Derleme
Yıl 2021,
Cilt: 30 Sayı: 3, 137 - 143, 30.09.2021
Öz
Bağırsak mikrobiyatası ve beyin birbiriyle çift yönlü iletişimde olan iki sistemdir. Çift yönlü bu iletişim bağırsak mikrobiyatasının beyinden etkilenmesini içerdiği kadar bağırsak mikrobiyatasının da beyni etkilemesi anlamına gelmektedir. Güncel veriler bu iletişimin biyokimyasal, immünolojik ve nörolojik yollarını gözler önüne serer. Bağırsak mikrobiyatasının gelişimi, bütünlüğü ve içeriği konağın metabolizması üzerinde oldukça etkindir. Bu derlemede bağırsak mikrobiyatasının konak metabolizmasına olan etkileri ve bağırsak mikrobiyatası-beyin ekseni biyokimyasal bakış açısıyla değerlendirilmiştir.
Anahtar Kelimeler
Bağırsak mikrobiyatası Bağırsak-Beyin Ekseni Konak metabolizması
Kaynakça
- Morais LH, Schreiber 4th HL, Mazmanian SK, The gut microbiota-brain axis in behaviour and brain disorders, Nature Reviews: Microbiology, 2020, doi: 10.1038/s41579-020-00460-0.
- Martin CR and Mayer EA, Gut-brains axis and behaviour, Nestle Nutr Inst Workshop Ser, 2018-1, doi: 10.1159%2F000461732.
- Grenham S et al., Brain-gut-microbiome communication in health and disease, ront. Physiol., 2011, doi.org/10.3389/fphys.2011.00094.
- Sherman MP, Zaghouani H and Niklas V, Gut microbiota, the immune system, and diet influence the neonatal gut-brain axis, Nature: Pediatric Research, 2014, doi:10.1038/pr.2014.161.
- Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J et al., The first microbial colonizers of the human gut: composition, activities, and health ımplications of the ınfant gut microbiota, Microbiology and Molecular Biology Reviews, 2017, 81:4.
- Thursby E and Juge N, Introduction to the human gut microbiata, 2017, Biochemical Journal, 474:1823-1836, doi: 10.1042/BCJ20160510.
- Tremaroli V and Backhed F, Functional interactions between the microbiata and host metabolism, 2012, Nature, doi:10.1038/nature11552.
- Donohoe DR, Garge N, Zhang X, Sun W, O’Connel TM, Bunger MK et al., The microbiome and butyrate energy metabolism and autophagy in the mammalian colon, 2011, Cell Metabolism, 13(5):517-526, doi:10.1016/j.cmet.2011.02.018.
- Dalile B, Oudenhove LV, Vervliet B and Verbek K, The role of short-chain fatty acids in microbiota-gut-brain communication, 2019, Nature Reviews: Gastroenterology and hepatology, doi:10.1038/s41575-019-0157-3.
- Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H et al., Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation, 2006, Nature, 436, doi: 10.1038/nature04330.
- İlhan N, Gut Microbiata and metabolism, 2018, International Journal of Medical Biochemistry, 1(3):115-28, doi: 10.14744/ijmb.2018.92400.
- Schoeler M and Ceasar R, Dietary lipids, gut microbiata and lipid metabolism, 2019, Reviews in Endocrine and Metabolic Disorders, 20:461-472, doi: 10.1007/s11154-019-09512-0.
- Rowland I, Gibson G, Heinken A, Scott A, Thiele I et al., Gut microbiota functions: metabolism of nutrients and other food components, 2018, European Journal of Nutrition, 57:1-24, doi: 10.1007/s00394-017-1445-8.
- Ramakrishna BS, Role of the gut microbiota in human nutrition and metabolism, 2013, Journal of Gastroenterology and Hepatology, doi: 10.1111/jgh.12294.
- Li Q and Zhou JM, The microbiata-gut-brain axis and its potential therapeutic role in autism spectrum disorder, 2016, Neuroscience 324: 131-139, doi:10.1016/j.neuroscience.2016.03.013.
- Dinan TG and Cryan JF, The microbiome-gut-brain axis in health and disease, 2016, Gastroenterol Clin N Am, doi:10.1016/j.gtc.2016.09.007.
- Fűlling C, Dinan TG and Cryan JF, Gut microbe to brain signaling: what happens in vagus, 2019, Cell Press, Neuron, doi: 10.1016/j.neuron.2019.02.008.
- Cryan JF and Dinan TG, Mind-altering microorganisms: the impact of gut microbes on brain and behaviour, 2012, Nature Reviews Neuroscience, doi: 10.1038/nrn3346.
- Abdel-Haq R, Schlachetzki JCM, Glass CK and Mazmanian SK, Microbiome-microglia connections via the gut-brain axis, 2018, Journal of Experimental Medicine, doi: 10.1084/jem.20180794.
- Appleton Jeremy, The gut-brain axis: ınfluence of microbiota on mood and mental health,2018, Integrative Medicine, 17:4, 28-32.
- Farzi A, Fröhlich EE and Holzer P, Gut microbiota and the neuroendocrine system, 2018, Neurotherapeutics, 15:5-22, doi:10.1007/s13311-017-0600-5
- Jelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G and Hyland NP, Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders, 2015, Neuroscience, doi: 10.3389/fncel.2015.00392.
- Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P and Theoharides TC, Gut-microbiata-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation, 2015, Clinical Therapeutics, doi: 10.1016/j.clinthera.2015.04.002.
- O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF, Serotonin, tryptophan metabolism and the brain-gut-microbiome axis, 2015, Behavioural Brain Research, 277:32-48, doi: 10.1016/j.bbr.2014.07.027.
Yıl 2021,
Cilt: 30 Sayı: 3, 137 - 143, 30.09.2021
Öz
The gut microbiota and the brain are two systems in bidirectional communication. It is desired that the intestinal microbiota affects the brain as much as this bidirectional intestinal microbiota is affected by the brain. Current data reveal the biochemical, immunological, and neurological pathways of this communication. It is highly effective on the development and integrity of the gut microbiota and the metabolism of the transferred host. In this review, the effects of intestinal microbiota on host metabolism and intestinal microbiota-brain axis were evaluated from a biochemical perspective.
Anahtar Kelimeler
Kaynakça
- Morais LH, Schreiber 4th HL, Mazmanian SK, The gut microbiota-brain axis in behaviour and brain disorders, Nature Reviews: Microbiology, 2020, doi: 10.1038/s41579-020-00460-0.
- Martin CR and Mayer EA, Gut-brains axis and behaviour, Nestle Nutr Inst Workshop Ser, 2018-1, doi: 10.1159%2F000461732.
- Grenham S et al., Brain-gut-microbiome communication in health and disease, ront. Physiol., 2011, doi.org/10.3389/fphys.2011.00094.
- Sherman MP, Zaghouani H and Niklas V, Gut microbiota, the immune system, and diet influence the neonatal gut-brain axis, Nature: Pediatric Research, 2014, doi:10.1038/pr.2014.161.
- Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J et al., The first microbial colonizers of the human gut: composition, activities, and health ımplications of the ınfant gut microbiota, Microbiology and Molecular Biology Reviews, 2017, 81:4.
- Thursby E and Juge N, Introduction to the human gut microbiata, 2017, Biochemical Journal, 474:1823-1836, doi: 10.1042/BCJ20160510.
- Tremaroli V and Backhed F, Functional interactions between the microbiata and host metabolism, 2012, Nature, doi:10.1038/nature11552.
- Donohoe DR, Garge N, Zhang X, Sun W, O’Connel TM, Bunger MK et al., The microbiome and butyrate energy metabolism and autophagy in the mammalian colon, 2011, Cell Metabolism, 13(5):517-526, doi:10.1016/j.cmet.2011.02.018.
- Dalile B, Oudenhove LV, Vervliet B and Verbek K, The role of short-chain fatty acids in microbiota-gut-brain communication, 2019, Nature Reviews: Gastroenterology and hepatology, doi:10.1038/s41575-019-0157-3.
- Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H et al., Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation, 2006, Nature, 436, doi: 10.1038/nature04330.
- İlhan N, Gut Microbiata and metabolism, 2018, International Journal of Medical Biochemistry, 1(3):115-28, doi: 10.14744/ijmb.2018.92400.
- Schoeler M and Ceasar R, Dietary lipids, gut microbiata and lipid metabolism, 2019, Reviews in Endocrine and Metabolic Disorders, 20:461-472, doi: 10.1007/s11154-019-09512-0.
- Rowland I, Gibson G, Heinken A, Scott A, Thiele I et al., Gut microbiota functions: metabolism of nutrients and other food components, 2018, European Journal of Nutrition, 57:1-24, doi: 10.1007/s00394-017-1445-8.
- Ramakrishna BS, Role of the gut microbiota in human nutrition and metabolism, 2013, Journal of Gastroenterology and Hepatology, doi: 10.1111/jgh.12294.
- Li Q and Zhou JM, The microbiata-gut-brain axis and its potential therapeutic role in autism spectrum disorder, 2016, Neuroscience 324: 131-139, doi:10.1016/j.neuroscience.2016.03.013.
- Dinan TG and Cryan JF, The microbiome-gut-brain axis in health and disease, 2016, Gastroenterol Clin N Am, doi:10.1016/j.gtc.2016.09.007.
- Fűlling C, Dinan TG and Cryan JF, Gut microbe to brain signaling: what happens in vagus, 2019, Cell Press, Neuron, doi: 10.1016/j.neuron.2019.02.008.
- Cryan JF and Dinan TG, Mind-altering microorganisms: the impact of gut microbes on brain and behaviour, 2012, Nature Reviews Neuroscience, doi: 10.1038/nrn3346.
- Abdel-Haq R, Schlachetzki JCM, Glass CK and Mazmanian SK, Microbiome-microglia connections via the gut-brain axis, 2018, Journal of Experimental Medicine, doi: 10.1084/jem.20180794.
- Appleton Jeremy, The gut-brain axis: ınfluence of microbiota on mood and mental health,2018, Integrative Medicine, 17:4, 28-32.
- Farzi A, Fröhlich EE and Holzer P, Gut microbiota and the neuroendocrine system, 2018, Neurotherapeutics, 15:5-22, doi:10.1007/s13311-017-0600-5
- Jelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G and Hyland NP, Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders, 2015, Neuroscience, doi: 10.3389/fncel.2015.00392.
- Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P and Theoharides TC, Gut-microbiata-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation, 2015, Clinical Therapeutics, doi: 10.1016/j.clinthera.2015.04.002.
- O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF, Serotonin, tryptophan metabolism and the brain-gut-microbiome axis, 2015, Behavioural Brain Research, 277:32-48, doi: 10.1016/j.bbr.2014.07.027.
Toplam 24 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Eylül 2021 |
| Kabul Tarihi | 6 Mayıs 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 30 Sayı: 3 |
