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Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters

Year 2020, Volume: 4 Issue: 2, 230 - 235, 15.06.2020

Naci Alayunt Bilal Ustundag

https://doi.org/10.31015/jaefs.2020.2.14

Abstract

The high level of fructose taken in the diet is one of the reasons for the increased prevalence of metabolic syndrome, which is increasing day by day globally in association with the effects of genetic and environmental factors. In the study, 21 male Sprague-Dawley rats of 220±20 gr body weight were used. The rats were assigned to 3 groups as the control group, metabolic syndrome group, and the group where Nigella sativa oil was administered. The serum homocysteine levels were increased in the metabolic syndrome group compared to the control group but without statistical significance (p>0.05). Homocysteine levels decreased significantly after Nigella sativa oil compared to metabolic syndrome group. LDH (p <0.001) and uric acid (p <0.05) levels which were higher in metabolic syndrome group were decreased in Nigella sativa oil group. Hyperhomocysteinemia is a risk factor for endothelial dysfunction. In our study, the treatment of the metabolic syndrome and regulation of the increased levels of homocysteine with Nigella sativa oil in metabolic syndrome were discussed. Some biochemical parameters and improvements in homocysteine levels with Nigella sativa oil has been identified. In this study, we have concluded that the occurrence of elevated levels of plasma homocysteine are closely associated with the development of inflammation, cellular adhesion, hepatic dysfunction, and cell proliferation and that the reduction in the serum levels of homocysteine by the administration of Nigella sativa oil will lead to favorable out comes.

Keywords

Homocysteine Metabolic syndrome Nigella sativa oil Vanillylmandelic acid

Supporting Institution

Fırat University Scientific Research Projects

Project Number

TF.14.41

Thanks

Thank you to Fırat University Scientific Research Projects

References

  • Basciano, H., Federico, L., and Adeli, K. (2005). Fructose, insulin resistance, and metabolic dyslipidemia. Nutrition & Metabolism, vol. 2, p.: 241–255.
  • Brent, E. (2004). Wisse. The inflammatory syndrome: The role of adipose tissue cytokines in metabolic syndrome. J Am Soc Nephrol.; 15 (11): 2792- 2800.
  • Bruce, K.D., Byrne, C.D. (2009). The metabolic syndrome: common origins of a multifactorial disorder. Postgrad Med J; 85: 614-621.
  • Busserolles, J., Zimowska, W., Rock, E., Rayssiguier, Y., and Mazur, A. (2002). Rats fed a high sucrose diet have altered heart antioxidant enzyme activity and gene expression. Life Sciences.; vol. 71, no. 1, pp. 1303–1312.
  • Carr, M.C., Brunzell, J.D. (2004). Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metabolic. 89:2601-7.
  • Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Rachael E. (2008). The Metabolic Syndrome. Endocr Rev. December 1, 29(7): 777–822.
  • Csaba, G. (2014). Hormones in the immune system and their possible role. A critical review. Acta microbiologica rt immunologica hungarica. 61: (3), 241–260.
  • Ford, E.S., Giles, W.H., Dietz, W.H. (2002). Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey JAMA. 287: 356–359.
  • Fulop, T., Tessier, D., Carpentier, A. (2006) The metabolic syndrome. Pathologie Biologie, 54: 375–386.
  • Gaby, A.R. (2005). Adverse effects of dietary fructose. Altern. Med. Rev.10(4): 294-306.
  • Hajhashemi, V., Ghannadi, A., Jafarabadi, H. (2004). Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res. 18(3): 195-199.
  • Hanson, R.L., Imperatore, G., Bennett, P.H., Knowler, W.C. (2002). Components of the metabolic syndrome and incidence of type 2 diabetes. Diabetes, 51(10): 3120-3127.
  • Hayden, M.R., and Tyagi, S.C. (2004). Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation. Nutrition Journal. vol. 3, no. 4, pp. 1–23.
  • Iannucci, C.V., Capoccia, D., Cababeia, M. et al. (2007). Metabolic syndrome and Adipose Tissue: New Clinical Aspects and Therapeutic Targets. Current Pharmaceutical Design, 13(21): 2148-2168.
  • Jobidon C, Nadeau A, Tancrède G, Nguyen MH, Rousseau-Migneron S. (1985). Plasma, adrenal, and heart catecholamines in physically trained normal and diabetic rats. Diabetes. Jun;34(6):532-5.
  • Korkmaz, A. (2008). Fructose; a hidden threat for chronic diseases. TAF Prev. Med. Bull.7(4): 343-346.
  • López, M., Hernández, A. (2013). Hyperglycemia and diabetes in myocardial infarction. in Diabetes mellitus – insights and perspectives. Ed., pp. 169–192,
  • Maulik, S.K., Prabhakar, P., Dinda, A.K., Seth, S. (2012). Genistein, sıçanlarda izoproterenol kaynaklı kardiyak hipertrofiyi önler. Can J Physiol Pharmacol. 90 (8): 1117–1125
  • Miller, A., Adeli, K. (2008). Dietary Fructose and Metabolic syndrome. Curr Opin Gastroenterol. 24(2):204-9.
  • Ohamed, M., Abdel-Daim, M., Shaheen, A., Toraih, M.S. (2018). Thymoquinone and diallyl sulfide protect against fipronil-induced oxidative injury in rats. Environmental Science and Pollution Research. pp 1–8 | Ci
  • Özgen, A.G. (2006). Metabolic syndrome and dyslipidemia. Turkey Klin. J Int Med Sci; 2: 43-54.
  • Panda, V., Mistry, K., Sudhamani, S., Nandave, M., and Ojha, S.K. (2017). Amelioration of Abnormalities Associated with the Metabolic Syndrome by Spinacia oleracea (Spinach) Consumption and Aerobic Exercise in Rats. Oxidative Medicine and Cellular Longevity. Article ID 2359389, 15 pages
  • Panda, V.S., Desai, Y.H., and Sudhamani, S. (2015). Protective effects of Macrotyloma uniflorum seeds (horse gram) in abnormalities associated with the metabolic syndrome in rats. Journal of Diabetes and Obesity. vol. 2, no. 2, pp. 1–10.
  • Perveen, T., Hainder, S. (2013). Increased 5-HT Levels Following Repeated Administration of Nigella sativa Oil Produce Antidepressant Effects in Rats. Sci Pharm. 218 (8): 1304-19.
  • Pyorala, M., Miettinen, H., Halonen, P., Laakso, M., Pyorala, K. (2000). Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol. 20: 538–544.
  • Ramadan, M.F. (2007). Nutritional value, functional properties and nutraceutical applications of black cumin (N sativa) L. London, Int J Food Sci Tech. 10(42): 1208-1218
  • Reaven, G.M. (1988). Banting lecture. Role of insulin resistance in human disease. Diabetes. 1988; Dec;37(12):1595-607.
  • Reddy, S.S., Ramatholisamma, P., Karuna, R., Saralakumari, D. (2009). Preventive effect of Tinospora cordifolia against high-fructose diet-induced insülin resistance and oxidative stress in male Wistar rats. Food Chem. Toxicol.47(9): 2224-2229.
  • Salem, M.L. (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 5(13-14): 1749-1770.
  • Sánchez-Lozada, L.G., Tapia, E., Jiménez, A., Bautista, P., Cristóbal, M., Nepomuceno, T., Franco, M. (2007). Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol. 292(1): F423-9.
  • Scott, M.G. (2004). Metabolic Syndrom Part I and II. Endorinol Metab Clin .N Am; 33: 267–282.
  • Sencer, E. (2001). Endocrinology, Metabolism and Nutritional Diseases. Nobel Medical Bookstore. 726-33.
  • Sreeja, S., Geetha, R., Priyadarshini, E., Bhavani, K., and Anuradha, C.V. (2014). Substitution of soy protein for casein prevents oxidative modification and inflammatory response induced in rats fed high fructose diet. ISRN Inflammation, vol., Article ID 641096, 8 pages.
  • Sridhar, R.E., Mahesh, K.K., Prasanna, M.D., Kranti, K., Reddy, E., Velidandla, S., and Manikya, S. (2016). Clinical Utility of Serum Homocysteine and Folate as Tumor Markers in Oral Squamous Cell Carcinoma - A Cross-Sectional Study. J Clin Diagn Res. 10(10): ZC24–ZC28.

Year 2020, Volume: 4 Issue: 2, 230 - 235, 15.06.2020

Naci Alayunt Bilal Ustundag

https://doi.org/10.31015/jaefs.2020.2.14

Abstract

Project Number

TF.14.41

References

  • Basciano, H., Federico, L., and Adeli, K. (2005). Fructose, insulin resistance, and metabolic dyslipidemia. Nutrition & Metabolism, vol. 2, p.: 241–255.
  • Brent, E. (2004). Wisse. The inflammatory syndrome: The role of adipose tissue cytokines in metabolic syndrome. J Am Soc Nephrol.; 15 (11): 2792- 2800.
  • Bruce, K.D., Byrne, C.D. (2009). The metabolic syndrome: common origins of a multifactorial disorder. Postgrad Med J; 85: 614-621.
  • Busserolles, J., Zimowska, W., Rock, E., Rayssiguier, Y., and Mazur, A. (2002). Rats fed a high sucrose diet have altered heart antioxidant enzyme activity and gene expression. Life Sciences.; vol. 71, no. 1, pp. 1303–1312.
  • Carr, M.C., Brunzell, J.D. (2004). Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metabolic. 89:2601-7.
  • Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Rachael E. (2008). The Metabolic Syndrome. Endocr Rev. December 1, 29(7): 777–822.
  • Csaba, G. (2014). Hormones in the immune system and their possible role. A critical review. Acta microbiologica rt immunologica hungarica. 61: (3), 241–260.
  • Ford, E.S., Giles, W.H., Dietz, W.H. (2002). Prevalence of the metabolic syndrome among US adults: findings from the Third National Health and Nutrition Examination Survey JAMA. 287: 356–359.
  • Fulop, T., Tessier, D., Carpentier, A. (2006) The metabolic syndrome. Pathologie Biologie, 54: 375–386.
  • Gaby, A.R. (2005). Adverse effects of dietary fructose. Altern. Med. Rev.10(4): 294-306.
  • Hajhashemi, V., Ghannadi, A., Jafarabadi, H. (2004). Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res. 18(3): 195-199.
  • Hanson, R.L., Imperatore, G., Bennett, P.H., Knowler, W.C. (2002). Components of the metabolic syndrome and incidence of type 2 diabetes. Diabetes, 51(10): 3120-3127.
  • Hayden, M.R., and Tyagi, S.C. (2004). Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation. Nutrition Journal. vol. 3, no. 4, pp. 1–23.
  • Iannucci, C.V., Capoccia, D., Cababeia, M. et al. (2007). Metabolic syndrome and Adipose Tissue: New Clinical Aspects and Therapeutic Targets. Current Pharmaceutical Design, 13(21): 2148-2168.
  • Jobidon C, Nadeau A, Tancrède G, Nguyen MH, Rousseau-Migneron S. (1985). Plasma, adrenal, and heart catecholamines in physically trained normal and diabetic rats. Diabetes. Jun;34(6):532-5.
  • Korkmaz, A. (2008). Fructose; a hidden threat for chronic diseases. TAF Prev. Med. Bull.7(4): 343-346.
  • López, M., Hernández, A. (2013). Hyperglycemia and diabetes in myocardial infarction. in Diabetes mellitus – insights and perspectives. Ed., pp. 169–192,
  • Maulik, S.K., Prabhakar, P., Dinda, A.K., Seth, S. (2012). Genistein, sıçanlarda izoproterenol kaynaklı kardiyak hipertrofiyi önler. Can J Physiol Pharmacol. 90 (8): 1117–1125
  • Miller, A., Adeli, K. (2008). Dietary Fructose and Metabolic syndrome. Curr Opin Gastroenterol. 24(2):204-9.
  • Ohamed, M., Abdel-Daim, M., Shaheen, A., Toraih, M.S. (2018). Thymoquinone and diallyl sulfide protect against fipronil-induced oxidative injury in rats. Environmental Science and Pollution Research. pp 1–8 | Ci
  • Özgen, A.G. (2006). Metabolic syndrome and dyslipidemia. Turkey Klin. J Int Med Sci; 2: 43-54.
  • Panda, V., Mistry, K., Sudhamani, S., Nandave, M., and Ojha, S.K. (2017). Amelioration of Abnormalities Associated with the Metabolic Syndrome by Spinacia oleracea (Spinach) Consumption and Aerobic Exercise in Rats. Oxidative Medicine and Cellular Longevity. Article ID 2359389, 15 pages
  • Panda, V.S., Desai, Y.H., and Sudhamani, S. (2015). Protective effects of Macrotyloma uniflorum seeds (horse gram) in abnormalities associated with the metabolic syndrome in rats. Journal of Diabetes and Obesity. vol. 2, no. 2, pp. 1–10.
  • Perveen, T., Hainder, S. (2013). Increased 5-HT Levels Following Repeated Administration of Nigella sativa Oil Produce Antidepressant Effects in Rats. Sci Pharm. 218 (8): 1304-19.
  • Pyorala, M., Miettinen, H., Halonen, P., Laakso, M., Pyorala, K. (2000). Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol. 20: 538–544.
  • Ramadan, M.F. (2007). Nutritional value, functional properties and nutraceutical applications of black cumin (N sativa) L. London, Int J Food Sci Tech. 10(42): 1208-1218
  • Reaven, G.M. (1988). Banting lecture. Role of insulin resistance in human disease. Diabetes. 1988; Dec;37(12):1595-607.
  • Reddy, S.S., Ramatholisamma, P., Karuna, R., Saralakumari, D. (2009). Preventive effect of Tinospora cordifolia against high-fructose diet-induced insülin resistance and oxidative stress in male Wistar rats. Food Chem. Toxicol.47(9): 2224-2229.
  • Salem, M.L. (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 5(13-14): 1749-1770.
  • Sánchez-Lozada, L.G., Tapia, E., Jiménez, A., Bautista, P., Cristóbal, M., Nepomuceno, T., Franco, M. (2007). Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol. 292(1): F423-9.
  • Scott, M.G. (2004). Metabolic Syndrom Part I and II. Endorinol Metab Clin .N Am; 33: 267–282.
  • Sencer, E. (2001). Endocrinology, Metabolism and Nutritional Diseases. Nobel Medical Bookstore. 726-33.
  • Sreeja, S., Geetha, R., Priyadarshini, E., Bhavani, K., and Anuradha, C.V. (2014). Substitution of soy protein for casein prevents oxidative modification and inflammatory response induced in rats fed high fructose diet. ISRN Inflammation, vol., Article ID 641096, 8 pages.
  • Sridhar, R.E., Mahesh, K.K., Prasanna, M.D., Kranti, K., Reddy, E., Velidandla, S., and Manikya, S. (2016). Clinical Utility of Serum Homocysteine and Folate as Tumor Markers in Oral Squamous Cell Carcinoma - A Cross-Sectional Study. J Clin Diagn Res. 10(10): ZC24–ZC28.
There are 34 citations in total.

Details

Primary Language English
Subjects Food Engineering
Journal Section Research Articles
Authors

Naci Alayunt 0000-0003-2215-0934

Bilal Ustundag This is me 0000-0001-6621-2450

Project Number TF.14.41
Publication Date June 15, 2020
Submission Date April 6, 2020
Acceptance Date June 6, 2020
Published in Issue Year 2020 Volume: 4 Issue: 2

Cite

APA Alayunt, N., & Ustundag, B. (2020). Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters. International Journal of Agriculture Environment and Food Sciences, 4(2), 230-235. https://doi.org/10.31015/jaefs.2020.2.14
AMA Alayunt N, Ustundag B. Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters. int. j. agric. environ. food sci. June 2020;4(2):230-235. doi:10.31015/jaefs.2020.2.14
Chicago Alayunt, Naci, and Bilal Ustundag. “Homocysteine Metabolism in Rats With Metabolic Syndrome and the Impacts of Nigella Sativa Oil on Some Biochemical Parameters”. International Journal of Agriculture Environment and Food Sciences 4, no. 2 (June 2020): 230-35. https://doi.org/10.31015/jaefs.2020.2.14.
EndNote Alayunt N, Ustundag B (June 1, 2020) Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters. International Journal of Agriculture Environment and Food Sciences 4 2 230–235.
IEEE N. Alayunt and B. Ustundag, “Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters”, int. j. agric. environ. food sci., vol. 4, no. 2, pp. 230–235, 2020, doi: 10.31015/jaefs.2020.2.14.
ISNAD Alayunt, Naci - Ustundag, Bilal. “Homocysteine Metabolism in Rats With Metabolic Syndrome and the Impacts of Nigella Sativa Oil on Some Biochemical Parameters”. International Journal of Agriculture Environment and Food Sciences 4/2 (June 2020), 230-235. https://doi.org/10.31015/jaefs.2020.2.14.
JAMA Alayunt N, Ustundag B. Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters. int. j. agric. environ. food sci. 2020;4:230–235.
MLA Alayunt, Naci and Bilal Ustundag. “Homocysteine Metabolism in Rats With Metabolic Syndrome and the Impacts of Nigella Sativa Oil on Some Biochemical Parameters”. International Journal of Agriculture Environment and Food Sciences, vol. 4, no. 2, 2020, pp. 230-5, doi:10.31015/jaefs.2020.2.14.
Vancouver Alayunt N, Ustundag B. Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters. int. j. agric. environ. food sci. 2020;4(2):230-5.
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