi, D., Ravikumar, G., Kalaiselvi, M., Devaki, K., & Uma, C. (2013). Efficacy of Evolvulus alsinoides (L.) L. on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats. J Diabetes Metab Disord, 12(1), 39-44.
  • Jagtap, A., & Patil, P. (2010). Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats. Food Chem Toxicol, 48(8), 2030-2036.
  • Jain, P. K., Ravichandran, V., Sharma, S., & Agrawal, R. K. (2008). The antioxidant activity of some medicinal plants. Turk J Biol, 32(3), 197-202.
  • Jalili-Nik, M., Soukhtanloo, M., Javanshir, S., Yazdi, A. J., Esmaeilizadeh, M., Jafarian, A. H., & Ghorbani, A. (2019). Effects of ethanolic extract of Ferula gummosa oleo-resin in a rat model of streptozotocin-induced diabetes. Res Pharm Sci, 14(2), 138.
  • Kaval, U., & Tonçer, O. (2020). A Revıew on Antibacterial, Antifungal and Antiviral Activities of Plants Included in the Apiaceae Lindley Family. Batman University Journal of Life Sciences, 10(2), 163-182.
  • Krishnasamy, G., Muthusamy, K., Chellappan, D. R., & Subbiah, N. (2016). Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats. Pharm Biol, 54(9), 1716-1726.
  • Kumar, V., Jain, P., Rathore, K., & Ahmed, Z. (2016). Biological evaluation of Pupalia lappacea for antidiabetic, antiadipogenic, and hypolipidemic activity both in vitro and in vivo. Scientifica (Cairo), 2016, 1-10. doi:10.1155/2016/1062430
  • Lazzaroni, E., Nasr, M. B., Loretelli, C., Pastore, I., Plebani, L., Lunati, M. E., Montefusco, L. (2021). Anti-diabetic drugs and weight loss in patients with type 2 diabetes. Pharmacol Res, 171, 105782.
  • Lowry, O. H., Rosebrough, N. J., Farr, A. L., & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem, 193, 265-275.
  • Meydan, I., Burhan, H., Gür, T., Seçkin, H., Tanhaei, B., & Sen, F. (2022). Characterization of Rheum ribes with ZnO nanoparticle and its antidiabetic, antibacterial, DNA damage prevention and lipid peroxidation prevention activity of in vitro. Environ Res, 204, 112363.
  • Moreno, M. N., Isla, M., Sampietro, A. R., & Vattuone, M. A. (2000). Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. J Ethnopharmacol, 71(1), 109-114.
  • Noriega-Cisneros, R., Ortiz-Avila, O., Esquivel-Gutiérrez, E., Clemente-Guerrero, M., Manzo-Avalos, S., Salgado-Garciglia, R., Saavedra-Molina, A. (2012). Hypolipidemic activity of Eryngium carlinae on streptozotocin-induced diabetic rats. Biochem Res İnt, 2012(ID 603501), 1-5.
  • Olela, B., Mbaria, J., Wachira, T., & Moriasi, G. (2020). Acute oral toxicity and anti-inflammatory and analgesic effects of aqueous and methanolic stem bark extracts of piliostigma thonningii (schumach.). Evidence-Based Complementary Alternative Medicine, 2020, Article ID 5651390.
  • Özdek, U., Başbuğan, Y., Yıldırım, S., Fırat, M., & Değer, Y. (2018). Activity, acute and sub-acute toxicity and safety assesment of the hydroalcholic root extract of Diplotaenia turcica. Indian J Anim Res, 52(12), 1688-1694. doi:DOI: 10.18805/ijar.B-901
  • Özdek, U., Yıldırım, S., & Değer, Y. (2020). The effect of Diplotaenia turcica root extract in streptozotocin-induced diabetic rats. Turk J Biochem, 45(2), 1-10. doi:https://doi.org/10.1515/tjb-2018-0411.
  • Placer, Z. A., Cushman, L. L., & Johnson, B. C. (1966). Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem, 16(2), 359-364.
  • Rais, N., Ved, A., Ahmad, R., Parveen, K., Gautam, G. K., Bari, D. G., Singh, A. P. (2021). Model of Streptozotocin-Nicotinamide Induced Type 2 Diabetes: A Comparative Review. Current diabetes reviews.
  • Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 87(1), 4-14.
  • Shukla, R., Padhye, S., Modak, M., Ghaskadbi, S. S., & Bhonde, R. R. (2007). Bis (quercetinato) oxovanadium IV reverses metabolic changes in streptozotocin-induced diabetic mice. Rev Diabet Stud, 4(1), 33-43.
  • Singleton, V. L., Orthofer, R., & Lamuela-Raventós, R. M. (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. In Methods in enzymology (Vol. 299, pp. 152-178): Elsevier.
  • Şenol, K., & Ocak, E. (2018). Antimicrobial and antioxidant properties of sirmo (Allium vineale L.), mendi (Chaerophyllum macropodum Boiss.) and siyabo (Ferula rigidula DC.). Academic Food Journal, 43(2), 294-302.
  • Yanardağ, R., Bolkent, Ş., Tabakoğlu-Oğuz, A., & Özsoy-Saçan, Ö. (2003). Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biol Pharm Bul, 26(8), 1206-1210.
  • Yusufoglu, H., Soliman, G., Abdel-Rahman, R., Abdel-Kader, M., Ganaie, M., Bedir, E., Öztürk, B. (2015). Antihyperglycemic and antihyperlipidemic effects of Ferula duranii in experimental type 2 diabetic rats. Int J Pharmacol, 11(6), 532-541.
There are 41 citations in total.

Details

Primary Language English
Subjects Agricultural Engineering
Journal Section Research Articles
Authors

Ayhan Beyazpolat 0000-0002-7222-0956

Ugur Ozdek 0000-0002-0709-1545

Yeter Değer 0000-0001-9346-3685

Early Pub Date June 30, 2023
Publication Date June 30, 2023
Submission Date May 18, 2023
Acceptance Date June 13, 2023
Published in Issue Year 2023 Volume: 6 Issue: 1

Cite

APA Beyazpolat, A., Ozdek, U., & Değer, Y. (2023). Effects of Ferula Rigidula plant extract on hyperglycemia, hyperlipidemia and pancreatic tissue oxidative stress in rats with experimental diabetes. Journal of Agriculture, 6(1), 46-59. https://doi.org/10.46876/ja.1298971