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Sleep Disorders in Epilepsy Patients: A Questionnaire Study

Yıl 2024, Cilt: 8 Sayı: 1, 56 - 61, 29.04.2024

Selcen Duran Asuman Çelikbilek Burc Esra Sahin Aysu Yetiş Naime Meric Konar

https://doi.org/10.46332/aemj.1308388

Öz

Purpose: Epilepsy and sleep disorders mutually affect each other negatively. The aim of this study was to investigate the common sleep disorders in epilepsy patients in our follow-up and their relationship with disease duration, seizure type and frequency, number and type of antiepileptic drugs (AEDs).

Materials and Methods: 99 patients diagnosed with epilepsy were included in this survey study. Demographic data, duration of epilepsy disease, seizure type and frequency, number and type of AEDs used were recorded by face-to-face questioning. Pittsburg sleep quality index (PSQI), Epworth sleepiness scale (ESS), Berlin sleep questionnaire (BSQ) and restless legs syndrome (RLS) questionnaire were applied to all patients.

Results: In our epilepsy patients, the number of patients with a PDQI score of 5 points or more was 56 (56.6%), the number of patients with an IQR score of 10 points or more was 9 (9.1%), and the number of patients at high risk for obstructive sleep apnea syndrome (OSAS) according to BUA was 53 (53.5%).

Conclusion: Our patients had a high rate of RLS, poor sleep quality and increased risk of OSAS. Poor sleep quality, excessive daytime sleepiness and OSAS risk were significantly higher in epilepsy patients with RLS compared to those without RLS. We think that the presence of sleep disorders in epileptic individuals should be questioned persistently.

Anahtar Kelimeler

epilepsy sleep sleep quality restless legs syndrome obstructive sleep apnea syndrome

Kaynakça

  • 1. Akdağ G, Algın D, Erdinç O. Epilepsi/epilepsy. OTD. 2016;38(1):35-41.
  • 2. Roliz AH, Kothare S. The Interaction Between Sleep and Epilepsy. Curr Neurol Neurosci Rep. 2022;22(9): 551-563.
  • 3. Maganti R, Hausman N, Koehn M, Sandok E, Glurich I, Mukesh BN. Excessive daytime sleepiness and sleep complaints among children with epilepsy. Epilepsy & Behavior. 2006;8(1):272-277.
  • 4. Jain SV, Glauser TA. Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia. 2014;55(1):26-37.
  • 5. Steriade M, Contreras D. Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity. J. Neurosci. 1995;15(1):623-642.
  • 6. Bazil CW. Effects of antiepileptic drugs on sleep structure: are all drugs equal? CNS drugs. 2003;17(10): 719-728.
  • 7. Ismayilova V, Demir AU, Tezer FI. Subjective sleep disturbance in epilepsy patients at an outpatient clinic: a questionnaire-based study on prevalence. Epilepsy Res. 2015;115:119-125.
  • 8. Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res. 2010;90(3):171-177.
  • 9. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512-521.
  • 10. Acaroğlu G, Yılmaz E. Epilepsili Hastalarda İlaç Uyumunun Yaşam Kalitesine Etkisi. Epilepsi: JTES 2016;22(1):17-25.
  • 11. Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213.
  • 12. Ağargün MY, Kara H, Anlar O. Pittsburgh uyku kalitesi indeksinin geçerliği ve güvenirliği. Turk Psikiyatri Derg. 1996;7(2):107-115.
  • 13. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540-545.
  • 14. Izci B, Ardic S, Firat H, Sahin A, Altinors M, Karacan I. Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale. Sleep Breath. 2008;12(2):161-168.
  • 15. Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131(7):485-491.
  • 16. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101-119.
  • 17. Derry CP, Duncan S. Sleep and epilepsy. Epilepsy & Behavior. 2013;26(3):394-404.
  • 18. Yazdi Z, Sadeghniiat-Haghighi K, Naimian S, Zohal MA, Ghaniri M. Prevalence of Sleep Disorders and their Effects on Sleep Quality in Epileptic Patients. Basic Clin Neurosci. 2013;4(1):36-41.
  • 19. Öztürk İ, Aslan K, Bozdemir H, Foldvary-Schaefer N. Frequency of Restless Legs Syndrome in adults with epilepsy in Turkey. Epilepsy Behav. 2016;57:192-195.
  • 20. Öztürk O, Kabeloğlu V, Ataklı D. Restless leg syndrome prevalence in epilepsy patients and its impact on quality of sleep. Sleep Biol. Rhythms. 2022;20(3):413-420.
  • 21. Geyer JD, Geyer EE, Fetterman Z, Carney PR. Epilepsy and restless legs syndrome. Epilepsy Behav. 2017;68:41-44.
  • 22. Li YS, Yeh WC, Chang YH, Hsu CY. Restless Legs Syndrome in Patients with Epilepsy: Risk analysis, Polysomnography, and Quality of Life evaluation. Sleep. 2023;zsad054.
  • 23. Manconi M, Ulfberg J, Berger K, et al. When gender matters: restless legs syndrome. Report of the "RLS and woman" workshop endorsed by the European RLS Study Group. Sleep Med Rev. 2012;16(4):297-307.
  • 24. Seeman MV. Why Are Women Prone to Restless Legs Syndrome? Int J Environ Res Public Health. 2020;17(1):368.
  • 25. Becker PM, Sharon D. Mood disorders in restless legs syndrome (Willis-Ekbom disease). J Clin Psychiatry. 2014;75(7):e679-694.
  • 26. Carvalho BMS, Chaves J, da Silva AM. Effects of antiepileptic drugs on sleep architecture parameters in adults. Sleep Sci. 2022;15(2):224-244.
  • 27. Liguori C, Toledo M, Kothare S. Effects of anti-seizure medications on sleep architecture and daytime sleepiness in patients with epilepsy: A literature review. Sleep Med Rev. 2021;60:101559.
  • 28. Yadav V, Nanda S, Kaushik JS, Bala K. Sleep Characteristics Among Children with Idiopathic Generalized Epilepsy: A Polysomnography-Based Study. Indian J Pediatr. 2021;88(9):925-927.
  • 29. Planas-Ballvé A, Grau-López L, Jiménez M, Ciurans J, Fumanal A, Becerra JL. Insomnia and poor sleep quality are associated with poor seizure control in patients with epilepsy. Neurologia (Engl Ed). 2022;37(8):639-646.
  • 30. Giorelli AS, Passos P, Carnaval T, Gomes Mda M. Excessive daytime sleepiness and epilepsy: a systematic review. Epilepsy Res Treat. 2013:629469.
  • 31. Lin Z, Si Q, Xiaoyi Z. Obstructive sleep apnoea in patients with epilepsy: a meta-analysis. Sleep Breath. 2017;21(2):263-270.
  • 32. Sethi NK. The Relationship Between Epilepsy, Obstructive Sleep Apnea, and Treatment Outcome. Sleep Med Clin. 2022;17(4):639-645.
  • 33. Oliveira AJ, Zamagni M, Dolso P, Bassetti MA, Gigli GL. Respiratory disorders during sleep in patients with epilepsy: effect of ventilatory therapy on EEG interictal epileptiform discharges. Clin Neurophysiol. 2000;111(2):141-145.
  • 34. Soylemez E, Ozturk O, Baslo SA, Balcik ZE, Atakli D. Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy. Epilepsy Behav. 2020;111:107296.

Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması

Yıl 2024, Cilt: 8 Sayı: 1, 56 - 61, 29.04.2024

Selcen Duran Asuman Çelikbilek Burc Esra Sahin Aysu Yetiş Naime Meric Konar

https://doi.org/10.46332/aemj.1308388

Öz

Amaç: Epilepsi ve uyku bozuklukları karşılıklı olarak birbirini olumsuz etkilemektedir. Bu çalışmanın amacı takibimizde olan epilepsi hastalarında sık görülen uyku bozukluklarını ve bu bozuklukların hastalık süresi, nöbet tipi ve sıklığı, antiepileptik ilaç (AEİ) sayısı ve türü ile ilişkisini incelemektir.

Araçlar ve Yöntem: 99 epilepsi tanılı hasta bu anket çalışmamıza dahil edildi. Demografik veriler, epilepsi hastalık süresi, nöbet tipi ve sıklığı, kullanılan AEİ sayısı ve türü yüz yüze sorgulanarak kaydedildi. Tüm hastalara, Pittsburg uyku kalite indeksi (PUKİ), Epworth uykululuk ölçeği (EUÖ), Berlin uyku anketi (BUA) ve huzursuz bacaklar sendromu (HBS) anketi uygulandı.

Bulgular: Epilepsi hastalarımızda PUKİ skoru 5 puan ve üzeri olan hasta sayısı 56 (%56.6), EUÖ skoru 10 puan ve üzeri olan hasta sayısı 9 (%9.1), BUA’ne göre obstrüktif uyku apne sendromu (OUAS) için yüksek riskli hasta sayısı 53 (%53.5) idi. Hastaların 25 (%25.3)’ inde HBS varlığı tespit edildi. PUKİ skoru jeneralize epilepsili hastalarda anlamlı yüksek (kötü uyku kalitesi) tespit edildi (p=0.045). PUKİ (p=0.035), EUÖ (p=0.043) ve BUA (p=0.039) skorlarının hepsi HBS var olan hastalarda, olmayanlara göre anlamlı yüksek idi.

Sonuç: Hastalarımızda yüksek oranda HBS, kötü uyku kalitesi ve artmış OUAS riski bulundu. HBS' si olan epilepsi hastalarımızda, olmayanlara göre kötü uyku kalitesi, gündüz aşırı uykululuk ve OUAS riskini anlamlı yüksek bulundu. Epileptik bireylerde uyku bozukluklarının varlığının ısrarla sorgulanması gerektiğini düşünüyoruz.

Anahtar Kelimeler

epilepsi huzursuz bacaklar sendromu obstrüktif uyku apne sendromu uyku uyku kalitesi

Destekleyen Kurum

yoktur.

Teşekkür

yoktur

Kaynakça

  • 1. Akdağ G, Algın D, Erdinç O. Epilepsi/epilepsy. OTD. 2016;38(1):35-41.
  • 2. Roliz AH, Kothare S. The Interaction Between Sleep and Epilepsy. Curr Neurol Neurosci Rep. 2022;22(9): 551-563.
  • 3. Maganti R, Hausman N, Koehn M, Sandok E, Glurich I, Mukesh BN. Excessive daytime sleepiness and sleep complaints among children with epilepsy. Epilepsy & Behavior. 2006;8(1):272-277.
  • 4. Jain SV, Glauser TA. Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia. 2014;55(1):26-37.
  • 5. Steriade M, Contreras D. Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity. J. Neurosci. 1995;15(1):623-642.
  • 6. Bazil CW. Effects of antiepileptic drugs on sleep structure: are all drugs equal? CNS drugs. 2003;17(10): 719-728.
  • 7. Ismayilova V, Demir AU, Tezer FI. Subjective sleep disturbance in epilepsy patients at an outpatient clinic: a questionnaire-based study on prevalence. Epilepsy Res. 2015;115:119-125.
  • 8. Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res. 2010;90(3):171-177.
  • 9. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512-521.
  • 10. Acaroğlu G, Yılmaz E. Epilepsili Hastalarda İlaç Uyumunun Yaşam Kalitesine Etkisi. Epilepsi: JTES 2016;22(1):17-25.
  • 11. Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213.
  • 12. Ağargün MY, Kara H, Anlar O. Pittsburgh uyku kalitesi indeksinin geçerliği ve güvenirliği. Turk Psikiyatri Derg. 1996;7(2):107-115.
  • 13. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540-545.
  • 14. Izci B, Ardic S, Firat H, Sahin A, Altinors M, Karacan I. Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale. Sleep Breath. 2008;12(2):161-168.
  • 15. Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131(7):485-491.
  • 16. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101-119.
  • 17. Derry CP, Duncan S. Sleep and epilepsy. Epilepsy & Behavior. 2013;26(3):394-404.
  • 18. Yazdi Z, Sadeghniiat-Haghighi K, Naimian S, Zohal MA, Ghaniri M. Prevalence of Sleep Disorders and their Effects on Sleep Quality in Epileptic Patients. Basic Clin Neurosci. 2013;4(1):36-41.
  • 19. Öztürk İ, Aslan K, Bozdemir H, Foldvary-Schaefer N. Frequency of Restless Legs Syndrome in adults with epilepsy in Turkey. Epilepsy Behav. 2016;57:192-195.
  • 20. Öztürk O, Kabeloğlu V, Ataklı D. Restless leg syndrome prevalence in epilepsy patients and its impact on quality of sleep. Sleep Biol. Rhythms. 2022;20(3):413-420.
  • 21. Geyer JD, Geyer EE, Fetterman Z, Carney PR. Epilepsy and restless legs syndrome. Epilepsy Behav. 2017;68:41-44.
  • 22. Li YS, Yeh WC, Chang YH, Hsu CY. Restless Legs Syndrome in Patients with Epilepsy: Risk analysis, Polysomnography, and Quality of Life evaluation. Sleep. 2023;zsad054.
  • 23. Manconi M, Ulfberg J, Berger K, et al. When gender matters: restless legs syndrome. Report of the "RLS and woman" workshop endorsed by the European RLS Study Group. Sleep Med Rev. 2012;16(4):297-307.
  • 24. Seeman MV. Why Are Women Prone to Restless Legs Syndrome? Int J Environ Res Public Health. 2020;17(1):368.
  • 25. Becker PM, Sharon D. Mood disorders in restless legs syndrome (Willis-Ekbom disease). J Clin Psychiatry. 2014;75(7):e679-694.
  • 26. Carvalho BMS, Chaves J, da Silva AM. Effects of antiepileptic drugs on sleep architecture parameters in adults. Sleep Sci. 2022;15(2):224-244.
  • 27. Liguori C, Toledo M, Kothare S. Effects of anti-seizure medications on sleep architecture and daytime sleepiness in patients with epilepsy: A literature review. Sleep Med Rev. 2021;60:101559.
  • 28. Yadav V, Nanda S, Kaushik JS, Bala K. Sleep Characteristics Among Children with Idiopathic Generalized Epilepsy: A Polysomnography-Based Study. Indian J Pediatr. 2021;88(9):925-927.
  • 29. Planas-Ballvé A, Grau-López L, Jiménez M, Ciurans J, Fumanal A, Becerra JL. Insomnia and poor sleep quality are associated with poor seizure control in patients with epilepsy. Neurologia (Engl Ed). 2022;37(8):639-646.
  • 30. Giorelli AS, Passos P, Carnaval T, Gomes Mda M. Excessive daytime sleepiness and epilepsy: a systematic review. Epilepsy Res Treat. 2013:629469.
  • 31. Lin Z, Si Q, Xiaoyi Z. Obstructive sleep apnoea in patients with epilepsy: a meta-analysis. Sleep Breath. 2017;21(2):263-270.
  • 32. Sethi NK. The Relationship Between Epilepsy, Obstructive Sleep Apnea, and Treatment Outcome. Sleep Med Clin. 2022;17(4):639-645.
  • 33. Oliveira AJ, Zamagni M, Dolso P, Bassetti MA, Gigli GL. Respiratory disorders during sleep in patients with epilepsy: effect of ventilatory therapy on EEG interictal epileptiform discharges. Clin Neurophysiol. 2000;111(2):141-145.
  • 34. Soylemez E, Ozturk O, Baslo SA, Balcik ZE, Atakli D. Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy. Epilepsy Behav. 2020;111:107296.
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Bilimsel Araştırma Makaleleri
Yazarlar

Selcen Duran 0000-0001-7553-2034

Asuman Çelikbilek 0000-0002-2367-1128

Burc Esra Sahin 0000-0003-1008-2743

Aysu Yetiş 0000-0003-2139-0848

Naime Meric Konar 0000-0002-6593-7617

Erken Görünüm Tarihi 5 Nisan 2024
Yayımlanma Tarihi 29 Nisan 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 8 Sayı: 1

Kaynak Göster

APA Duran, S., Çelikbilek, A., Sahin, B. E., Yetiş, A., vd. (2024). Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması. Ahi Evran Medical Journal, 8(1), 56-61. https://doi.org/10.46332/aemj.1308388
AMA Duran S, Çelikbilek A, Sahin BE, Yetiş A, Konar NM. Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması. Ahi Evran Med J. Nisan 2024;8(1):56-61. doi:10.46332/aemj.1308388
Chicago Duran, Selcen, Asuman Çelikbilek, Burc Esra Sahin, Aysu Yetiş, ve Naime Meric Konar. “Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması”. Ahi Evran Medical Journal 8, sy. 1 (Nisan 2024): 56-61. https://doi.org/10.46332/aemj.1308388.
EndNote Duran S, Çelikbilek A, Sahin BE, Yetiş A, Konar NM (01 Nisan 2024) Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması. Ahi Evran Medical Journal 8 1 56–61.
IEEE S. Duran, A. Çelikbilek, B. E. Sahin, A. Yetiş, ve N. M. Konar, “Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması”, Ahi Evran Med J, c. 8, sy. 1, ss. 56–61, 2024, doi: 10.46332/aemj.1308388.
ISNAD Duran, Selcen vd. “Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması”. Ahi Evran Medical Journal 8/1 (Nisan 2024), 56-61. https://doi.org/10.46332/aemj.1308388.
JAMA Duran S, Çelikbilek A, Sahin BE, Yetiş A, Konar NM. Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması. Ahi Evran Med J. 2024;8:56–61.
MLA Duran, Selcen vd. “Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması”. Ahi Evran Medical Journal, c. 8, sy. 1, 2024, ss. 56-61, doi:10.46332/aemj.1308388.
Vancouver Duran S, Çelikbilek A, Sahin BE, Yetiş A, Konar NM. Epilepsi Hastalarında Uyku Bozuklukları: Anket Çalışması. Ahi Evran Med J. 2024;8(1):56-61.
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