THE EFFECTS OF 5,5'-BUTANE-1,4-DIYLBIS[4-ALLYL-2-({4-[3- (TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL}METHYL)- 2,4-DIHYDRO-3H-1,2,4- TRIAZOLE-3-THIONE] COMPOUND ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS
Abstract
The 1,2,4-triazole along with its derivatives were reported to exhibit various pharmacological activities [1]. 1,2,4-triazole moieties have been incorporated into a wide variety of therapeutically interesting drug candidates, including anti-inflammatories, CNS stimulants, sedatives, anti-anxiety compounds, antimicrobial agents, as well as anti-mycotic ones such as fluconazole, intraconazole andvoriconazole [2]. As previously reported, Aminomethyl derivatives were synthesized. In this study, the effects of newly synthesized bis1,2,4-triazole containing aminomethyl derivatives on the level of malondialdehyde(MDA)and antioxidant vitamins (A,E,C) of the serum, liver and kidney of rats have been investigated. In addition, level of malondialdehyde (MDA) and vitamins (A,E,C) has been determined by HPLC [3]. Most of the compounds showed satisfactory performance when compared to the control group [4]
Keywords
References
- Koparir, M., (2013). Synthesis and Biological Activities of Some New Mannich Bases of 5,5_-Butane-1,4-diylbis[4-ethyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones. Chem Sci Trans., 2(3), 701-710, http://www.e-journals.in/PDF/V2N3/701-710.pdf (2015).
- Karegoudar, P., (2008). Synthesis, Antimicrobial and Anti-Inflammatory Activities of Some 1,2,4-triazolo[3,4-b][1,3,4] Thia-diazoles and 1,2,4-triazolo[3,4-b][1,3,4] Thiadiazines bearing Trichlorophenyl Moiety, European Journal of Medicinal Chemistry.
- Karahan, I., (2010).The Relations of Antioxidant Vitamins A, E, and C with MDA Levels in Serum and Liver of Rats Treated with Nit-rosamines, Toxicological and Environmental Chemistry.
- Tae-Hyun, Y., Dong-Hoon, L., Seung-Gun, W., Chang-Six, R., and Je-ong-Dae, K., (2014). Effects of Dietary Supplementation of Magne-sium Hydrogen Phosphate (MgHP[O.sub.4]) as an Alternative Phospho-rus Source on Growth and Feed Utilization of Juvenile Far Eastern Catfish (Silurusasotus)., http://www.thefreelibrary.com/Effects+of+dietary+supplementation+of+magnesium+hydrogen+phosphate...-a0376272733.
- Heindel, N.D. and Reid, J.R., (1980). J Heterocycl Chem., 17, 1087-1088.
- Holla, B.S., Kalluraya, B., Sridhar, K.R., Drake, E., Thomas, L.M., Bhandary, K.K., and Levine, M.S., (1994). Eur J Med Chem., 29(4), 301-306.
- Mathew, V., Keshavayya, J., Vidya, V.P., Acharya, and Reddy, B.M., (2006). Eur J Med Chem., 41(9), 1048-1058.
- The Merck Index, (1996). 12rd Ed., Merck Co. Inc., USA.
- Haber, J.,( 2001).Cas Lek Cesk, 140, 596-604.
- Li, N.H., 1988. X-Ray Crystallographic Studies of a 4-Demethoxythiodaunomycinone Derivative and 1,2,4-triazole, FGS Electronic, Theses & Dissertations, (Public), http://mspace.lib.umanitoba.ca/handle/1993/16753(2015).
- Turkoglu, S., Parlak, A.E., Yildirim, I., Karagozoglu, Y., and Alayunt, N.O., (2014). The Effects Hydroxyurea Derivative Schiff Bases on Fatty Acids and Lypophilic Vitamins in Liver of Rats, D. J. of N. and B. Vol. 9, No. 1, 159–165.
- Ebrahımı, S., (2010). Synthesis of Some Pyridyl and Cyclohexyl Substituted 1,2,4-Triazole, 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Derivatives. European Journal of Chemistry, 322-324,. Available at: <http://www.eurjchem.com/index.php/eurjchem/article/view/65>. Date accessed: 2015. doi:http://dx.doi.org/10.5155/eurjchem.1.4.322-324.65(2015).
- Keser, S., Erman, O., Yılmaz, O., Irtegun, S., and Tuzcu, M., (2012). Effects of Antioxidants Resveratrol, Catechin and Lipoic Acid and Carcinogen Kbro3 on Lipophylic Vitamins and Cholesterol İn Lung, Liver and Kidney of Wistar Rats, TUBITAK.
- Varvaresou, A., Tsantili-Kakoulidou, A., Siatra-Papastaikoudi, T. et al, (2000). Arzneimittelforschung 50, 48.
- Karagozoglu, Y., Turkoglu, S., Parlak, A.E., and Alayunt, N.O., (2013). The effects of Hydroxyurea Derivative 1,3,4- Thiadiazoles on Serum Biochemical Parameters and Antioxidant Status In Liver of Rats Digest. Journal of Nanomaterials and Biostructures, Vol.:8, No:1, 247–253. http://www.chalcogen.ro/247_Turkoglu.pdf(2015).
- Cesur, N., Birteksöz, S., and Ötük, G., (2013). Acta Pharm Turcica 44, 23 (2002).
- Özkaya, A., Çelik, S., Yüce, A., Şahin, Z., and Yılmaz, Ö., (2010). The Effects of Ellagic Acid on Some Biochemical Parameters in the Liver of Rats Against Oxidative Stress Induced by Aluminum, Kafkas Üniversitesi.
- Koparır, M. and Orek, C., (2013). Chem Sci Trans., 2(S1),181-191.
- Stanger, O., (2002). Physiology of Folic Acid in Health and Disea-se , Current Drug Metabolism.
- Jalali, S., (2013). Boskabady, M.H., Haeri-Rohani, A., and Eidi, A., The Effect of Carvacrol on Serum Cytokines and Endothelin Le-vels of Ovalbumin Sensitized Guinea-Pigs, Iranian Journal of Basic Medical Sciences,.
- Cetinkaya, N. and Ozcan, H., (1991). Comp Biochem Physiol A Comp Physiol; 8,100:1003.
- Karatepe, M., (2004). LC-GC North America. 22,362-5.
- Catignani, G.L., (1983). Clin. Chem., 2914,708-712.
- Henning, S.M., Swendseid, M.E., and Ivandic, B.T., (1997). F. Liao, Free Radic. Biol.Med., 23(6):936-42.
- WHO Drug Information, (2003). International Nonproprietary Names for Pharmaceutical Substances (INN).
- Zhou, Y., Yiwen Q., Junlin, H., Xuemei. C., Yubing. D., Yingxiong W., and Xueqing. L., (2013). The Toxicity Mechanism of Sodium Flu-oride on Fertility in Female Rats, Food and Chemical Toxicology.
- Bilginoğlu, A., Aydın, D., Özsoy, Ş., and Aygün, H., (2014). Pro-tective Effect of Melatonin on Adriamycin-Induced Cardiotoxicity in Rats, Türk Kardiyoloji Derneği.
- Tecco, S., (2005). Evaluation of Cervical Spine Posture After Functional Therapy with FR-2: A Longitudinal Study, CRANIO: The Journal of Craniomandibular Practice.
5,5'-BÜTAN-1,4-DIILBIS[4-ALLIL-2-({4-[3 (TRIFLOROMETIL)FENIL]PIPERAZIN-1-IL}METIL)-2,4-DIHIDRO-3H-1,2,4- TRIAZOL-3-TIYON BİLEŞİĞİNİN FARELERİN BÖBREK, KARACİĞER VE SERUMLARINDAKİ MDA VE VİTAMİN DÜZEYLERİNE ETKİSİ
Abstract
1,2,4-triazol türevleri çeşitli farmakolojik aktivite gösterdikleri bilinmektedir. flukonazol, intraconazole, vorikonazol gibi 1,2,4-triazol türevleri içeren kısımlar çeşitli uyuşturucu ve
terapötik ilaçlar da dahil olmak üzere anti-enflamatuar, CNS uyarıcılar, yatıştırıcılar, sakinleştirici maddeler, antibiyotik antimikotik etkilere sahiptir. Kullanılan aminometil türevi daha önce bildirildiği gibi yeniden sentezlendi. Bu çalışmada, yeni sentezlenmiş bis-1,2,4-triazol içeren aminometil türevi bileşik rat serum, karaciğer ve böbrek dokularında malondialdehit(MDA)ve antioksidan vitamin (A,E,C)düzeyleri incelendi. Malondialdehit düzeyi (MDA) ve vitaminler (A,E,C) HPLC cihazı kullanılarak belirlendi. L bileşiği kontrol ile karşılaştırıldığında iyi aktivite gösterdiği belirlendi.
Keywords
1 2 4 - Triazole Vitamin Serum Aminometil Türevi Karaciğer Böbrek Fare
References
- Koparir, M., (2013). Synthesis and Biological Activities of Some New Mannich Bases of 5,5_-Butane-1,4-diylbis[4-ethyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones. Chem Sci Trans., 2(3), 701-710, http://www.e-journals.in/PDF/V2N3/701-710.pdf (2015).
- Karegoudar, P., (2008). Synthesis, Antimicrobial and Anti-Inflammatory Activities of Some 1,2,4-triazolo[3,4-b][1,3,4] Thia-diazoles and 1,2,4-triazolo[3,4-b][1,3,4] Thiadiazines bearing Trichlorophenyl Moiety, European Journal of Medicinal Chemistry.
- Karahan, I., (2010).The Relations of Antioxidant Vitamins A, E, and C with MDA Levels in Serum and Liver of Rats Treated with Nit-rosamines, Toxicological and Environmental Chemistry.
- Tae-Hyun, Y., Dong-Hoon, L., Seung-Gun, W., Chang-Six, R., and Je-ong-Dae, K., (2014). Effects of Dietary Supplementation of Magne-sium Hydrogen Phosphate (MgHP[O.sub.4]) as an Alternative Phospho-rus Source on Growth and Feed Utilization of Juvenile Far Eastern Catfish (Silurusasotus)., http://www.thefreelibrary.com/Effects+of+dietary+supplementation+of+magnesium+hydrogen+phosphate...-a0376272733.
- Heindel, N.D. and Reid, J.R., (1980). J Heterocycl Chem., 17, 1087-1088.
- Holla, B.S., Kalluraya, B., Sridhar, K.R., Drake, E., Thomas, L.M., Bhandary, K.K., and Levine, M.S., (1994). Eur J Med Chem., 29(4), 301-306.
- Mathew, V., Keshavayya, J., Vidya, V.P., Acharya, and Reddy, B.M., (2006). Eur J Med Chem., 41(9), 1048-1058.
- The Merck Index, (1996). 12rd Ed., Merck Co. Inc., USA.
- Haber, J.,( 2001).Cas Lek Cesk, 140, 596-604.
- Li, N.H., 1988. X-Ray Crystallographic Studies of a 4-Demethoxythiodaunomycinone Derivative and 1,2,4-triazole, FGS Electronic, Theses & Dissertations, (Public), http://mspace.lib.umanitoba.ca/handle/1993/16753(2015).
- Turkoglu, S., Parlak, A.E., Yildirim, I., Karagozoglu, Y., and Alayunt, N.O., (2014). The Effects Hydroxyurea Derivative Schiff Bases on Fatty Acids and Lypophilic Vitamins in Liver of Rats, D. J. of N. and B. Vol. 9, No. 1, 159–165.
- Ebrahımı, S., (2010). Synthesis of Some Pyridyl and Cyclohexyl Substituted 1,2,4-Triazole, 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Derivatives. European Journal of Chemistry, 322-324,. Available at: <http://www.eurjchem.com/index.php/eurjchem/article/view/65>. Date accessed: 2015. doi:http://dx.doi.org/10.5155/eurjchem.1.4.322-324.65(2015).
- Keser, S., Erman, O., Yılmaz, O., Irtegun, S., and Tuzcu, M., (2012). Effects of Antioxidants Resveratrol, Catechin and Lipoic Acid and Carcinogen Kbro3 on Lipophylic Vitamins and Cholesterol İn Lung, Liver and Kidney of Wistar Rats, TUBITAK.
- Varvaresou, A., Tsantili-Kakoulidou, A., Siatra-Papastaikoudi, T. et al, (2000). Arzneimittelforschung 50, 48.
- Karagozoglu, Y., Turkoglu, S., Parlak, A.E., and Alayunt, N.O., (2013). The effects of Hydroxyurea Derivative 1,3,4- Thiadiazoles on Serum Biochemical Parameters and Antioxidant Status In Liver of Rats Digest. Journal of Nanomaterials and Biostructures, Vol.:8, No:1, 247–253. http://www.chalcogen.ro/247_Turkoglu.pdf(2015).
- Cesur, N., Birteksöz, S., and Ötük, G., (2013). Acta Pharm Turcica 44, 23 (2002).
- Özkaya, A., Çelik, S., Yüce, A., Şahin, Z., and Yılmaz, Ö., (2010). The Effects of Ellagic Acid on Some Biochemical Parameters in the Liver of Rats Against Oxidative Stress Induced by Aluminum, Kafkas Üniversitesi.
- Koparır, M. and Orek, C., (2013). Chem Sci Trans., 2(S1),181-191.
- Stanger, O., (2002). Physiology of Folic Acid in Health and Disea-se , Current Drug Metabolism.
- Jalali, S., (2013). Boskabady, M.H., Haeri-Rohani, A., and Eidi, A., The Effect of Carvacrol on Serum Cytokines and Endothelin Le-vels of Ovalbumin Sensitized Guinea-Pigs, Iranian Journal of Basic Medical Sciences,.
- Cetinkaya, N. and Ozcan, H., (1991). Comp Biochem Physiol A Comp Physiol; 8,100:1003.
- Karatepe, M., (2004). LC-GC North America. 22,362-5.
- Catignani, G.L., (1983). Clin. Chem., 2914,708-712.
- Henning, S.M., Swendseid, M.E., and Ivandic, B.T., (1997). F. Liao, Free Radic. Biol.Med., 23(6):936-42.
- WHO Drug Information, (2003). International Nonproprietary Names for Pharmaceutical Substances (INN).
- Zhou, Y., Yiwen Q., Junlin, H., Xuemei. C., Yubing. D., Yingxiong W., and Xueqing. L., (2013). The Toxicity Mechanism of Sodium Flu-oride on Fertility in Female Rats, Food and Chemical Toxicology.
- Bilginoğlu, A., Aydın, D., Özsoy, Ş., and Aygün, H., (2014). Pro-tective Effect of Melatonin on Adriamycin-Induced Cardiotoxicity in Rats, Türk Kardiyoloji Derneği.
- Tecco, S., (2005). Evaluation of Cervical Spine Posture After Functional Therapy with FR-2: A Longitudinal Study, CRANIO: The Journal of Craniomandibular Practice.
Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Chemistry |
| Authors | |
| Publication Date | April 7, 2015 |
| Published in Issue | Year 2015 |