Research Article
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Diagnostic Contribution of Hematological Parameters in Patients with Lung İnvolvement in Rheumatoid Arthritis

Year 2024, Volume: 9 Issue: 1, 56 - 60, 30.04.2024

Seda Atik , Deniz Apalan , İrfan Atik

https://doi.org/10.51754/cusbed.1423583

Abstract

Rheumatoid arthritis (RA) is a prevalent autoimmune condition, with lung involvement being its most frequent extra-articular manifestation. Our study aims to investigate the contribution of hematological parameters to diagnosing lung involvement in patients with RA. Individuals with RA were divided into two groups according to lung involvement in thorax computed tomography. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and systemic immune-inflammatory index (SII) were evaluated in all patients. Twenty-nine of the seventy-five RA patients were found to have lung involvement, and lung involvement was not observed in forty-six patients. CRP, ESR, and neutrophils were high in patients with lung involvement and a statistically notable distinction was observed. Lymphocyte count was low in patients with lung involvement and was statistically significant. NLR, NMO, and SII rates were high in patients with lung involvement and were statistically significant. It is observed that hematological parameters contribute to diagnosing RA lung involvement.

Keywords

Rheumatoid arthritis lung inflammation hematological tests

References

  • Alunno, A., Gerli, R., Giacomelli, R., & Carubbi, F. (2017). Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis. BioMed research international, 7915340. https://doi.org/10.1155/2017/7915340
  • Chandrashekara, S., Mukhtar Ahmad, M., Renuka, P., Anupama, K. R., & Renuka, K. (2017). Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. International journal of rheumatic diseases, 20(10), 1457–1467. https://doi.org/10.1111/1756-185X.13157
  • Dawson, J. K., Fewins, H. E., Desmond, J., Lynch, M. P., & Graham, D. R. (2001). Fibrosing alveolitis in patients with rheumatoid arthritis as assessed by high resolution computed tomography, chest radiography, and pulmonary function tests. Thorax, 56(8), 622–627. https://doi.org/10.1136/thorax.56.8.622
  • Dawson, J. K., Fewins, H. E., Desmond, J., Lynch, M. P., & Graham, D. R. (2002). Predictors of progression of HRCT diagnosed fibrosing alveolitis in patients with rheumatoid arthritis. Annals of the rheumatic diseases, 61(6), 517–521. https://doi.org/10.1136/ard.61.6.517
  • Doyle, T. J., Dellaripa, P. F., & Rosas, I. O. (2018). Risk Factors and Biomarkers of RA-ILD. Lung Disease in Rheumatoid Arthritis, 59-72.
  • Duarte, A. C., Porter, J. C., & Leandro, M. J. (2019). The lung in a cohort of rheumatoid arthritis patients-an overview of different types of involvement and treatment. Rheumatology (Oxford, England), 58(11), 2031–2038. https://doi.org/10.1093/rheumatology/kez177
  • Ha, Y. J., Lee, Y. J., & Kang, E. H. (2018). Lung Involvements in Rheumatic Diseases: Update on the Epidemiology, Pathogenesis, Clinical Features, and Treatment. BioMed research international, 6930297. https://doi.org/10.1155/2018/6930297
  • Hyldgaard, C., Hilberg, O., Pedersen, A. B., Ulrichsen, S. P., Løkke, A., Bendstrup, E., & Ellingsen, T. (2017). A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality. Annals of the rheumatic diseases, 76(10), 1700–1706. https://doi.org/10.1136/annrheumdis-2017-211138
  • Hozumi, H., Nakamura, Y., Johkoh, T., Sumikawa, H., Colby, T. V., Kono, M., Hashimoto, D., Enomoto, N., Fujisawa, T., Inui, N., Suda, T., & Chida, K. (2013). Acute exacerbation in rheumatoid arthritis-associated interstitial lung disease: a retrospective case control study. BMJ open, 3(9), e003132. https://doi.org/10.1136/bmjopen-2013-003132
  • Kelesoglu Dincer, A. B., & Sezer, S. (2022). Systemic Immune Inflammation Index as a Reliable Disease Activity Marker in Psoriatic Arthritis. Journal of the College of Physicians and Surgeons--Pakistan: JCPSP, 32(6), 773–778. https://doi.org/10.29271/jcpsp.2022.06.773
  • Kim, E. J., Collard, H. R., & King, T. E., Jr (2009). Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic pattern. Chest, 136(5), 1397–1405. https://doi.org/10.1378/chest.09-0444
  • Kristen Demoruelle, M., Olson, A. L., & Solomon, J. J. (2018). The epidemiology of rheumatoid arthritis-associated lung disease. Lung disease in rheumatoid arthritis, 45-58.
  • McInnes, I. B., & Schett, G. (2011). The pathogenesis of rheumatoid arthritis. The New England journal of medicine, 365(23), 2205–2219. https://doi.org/10.1056/NEJMra1004965
  • Norton, S., Koduri, G., Nikiphorou, E., Dixey, J., Williams, P., & Young, A. (2013). A study of baseline prevalence and cumulative incidence of comorbidity and extra-articular manifestations in RA and their impact on outcome. Rheumatology (Oxford, England), 52(1), 99–110. https://doi.org/10.1093/rheumatology/kes262
  • Prete, M., Racanelli, V., Digiglio, L., Vacca, A., Dammacco, F., & Perosa, F. (2011). Extra-articular manifestations of rheumatoid arthritis: An update. Autoimmunity reviews, 11(2), 123–131. https://doi.org/10.1016/j.autrev.2011.09.001
  • Salaffi, F., Carotti, M., Di Carlo, M., Tardella, M., & Giovagnoni, A. (2019). High-resolution computed tomography of the lung in patients with rheumatoid arthritis: Prevalence of interstitial lung disease involvement and determinants of abnormalities. Medicine, 98(38), e17088. https://doi.org/10.1097/MD.0000000000017088
  • Scott, M. K. D., Quinn, K., Li, Q., Carroll, R., Warsinske, H., Vallania, F., Chen, S., Carns, M. A., Aren, K., Sun, J., Koloms, K., Lee, J., Baral, J., Kropski, J., Zhao, H., Herzog, E., Martinez, F. J., Moore, B. B., Hinchcliff, M., Denny, J., … Khatri, P. (2019). Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study. The Lancet. Respiratory medicine, 7(6), 497–508. https://doi.org/10.1016/S2213-2600(18)30508-3
  • Shaw, M., Collins, B. F., Ho, L. A., & Raghu, G. (2015). Rheumatoid arthritis-associated lung disease. European respiratory review: an official journal of the European Respiratory Society, 24(135), 1–16. https://doi.org/10.1183/09059180.00008014
  • Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016). Rheumatoid arthritis. Lancet (London, England), 388(10055), 2023–2038. https://doi.org/10.1016/S0140-6736(16)30173-8
  • Solomon, J. J., Chung, J. H., Cosgrove, G. P., Demoruelle, M. K., Fernandez-Perez, E. R., Fischer, A., Frankel, S. K., Hobbs, S. B., Huie, T. J., Ketzer, J., Mannina, A., Olson, A. L., Russell, G., Tsuchiya, Y., Yunt, Z. X., Zelarney, P. T., Brown, K. K., & Swigris, J. J. (2016). Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease. The European respiratory journal, 47(2), 588–596. https://doi.org/10.1183/13993003.00357-2015
  • Uslu, A. U., Küçük, A., Şahin, A., Ugan, Y., Yılmaz, R., Güngör, T., Bağcacı, S., & Küçükşen, S. (2015). Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. International journal of rheumatic diseases, 18(7), 731–735. https://doi.org/10.1111/1756-185X.12582
  • Wilsher, M., Voight, L., Milne, D., Teh, M., Good, N., Kolbe, J., Williams, M., Pui, K., Merriman, T., Sidhu, K., & Dalbeth, N. (2012). Prevalence of airway and parenchymal abnormalities in newly diagnosed rheumatoid arthritis. Respiratory medicine, 106(10), 1441–1446. https://doi.org/10.1016/j.rmed.2012.06.020
  • Zhang, Y., Li, H., Wu, N., Dong, X., & Zheng, Y. (2017). Retrospective study of the clinical characteristics and risk factors of rheumatoid arthritis-associated interstitial lung disease. Clinical rheumatology, 36(4), 817–823. https://doi.org/10.1007/s10067-017-3561-5

Romatoid Artrit Akciğer Tutulumu Olan Hastalarda Hematolojik Parametrelerin Tanıya Katkısı

Year 2024, Volume: 9 Issue: 1, 56 - 60, 30.04.2024

Seda Atik , Deniz Apalan , İrfan Atik

https://doi.org/10.51754/cusbed.1423583

Abstract

Romatoid artrit (RA) yaygın otoimmün bir hastalık olup akciğer tutulumu en sık görülen eklem dışı bulgudur. Çalışmamız RA'li hastalarda hematolojik parametrelerin akciğer tutulumu tanısına katkısını araştırmayı amaçlamaktadır. RA tanısı alan bireyler Toraks Bilgisayarlı Tomografideki akciğer tutulumuna göre iki gruba ayrıldı. Tüm hastalarda C-reaktif protein (CRP), eritrosit sedimantasyon hızı (ESH), nötrofil, lenfosit, monosit, trombosit, nötrofil/lenfosit oranı (NLO), monosit/lenfosit oranı (MLO), sistemik inflamatuar indeks (Sİİ) değerlendirildi. 75 RA hastasının 29'unda akciğer tutulumu saptanırken, 46 hastada akciğer tutulumu görülmedi. Akciğer tutulumu olan hastalarda CRP, ESR ve nötrofiller yüksekti ve istatistiksel olarak belirgin anlamlı fark izlendi. Akciğer tutulumu olan hastalarda lenfosit sayısı düşüktü ve istatistiksel olarak anlamlıydı. Akciğer tutulumu olan hastalarda NLR, NMO ve SII oranları yüksekti ve istatistiksel olarak anlamlıydı. Bu çalışmada hematolojik parametrelerin RA akciğer tutulumunun tanısına katkı sağladığı görülmektedir.

Keywords

Romatoid Artrit Hematolojik Testler Akciğer İnflamasyonu

References

  • Alunno, A., Gerli, R., Giacomelli, R., & Carubbi, F. (2017). Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis. BioMed research international, 7915340. https://doi.org/10.1155/2017/7915340
  • Chandrashekara, S., Mukhtar Ahmad, M., Renuka, P., Anupama, K. R., & Renuka, K. (2017). Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. International journal of rheumatic diseases, 20(10), 1457–1467. https://doi.org/10.1111/1756-185X.13157
  • Dawson, J. K., Fewins, H. E., Desmond, J., Lynch, M. P., & Graham, D. R. (2001). Fibrosing alveolitis in patients with rheumatoid arthritis as assessed by high resolution computed tomography, chest radiography, and pulmonary function tests. Thorax, 56(8), 622–627. https://doi.org/10.1136/thorax.56.8.622
  • Dawson, J. K., Fewins, H. E., Desmond, J., Lynch, M. P., & Graham, D. R. (2002). Predictors of progression of HRCT diagnosed fibrosing alveolitis in patients with rheumatoid arthritis. Annals of the rheumatic diseases, 61(6), 517–521. https://doi.org/10.1136/ard.61.6.517
  • Doyle, T. J., Dellaripa, P. F., & Rosas, I. O. (2018). Risk Factors and Biomarkers of RA-ILD. Lung Disease in Rheumatoid Arthritis, 59-72.
  • Duarte, A. C., Porter, J. C., & Leandro, M. J. (2019). The lung in a cohort of rheumatoid arthritis patients-an overview of different types of involvement and treatment. Rheumatology (Oxford, England), 58(11), 2031–2038. https://doi.org/10.1093/rheumatology/kez177
  • Ha, Y. J., Lee, Y. J., & Kang, E. H. (2018). Lung Involvements in Rheumatic Diseases: Update on the Epidemiology, Pathogenesis, Clinical Features, and Treatment. BioMed research international, 6930297. https://doi.org/10.1155/2018/6930297
  • Hyldgaard, C., Hilberg, O., Pedersen, A. B., Ulrichsen, S. P., Løkke, A., Bendstrup, E., & Ellingsen, T. (2017). A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality. Annals of the rheumatic diseases, 76(10), 1700–1706. https://doi.org/10.1136/annrheumdis-2017-211138
  • Hozumi, H., Nakamura, Y., Johkoh, T., Sumikawa, H., Colby, T. V., Kono, M., Hashimoto, D., Enomoto, N., Fujisawa, T., Inui, N., Suda, T., & Chida, K. (2013). Acute exacerbation in rheumatoid arthritis-associated interstitial lung disease: a retrospective case control study. BMJ open, 3(9), e003132. https://doi.org/10.1136/bmjopen-2013-003132
  • Kelesoglu Dincer, A. B., & Sezer, S. (2022). Systemic Immune Inflammation Index as a Reliable Disease Activity Marker in Psoriatic Arthritis. Journal of the College of Physicians and Surgeons--Pakistan: JCPSP, 32(6), 773–778. https://doi.org/10.29271/jcpsp.2022.06.773
  • Kim, E. J., Collard, H. R., & King, T. E., Jr (2009). Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic pattern. Chest, 136(5), 1397–1405. https://doi.org/10.1378/chest.09-0444
  • Kristen Demoruelle, M., Olson, A. L., & Solomon, J. J. (2018). The epidemiology of rheumatoid arthritis-associated lung disease. Lung disease in rheumatoid arthritis, 45-58.
  • McInnes, I. B., & Schett, G. (2011). The pathogenesis of rheumatoid arthritis. The New England journal of medicine, 365(23), 2205–2219. https://doi.org/10.1056/NEJMra1004965
  • Norton, S., Koduri, G., Nikiphorou, E., Dixey, J., Williams, P., & Young, A. (2013). A study of baseline prevalence and cumulative incidence of comorbidity and extra-articular manifestations in RA and their impact on outcome. Rheumatology (Oxford, England), 52(1), 99–110. https://doi.org/10.1093/rheumatology/kes262
  • Prete, M., Racanelli, V., Digiglio, L., Vacca, A., Dammacco, F., & Perosa, F. (2011). Extra-articular manifestations of rheumatoid arthritis: An update. Autoimmunity reviews, 11(2), 123–131. https://doi.org/10.1016/j.autrev.2011.09.001
  • Salaffi, F., Carotti, M., Di Carlo, M., Tardella, M., & Giovagnoni, A. (2019). High-resolution computed tomography of the lung in patients with rheumatoid arthritis: Prevalence of interstitial lung disease involvement and determinants of abnormalities. Medicine, 98(38), e17088. https://doi.org/10.1097/MD.0000000000017088
  • Scott, M. K. D., Quinn, K., Li, Q., Carroll, R., Warsinske, H., Vallania, F., Chen, S., Carns, M. A., Aren, K., Sun, J., Koloms, K., Lee, J., Baral, J., Kropski, J., Zhao, H., Herzog, E., Martinez, F. J., Moore, B. B., Hinchcliff, M., Denny, J., … Khatri, P. (2019). Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study. The Lancet. Respiratory medicine, 7(6), 497–508. https://doi.org/10.1016/S2213-2600(18)30508-3
  • Shaw, M., Collins, B. F., Ho, L. A., & Raghu, G. (2015). Rheumatoid arthritis-associated lung disease. European respiratory review: an official journal of the European Respiratory Society, 24(135), 1–16. https://doi.org/10.1183/09059180.00008014
  • Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016). Rheumatoid arthritis. Lancet (London, England), 388(10055), 2023–2038. https://doi.org/10.1016/S0140-6736(16)30173-8
  • Solomon, J. J., Chung, J. H., Cosgrove, G. P., Demoruelle, M. K., Fernandez-Perez, E. R., Fischer, A., Frankel, S. K., Hobbs, S. B., Huie, T. J., Ketzer, J., Mannina, A., Olson, A. L., Russell, G., Tsuchiya, Y., Yunt, Z. X., Zelarney, P. T., Brown, K. K., & Swigris, J. J. (2016). Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease. The European respiratory journal, 47(2), 588–596. https://doi.org/10.1183/13993003.00357-2015
  • Uslu, A. U., Küçük, A., Şahin, A., Ugan, Y., Yılmaz, R., Güngör, T., Bağcacı, S., & Küçükşen, S. (2015). Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. International journal of rheumatic diseases, 18(7), 731–735. https://doi.org/10.1111/1756-185X.12582
  • Wilsher, M., Voight, L., Milne, D., Teh, M., Good, N., Kolbe, J., Williams, M., Pui, K., Merriman, T., Sidhu, K., & Dalbeth, N. (2012). Prevalence of airway and parenchymal abnormalities in newly diagnosed rheumatoid arthritis. Respiratory medicine, 106(10), 1441–1446. https://doi.org/10.1016/j.rmed.2012.06.020
  • Zhang, Y., Li, H., Wu, N., Dong, X., & Zheng, Y. (2017). Retrospective study of the clinical characteristics and risk factors of rheumatoid arthritis-associated interstitial lung disease. Clinical rheumatology, 36(4), 817–823. https://doi.org/10.1007/s10067-017-3561-5
There are 23 citations in total.

Details

Primary Language English
Subjects Radiology and Organ Imaging, Rheumatology and Arthritis
Journal Section Research Article
Authors

Seda Atik 0000-0002-7164-6592

Deniz Apalan 0000-0003-4909-5509

İrfan Atik 0000-0002-9026-2076

Early Pub Date April 29, 2024
Publication Date April 30, 2024
Submission Date January 22, 2024
Acceptance Date March 31, 2024
Published in Issue Year 2024Volume: 9 Issue: 1

Cite

Vancouver Atik S, Apalan D, Atik İ. Diagnostic Contribution of Hematological Parameters in Patients with Lung İnvolvement in Rheumatoid Arthritis. J Cumhuriyet Univ Health Sci Inst. 2024;9(1):56-60.
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The Journal of Sivas Cumhuriyet University Institute of Health Sciences is an international, peer-reviewed scientific journal published by Sivas Cumhuriyet University, Institute of Health Sciences.