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Di (2-Etilhekzil) Fitalatın Ratlarda Doku Lipid Peroksidasyonu ve Antioksidan Düzeylerine Etkisi

Year 2022, Volume: 15 Issue: 3, 301 - 311, 30.12.2022

Ozan Gülboy Emine Altın Ali Ertekin

https://doi.org/10.52976/vansaglik.1134285

Abstract

ÖZET
Amaç: Bu çalışma ratlarda di (2-etilhekzil) fitalatın (DEHP) karaciğer, böbrek ve uterus dokularında lipid peroksidasyonu ve antioksidan düzeyleri üzerine etkisini irdelemek amacıyla planlandı.
Materyal Metot: Çalışmada 3-4 aylık, 250-300 gr ağırlığında 40 Wistar-Albino dişi rat kullanıldı. Ratlar 5 gruba ayrıldı (1. grup: kontrol, 2. grup: yağ kontrol, 3. grup: 20 mg fitalat, 4. grup: 100 mg fitalat, 5. grup: 500 mg fitalat grubu). Fitalat ve mısır yağı karışımı gastrik gavaj ile verildi. Deneme süresi 14 gün olarak planlandı. Çalışmanın sonunda alınan karaciğer, böbrek ve uterus doku örneklerinde vitamin C, redükte glutatyon (GSH), katalaz (CAT), malondialdehit (MDA) ve total protein düzeyleri ölçüldü.
Bulgular: Karaciğer dokusu C vitamini miktarı tüm gruplarda azaldı (p<0.001). GSH seviyeleri 20 mg ve 100 mg fitalat gruplarında arttı, 500 mg fitalat grubunda azaldı (p<0.05). Total protein miktarı tüm gruplarda azaldı. CAT ve MDA düzeylerinde ise arttı (p<0.05). Böbrek dokusu C vitamini miktarı tüm gruplarda azalırken; GSH, CAT, MDA ve total protein düzeyleri tüm gruplarda arttı (p<0.001). Uterus dokusu C vitamini miktarı tüm gruplarda azaldı (p<0.01). GSH, CAT, MDA ve total protein düzeyleri 100 mg ve 500 mg fitalat gruplarında arttı (p<0.001). Total protein miktarı 20 mg fitalat grubunda azaldı.
Sonuç: Vitamin C, GSH, CAT, MDA ve total protein düzeylerinde gözlenen değişiklikler, oksidatif stres nedeniyle hücrelerde olası hasarın meydana gelmiş olabileceğini göstermektedir. Maruz kaldığımız birçok kimyasalın zararlı etkilerinden korunmak için bu konularda yapılan çalışmaların öne çıkarılması, epidemiyolojik çalışmalarla sonuçların detaylı olarak araştırılması ve sonuçların kamuoyu ile paylaşılması gerekmektedir. Bu sebeple vücutta oksidatif strese neden olabilecek DEHP içeren plastik ürünlerin kullanımından mümkün olduğunca kaçınılmalıdır.

Keywords

Antioksidan böbrek fitalat karaciğer lipit peroksidasyonu uterus.

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Year 2022, Volume: 15 Issue: 3, 301 - 311, 30.12.2022

Ozan Gülboy Emine Altın Ali Ertekin

https://doi.org/10.52976/vansaglik.1134285

Abstract

References

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  • Allen SF, Ellis F, Mitchell C, Wang X, Boogert NJ, Lin CY, ve ark. (2021). Phthalate diversity in eggs and associations with oxidative stress in the European herring gull (Larus argentatus). Marine pollution bulletin, 169, 112564. https://doi.org/10.1016/j.marpolbul.2021.112564
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Details

Primary Language Turkish
Subjects Veterinary Surgery
Journal Section Original Research Articles
Authors

Ozan Gülboy 0000-0002-4531-7322

Emine Altın 0000-0002-3310-3044

Ali Ertekin 0000-0002-6299-9716

Publication Date December 30, 2022
Submission Date June 22, 2022
Published in Issue Year 2022 Volume: 15 Issue: 3

Cite

APA Gülboy, O., Altın, E., & Ertekin, A. (2022). Di (2-Etilhekzil) Fitalatın Ratlarda Doku Lipid Peroksidasyonu ve Antioksidan Düzeylerine Etkisi. Van Sağlık Bilimleri Dergisi, 15(3), 301-311. https://doi.org/10.52976/vansaglik.1134285
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