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5,5'-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1YL)METHYL]-4-ETHYL2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} MANNICH BAZININ FARELERİN BÖBREK, KARACİĞER VE SERUMLARINDAKİ MDA VE VİTAMİN DÜZEYLERİNE ETKİSİ

Year 2015, , 29 - 36, 07.04.2015

Akif Parlak Sait Çelik Mustafa Karatepe Metin Koparır

https://doi.org/10.12739/NWSA.2015.10.2.3A0070

Abstract

1,2,4-triazol ve türevlerinin çeşitli farmakolojik aktivite gösterdiği bildirilmiştir. Mannich bazlar antibakteriyel, antienflamatuar, antifungal, sıtma ve pestisit özellikleri gibi güçlü biyolojik aktivitelere sahiptir. Mannich bazları türevleri daha önce bildirildiği gibi yeniden sentezlendi[1]. Bu çalışmada, bis-1,2,4 – triazol içeren bir Mannich bazı bileşiğinin farelerin serum, karaciğer ve böbreklerindeki malondialdehit (MDA) ve antioksidan vitaminler (A,E,C) seviyelerine olan etkileri incelendi. Malondialdehit düzeyi ve vitaminler HPLC tarafından belirlendi. Bileşik kontrol ile karşılaştırıldığında iyi aktivite gösterdi.

Keywords

1,2,4- Triazol Mannich Baz Vitamin Serum Karaciğer Böbrek Fare

References

  • Koparır, M., (2013). Synthesis and Biological Activities of Some New Mannich Bases of 5,5_-Butane-1,4-diylbis[4-ethyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones. Chem Sci Trans., 2(3), 701-710, http://www.e-journals.in/PDF/V2N3/701-710.pdf (2015).
  • Hazra, K.G., Nargund, L.V., Rashmi, P., Chandraa, J.N., Narendra, S. and Nandha, B,. (2011). "Synthesis of Some Novel 2H-[1,3,5]thiadiazino[4,3-b][1,3]benzothiazole-3,3-dioxideby [4+2] Diels--Alder Cycloaddition Reaction as Antioxidant Agents", Journal of Pharmacy Research.
  • Wahi, A.K., and Singh, A., (2011). Triazole: Recent development and biological activities. Asian Journal of Biochemical and Pharmaceutical Research; 1(2): 193-205.
  • Legrand, C., Ropaa, P., Vulturescu, B., Hogeac, A.M., Surpateanu, G.G., Cazier, F., Woisel, P. and Surpateanu, G., (2005). Progress in Organic Coatings, 53, 106-111.
  • Ewiss, N.F., Bahajaj, A.A., and Elsherbini, E.A., (1986). J Heterocycl Chem., 23, 1451-1458.
  • Eweiss, N.F. and Bahajaj, A.A., (1987). J Heterocycl Chem.,24, 1173.
  • Prasad, A., Ramalingam, R.J., Rao, A.B., Diwan, P.V., and Sattur, P.B., (1989). Eur J Med Chem., 24, 199-201.
  • Lopes, F., Capela, R., Goncaves, J.O., Horton, P.N., Hursthouse, M. B., Iley, J., Casimiro, C.M., Bom, J. and Moreire, R., (2004). Tetrahedron Lett, 45, 7663-7666.
  • Sriram, D., Bal, T.R. and Yogeesswari, P., (2005). Med Chem Res., 14, 11-28.
  • Knabe, J., Buch, H.P., and Schmitt, W., 1983). Arch Pharm Chem Life Sci., (316, 1051- 1053.
  • Varvaresou, A., Tsantili-Kakoulidou, A., Siatra-Papastaikoudi, T., et al., (2000). Arzneimittel for schung 50, 48.
  • Cesur, N., Birteksöz, S. ve Ötük, G., (2002). Acta Pharm Turcica, 44, 23.
  • Yue, K.K., (2003). “Redox changes precede the occurrence of oxidative stress in eyes and aorta, but not in kidneys of diabetic rats”, Life Sciences, 1003.
  • Karahan, I., (2010). "The relations of antioxidant vitamins A, E, and C with MDA levels in serum and liver of rats treated with nitrosamines", Toxicological and Environmental Chemistry.
  • Cetinkaya, N. ve Ozcan, H., (1991). Comp Biochem Physiol A Comp Physiol; 8,100:1003.
  • Karatepe, M., (2004).LC-GC North America. 22,362-5.
  • Catignani, G.L., (1983). Clin. Chem., 2914, 708-712.
  • Henning, S.M., Swendseid, M.E., Ivandic, B.T., and Liao, F., (1997). Free Radic. Biol.Med., 23(6):936-42.
  • Anoopkumar-Dukie, S., Walker, RB., Daya, S.A., (2001). J Pharm Pharmacol; 53: 263-6.
  • Cordis, GA., Das, D.K., Riedel, W., (1998). J Chromatogr A; 798: 117-23.
  • Templar, J., Kon, S.P., Milligan, T.P., Newman, D.J., Raftery M.J., (1999). Neprol Dial Transplant; 14: 946-51.
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  • Pilz, J., Meineke, I., Gleiter, C.H., (2000). J Chromatogr B Biomed Sci Appl; 742: 315-25.
  • Dib, M., Garrel, C., Favier, A., Robin, V., and Desnuelle, C., (2002). J Neurol; 249: 367-74.
  • Verbunt, R.J., and Egas, J.M., (1996). A Van der Laarse. Cardiovasc Res; 31: 603-6,
  • Albers, D.S., Augood, S.J., Martin, D.M., Standaert, D.G., Vonsatte, J.P., Beal, M.F., (1999). J Neurochem; 73: 881-4.
  • Tanumihardjo, S.A., (2011). The American Journal of Clinical Nutrition 94 (2): 658S–665S.
  • Slater, T.F., (1978). In Biochemical Mechanisms of Liver Injury 745–801.
  • Tüközkan, N., Erdamar, H. ve Seven, I., (2006). Measurement of To-tal Malondialdehyde in Plasma and Tissues by High-Performance Liquid Chromatography and Thiobarbituric Acid Assay 11, Sayı 2, 088-092,http://www.firattipdergisi.com/text.php3?id=334 (2015).
  • Turkoglu, S., Parlak, A.E., Yildirim, I., Karagozoglu, Y. and Alayunt, N.O., (2014). The effects hydroxyurea derivative schiff bases on fatty acids and lypophilic vitamins in liver of rats, D. J. of N. and B. Vol. 9, No. 1, 159 – 165.
  • Packer, J.E., Slater, T.F., and Willson, R.L., (1979). Direct observation of a free radical interaction between vitamin E and vi-tamin CNature 278, 737 - 738 doi:10.1038/278737a0 http://www.nature.com/nature/journal/v278/n5706/abs/278737a0.html(2015).
  • Karagozoglu, Y., Turkoglu, S., Parlak, A.E., ve Alayunt, N.O., (2013). The effects of hydroxyurea derivative 1, 3, 4- thiadiazoles on serum biochemical parameters and antioxidant status in liver of rats digest journal of nanomaterials and biostructures vol. 8, no. 1, 247 - 253 http://www.chalcogen.ro/247_Turkoglu.pdf (2015).
  • Keser, S., Erman, O., Yılmaz, O., Irtegun, S. and Tuzcu, M., (2012). "Effects of antioxidants resveratrol, catechin and lipoic acid and carcinogen kbro3 on lipophylic vitamins and cholesterol in lung, liver and kidney of wistar rats", Kafkas Univ Vet Fak Dergi-si, 18 (3), 367-372.

THE EFFECTS OF 5,5'-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS

Year 2015, , 29 - 36, 07.04.2015

Akif Parlak Sait Çelik Mustafa Karatepe Metin Koparır

https://doi.org/10.12739/NWSA.2015.10.2.3A0070

Abstract

The 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities. Mannich bases possess potent biological advantages due to being antibacterial, antifungal, antiinflammatory, antimalarial and. They also have pesticide properties. As previously reported, Mannich bases derivatives were synthesized [1]. In this study, the effects of newly synthesized a Mannich base compound which contain bis-1,2,4– triazole on the level of malondialdehyde (MDA) and antioxidant vitamins (A,E,C) of the serum, liver and kidney of rats have been investigated. Besides, the level of malondialdehyde and vitamins has been determined by HPLC. Compared to the control group, the compound showed satisfactory performance

Keywords

1 2 4- Triazole Mannich Bases Vitamin Serum Kidney Liver Rat

References

  • Koparır, M., (2013). Synthesis and Biological Activities of Some New Mannich Bases of 5,5_-Butane-1,4-diylbis[4-ethyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones. Chem Sci Trans., 2(3), 701-710, http://www.e-journals.in/PDF/V2N3/701-710.pdf (2015).
  • Hazra, K.G., Nargund, L.V., Rashmi, P., Chandraa, J.N., Narendra, S. and Nandha, B,. (2011). "Synthesis of Some Novel 2H-[1,3,5]thiadiazino[4,3-b][1,3]benzothiazole-3,3-dioxideby [4+2] Diels--Alder Cycloaddition Reaction as Antioxidant Agents", Journal of Pharmacy Research.
  • Wahi, A.K., and Singh, A., (2011). Triazole: Recent development and biological activities. Asian Journal of Biochemical and Pharmaceutical Research; 1(2): 193-205.
  • Legrand, C., Ropaa, P., Vulturescu, B., Hogeac, A.M., Surpateanu, G.G., Cazier, F., Woisel, P. and Surpateanu, G., (2005). Progress in Organic Coatings, 53, 106-111.
  • Ewiss, N.F., Bahajaj, A.A., and Elsherbini, E.A., (1986). J Heterocycl Chem., 23, 1451-1458.
  • Eweiss, N.F. and Bahajaj, A.A., (1987). J Heterocycl Chem.,24, 1173.
  • Prasad, A., Ramalingam, R.J., Rao, A.B., Diwan, P.V., and Sattur, P.B., (1989). Eur J Med Chem., 24, 199-201.
  • Lopes, F., Capela, R., Goncaves, J.O., Horton, P.N., Hursthouse, M. B., Iley, J., Casimiro, C.M., Bom, J. and Moreire, R., (2004). Tetrahedron Lett, 45, 7663-7666.
  • Sriram, D., Bal, T.R. and Yogeesswari, P., (2005). Med Chem Res., 14, 11-28.
  • Knabe, J., Buch, H.P., and Schmitt, W., 1983). Arch Pharm Chem Life Sci., (316, 1051- 1053.
  • Varvaresou, A., Tsantili-Kakoulidou, A., Siatra-Papastaikoudi, T., et al., (2000). Arzneimittel for schung 50, 48.
  • Cesur, N., Birteksöz, S. ve Ötük, G., (2002). Acta Pharm Turcica, 44, 23.
  • Yue, K.K., (2003). “Redox changes precede the occurrence of oxidative stress in eyes and aorta, but not in kidneys of diabetic rats”, Life Sciences, 1003.
  • Karahan, I., (2010). "The relations of antioxidant vitamins A, E, and C with MDA levels in serum and liver of rats treated with nitrosamines", Toxicological and Environmental Chemistry.
  • Cetinkaya, N. ve Ozcan, H., (1991). Comp Biochem Physiol A Comp Physiol; 8,100:1003.
  • Karatepe, M., (2004).LC-GC North America. 22,362-5.
  • Catignani, G.L., (1983). Clin. Chem., 2914, 708-712.
  • Henning, S.M., Swendseid, M.E., Ivandic, B.T., and Liao, F., (1997). Free Radic. Biol.Med., 23(6):936-42.
  • Anoopkumar-Dukie, S., Walker, RB., Daya, S.A., (2001). J Pharm Pharmacol; 53: 263-6.
  • Cordis, GA., Das, D.K., Riedel, W., (1998). J Chromatogr A; 798: 117-23.
  • Templar, J., Kon, S.P., Milligan, T.P., Newman, D.J., Raftery M.J., (1999). Neprol Dial Transplant; 14: 946-51.
  • Slatter, D.A., Bolton, C.H., Diabetologia, A.J., (2000). 43: 550-7.
  • Pilz, J., Meineke, I., Gleiter, C.H., (2000). J Chromatogr B Biomed Sci Appl; 742: 315-25.
  • Dib, M., Garrel, C., Favier, A., Robin, V., and Desnuelle, C., (2002). J Neurol; 249: 367-74.
  • Verbunt, R.J., and Egas, J.M., (1996). A Van der Laarse. Cardiovasc Res; 31: 603-6,
  • Albers, D.S., Augood, S.J., Martin, D.M., Standaert, D.G., Vonsatte, J.P., Beal, M.F., (1999). J Neurochem; 73: 881-4.
  • Tanumihardjo, S.A., (2011). The American Journal of Clinical Nutrition 94 (2): 658S–665S.
  • Slater, T.F., (1978). In Biochemical Mechanisms of Liver Injury 745–801.
  • Tüközkan, N., Erdamar, H. ve Seven, I., (2006). Measurement of To-tal Malondialdehyde in Plasma and Tissues by High-Performance Liquid Chromatography and Thiobarbituric Acid Assay 11, Sayı 2, 088-092,http://www.firattipdergisi.com/text.php3?id=334 (2015).
  • Turkoglu, S., Parlak, A.E., Yildirim, I., Karagozoglu, Y. and Alayunt, N.O., (2014). The effects hydroxyurea derivative schiff bases on fatty acids and lypophilic vitamins in liver of rats, D. J. of N. and B. Vol. 9, No. 1, 159 – 165.
  • Packer, J.E., Slater, T.F., and Willson, R.L., (1979). Direct observation of a free radical interaction between vitamin E and vi-tamin CNature 278, 737 - 738 doi:10.1038/278737a0 http://www.nature.com/nature/journal/v278/n5706/abs/278737a0.html(2015).
  • Karagozoglu, Y., Turkoglu, S., Parlak, A.E., ve Alayunt, N.O., (2013). The effects of hydroxyurea derivative 1, 3, 4- thiadiazoles on serum biochemical parameters and antioxidant status in liver of rats digest journal of nanomaterials and biostructures vol. 8, no. 1, 247 - 253 http://www.chalcogen.ro/247_Turkoglu.pdf (2015).
  • Keser, S., Erman, O., Yılmaz, O., Irtegun, S. and Tuzcu, M., (2012). "Effects of antioxidants resveratrol, catechin and lipoic acid and carcinogen kbro3 on lipophylic vitamins and cholesterol in lung, liver and kidney of wistar rats", Kafkas Univ Vet Fak Dergi-si, 18 (3), 367-372.
There are 33 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Chemistry
Authors

Akif Parlak This is me

Sait Çelik

Mustafa Karatepe

Metin Koparır

Publication Date April 7, 2015
Published in Issue Year 2015

Cite

APA Parlak, A., Çelik, S., Karatepe, M., Koparır, M. (2015). THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS. Physical Sciences29-36. https://doi.org/10.12739/NWSA.2015.10.2.3A0070
AMA Parlak A, Çelik S, Karatepe M, Koparır M. THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS. Physical Sciences. Published online April 1, 2015:29-36. doi:10.12739/NWSA.2015.10.2.3A0070
Chicago Parlak, Akif, Sait Çelik, Mustafa Karatepe, and Metin Koparır. “THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS”. Physical Sciences, April (April 2015), 29-36. https://doi.org/10.12739/NWSA.2015.10.2.3A0070.
EndNote Parlak A, Çelik S, Karatepe M, Koparır M (April 1, 2015) THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS. Physical Sciences 29–36.
IEEE A. Parlak, S. Çelik, M. Karatepe, and M. Koparır, “THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS”, Physical Sciences, pp. 29–36, April 2015, doi: 10.12739/NWSA.2015.10.2.3A0070.
ISNAD Parlak, Akif et al. “THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS”. Physical Sciences. April 2015. 29-36. https://doi.org/10.12739/NWSA.2015.10.2.3A0070.
JAMA Parlak A, Çelik S, Karatepe M, Koparır M. THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS. Physical Sciences. 2015;:29–36.
MLA Parlak, Akif et al. “THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS”. Physical Sciences, 2015, pp. 29-36, doi:10.12739/NWSA.2015.10.2.3A0070.
Vancouver Parlak A, Çelik S, Karatepe M, Koparır M. THE EFFECTS OF 5,5’-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS. Physical Sciences. 2015:29-36.