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Ketogenic Diet and Cancer

Yıl 2022, Cilt: 5 Sayı: 1, 11 - 19, 31.01.2022

Hatice Kübra Yılmaz Rabia Müge Özer

https://doi.org/10.48124/husagbilder.917342
Cited By: 1

Öz

Cancer is the most common health problem in today's world. Cancer is a disease that occurs when the cell or its community multiplies abnormally by various environmental or genetic factors. Cancer problems are increasing day by day, especially in the developing world. Cancer, which is an important and serious public health problem, does not have a complete and definitive treatment. Cancer is kept under control with many treatment methods such as chemotherapy, radiotherapy, and surgical operations. Recently, besides these medical treatments, medical nutrition treatments have come to the fore and there are many studies. One of them is the ketogenic diet that has been used in the treatment of epilepsy patients since the 1920s. Studies have presented that ketogenic diet therapy will be an anticancer element controlling tumor growth in patients with cancer. In the ketogenic diet treatment, successful results have been obtained in many types of cancer, not specific to a single cancer type.

Anahtar Kelimeler

Cancer Ketogenic diet Medical nutrition therapy

Kaynakça

  • Çevik, B. A., Pirinçci, E. Beslenme ve Kanser. Fırat Tıp Derg. 2017; 22(1): 1-7.
  • Akbulut G. Kanserde Beslenme Tedavisi, Ankara: Ankara Nobel Tıp Kitabevleri, 2019.
  • Chung HY, Park YK. Rationale, Feasibility and Acceptability of Ketogenic Diet for Cancer Treatment. J Cancer Prev. 2017 Sep;22(3):127-134.
  • Tervonen H., Foliaki S., Bray F., Roder D. Cancer epidemiology in the small nations of Pacific Islands. Cancer Epidemiology. 50 (2017) 184-192.
  • Søreide K., Sandvik O.M., Søreide J.A., Giljaca V., Jureckova A., Bulusu V.R. Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies. Clinical Nutrition. 40 (2016) 39-46.
  • Horn S.R., Stoltzfuz K.C., Lehrer E.J., Dawson L.A., Tchelebi L., Gusani N.J., Sharma N.K., Chen H., Trifiletti D.M., Zaorsky N.G. Epidemiology of liver metastases. Cancer Epidemiology. 67 (2020) 101760.
  • Lewandowska A.M., Rudzki M., Rudzki S., Lewandowski T., Laskowska B. Environmental risk factors for cancer – review paper. Annals of Agricultural and Environmental Medicine 2019, Vol 26, No 1, 1–7.
  • Rustagi T., Dasanu C.A. Risk Factors for Gallbladder Cancer and Cholangiocarcinoma: Similarities, Differences and Updates. Journal of Gastrointestinal Cancer. (2012) 43:137–147.
  • De Pergola G, Silvestris F. Obesity as a major risk factor for cancer. J Obes. 2013;2013:291546.
  • Moazeni M, Heidari Z, Golipour S, Ghaisari L, Sillanpää M, Ebrahimi A. Dietary intake and health risk assessment of nitrate, nitrite, and nitrosamines: a Bayesian analysis and Monte Carlo simulation. Environ Sci Pollut Res Int. 2020 Dec;27(36):45568-45580.
  • Plotti F, Terranova C, Luvero D, Bartolone M, Messina G, Feole L, Cianci S, Scaletta G, Marchetti C, Di Donato V, Fagotti A, Scambia G, Benedetti Panici P, Angioli R. Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment. Chemotherapy. 2020;65(3-4):77-84.
  • Talib WH. A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft. Nutrition. 2020 Apr; 72:110659.
  • Bradley JA, Mendenhall NP. Novel Radiotherapy Techniques for Breast Cancer. Annu Rev Med. 2018 Jan 29; 69:277-288.
  • Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B. Ketogenic diet in the treatment of cancer- Where do we stand? Mol Metab. 2020 Mar; 33:102-121.
  • Heber D, Li Z. Nutrition Intervention in Cancer. Med Clin North Am. 2016 Nov;100(6):1329-1340.
  • Minzer S. Effectiveness of Ketogenic Diets on the Survival of Adult Oncological Patients. Nutr Cancer. 2020 Oct 19:1-11.
  • Wang YH, Suk FM, Liao YJ. Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer. Cancers (Basel). 2020 Jul 4;12(7):1797.
  • Klement RJ, Schäfer G, Sweeney RA. A ketogenic diet exerts beneficial effects on body composition of cancer patients during radiotherapy: An interim analysis of the KETOCOMP study. J Tradit Complement Med. 2019 Mar 21;10(3):180-187.
  • Woolf EC, Scheck AC. The ketogenic diet for the treatment of malignant glioma. J Lipid Res. 2015 Jan;56(1):5-10.
  • Khodabakhshi A, Akbari ME, Mirzaei HR, Seyfried TN, Kalamian M, Davoodi SH. Effects of Ketogenic metabolic therapy on patients with breast cancer: A randomized controlled clinical trial. Clin Nutr. 2021 Mar;40(3):751-758.
  • Hagihara K, Kajimoto K, Osaga S, Nagai N, Shimosegawa E, Nakata H, Saito H, Nakano M, Takeuchi M, Kanki H, Kagitani-Shimono K, Kijima T. Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer. Nutrients. 2020 May 19;12(5):1473.
  • Klement RJ. The emerging role of ketogenic diets in cancer treatment. Curr Opin Clin Nutr Metab Care. 2019 Mar;22(2):129-134.
  • Cohen CW, Fontaine KR, Arend RC, Alvarez RD, Leath CA III, Huh WK, Bevis KS, Kim KH, Straughn JM Jr, Gower BA. A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer. J Nutr. 2018 Aug 1;148(8):1253-1260.
  • Cohen CW, Fontaine KR, Arend RC, Gower BA. A Ketogenic Diet Is Acceptable in Women with Ovarian and Endometrial Cancer and Has No Adverse Effects on Blood Lipids: A Randomized, Controlled Trial. Nutr Cancer. 2020;72(4):584-594.
  • Cohen CW, Fontaine KR, Arend RC, Soleymani T, Gower BA. Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial. Nutrients. 2018 Aug 30;10(9):1187.
  • Mann S DO, Sidhu M DO, Gowin K DO. Understanding the Mechanisms of Diet and Outcomes in Colon, Prostate, and Breast Cancer; Malignant Gliomas; and Cancer Patients on Immunotherapy. Nutrients. 2020 Jul 26;12(8):2226.
  • Ciusani E, Vasco C, Rizzo A, Girgenti V, Padelli F, Pellegatta S, Fariselli L, Bruzzone MG, Salmaggi A. MR-Spectroscopy and Survival in Mice with High Grade Glioma Undergoing Unrestricted Ketogenic Diet. Nutr Cancer. 2020 Sep 21:1-8.
  • Rieger J, Bähr O, Maurer GD, Hattingen E, Franz K, Brucker D, Walenta S, Kämmerer U, Coy JF, Weller M, Steinbach JP. ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Int J Oncol. 2014 Jun;44(6):1843-52.
  • Van der Louw, E. J., Olieman, J. F., van den Bemt, P. M., Bromberg, J. E., Oomen-de Hoop, E., Neuteboom, R. F., ... & Vincent, A. J. (2019). Ketogenic diet treatment as adjuvant to standard treatment of glioblastoma multiforme: a feasibility and safety study. Therapeutic advances in medical oncology, 11, 1758835919853958.
  • Thomas JG, Veznedaroglu E. Ketogenic Diet for Malignant Gliomas: a Review. Curr Nutr Rep. 2020 Sep;9(3):258-263.
  • Zou Y, Fineberg S, Pearlman A, Feinman RD, Fine EJ. The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer. PLoS One. 2020 Dec 3;15(12):e0233662.
  • Khodabakhshi A, Seyfried TN, Kalamian M, Beheshti M, Davoodi SH. Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled clinical trial. Nutr J. 2020 Aug 22;19(1):87.
  • Branca JJ, Pacini S, Ruggiero M. Effects of Pre-surgical Vitamin D Supplementation and Ketogenic Diet in a Patient with Recurrent Breast Cancer. Anticancer Res. 2015 Oct;35(10):5525-32.
  • Tella SH, Kommalapati A, Esquivel MA, Correa R. Potential Role of Metabolic Intervention in the Management of Advanced Differentiated Thyroid Cancer. Front Oncol. 2017 Jul 25 ;7:160.
  • Aggarwal A, Yuan Z, Barletta JA, Lorch JH, Nehs MA. Ketogenic diet combined with antioxidant N-acetylcysteine inhibits tumor growth in a mouse model of anaplastic thyroid cancer. Surgery. 2020 Jan;167(1):87-93.
  • Iyikesici MS. Survival outcomes of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy in advanced gastric cancer. Niger J Clin Pract. 2020 May;23(5):734-740.
  • Noorlag L, De Vos FY, Kok A, Broekman MLD, Seute T, Robe PA, Snijders TJ. Treatment of malignant gliomas with ketogenic or caloric restricted diets: A systematic review of preclinical and early clinical studies. Clin Nutr. 2019 Oct;38(5):1986-1994.

Ketojenik Diyet ve Kanser

Yıl 2022, Cilt: 5 Sayı: 1, 11 - 19, 31.01.2022

Hatice Kübra Yılmaz Rabia Müge Özer

https://doi.org/10.48124/husagbilder.917342
Cited By: 1

Öz

Kanser, günümüz dünyasında en sık karşılaşılan bir sağlık sorunudur. Kanser, hücre veya hücre topluluğunun çeşitli çevresel veya genetik etmenlerle anormal bir şekilde çoğalması durumunda oluşan bir hastalıktır. Özellikle gelişen dünyada kanser sorunları gün geçtikçe artmaktadır. Önemli ve ciddi bir halk sağlığı sorunu olan kanserin tam ve kesin bir tedavisi yoktur. Kanser, kemoterapi, radyoterapi, cerrahi operasyonlar gibi birçok tedavi yöntemiyle kontrol altında tutulmaya çalışılmaktadır. Son zamanlarda bu tıbbi tedavilerin yanında tıbbi beslenme tedavileri de ön plana çıkmakta ve birçok çalışma bulunmaktadır. Bunlardan biri ise 1920’lerden beri epilepsi hastalarının tedavisinde kullanılan ketojenik diyettir. Ketojenik diyet tedavisinin kanserli hastalarda tümör büyümesini kontrol altına alan bir antikanser öge olacağı çalışmalarda sunulmuştur. Ketojenik diyet tedavisinde tek bir kanser türüne özgü olarak değil birçok kanser türünde başarılı sonuçlar elde edilmiştir.

Anahtar Kelimeler

ketojenik diyet kanser tıbbi beslenme tedavisi

Kaynakça

  • Çevik, B. A., Pirinçci, E. Beslenme ve Kanser. Fırat Tıp Derg. 2017; 22(1): 1-7.
  • Akbulut G. Kanserde Beslenme Tedavisi, Ankara: Ankara Nobel Tıp Kitabevleri, 2019.
  • Chung HY, Park YK. Rationale, Feasibility and Acceptability of Ketogenic Diet for Cancer Treatment. J Cancer Prev. 2017 Sep;22(3):127-134.
  • Tervonen H., Foliaki S., Bray F., Roder D. Cancer epidemiology in the small nations of Pacific Islands. Cancer Epidemiology. 50 (2017) 184-192.
  • Søreide K., Sandvik O.M., Søreide J.A., Giljaca V., Jureckova A., Bulusu V.R. Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies. Clinical Nutrition. 40 (2016) 39-46.
  • Horn S.R., Stoltzfuz K.C., Lehrer E.J., Dawson L.A., Tchelebi L., Gusani N.J., Sharma N.K., Chen H., Trifiletti D.M., Zaorsky N.G. Epidemiology of liver metastases. Cancer Epidemiology. 67 (2020) 101760.
  • Lewandowska A.M., Rudzki M., Rudzki S., Lewandowski T., Laskowska B. Environmental risk factors for cancer – review paper. Annals of Agricultural and Environmental Medicine 2019, Vol 26, No 1, 1–7.
  • Rustagi T., Dasanu C.A. Risk Factors for Gallbladder Cancer and Cholangiocarcinoma: Similarities, Differences and Updates. Journal of Gastrointestinal Cancer. (2012) 43:137–147.
  • De Pergola G, Silvestris F. Obesity as a major risk factor for cancer. J Obes. 2013;2013:291546.
  • Moazeni M, Heidari Z, Golipour S, Ghaisari L, Sillanpää M, Ebrahimi A. Dietary intake and health risk assessment of nitrate, nitrite, and nitrosamines: a Bayesian analysis and Monte Carlo simulation. Environ Sci Pollut Res Int. 2020 Dec;27(36):45568-45580.
  • Plotti F, Terranova C, Luvero D, Bartolone M, Messina G, Feole L, Cianci S, Scaletta G, Marchetti C, Di Donato V, Fagotti A, Scambia G, Benedetti Panici P, Angioli R. Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment. Chemotherapy. 2020;65(3-4):77-84.
  • Talib WH. A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft. Nutrition. 2020 Apr; 72:110659.
  • Bradley JA, Mendenhall NP. Novel Radiotherapy Techniques for Breast Cancer. Annu Rev Med. 2018 Jan 29; 69:277-288.
  • Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B. Ketogenic diet in the treatment of cancer- Where do we stand? Mol Metab. 2020 Mar; 33:102-121.
  • Heber D, Li Z. Nutrition Intervention in Cancer. Med Clin North Am. 2016 Nov;100(6):1329-1340.
  • Minzer S. Effectiveness of Ketogenic Diets on the Survival of Adult Oncological Patients. Nutr Cancer. 2020 Oct 19:1-11.
  • Wang YH, Suk FM, Liao YJ. Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer. Cancers (Basel). 2020 Jul 4;12(7):1797.
  • Klement RJ, Schäfer G, Sweeney RA. A ketogenic diet exerts beneficial effects on body composition of cancer patients during radiotherapy: An interim analysis of the KETOCOMP study. J Tradit Complement Med. 2019 Mar 21;10(3):180-187.
  • Woolf EC, Scheck AC. The ketogenic diet for the treatment of malignant glioma. J Lipid Res. 2015 Jan;56(1):5-10.
  • Khodabakhshi A, Akbari ME, Mirzaei HR, Seyfried TN, Kalamian M, Davoodi SH. Effects of Ketogenic metabolic therapy on patients with breast cancer: A randomized controlled clinical trial. Clin Nutr. 2021 Mar;40(3):751-758.
  • Hagihara K, Kajimoto K, Osaga S, Nagai N, Shimosegawa E, Nakata H, Saito H, Nakano M, Takeuchi M, Kanki H, Kagitani-Shimono K, Kijima T. Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer. Nutrients. 2020 May 19;12(5):1473.
  • Klement RJ. The emerging role of ketogenic diets in cancer treatment. Curr Opin Clin Nutr Metab Care. 2019 Mar;22(2):129-134.
  • Cohen CW, Fontaine KR, Arend RC, Alvarez RD, Leath CA III, Huh WK, Bevis KS, Kim KH, Straughn JM Jr, Gower BA. A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer. J Nutr. 2018 Aug 1;148(8):1253-1260.
  • Cohen CW, Fontaine KR, Arend RC, Gower BA. A Ketogenic Diet Is Acceptable in Women with Ovarian and Endometrial Cancer and Has No Adverse Effects on Blood Lipids: A Randomized, Controlled Trial. Nutr Cancer. 2020;72(4):584-594.
  • Cohen CW, Fontaine KR, Arend RC, Soleymani T, Gower BA. Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial. Nutrients. 2018 Aug 30;10(9):1187.
  • Mann S DO, Sidhu M DO, Gowin K DO. Understanding the Mechanisms of Diet and Outcomes in Colon, Prostate, and Breast Cancer; Malignant Gliomas; and Cancer Patients on Immunotherapy. Nutrients. 2020 Jul 26;12(8):2226.
  • Ciusani E, Vasco C, Rizzo A, Girgenti V, Padelli F, Pellegatta S, Fariselli L, Bruzzone MG, Salmaggi A. MR-Spectroscopy and Survival in Mice with High Grade Glioma Undergoing Unrestricted Ketogenic Diet. Nutr Cancer. 2020 Sep 21:1-8.
  • Rieger J, Bähr O, Maurer GD, Hattingen E, Franz K, Brucker D, Walenta S, Kämmerer U, Coy JF, Weller M, Steinbach JP. ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Int J Oncol. 2014 Jun;44(6):1843-52.
  • Van der Louw, E. J., Olieman, J. F., van den Bemt, P. M., Bromberg, J. E., Oomen-de Hoop, E., Neuteboom, R. F., ... & Vincent, A. J. (2019). Ketogenic diet treatment as adjuvant to standard treatment of glioblastoma multiforme: a feasibility and safety study. Therapeutic advances in medical oncology, 11, 1758835919853958.
  • Thomas JG, Veznedaroglu E. Ketogenic Diet for Malignant Gliomas: a Review. Curr Nutr Rep. 2020 Sep;9(3):258-263.
  • Zou Y, Fineberg S, Pearlman A, Feinman RD, Fine EJ. The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer. PLoS One. 2020 Dec 3;15(12):e0233662.
  • Khodabakhshi A, Seyfried TN, Kalamian M, Beheshti M, Davoodi SH. Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled clinical trial. Nutr J. 2020 Aug 22;19(1):87.
  • Branca JJ, Pacini S, Ruggiero M. Effects of Pre-surgical Vitamin D Supplementation and Ketogenic Diet in a Patient with Recurrent Breast Cancer. Anticancer Res. 2015 Oct;35(10):5525-32.
  • Tella SH, Kommalapati A, Esquivel MA, Correa R. Potential Role of Metabolic Intervention in the Management of Advanced Differentiated Thyroid Cancer. Front Oncol. 2017 Jul 25 ;7:160.
  • Aggarwal A, Yuan Z, Barletta JA, Lorch JH, Nehs MA. Ketogenic diet combined with antioxidant N-acetylcysteine inhibits tumor growth in a mouse model of anaplastic thyroid cancer. Surgery. 2020 Jan;167(1):87-93.
  • Iyikesici MS. Survival outcomes of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy in advanced gastric cancer. Niger J Clin Pract. 2020 May;23(5):734-740.
  • Noorlag L, De Vos FY, Kok A, Broekman MLD, Seute T, Robe PA, Snijders TJ. Treatment of malignant gliomas with ketogenic or caloric restricted diets: A systematic review of preclinical and early clinical studies. Clin Nutr. 2019 Oct;38(5):1986-1994.
Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Hatice Kübra Yılmaz 0000-0001-7750-6024

Rabia Müge Özer 0000-0001-8749-2738

Yayımlanma Tarihi 31 Ocak 2022
Gönderilme Tarihi 16 Nisan 2021
Kabul Tarihi 4 Mayıs 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 5 Sayı: 1

Kaynak Göster

Vancouver Yılmaz HK, Özer RM. Ketojenik Diyet ve Kanser. Haliç Üniversitesi Sağlık Bilimleri Dergisi. 2022;5(1):11-9.

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https://doi.org/10.1007/s00520-023-08156-w