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Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children with Rotavirus Diagnosis

Year 2023, Volume: 12 Issue: 3, 41 - 44, 27.09.2023
https://doi.org/10.46810/tdfd.1306898

Abstract

Aim: This study aims to evaluate glucose, AST, ALT, urea and albumin parameters in patients diagnosed with rotavirus.
Materials and Methods: Children who applied to Şırnak State Hospital Pediatrics Polyclinics (6 months to 18 years of age), whose fecal samples were sent to the laboratory by the pediatrician considering the diagnosis of rotavirus, and whose microbiological examinations were confirmed by immunochromatographic methods (6 months to 18 years), were included in the study by scanning the system.
Results: When the mean ages of glucose, ALT, AST, urea, and albumin data of the rotavirus negative group were evaluated, they were found to be 1.82±2.66, 1.77±2.72, 1.76±2.72, 1.69±2.68, 1.87±2.88, respectively. and in rotavirus positives, respectively; It was found to be 1.16±1.35, 1.09±1.31, 1.09±1.31, 1.10±1.32, 1.11±1.30. While the median values of glucose, AST, ALT, urea and albumin in rotavirus negatives were 84 mg/dl, 36 U/L, 19 U/L, 14 mg/dL, 3.79 g/dL, respectively, the median values in rotavirus positives were 75 mg, respectively. /dL, 45 U/L, 26 U/L, 18 mg/dL, 3.98 g/dL were detected. All parameters were statistically significant (p<0.01).
Conclusion: We think that laboratory parameters (glucose, AST, ALT, urea and albumin) in gastroenteritis due to rotavirus should definitely be evaluated in determining the prognosis of patients with rotavirus diagnosis.

Thanks

We would like to thank Child Health Specialist Dr. Erhan SÖNMEZ for her data contribution to the study

References

  • [1] Lundgren O, Svensson L. Pathogenesis of rotavirus diarrhea. Microbes Infect. 2001;3(13):1145-1156.
  • [2] Crawford SE, Ramani S, Tate JE, Parashar UD, Svensson L, Hagbom M, et al. Rotavirus infection. Nat Rev Dis Primers. 2017; 3:17083.
  • [3] Marchetti F, Lamiani G, Bona M, Amerighi C, Ruffato B, Conforti G. Developing communication tools on rotavirus vaccination to support family paediatricians in Italy. Vaccine. 2022;40(49):7108-7114.
  • [4] World Health Organization, The treatment of diarrhoea: a manual for physicians and other senior health workers. 2005.
  • [5] Florez ID, Niño-Serna LF, Beltrán-Arroyave CP. Acute Infectious Diarrhea and Gastroenteritis in Children. Curr Infect Dis Rep. 2020;22(2):4
  • [6] Available from: https://www.cdc.gov/rotavirus/surveillance.html (Access Date: 20.05.2023).
  • [7] Kurugöl Z. Rotavirus aşıları Derleme. Türk Pediatri Arşivi. 2007; 42(11): 36-42.
  • [8] Tapisiz A, Bedir Demirdag T, Cura Yayla BC, et al. Rotavirus infections in children in Turkey: A systematic review. Rev Med Virol. 2019;29(1):e2020.
  • [9] Milne RJ, Grimwood K. Budget impact and cost-effectiveness of including a pentavalent rotavirus vaccine in the New Zealand childhood immunization schedule. Value Health. 2009;12(6):888-898.
  • [10] Giammanco MD, Coniglio MA, Pignato S, Giammanco G. An economic analysis of rotavirus vaccination in Italy. Vaccine. 2009;27(29):3904-3911.
  • [11] Widdowson MA, Meltzer MI, Zhang X, Bresee JS, Parashar UD, Glass RI. Cost-effectiveness and potential impact of rotavirus vaccination in the United States. Pediatrics. 2007;119(4):684-697.
  • [12] Tate JE, Chitambar S, Esposito DH, Sarkar R, Gladstone B, Ramani S, et al. Disease and economic burden of rotavirus diarrhoea in India. Vaccine. 2009;27(5):18-24.
  • [13] Sancar M, Dalgış N, Haşim Ö, Pullu M. Bir Eğitim ve Araştırma Hastanesindeki rotavirüslü çocuklarda yatış maliyeti. Çocuk Enfeksiyon Dergisi. 2011; 5(1): 7- 11.
  • [14] Ceyhan M, Alhan E, Salman N, Kurugol Z, Yildirim I, Celik U, et al. Multicenter prospective study on the burden of rotavirus gastroenteritis in Turkey, 2005-2006: a hospital-based study. J Infect Dis. 2009;200 (1): 234-238.
  • [15] Leung AK, Hon KL. Paediatrics: how to manage viral gastroenteritis. Drugs Context. 2021; 10:2020-11-17.
  • [16] Karslıgil T, Kılıç İH, Balcı İ. 0-6 yaş çocuklarda rotavirus gastroenteritleri ve bunun laktoz intoleransi üzerine etkisi. Türk Mikrobiyol Cem Derg 2003; 33: 137-142.
  • [17] Kovacs A, Chan L, Hotrakitya C, Overturf G, Portnoy B. Serum transaminase elevations in infants with rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr. 1986;5(6):873-877
  • [18] Işık I, Tokgöz Y, Erdur B, Arslan N. Aminotransferase elevations in rotavirus positive and negative acute gastroenteritis and its relation with disease severity. Minerva Pediatr. 2017;69(1):36-41.
  • [19] Çubuk E, Aktar F, Yılmaz K, Sabaz M, Solmaz M, Asena M, Devecioğlu M. 2011-2015 Yılları Arasında Üniversitemiz Çocuk Polikliniklerine ishal Şikâyeti Ile Başvuran ve Adenovirüs ve/veya Rotavirüs Pozitifliği Saptanan Hastaların Retrospektif Değerlendirilmesi. Van Tıp Dergisi. 2018; 25(3): 374- 380.
  • [20] Qadori M, Flem E, Bekkevold T, et al. Hypoglycaemia was common in acute gastroenteritis in a prospective hospital-based study, but electrolyte imbalances were not. Acta Paediatr. 2018;107(8):1455-1460.
  • [21] Asena M., Canan A., Öztürk Ü., Aydın Öztürk P., Pirinççioğlu A. G. Gastroenterit Nedeniyle Yatırılan Pediatrik Hastaların Rotavirüs/Adenovirüs Açısından Değerlendirilmesi. Dicle Tıp Dergisi. 2019; 46(4): 799-806.

Rotavirüs Tanılı Çocuklarda Glukoz, AST, ALT, Üre ve Albümin Parametrelerin Değerlendirilmesi

Year 2023, Volume: 12 Issue: 3, 41 - 44, 27.09.2023
https://doi.org/10.46810/tdfd.1306898

Abstract

Amaç: Bu çalışma rotavirüs tanılı hastalarda glukoz, AST, ALT, üre ve albümin parametrelerinin değerlendirilmesini amaçlamaktadır.
Gereç ve Yöntemler: Şırnak Devlet Hastanesi Çocuk Hastalıkları Polikliniklerine başvuran çocuklardan, pediatrist tarafından rotavirüs tanısı düşünülerek laboratuvara fekal örnekleri gönderilen ve mikrobiyolojik tetkikleri immünokromatografik yöntemler ile Rotavirüs tanısı doğrulanmış (6 aylık-18 yaş arası) çocuklar sistemden taranarak çalışmaya dahil edildi.
Bulgular: Rotavirüs negatif grubun glukoz, ALT, AST, üre, albumin verilerilerinin ortalama yaşları değerlendirildiğinde sırasıyla 1.82±2.66, 1.77±2.72, 1,76±2,72, 1,69±2,68, 1,87±2,88 yaş ortalamasına, rotavirüs pozitiflerde ise sırasıyla; 1.16±1.35, 1.09±1.31, 1.09±1.31, 1.10±1.32, 1,11±1,30 olduğu tespit edildi. Glukoz, AST, ALT, üre ve albüminin rotavirüs negatiflerde medyan değerleri sırasıyla 84 mg/dl, 36 U/L, 19 U/L, 14 mg/dL, 3,79 g/dL iken, rotavirüs pozitiflerde ise medyan değerleri sırasıyla 75 mg/dL, 45 U/L, 26 U/L, 18 mg/dL, 3,98 g/dL tespit edildi. Tüm parametreler istatistiksel olarak anlamlı bulundu (p<0.01).
Sonuç: Rotavirüse bağlı gastroenteritlerde laboratuvar parametrelerinden (glukoz, AST, ALT, üre ve albüminin) rotavirüs tanılı hastaların prognozunun tespitinde mutlaka değerlendirilmesi gerektiğini düşünmekteyiz.

References

  • [1] Lundgren O, Svensson L. Pathogenesis of rotavirus diarrhea. Microbes Infect. 2001;3(13):1145-1156.
  • [2] Crawford SE, Ramani S, Tate JE, Parashar UD, Svensson L, Hagbom M, et al. Rotavirus infection. Nat Rev Dis Primers. 2017; 3:17083.
  • [3] Marchetti F, Lamiani G, Bona M, Amerighi C, Ruffato B, Conforti G. Developing communication tools on rotavirus vaccination to support family paediatricians in Italy. Vaccine. 2022;40(49):7108-7114.
  • [4] World Health Organization, The treatment of diarrhoea: a manual for physicians and other senior health workers. 2005.
  • [5] Florez ID, Niño-Serna LF, Beltrán-Arroyave CP. Acute Infectious Diarrhea and Gastroenteritis in Children. Curr Infect Dis Rep. 2020;22(2):4
  • [6] Available from: https://www.cdc.gov/rotavirus/surveillance.html (Access Date: 20.05.2023).
  • [7] Kurugöl Z. Rotavirus aşıları Derleme. Türk Pediatri Arşivi. 2007; 42(11): 36-42.
  • [8] Tapisiz A, Bedir Demirdag T, Cura Yayla BC, et al. Rotavirus infections in children in Turkey: A systematic review. Rev Med Virol. 2019;29(1):e2020.
  • [9] Milne RJ, Grimwood K. Budget impact and cost-effectiveness of including a pentavalent rotavirus vaccine in the New Zealand childhood immunization schedule. Value Health. 2009;12(6):888-898.
  • [10] Giammanco MD, Coniglio MA, Pignato S, Giammanco G. An economic analysis of rotavirus vaccination in Italy. Vaccine. 2009;27(29):3904-3911.
  • [11] Widdowson MA, Meltzer MI, Zhang X, Bresee JS, Parashar UD, Glass RI. Cost-effectiveness and potential impact of rotavirus vaccination in the United States. Pediatrics. 2007;119(4):684-697.
  • [12] Tate JE, Chitambar S, Esposito DH, Sarkar R, Gladstone B, Ramani S, et al. Disease and economic burden of rotavirus diarrhoea in India. Vaccine. 2009;27(5):18-24.
  • [13] Sancar M, Dalgış N, Haşim Ö, Pullu M. Bir Eğitim ve Araştırma Hastanesindeki rotavirüslü çocuklarda yatış maliyeti. Çocuk Enfeksiyon Dergisi. 2011; 5(1): 7- 11.
  • [14] Ceyhan M, Alhan E, Salman N, Kurugol Z, Yildirim I, Celik U, et al. Multicenter prospective study on the burden of rotavirus gastroenteritis in Turkey, 2005-2006: a hospital-based study. J Infect Dis. 2009;200 (1): 234-238.
  • [15] Leung AK, Hon KL. Paediatrics: how to manage viral gastroenteritis. Drugs Context. 2021; 10:2020-11-17.
  • [16] Karslıgil T, Kılıç İH, Balcı İ. 0-6 yaş çocuklarda rotavirus gastroenteritleri ve bunun laktoz intoleransi üzerine etkisi. Türk Mikrobiyol Cem Derg 2003; 33: 137-142.
  • [17] Kovacs A, Chan L, Hotrakitya C, Overturf G, Portnoy B. Serum transaminase elevations in infants with rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr. 1986;5(6):873-877
  • [18] Işık I, Tokgöz Y, Erdur B, Arslan N. Aminotransferase elevations in rotavirus positive and negative acute gastroenteritis and its relation with disease severity. Minerva Pediatr. 2017;69(1):36-41.
  • [19] Çubuk E, Aktar F, Yılmaz K, Sabaz M, Solmaz M, Asena M, Devecioğlu M. 2011-2015 Yılları Arasında Üniversitemiz Çocuk Polikliniklerine ishal Şikâyeti Ile Başvuran ve Adenovirüs ve/veya Rotavirüs Pozitifliği Saptanan Hastaların Retrospektif Değerlendirilmesi. Van Tıp Dergisi. 2018; 25(3): 374- 380.
  • [20] Qadori M, Flem E, Bekkevold T, et al. Hypoglycaemia was common in acute gastroenteritis in a prospective hospital-based study, but electrolyte imbalances were not. Acta Paediatr. 2018;107(8):1455-1460.
  • [21] Asena M., Canan A., Öztürk Ü., Aydın Öztürk P., Pirinççioğlu A. G. Gastroenterit Nedeniyle Yatırılan Pediatrik Hastaların Rotavirüs/Adenovirüs Açısından Değerlendirilmesi. Dicle Tıp Dergisi. 2019; 46(4): 799-806.
There are 21 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Veysel Tahiroğlu 0000-0003-3516-5561

Cihat Öztürk 0000-0003-2868-2317

Early Pub Date September 27, 2023
Publication Date September 27, 2023
Published in Issue Year 2023 Volume: 12 Issue: 3

Cite

APA Tahiroğlu, V., & Öztürk, C. (2023). Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children with Rotavirus Diagnosis. Türk Doğa Ve Fen Dergisi, 12(3), 41-44. https://doi.org/10.46810/tdfd.1306898
AMA Tahiroğlu V, Öztürk C. Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children with Rotavirus Diagnosis. TJNS. September 2023;12(3):41-44. doi:10.46810/tdfd.1306898
Chicago Tahiroğlu, Veysel, and Cihat Öztürk. “Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children With Rotavirus Diagnosis”. Türk Doğa Ve Fen Dergisi 12, no. 3 (September 2023): 41-44. https://doi.org/10.46810/tdfd.1306898.
EndNote Tahiroğlu V, Öztürk C (September 1, 2023) Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children with Rotavirus Diagnosis. Türk Doğa ve Fen Dergisi 12 3 41–44.
IEEE V. Tahiroğlu and C. Öztürk, “Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children with Rotavirus Diagnosis”, TJNS, vol. 12, no. 3, pp. 41–44, 2023, doi: 10.46810/tdfd.1306898.
ISNAD Tahiroğlu, Veysel - Öztürk, Cihat. “Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children With Rotavirus Diagnosis”. Türk Doğa ve Fen Dergisi 12/3 (September 2023), 41-44. https://doi.org/10.46810/tdfd.1306898.
JAMA Tahiroğlu V, Öztürk C. Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children with Rotavirus Diagnosis. TJNS. 2023;12:41–44.
MLA Tahiroğlu, Veysel and Cihat Öztürk. “Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children With Rotavirus Diagnosis”. Türk Doğa Ve Fen Dergisi, vol. 12, no. 3, 2023, pp. 41-44, doi:10.46810/tdfd.1306898.
Vancouver Tahiroğlu V, Öztürk C. Evaluation of Glucose, AST, ALT, Urea and Albumin Parameters in Children with Rotavirus Diagnosis. TJNS. 2023;12(3):41-4.

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