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Otizm Spektrum Bozukluğunda Beslenme Tedavisi

Yıl 2022, Cilt: 7 Sayı: 1, 55 - 60, 30.04.2022

İbrahim Hakkı Çağıran , Dursun Alper Yılmaz

https://doi.org/10.51754/cusbed.1038009

Öz

Otizim spekrum bozukluğu nörolojik hastalıklar grubunda yer almaktadır. Bu hastalığın bilinen bir tedavisi bulunmamaktadır. Bu hastalığa dönük tedavi yöntemleri, davranışsal farklılık ve diğer semptomları azaltmayı amaçlayan uygulamalardır. Beslenme tedavisi bu yöntemler arasında yaygın olarak kullanılmaktadır. Bağırsak geçirgenliğinin artmış olması nedeniyle OSB’de uygulanan diyet tedavisi beyin-bağırsak iletişimini düzelterek davranışlar üzerinde etkili olabilir. Özellikle yaygın olarak kullanılan karbonhidrat kısıtlı diyetler septomların azalmasında önemli etkisi olmaktadır. Ek olarak protein kaynaklarından olan gluten ve kazein’den fakir diyetlerinde OSB’de görülen faklılıkların iyileşmesinde etkili olabilir. Bu derleme makale gluten ve kezeinden fakir diyetin otizm spekrum bozukluğu üzerine etkisini araştırmak amacıyla yazılmıştır.

Anahtar Kelimeler

Kazein gluten kazeimorfin glutemorfin otizm

Kaynakça

  • Brigandi S, Shao H, Qian S, Shen Y, Wu BL, Kang J (2015). Autistic Children Exhibit Decreased Levels of Essential Fatty Acids in Red Blood Cells. International Journal of Molecular Sciences, 16(12), 10061–10076. https://doi.org/10.3390/ijms160510061
  • Buie T, Mulloy A, Lang R, O’Reilly M, Sigafoos J, Lancioni G, Rispoli M, Elder J H, Wightley P, Shattock P, Savery D, Rodgers J, Whiteley P, Shattock P, Knivsberg AM, Seim A, Reichelt KL, Todd L, Carr K, … Reissmann A (2010). Gluten-free and casein-free diets in the treatment of autism spectrum disorders: A systematic review. Research in Autism Spectrum Disorders, 4(6), 328–339. https://doi.org/10.1016/j.rasd.2009.10.008
  • Cass H, Gringras P, March J, McKendrick I, O’Hare AE, Owen, L, Pollin C (2008). Absence of urinary opioid peptides in children with autism. Archives of Disease in Childhood, 93(9), 745–750. https://doi.org/10.1136/adc.2006.114389
  • Cekici H, Sanlier N (2019). Current nutritional approaches in managing autism spectrum disorder: A review. Nutritional Neuroscience, 22(3), 145–155. https://doi.org/10.1080/1028415X.2017.1358481
  • Cusco I, Medrano A, Gener B, Vilardell M, Gallastegui F, Villa O, Gonzalez E, Rodriguez-Santiago B, Vilella E, Del Campo M, Perez-Jurado LA (2009). Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder. Human Molecular Genetics, 18(10), 1795–1804. https://doi.org/10.1093/hmg/ddp092
  • Dohan FC, Grasberger JC, Lowell FM, Johnston HT, Arbegast AW (1969). Relapsed Schizophrenics: More Rapid Improvement on a Milk- and Cereal-free Diet. British Journal of Psychiatry, 115(522), 595–596. https://doi.org/10.1192/bjp.115.522.595
  • Francis K (2005). Autism interventions: a critical update. Developmental Medicine & Child Neurology, 47(7), 493–499. https://doi.org/10.1017/S0012162205000952
  • Fujiwara T, Morisaki N, Honda Y, Sampei M, Tani Y (2016). Chemicals, Nutrition, and Autism Spectrum Disorder: A Mini-Review. Frontiers in Neuroscience, 10. https://doi.org/10.3389/fnins.2016.00174
  • Hallböök T, Sjölander A, Åmark P, Miranda M, Bjurulf B, Dahlin M (2015). Effectiveness of the ketogenic diet used to treat resistant childhood epilepsy in Scandinavia. European Journal of Paediatric Neurology, 19(1), 29–36. https://doi.org/10.1016/j.ejpn.2014.09.005
  • Hanson E, Kalish LA, Bunce E, Curtis C, McDaniel S, Ware J, Petry J (2007). Use of Complementary and Alternative Medicine among Children Diagnosed with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 37(4), 628–636. https://doi.org/10.1007/s10803-006-0192-0
  • Harrington JW, Rosen L, Garnecho A, Patrick PA (2006). Parental Perceptions and Use of Complementary and Alternative Medicine Practices for Children with Autistic Spectrum Disorders in Private Practice. Journal of Developmental & Behavioral Pediatrics, 27(Supplement 2), S156–S161. https://doi.org/10.1097/00004703-200604002-00014
  • Heilskov Rytter MJ, Andersen LBB, Houmann T, Bilenberg N, Hvolby A, Mølgaard C, Michaelsen KF, Lauritzen L (2015). Diet in the treatment of ADHD in children—A systematic review of the literature. Nordic Journal of Psychiatry, 69(1), 1–18. https://doi.org/10.3109/08039488.2014.921933
  • Hsu CL, Lin DCY, Chen CL, Wang CM, Wong AMK (2009). The effects of a gluten and casein-free diet in children with autism: A case report. Chang Gung Medical Journal, 32(4), 459–465.
  • Huang AX, Wheeler JJ (2006). High-functional autism: An overview of characteristics and related issues. International Journal of Special Education, 21(2), 109–122.
  • Knivsberg A, Reichelt KL, N⊘dland, M., & H⊘ien, T. (1995). Autistic Syndromes and Diet: a follow‐up study. Scandinavian Journal of Educational Research, 39(3), 223–236. https://doi.org/10.1080/0031383950390304
  • Lange KW, Hauser J, Reissmann A (2015). Gluten-free and casein-free diets in the therapy of autism. Current Opinion in Clinical Nutrition and Metabolic Care, 18(6), 572–575. https://doi.org/10.1097/MCO.0000000000000228
  • Maenner MJ, Shaw KA, Baio J, Washington A, Patrick M, DiRienzo M, Christensen DL, Wiggins LD, Pettygrove S, Andrews JG, Lopez M, Hudson A, Baroud T, Schwenk Y, White T, Rosenberg CR, Lee LC, Harrington RA, Huston M, Dietz PM (2020). Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016. MMWR. Surveillance Summaries, 69(4), 1–12. https://doi.org/10.15585/mmwr.ss6904a1
  • Mattila ML, Kielinen M, Linna SL, Jussila K, Ebeling H, Bloigu R, Joseph RM, Moilanen I (2011). Autism Spectrum Disorders According to DSM-IV-TR and Comparison With DSM-5 Draft Criteria: An Epidemiological Study. Journal of the American Academy of Child & Adolescent Psychiatry, 50(6), 583-592.e11. https://doi.org/10.1016/j.jaac.2011.04.001
  • Napoli E, Dueñas N, Giulivi C. (2014). Potential Therapeutic Use of the Ketogenic Diet in Autism Spectrum Disorders. Frontiers in Pediatrics, 2. https://doi.org/10.3389/fped.2014.00069
  • Panksepp J (1979). A neurochemical theory of autism. Trends in Neurosciences, 2, 174–177. https://doi.org/10.1016/0166-2236(79)90071-7
  • Patel K, Curtis LT (2007). A Comprehensive Approach to Treating Autism and Attention-Deficit Hyperactivity Disorder: A Prepilot Study. The Journal of Alternative and Complementary Medicine, 13(10), 1091–1098. https://doi.org/10.1089/acm.2007.0611
  • Pennesi CM, Klein LC (2012). Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: Based on parental report. Nutritional Neuroscience, 15(2), 85–91. https://doi.org/10.1179/1476830512Y.0000000003
  • Ruskin DN, Murphy MI, Slade SL, Masino SA (2017). Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder. PLOS ONE, 12(2), e0171643. https://doi.org/10.1371/journal.pone.0171643
  • Vahia V (2013). Diagnostic and statistical manual of mental disorders 5: A quick glance. Indian Journal of Psychiatry, 55(3), 220. https://doi.org/10.4103/0019-5545.117131
  • van Wijngaarden, E., Davidson, P. W., Smith, T. H., Evans, K., Yost, K., Love, T., Thurston, S. W., Watson, G. E., Zareba, G., Burns, C. M., Shamlaye, C. F., & Myers, G. J. (2013). Autism Spectrum Disorder Phenotypes and Prenatal Exposure to Methylmercury. Epidemiology, 24(5), 651–659. https://doi.org/10.1097/EDE.0b013e31829d2651
  • Verpeut JL, DiCicco-Bloom E, Bello NT (2016). Ketogenic diet exposure during the juvenile period increases social behaviors and forebrain neural activation in adult Engrailed 2 null mice. Physiology & Behavior, 161, 90–98. https://doi.org/10.1016/j.physbeh.2016.04.001
  • Whiteley P, Shattock P, Knivsberg AM, Seim A, Reichelt KL, Todd L, Carr K, Hooper M (2013). Gluten- and casein-free dietary intervention for autism spectrum conditions. Frontiers in Human Neuroscience, 6. https://doi.org/10.3389/fnhum.2012.00344

Nutritional Therapy for Autism Spectrum Disorder

Yıl 2022, Cilt: 7 Sayı: 1, 55 - 60, 30.04.2022

İbrahim Hakkı Çağıran , Dursun Alper Yılmaz

https://doi.org/10.51754/cusbed.1038009

Öz

Autism spectrum disorder is in the group of neurological diseases. There is no known cure for this disease. Treatment methods for this disease are practices aimed at reducing behavioral differences and other symptoms. Nutrition therapy is widely used among these methods. Due to increased intestinal permeability, diet therapy applied in ASD may have an effect on behaviors by improving brain-intestinal communication. In particular, carbohydrate-restricted diets, which are widely used, have a significant effect on the reduction of symptoms. In addition, diets poor in gluten and casein, which are protein sources, may be effective in improving the differences seen in ASD. This review article was written to investigate the effect of gluten- and cetinine-free diet on autism spectrum disorder.

Anahtar Kelimeler

Casein gluten casimorphy gluten morphine autism

Kaynakça

  • Brigandi S, Shao H, Qian S, Shen Y, Wu BL, Kang J (2015). Autistic Children Exhibit Decreased Levels of Essential Fatty Acids in Red Blood Cells. International Journal of Molecular Sciences, 16(12), 10061–10076. https://doi.org/10.3390/ijms160510061
  • Buie T, Mulloy A, Lang R, O’Reilly M, Sigafoos J, Lancioni G, Rispoli M, Elder J H, Wightley P, Shattock P, Savery D, Rodgers J, Whiteley P, Shattock P, Knivsberg AM, Seim A, Reichelt KL, Todd L, Carr K, … Reissmann A (2010). Gluten-free and casein-free diets in the treatment of autism spectrum disorders: A systematic review. Research in Autism Spectrum Disorders, 4(6), 328–339. https://doi.org/10.1016/j.rasd.2009.10.008
  • Cass H, Gringras P, March J, McKendrick I, O’Hare AE, Owen, L, Pollin C (2008). Absence of urinary opioid peptides in children with autism. Archives of Disease in Childhood, 93(9), 745–750. https://doi.org/10.1136/adc.2006.114389
  • Cekici H, Sanlier N (2019). Current nutritional approaches in managing autism spectrum disorder: A review. Nutritional Neuroscience, 22(3), 145–155. https://doi.org/10.1080/1028415X.2017.1358481
  • Cusco I, Medrano A, Gener B, Vilardell M, Gallastegui F, Villa O, Gonzalez E, Rodriguez-Santiago B, Vilella E, Del Campo M, Perez-Jurado LA (2009). Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder. Human Molecular Genetics, 18(10), 1795–1804. https://doi.org/10.1093/hmg/ddp092
  • Dohan FC, Grasberger JC, Lowell FM, Johnston HT, Arbegast AW (1969). Relapsed Schizophrenics: More Rapid Improvement on a Milk- and Cereal-free Diet. British Journal of Psychiatry, 115(522), 595–596. https://doi.org/10.1192/bjp.115.522.595
  • Francis K (2005). Autism interventions: a critical update. Developmental Medicine & Child Neurology, 47(7), 493–499. https://doi.org/10.1017/S0012162205000952
  • Fujiwara T, Morisaki N, Honda Y, Sampei M, Tani Y (2016). Chemicals, Nutrition, and Autism Spectrum Disorder: A Mini-Review. Frontiers in Neuroscience, 10. https://doi.org/10.3389/fnins.2016.00174
  • Hallböök T, Sjölander A, Åmark P, Miranda M, Bjurulf B, Dahlin M (2015). Effectiveness of the ketogenic diet used to treat resistant childhood epilepsy in Scandinavia. European Journal of Paediatric Neurology, 19(1), 29–36. https://doi.org/10.1016/j.ejpn.2014.09.005
  • Hanson E, Kalish LA, Bunce E, Curtis C, McDaniel S, Ware J, Petry J (2007). Use of Complementary and Alternative Medicine among Children Diagnosed with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 37(4), 628–636. https://doi.org/10.1007/s10803-006-0192-0
  • Harrington JW, Rosen L, Garnecho A, Patrick PA (2006). Parental Perceptions and Use of Complementary and Alternative Medicine Practices for Children with Autistic Spectrum Disorders in Private Practice. Journal of Developmental & Behavioral Pediatrics, 27(Supplement 2), S156–S161. https://doi.org/10.1097/00004703-200604002-00014
  • Heilskov Rytter MJ, Andersen LBB, Houmann T, Bilenberg N, Hvolby A, Mølgaard C, Michaelsen KF, Lauritzen L (2015). Diet in the treatment of ADHD in children—A systematic review of the literature. Nordic Journal of Psychiatry, 69(1), 1–18. https://doi.org/10.3109/08039488.2014.921933
  • Hsu CL, Lin DCY, Chen CL, Wang CM, Wong AMK (2009). The effects of a gluten and casein-free diet in children with autism: A case report. Chang Gung Medical Journal, 32(4), 459–465.
  • Huang AX, Wheeler JJ (2006). High-functional autism: An overview of characteristics and related issues. International Journal of Special Education, 21(2), 109–122.
  • Knivsberg A, Reichelt KL, N⊘dland, M., & H⊘ien, T. (1995). Autistic Syndromes and Diet: a follow‐up study. Scandinavian Journal of Educational Research, 39(3), 223–236. https://doi.org/10.1080/0031383950390304
  • Lange KW, Hauser J, Reissmann A (2015). Gluten-free and casein-free diets in the therapy of autism. Current Opinion in Clinical Nutrition and Metabolic Care, 18(6), 572–575. https://doi.org/10.1097/MCO.0000000000000228
  • Maenner MJ, Shaw KA, Baio J, Washington A, Patrick M, DiRienzo M, Christensen DL, Wiggins LD, Pettygrove S, Andrews JG, Lopez M, Hudson A, Baroud T, Schwenk Y, White T, Rosenberg CR, Lee LC, Harrington RA, Huston M, Dietz PM (2020). Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016. MMWR. Surveillance Summaries, 69(4), 1–12. https://doi.org/10.15585/mmwr.ss6904a1
  • Mattila ML, Kielinen M, Linna SL, Jussila K, Ebeling H, Bloigu R, Joseph RM, Moilanen I (2011). Autism Spectrum Disorders According to DSM-IV-TR and Comparison With DSM-5 Draft Criteria: An Epidemiological Study. Journal of the American Academy of Child & Adolescent Psychiatry, 50(6), 583-592.e11. https://doi.org/10.1016/j.jaac.2011.04.001
  • Napoli E, Dueñas N, Giulivi C. (2014). Potential Therapeutic Use of the Ketogenic Diet in Autism Spectrum Disorders. Frontiers in Pediatrics, 2. https://doi.org/10.3389/fped.2014.00069
  • Panksepp J (1979). A neurochemical theory of autism. Trends in Neurosciences, 2, 174–177. https://doi.org/10.1016/0166-2236(79)90071-7
  • Patel K, Curtis LT (2007). A Comprehensive Approach to Treating Autism and Attention-Deficit Hyperactivity Disorder: A Prepilot Study. The Journal of Alternative and Complementary Medicine, 13(10), 1091–1098. https://doi.org/10.1089/acm.2007.0611
  • Pennesi CM, Klein LC (2012). Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: Based on parental report. Nutritional Neuroscience, 15(2), 85–91. https://doi.org/10.1179/1476830512Y.0000000003
  • Ruskin DN, Murphy MI, Slade SL, Masino SA (2017). Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder. PLOS ONE, 12(2), e0171643. https://doi.org/10.1371/journal.pone.0171643
  • Vahia V (2013). Diagnostic and statistical manual of mental disorders 5: A quick glance. Indian Journal of Psychiatry, 55(3), 220. https://doi.org/10.4103/0019-5545.117131
  • van Wijngaarden, E., Davidson, P. W., Smith, T. H., Evans, K., Yost, K., Love, T., Thurston, S. W., Watson, G. E., Zareba, G., Burns, C. M., Shamlaye, C. F., & Myers, G. J. (2013). Autism Spectrum Disorder Phenotypes and Prenatal Exposure to Methylmercury. Epidemiology, 24(5), 651–659. https://doi.org/10.1097/EDE.0b013e31829d2651
  • Verpeut JL, DiCicco-Bloom E, Bello NT (2016). Ketogenic diet exposure during the juvenile period increases social behaviors and forebrain neural activation in adult Engrailed 2 null mice. Physiology & Behavior, 161, 90–98. https://doi.org/10.1016/j.physbeh.2016.04.001
  • Whiteley P, Shattock P, Knivsberg AM, Seim A, Reichelt KL, Todd L, Carr K, Hooper M (2013). Gluten- and casein-free dietary intervention for autism spectrum conditions. Frontiers in Human Neuroscience, 6. https://doi.org/10.3389/fnhum.2012.00344
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

İbrahim Hakkı Çağıran 0000-0003-3125-1198

Dursun Alper Yılmaz 0000-0001-8096-5504

Erken Görünüm Tarihi 29 Nisan 2022
Yayımlanma Tarihi 30 Nisan 2022
Yayımlandığı Sayı Yıl 2022Cilt: 7 Sayı: 1

Kaynak Göster

APA Çağıran, İ. H., & Yılmaz, D. A. (2022). Otizm Spektrum Bozukluğunda Beslenme Tedavisi. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 7(1), 55-60. https://doi.org/10.51754/cusbed.1038009
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