Research Article
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Investigation of the immunomodulatory effect of inactive parapoxvirus (iPPVO) on infectious bovine rhinotracheitis (IBR) vaccine in cattle

Year 2023, Volume: 8 Issue: 3, 183 - 189, 31.12.2023

Süleyman Erbasan Nuri Mamak

https://doi.org/10.24880/maeuvfd.1310119

Abstract

In the study, alterations in antibody titers, proinflammatory and antiinflammatory cytokine levels were determined in serum samples collected at various periods before and after administration of inactive IBR and iPPVO to cattle. It was aimed to investigate the immunomodulatory effects of inactivated parapoxvirus ovis (iPPVO) in cattle vaccinated with inactivated-IBR vaccine. In the study, 40 unvaccinated, clinically healthy cattle of different breeds aged older then 3 months were used. Three groups of cattle were formed as control group 1 (n=10), control group 2 (n=10) and experimental group (n=20). iPPVO was applied to the cattle in the control group 1 and experimental groups on the 0, 2nd, and 4th days. Blood samples were colleted from all the animals after 6th hours of the injections applied on 0th and 4th days of the study. Commercially available ELISA kits were used to determine serum levels of of IL-2, IL-6, IL-12 and IFN-γ. Furthermore, virus neutralization test was also performed to detect virus neutralizing antibody titres. In the present study, serum levels of IL-2, IL-6 IL-12, and IFN-γ levels were found to be significantly higher in the experimental group compared to that of the control group 1 and control group 2 (p<0,05). The differences between control group 1 and control group 2 groups were not statistically significant.
In conclusion, iPPVO increased the levels of cytokines in IBR vaccinated cattle due to its immunomodulatory effects. In addition, virüs neutralizing antibody titers were found to be significantly higher in cattle that received vaccine and iPPVO.

Keywords

Infectious Bovine Rhinotracheitis (IBR) inactive Parapoxvirus (iPPVO) immunomodulator cattle vaccination.

Supporting Institution

Scientific Research Projects Commission of Burdur Mehmet Akif Ersoy University

Project Number

0571-YL-19

Thanks

This work was supported by the Scientific Research Projects Commission of Burdur Mehmet Akif Ersoy University. (Project No: 0571-YL-19).

References

  • Alkan, F., Bilge-Dagalp, S., Karapınar, Z., Timurkan, M.O., Coskun, N., & Burgu, I. (2018). Long-term study (2005–2010) on the vaccination with BoHV-1 glycoprotein E-deleted marker vaccine in selected two dairy herds in Turkey. Tropical Animal Health and Production, 50(2), 353-363. https://doi.org/10.1007/s11250-017-1440-3
  • Anziliero, D., Weiblen, R., Kreutz, L.C., Spilki, F., & Flores, E.F. (2014). Inactivated Parapoxvirus ovis induces a transient increase in the expression of proinflammatory, Th1-related, and autoregulatory cytokines in mice. Brazilian journal of medical and biological research. 47(2), 110- 118. https://doi.org/10.1590/1414-431X20133358
  • Arai, K.I., Lee, F., Miyajima, A., Miyatake, S., Arai, N., & Yokota, T. (1990). Cytokines: coordinators of immune and inflammatory responses. Annual review of biochemistry. 59, 783-836. https://doi.org/10.1146/annurev.bi.59.070190.004031
  • Avci, O., Bulut, O., & Dik I. (2016). Effects of inactive parapoxvirus ovis on cytokine levels in rats. Journal of Veterinary Medical Science. 78(1), 129-131. https://doi.org/10.1292/jvms.15-0231
  • Coşkun, D. (2017). Veteriner Destek Tedavi: Tarantula Cubensis Alkolik Ekstraktı, İnaktif Parapoxvirüs Ovis ve Corynebacterium Cutis Lizatı. Dicle Üniversitesi Veteriner Fakültesi Dergisi.10(1), 30-37.
  • Dinarello, C.A. (2000). Proinflammatory cytokines. Chest. 118(2), 503-508. https://doi.org/10.1378/chest.118.2.503.
  • Dreismann, G.M. (2010). Effects of the homeopathic preparation Engystol® ad us. vet. on stress induced parameters in weaning foals. Tieraerztliche Umschau, 65(12), 484-490.
  • Duman, R., Yavru, S., Bulut, O., & Avcı, O. (2013). Sığırlarda Bovine Herpesvirus-1 Enfeksiyonlarının Enzyme-Linked Immunosorbent Assay ve Mikronötralizasyon Testi ile Karşılaştırmalı Tespiti. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 8(2), 129-136.
  • Frey, H.R., & Liess, B. (1971). Vermehrungskinetik und verwendbarkeit eines stark zytopatogenen VDMD-Virusstammes für diagnostische untersuchungen mit der Mikrotiter-Methode. Zentralblatt für Veterinärmedizin Reihe B. 18(1), 61-71. https://doi.org/10.1111/j.1439-0450.1971.tb00343.x Friebe, A., Siegling, A., Friederichs, S., Volk, H.D., & Weber, O. (2004). Immunomodulatory effects of inactivated parapoxvirus ovis (ORF virus) on human peripheral immune cells: induction of cytokine secretion in monocytes and Th1-like cells. Journal of Virology. 78(17), 9400–9411. https://doi.org/10.1128/jvi.78.17.9400-9411.2004
  • Horohov, D.W., Breathnach, C.C., Sturgill, T.L., Rashid, C., Stiltner, J.L., Strong, D., Nieman, N., & Holland, R.E. (2008). In vitro and in vivo modulation of the equine immune response by parapoxvirus ovis. Equine Veterinary Journal 40, 468-472. https://doi.org/10.2746/042516408X322111
  • Jones, C., & Chowdhury, S. (2010). Bovine herpes virus I (BHV-1) is an important cofactor in the bovine respiratory disease complex. The Veterinary Clinics of North America: Food Animal Practice. 26(2), 303-321. https://doi.org/10.1016/j.cvfa.2010.04.007
  • Kaeber, G. (1964). In Diagnostic Procedures For Virus And Rickettsial Disease. Public Health Association. 3, 48-50. Kook, I., Henley, C., Meyer, F., Hoffmann, F.G., & Jones, C. (2015). Bovine herpesvirus 1 productive infection and immediate early transcription unit 1 promoter are stimulated by the synthetic corticosteroid dexamethasone. Virology, 484, 377-385. https://doi.org/10.1016/j.virol.2015.06.010
  • Kyriakis, S.C., Tzika, E.D., Lyras, D.N., Tsinas, A.C., Saoulidis, K., & Sarris, K. (1998). Effect of an Inactivated Parapoxvirus Based Immunomodulator (Baypamun) on Post Weaning Diarrhoea Syndrome and Wasting Pig Syndrome of Piglets. Research in Veterinary Science. 64(3), 187-190. https://doi.org/10.1016/S0034-5288(98)90122-9
  • Ons, E., Van Brussel, L., Lane, S., King, V., Cullinane, A., Kenna, R., Lyons, P., Hammond, T.A., Salt, J., & Raue R. (2014). Efficacy of a Parapoxvirus ovis-based immunomodulator against equine herpesvirus type 1 and Streptococcus equi equi infections in horses. Veterinary Microbiology. 173(3-4), 232-240. https://doi.org/10.1016/j.vetmic.2014.07.015
  • Raaperi, K., Bougeard, S., Aleksejev, A., Orro, T., & Viltrop, A. (2012). Association of herd BRSV and BHV-1 seroprevalence with respiratory disease and reproductive performance in adult dairy cattle. Acta Veterinaria Scandinavica. 54, 4. https://doi.org/10.1186/1751-0147-54-4
  • Schütze, N., Raue, R., Buttner, M., & Alber, G. (2009): Inactivated parapoxvirus ovis activates canine blood phagocytes and T lymphocytes. Veterinary Microbiology. 137 (3-4): 260-267. https://doi.org/10.1016/j.vetmic.2009.01.035
  • Weber, O., Mercer, A.A., Friebe, A., Knolle, P., & Volk, H.D. (2013). Therapeutic immunomodulation using a virus-the potential of inactivated orf virus. European Society of Clinical Microbiolog. 32, 451‐460. https://doi.org/10.1007/s10096-012-1780-x
  • Weber, O., Siegling, A., Friebe, A., Limmer, A., Schlapp, T., Knolle, P., Mercer, A, Schaller, H., & Volk, H.D. (2003). Inactivated parapoxvirus ovis (Orf Virus) has antiviral activity against hepatitis B virus and herpes simplex virus. The Journal of general virology. 84(7), 1843-52. https://doi.org/10.1099/vir.0.19138-0
  • Winkler, M.T., Doster, A., & Jones, C. (2000). Persistence and reactivation of bovine herpesvirus 1 in the tonsils of latently infected calves. Journal of virology. 74, 5337-5346. https://doi.org/10.1128/jvi.74.11.5337-5346.2000
  • Yanbakan S. (2005). A comparative evaluation of bovine herpesvirus–1 infection by enzyme linked immunosorbent assay and serum neutralization test in Konya province. Hayvancılık Araştırma Dergisi. 15(1), 5-8.

Year 2023, Volume: 8 Issue: 3, 183 - 189, 31.12.2023

Süleyman Erbasan Nuri Mamak

https://doi.org/10.24880/maeuvfd.1310119

Abstract

Project Number

0571-YL-19

References

  • Alkan, F., Bilge-Dagalp, S., Karapınar, Z., Timurkan, M.O., Coskun, N., & Burgu, I. (2018). Long-term study (2005–2010) on the vaccination with BoHV-1 glycoprotein E-deleted marker vaccine in selected two dairy herds in Turkey. Tropical Animal Health and Production, 50(2), 353-363. https://doi.org/10.1007/s11250-017-1440-3
  • Anziliero, D., Weiblen, R., Kreutz, L.C., Spilki, F., & Flores, E.F. (2014). Inactivated Parapoxvirus ovis induces a transient increase in the expression of proinflammatory, Th1-related, and autoregulatory cytokines in mice. Brazilian journal of medical and biological research. 47(2), 110- 118. https://doi.org/10.1590/1414-431X20133358
  • Arai, K.I., Lee, F., Miyajima, A., Miyatake, S., Arai, N., & Yokota, T. (1990). Cytokines: coordinators of immune and inflammatory responses. Annual review of biochemistry. 59, 783-836. https://doi.org/10.1146/annurev.bi.59.070190.004031
  • Avci, O., Bulut, O., & Dik I. (2016). Effects of inactive parapoxvirus ovis on cytokine levels in rats. Journal of Veterinary Medical Science. 78(1), 129-131. https://doi.org/10.1292/jvms.15-0231
  • Coşkun, D. (2017). Veteriner Destek Tedavi: Tarantula Cubensis Alkolik Ekstraktı, İnaktif Parapoxvirüs Ovis ve Corynebacterium Cutis Lizatı. Dicle Üniversitesi Veteriner Fakültesi Dergisi.10(1), 30-37.
  • Dinarello, C.A. (2000). Proinflammatory cytokines. Chest. 118(2), 503-508. https://doi.org/10.1378/chest.118.2.503.
  • Dreismann, G.M. (2010). Effects of the homeopathic preparation Engystol® ad us. vet. on stress induced parameters in weaning foals. Tieraerztliche Umschau, 65(12), 484-490.
  • Duman, R., Yavru, S., Bulut, O., & Avcı, O. (2013). Sığırlarda Bovine Herpesvirus-1 Enfeksiyonlarının Enzyme-Linked Immunosorbent Assay ve Mikronötralizasyon Testi ile Karşılaştırmalı Tespiti. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 8(2), 129-136.
  • Frey, H.R., & Liess, B. (1971). Vermehrungskinetik und verwendbarkeit eines stark zytopatogenen VDMD-Virusstammes für diagnostische untersuchungen mit der Mikrotiter-Methode. Zentralblatt für Veterinärmedizin Reihe B. 18(1), 61-71. https://doi.org/10.1111/j.1439-0450.1971.tb00343.x Friebe, A., Siegling, A., Friederichs, S., Volk, H.D., & Weber, O. (2004). Immunomodulatory effects of inactivated parapoxvirus ovis (ORF virus) on human peripheral immune cells: induction of cytokine secretion in monocytes and Th1-like cells. Journal of Virology. 78(17), 9400–9411. https://doi.org/10.1128/jvi.78.17.9400-9411.2004
  • Horohov, D.W., Breathnach, C.C., Sturgill, T.L., Rashid, C., Stiltner, J.L., Strong, D., Nieman, N., & Holland, R.E. (2008). In vitro and in vivo modulation of the equine immune response by parapoxvirus ovis. Equine Veterinary Journal 40, 468-472. https://doi.org/10.2746/042516408X322111
  • Jones, C., & Chowdhury, S. (2010). Bovine herpes virus I (BHV-1) is an important cofactor in the bovine respiratory disease complex. The Veterinary Clinics of North America: Food Animal Practice. 26(2), 303-321. https://doi.org/10.1016/j.cvfa.2010.04.007
  • Kaeber, G. (1964). In Diagnostic Procedures For Virus And Rickettsial Disease. Public Health Association. 3, 48-50. Kook, I., Henley, C., Meyer, F., Hoffmann, F.G., & Jones, C. (2015). Bovine herpesvirus 1 productive infection and immediate early transcription unit 1 promoter are stimulated by the synthetic corticosteroid dexamethasone. Virology, 484, 377-385. https://doi.org/10.1016/j.virol.2015.06.010
  • Kyriakis, S.C., Tzika, E.D., Lyras, D.N., Tsinas, A.C., Saoulidis, K., & Sarris, K. (1998). Effect of an Inactivated Parapoxvirus Based Immunomodulator (Baypamun) on Post Weaning Diarrhoea Syndrome and Wasting Pig Syndrome of Piglets. Research in Veterinary Science. 64(3), 187-190. https://doi.org/10.1016/S0034-5288(98)90122-9
  • Ons, E., Van Brussel, L., Lane, S., King, V., Cullinane, A., Kenna, R., Lyons, P., Hammond, T.A., Salt, J., & Raue R. (2014). Efficacy of a Parapoxvirus ovis-based immunomodulator against equine herpesvirus type 1 and Streptococcus equi equi infections in horses. Veterinary Microbiology. 173(3-4), 232-240. https://doi.org/10.1016/j.vetmic.2014.07.015
  • Raaperi, K., Bougeard, S., Aleksejev, A., Orro, T., & Viltrop, A. (2012). Association of herd BRSV and BHV-1 seroprevalence with respiratory disease and reproductive performance in adult dairy cattle. Acta Veterinaria Scandinavica. 54, 4. https://doi.org/10.1186/1751-0147-54-4
  • Schütze, N., Raue, R., Buttner, M., & Alber, G. (2009): Inactivated parapoxvirus ovis activates canine blood phagocytes and T lymphocytes. Veterinary Microbiology. 137 (3-4): 260-267. https://doi.org/10.1016/j.vetmic.2009.01.035
  • Weber, O., Mercer, A.A., Friebe, A., Knolle, P., & Volk, H.D. (2013). Therapeutic immunomodulation using a virus-the potential of inactivated orf virus. European Society of Clinical Microbiolog. 32, 451‐460. https://doi.org/10.1007/s10096-012-1780-x
  • Weber, O., Siegling, A., Friebe, A., Limmer, A., Schlapp, T., Knolle, P., Mercer, A, Schaller, H., & Volk, H.D. (2003). Inactivated parapoxvirus ovis (Orf Virus) has antiviral activity against hepatitis B virus and herpes simplex virus. The Journal of general virology. 84(7), 1843-52. https://doi.org/10.1099/vir.0.19138-0
  • Winkler, M.T., Doster, A., & Jones, C. (2000). Persistence and reactivation of bovine herpesvirus 1 in the tonsils of latently infected calves. Journal of virology. 74, 5337-5346. https://doi.org/10.1128/jvi.74.11.5337-5346.2000
  • Yanbakan S. (2005). A comparative evaluation of bovine herpesvirus–1 infection by enzyme linked immunosorbent assay and serum neutralization test in Konya province. Hayvancılık Araştırma Dergisi. 15(1), 5-8.
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Details

Primary Language English
Subjects Veterinary Sciences (Other)
Journal Section Research Articles
Authors

Süleyman Erbasan 0009-0009-4957-3276

Nuri Mamak 0000-0001-9752-9709

Project Number 0571-YL-19
Publication Date December 31, 2023
Submission Date June 5, 2023
Published in Issue Year 2023 Volume: 8 Issue: 3

Cite

APA Erbasan, S., & Mamak, N. (2023). Investigation of the immunomodulatory effect of inactive parapoxvirus (iPPVO) on infectious bovine rhinotracheitis (IBR) vaccine in cattle. Veterinary Journal of Mehmet Akif Ersoy University, 8(3), 183-189. https://doi.org/10.24880/maeuvfd.1310119
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