Öz
Introduction: In December 2019, a novel type of coronavirus infection (SARS-CoV-2) emerged in China and started to spread rapidly. It is unclear whether the thyroid gland is affected in patients with COVID-19. We aimed to investigate the changes in thyroid function in pediatric patients with COVID-19.
Methods: This study enrolled 79 patients aged 0-18 years with confirmed COVID-19 and the control group consisted of 57 healthy children. All patients thyroid function tests and acute phase reactants were studied.
Results: The median age was 132 months in the patient group and 108 months in the control group. TSH level was lower in the COVID-19 patients compared to the controls although the difference did not statistical significance (p=0.051). Free T3 level was significantly lower in the patient group compared to the control group (p<0.001). All patients with COVID-19 had normal TSH levels and fT3 was lower in 7 (8.8%) of 79 patients. Correlation analysis showed a negative correlation between fT3 level and CRP, procalcitonin levels. No significant correlation was found between disease severity and thyroid hormone levels.
Conclusion: as far as we know, our study is the first to evaluate thyroid functions in children with COVID-19. As in many other severe disease states, ESS may develop in COVID-19. It can be concluded that the pituitary-thyroid axis is not severely affected in pediatric patients COVID-19, especially in those with asymptomatic or mildly symptomatic disease. It should be remembered that the disease course may be more severe particularly in patients who develop ESS.
Anahtar Kelimeler
Teşekkür
We also thanks Velat Sen for his support.
Kaynakça
- World Health Organization. Available from: https: //covid19.who.int/.
- Li Y, He F, Zhou N, et al. Organ function support in patients with coronavirus disease 2019: Tongji experience. Front Med 2020; 14: 232-48. doi: 10.1007/s11684-020-0774-9
- Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. Endocr Rev 2011; 32: 670-93.
- Lee S, Farwell AP. Euthyroid Sick Syndrome. Compr Physiol 2016; 6: 1071-80.
- Scoscia E, Baglioni S, Eslami A, Iervasi G, Monti S, Todisco T. Low triiodothyronine (T3) state: a predictor of outcome in respiratory failure? Results of a clinical pilot study. Eur J Endocrinol 2004; 151: 557-60.
- Bertoli A, Valentini A, Cianfarani MA, Gasbarra E, Tarantino U, Federici M. Low FT3: a possible marker of frailty in the elderly. Clin Interv Aging 2017; 12: 335-41.
- Wei L, Sun S, Xu CH, et al. Pathology of the thyroid in severe acute respiratory syndrome. Hum Pathol 2007; 38: 95-102.
- Wang W, Ye YX, Yao H, Sun LQ, Wang AS, Wang ZY. Evaluation and observation of serum thyroid hormone and parathyroid hormone in patients with severe acute respiratory syndrome. J Chin Antituberculous Assoc 2003; 25: 232-4.
- Wei L, Sun S, Zhang J, et al. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Biochem Cell Biol 2010; 88: 723-30.
- Li MY, Li L, Zhang Y, Wang XS. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty 2020; 9: 45. doi: 10.1186/s40249-020-00662-x
- Wang W, Su X, Ding Y, et al. Thyroid function abnormalities in COVID-19 patients. MedRXiv 2020 Jan 1. doi: 10.1101/2020.06.15.20130807
- Chen M, Zhou W, Xu W. Thyroid Function Analysis in 50 Patients with COVID-19: A Retrospective Study. Thyroid 2021; 31: 8-11. doi: 10.1089/thy.2020.0363
- Zou R, Wu C, Zhang S, et al. Euthyroid Sick Syndrome in Patients With COVID-19. Front Endocrinol (Lausanne) 2020; 11: 566439. doi: 10.3389/fendo.2020.566439
- Gao W, Guo W, Guo Y, et al. Thyroid hormone concentrations in severely or critically ill patients with COVID-19. J Endocrinol Invest 2020; 1-10. doi: 10.1007/s40618-020-01460-w
- Rothberger GD, Valestra PK, Knight K, Desai AK, Calixte R, Shapiro LE. Low free T3 ıs associated with worse outcomes in patients in the ICU requiring ınvasive mechanical ventilation. J Intensive Care Med 2019; 885066619890822. doi: 10.1177/0885066619890822
- Bello G, Pennisi MA, Montini L, et al. Nonthyroidal illness syndrome and prolonged mechanical ventilation in patients admitted to the ICU. Chest 2009; 135: 1448-54.
Öz
Kaynakça
- World Health Organization. Available from: https: //covid19.who.int/.
- Li Y, He F, Zhou N, et al. Organ function support in patients with coronavirus disease 2019: Tongji experience. Front Med 2020; 14: 232-48. doi: 10.1007/s11684-020-0774-9
- Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. Endocr Rev 2011; 32: 670-93.
- Lee S, Farwell AP. Euthyroid Sick Syndrome. Compr Physiol 2016; 6: 1071-80.
- Scoscia E, Baglioni S, Eslami A, Iervasi G, Monti S, Todisco T. Low triiodothyronine (T3) state: a predictor of outcome in respiratory failure? Results of a clinical pilot study. Eur J Endocrinol 2004; 151: 557-60.
- Bertoli A, Valentini A, Cianfarani MA, Gasbarra E, Tarantino U, Federici M. Low FT3: a possible marker of frailty in the elderly. Clin Interv Aging 2017; 12: 335-41.
- Wei L, Sun S, Xu CH, et al. Pathology of the thyroid in severe acute respiratory syndrome. Hum Pathol 2007; 38: 95-102.
- Wang W, Ye YX, Yao H, Sun LQ, Wang AS, Wang ZY. Evaluation and observation of serum thyroid hormone and parathyroid hormone in patients with severe acute respiratory syndrome. J Chin Antituberculous Assoc 2003; 25: 232-4.
- Wei L, Sun S, Zhang J, et al. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Biochem Cell Biol 2010; 88: 723-30.
- Li MY, Li L, Zhang Y, Wang XS. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty 2020; 9: 45. doi: 10.1186/s40249-020-00662-x
- Wang W, Su X, Ding Y, et al. Thyroid function abnormalities in COVID-19 patients. MedRXiv 2020 Jan 1. doi: 10.1101/2020.06.15.20130807
- Chen M, Zhou W, Xu W. Thyroid Function Analysis in 50 Patients with COVID-19: A Retrospective Study. Thyroid 2021; 31: 8-11. doi: 10.1089/thy.2020.0363
- Zou R, Wu C, Zhang S, et al. Euthyroid Sick Syndrome in Patients With COVID-19. Front Endocrinol (Lausanne) 2020; 11: 566439. doi: 10.3389/fendo.2020.566439
- Gao W, Guo W, Guo Y, et al. Thyroid hormone concentrations in severely or critically ill patients with COVID-19. J Endocrinol Invest 2020; 1-10. doi: 10.1007/s40618-020-01460-w
- Rothberger GD, Valestra PK, Knight K, Desai AK, Calixte R, Shapiro LE. Low free T3 ıs associated with worse outcomes in patients in the ICU requiring ınvasive mechanical ventilation. J Intensive Care Med 2019; 885066619890822. doi: 10.1177/0885066619890822
- Bello G, Pennisi MA, Montini L, et al. Nonthyroidal illness syndrome and prolonged mechanical ventilation in patients admitted to the ICU. Chest 2009; 135: 1448-54.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Orijinal Makale |
| Yazarlar | |
| Yayımlanma Tarihi | 21 Mayıs 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 4 Sayı: 3 |
Cited By
SARS-CoV-2 infection and thyroid dysfunction in children
The Ukrainian Biochemical Journal
https://doi.org/10.15407/ubj95.03.012
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