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Kanser Metabolizmasında ve Metastazında Glikanların Önemi

Yıl 2021, Cilt: 6 Sayı: 2, 112 - 119, 30.08.2021

Nebiye Pelin Türker , Elvan Bakar

https://doi.org/10.51754/cusbed.867416
Cited By: 1

Öz

Glikobiyolojinin kanser mekanizmalarının anlaşılmasındaki rolü, teşhis uygulamaları ve terapötik stratejiler için bir dizi hedef sağlaması, bu bilim alanının kanser araştırmalarındaki önemini her geçen gün arttırmaktadır. Glikozilasyonun, çeşitli fizyopatolojik süreçleri kontrol eden önemli düzenleyici bir mekanizma olarak işlev görebileceği ön görülmektedir. Hücrelerdeki glikozilasyon değişimleri ve bu değişimlerin hastalıklarla olan bağlantıları, glikomun önemli ölçüde biyolojik bilgi içerdiğini göstermektedir. Glikan zincirlerinin dallanma ve uzunluklarındaki değişiklikler, yapılarında yer alan karbohidratların çeşidi, bu moleküllerin biyolojik fonksiyonlarının değişmesine neden olmaktadır. Bununla birlikte glikan bağlayıcı proteinlerin biyolojik fonksiyonlarının karakterize edilmesi, kanser araştırmalarına önemli katkılar sağlamaktadır. Farklı glikokonjugat tipleri, anahtar kanser hücresi süreçlerine ve aynı zamanda tümör mikro-ortamına müdahale ederek, kanserin ilerlemesine yol açmaktadır.

Anahtar Kelimeler

Kanser Metastaz Glikan Glikolizasyon

Kaynakça

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The Importance of Glycans in Cancer Metabolism and Metastasis

Yıl 2021, Cilt: 6 Sayı: 2, 112 - 119, 30.08.2021

Nebiye Pelin Türker , Elvan Bakar

https://doi.org/10.51754/cusbed.867416
Cited By: 1

Öz

The role of glycobiology in understanding cancer mechanisms, providing a set of targets for diagnostic applications and therapeutic strategies increases the importance of this field of science in cancer research day by day. It is predicted that glycosylation may function as an important regulatory mechanism controlling a variety of physiopathological processes. Glycosylation changes in cells and their links with disease show that the glycome contains significant biological information. Changes in the branching and length of the glycan chains, the variety of carbohydrates in their structure cause the biological functions of these molecules to change. However, characterization of the biological functions of glycan binding proteins makes important contributions to cancer research. Different types of glycoconjugates lead to cancer progression by interfering with key cancer cell processes as well as the tumor microenvironment.

Anahtar Kelimeler

Cancer Metastasis Glycan Glycosylation

Kaynakça

  • Arnold JN, Saldova R, Hamid UM, Rudd PM (2008) Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation. Proteomics, 8: 3284-93. https://doi.org/10.1002/pmic.200800163
  • Aryal RP, Ju T, Cummings RD (2010) The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase. J Biol Chem, 285: 2456-62. https://doi.org/10.1074/jbc.M109.065169
  • Baldus SE, Zirbes TK, Monig SP, Engel S, Monaca E, Rafiqpoor K, Hanisch FG, Hanski C, Thiele J, Pichlmaier H, Dienes HP (1998) Histopathological subtypes and prognosis of gastric cancer are correlated with the expression of mucin-associated sialylated antigens: Sialosyl-Lewis(a), Sialosyl-Lewis(x) and sialosyl-Tn. Tumour Biol, 19: 445-53. https://doi.org/10.1159/000030036
  • Bharadwaj AG, Kovar JL, Loughman E, Elowsky C, Oakley GG, Simpson MA (2009) Spontaneous Metastasis of Prostate Cancer Is Promoted by Excess Hyaluronan Synthesis and Processing. American Journal of Pathology, 174: 1027-1036. https://doi.org/10.2353/ajpath.2009.080501
  • Borsig L, Wong R, Feramisco J, Nadeau DR, Varki NM, Varki A (2001) Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis (vol 98, pg 3352, 2001).
  • Proceedings of the National Academy of Sciences of the United States of America, 98: 5369-5369.
  • Carvalho AS, Harduin-Lepers A, Magalhaes A, Machado E, Mendes N, Costa LT, Matthiesen R, Almeida R, Costa J, Reis CA (2010) Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells. Int J Biochem Cell Biol, 42: 80-9. https://doi.org/10.1016/j.biocel.2009.09.010
  • Croci DO, Cerliani JP, Dalotto-Moreno T, Mendez-Huergo SP, Mascanfroni ID, Dergan-Dylon S, Toscano MA, Caramelo JJ, Garcia-Vallejo JJ, Ouyang J, Mesri EA, Junttila MR, Bais C, Shipp MA, Salatino M, Rabinovich GA (2014) Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell, 156: 744-58. https://doi.org/10.1016/j.cell.2014.01.043
  • da Cunha CB, Oliveira C, Wen X, Gomes B, Sousa S, Suriano G, Grellier M, Huntsman DG, Carneiro F, Granja PL, Seruca R (2010) De novo expression of CD44 variants in sporadic and hereditary gastric cancer. Lab Invest, 90: 1604-14. https://doi.org/10.1038/labinvest.2010.155
  • Dall'Olio F, Malagolini N, Trinchera M, Chiricolo M (2012) Mechanisms of cancer-associated glycosylation changes. Front Biosci (Landmark Ed), 17: 670-99. https://doi.org/10.2741/3951
  • Dalziel M, Whitehouse C, McFarlane I, Brockhausen I, Gschmeissner S, Schwientek T, Clausen H, Burchell JM, Taylor-Papadimitriou J (2001) The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1. J Biol Chem, 276: 11007-15. https://doi.org/10.1074/jbc.M006523200
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  • Pinho SS, Oliveira P, Cabral J, Carvalho S, Huntsman D, Gartner F, Seruca R, Reis CA, Oliveira C (2012) Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions. PLoS One, 7: e33191. https://doi.org/10.1371/journal.pone.0033191
  • Potapenko IO, Haakensen VD, Luders T, Helland A, Bukholm I, Sorlie T, Kristensen VN, Lingjaerde OC, Borresen-Dale AL (2010) Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression. Mol Oncol, 4: 98-118. https://doi.org/10.1016/j.molonc.2009.12.001
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  • Wolff EA, Greenfield B, Taub DD, Murphy WJ, Bennett KL, Aruffo A (1999) Generation of artificial proteoglycans containing glycosaminoglycan-modified CD44 - Demonstration of the interaction between RANTES and chondroitin sulfate. Journal of Biological Chemistry, 274: 2518-2524. https://doi.org/DOI 10.1074/jbc.274.4.2518
  • Yuecheng Zhang, Kushtrim Llapashtica, Sudhirkumar Shinde, Börje Sellergren, Zahra El-Schich, Wingren AG (2019) Determination of cytokine regulated glycan expression by using molecularly imprinted polymers targeting sialic acid. Journal of Cancer Metastasis and Treatment, 5:56. https://doi.org/10.20517/2394-4722.2018.112
  • Zachara NE, Hart GW (2006) Cell signaling, the essential role of O-GlcNAc! Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids, 1761: 599-617. https://doi.org/10.1016/j.bbalip.2006.04.007
Toplam 70 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Nebiye Pelin Türker 0000-0001-6060-3557

Elvan Bakar 0000-0001-5703-3469

Yayımlanma Tarihi 30 Ağustos 2021
Yayımlandığı Sayı Yıl 2021Cilt: 6 Sayı: 2

Kaynak Göster

APA Türker, N. P., & Bakar, E. (2021). Kanser Metabolizmasında ve Metastazında Glikanların Önemi. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 6(2), 112-119. https://doi.org/10.51754/cusbed.867416

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