Araştırma Makalesi
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Yıl 2023, Cilt: 13 Sayı: 3, 265 - 270, 30.12.2023

Sevda Soydan Nurşad Çifçi Feray Ferda Şenol

Öz

Kaynakça

  • 1. Ray GT, Suaya JA, Baxter R. Incidence, microbiology, and patient characteristics of skin and soft-tissue infections in a U.S. population: a retrospective population-based study. BMC Infect Dis. 2013;13:252.
  • 2. Erdemoglu A, Ozsoy MF, Emekdas G, Oncul O, Pahsa A. The resistance of Staphylococci isolated from urine to fu- sidic acid and other antimicrobials. Türk Mikrobiol Cem Derg. 2000;30:6-12.
  • 3. Akcay SS, Oguzoglu N, Inan AS, Kucukercan M, Cobanoglu F. Fucidic acid and mupirocin sensitivity of methicillin-resistant Staphylococcus aureus isolated from skin and soft tissue in- fections. Klimik Derg. 2005;18:117-120.
  • 4. Howe RA, Wootton M, Walsh TR, Bennett PM, Macgowan AP. Heterogeneous resistance to vancomycin in Staphylococcus aureus. J Antimicrob Chemother. 2000;45(1):130-132.
  • 5. Bonamonte D, Belloni Fortina A, Neri L, Patrizi A. Fusidic acid in skin infections and infected atopic eczema. G Ital Dermatol Venereol. 2014;149(4):453-459.
  • 6. Shanson DC. Clinical relevance of resistance to fusidic acid. J Antimicrob Chemother. 1990; 25: 15-21.
  • 7. Clinical and laboratory standards institute. performance standards for antimicrobial susceptibility testing; 20th Informational Supplement, M100-S20. Wayne, PA: CLSI; 2010.p.60-74.
  • 8. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 5.0, 2015.
  • 9. Evirgen Ö. Empirical treatment of skin and soft tissue infections. Yoğun Bakım Dergisi. 2012; 3: 120-127.
  • 10. Demir B, Denk A, Karlıdağ EG, Uçak H. Antibiotic susceptibility of microorganisms isolated from the bacterial skin infections and evaluation of empirical antibiotic therapy. F Ü Sağ Bil Tıp Dergisi. 2014; 1: 05 -10.
  • 11. Ippolito G, Leone S, Lauria FN, Nicastri E, Wenzel RP. Methicillin-resistant Staphylococcus aureus: the superbug. Int J Infect Dis. 2010;14 Suppl 4:S7-S11.
  • 12. Liu Y, Zhang J, Ji Y. PCR-based approaches for the detection of clinical methicillin-resistant Staphylococcus aureus. The Open Micr Journ. 2016; 10: 45-56.
  • 13. Belbase A, Pant ND, Nepal K, Neupane B, Baidhya R, Baidya R, et al. Antibiotic resistance and biofilm production among the strains of Staphylococcus aureus isolated from pus/wound swab samples in a tertiary care hospital in Nepal. Ann Clin Microbiol Antimicrob. 2017 Mar 23;16(1):15. doi: 10.1186/s12941-017-0194-0. Erratum in: Ann Clin Microbiol Antimicrob. 2017 Apr 13;16(1):30.
  • 14. Yazgı H, Ertek M, Aktaş O. İnvestigation of fusidic acid susceptibility of staphylococcus strains isolated from various clinical specimens.Turk Mikrobiyol Cem Derg. 2003; 33: 12-15.
  • 15. Yurtsever SG, Kurultay N, Çeken N, Yurtsever Ş, Afşar İ, Şener A. et al. Evaluation of the microorganisms isolated from wound specimens and their antibiotic susceptibility. Ankem Derg.2009;1:34-8.
  • 16. Liu Y, Geng W, Yang Y, Wang C, Zheng Y, Shang Y. et al. Susceptibility to and resistance determinants of fusidic acid in Staphylococcus aureus isolated from Chinese children with skin and soft tissue infections. FEMS İmmunology&Medical Microbiology. 2012;2: 212-218.
  • 17. Buzaid N, Elzouki AN, Taher I, Ghenghesh KS. Methicillin resistant Staphylococcus aureus (MRSA) in a tertiary surgical and trauma hospital in Benghazi, Libya. J Infect Dev Ctries, 2011;13;5(10): 723-6.
  • 18. Gosbell IB. Methicillin-resistant Staphylococcus aureus. Am J Clin Dermatol. 2004; 4:239-59.
  • 19. Renniea RP, Jonesb RN, Mutnickb AH. Occurrence and antimicrobial susceptibility patterns of pathogens isolated from skin and soft tissue infections: report from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 2000). Diagnostic Microbiology and Infectious Disease. 2003; 45: 287-293.
  • 20. Doğan M, Feyzioğlu B, Baykan M. The change of antibiotic resistance in S. aureus strains within ten year periods. Abant Medical Journal. 2014;3: 237-241.
  • 21. DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010;375(9725):1557-1568.
  • 22. Wang HK, Huang CY, Huang YC. Clinical features and molecular characteristics of childhood community-associated methicillin-resistant Staphylococcus aureus infection in a medical center in northern Taiwan, 2012. BMC Infect Dis. 2017;17(1):470.
  • 23. Khawcharoenporn T, Alan T. Oral antibiotic treatment for methicillin-resistant Staphylococcus aureus skin and soft tissue infections: review of the literature, Hawaii Med J.2006 ;65(10):290-3.
  • 24. İskender S, Yılmaz G, Aydın K, Sucu N, Aktoz Boz G, Çaylan R. et al. İnvestigation of susceptibility of methicillin resistant Staphylococcus aureus strains to fusidic acid and trimetophrim-sulfamethoxazole with disc diffusion method. Flora derg. 2007;12(3):153-156.
  • 25. Geisel R, Schmitz FJ, Fluit AC, Labischinski H. Emergence, mechanism, and clinical implications of reduced glycopeptide susceptibility in Staphylococcus aureus. Eur J Clin Microbiol Infect Dis. 2001;20(10):685-697.
  • 26. Yaman G, Çıkman A, Berktaş M, Paelak M, Güdücüoğlu H, Karahocagil MK. MLSB,fusidic acid and various antibiotic resistance rates of nosocomial Staphylococcus aureus isolates. Ankem Derg. 2010;24(3):130-135.
  • 27. Altun B, Kocagöz S, Hasçelik G, Uzun Ö, Akova M, Ünal S. Susceptibilities to fusidic acid and frequently used antibiotics of staphylococcus strains isolated in various hospitals. Turk Mikrobiyol Cem Derg. 2003; 33: 8-11.
  • 28. Doğan SŞ, Paköz NİE, Aral M.The distribution and antibiotic susceptibility of the microorganisma isolated from wound specimens. Türk Mikrobiyol Cem Derg. 2010; 40 (4): 243 – 249.
  • 29. Nishijima S, Kurokawa I. Antimicrobial resistance of Staphylococcus aureus isolated from skin infections. Int J Antimicrob Agents 2002; 19: 241-3.
  • 30. Atmaca S, Özekinci T, Yakut S, Akpolat N, Gül K. Üç farklı zaman aralığında (2001, 2011, 2017) hastanemizde izole edilen Staphylococcus aureus suşlarının fusidik aside karşı direnç durumları. ANKEM Derg. 2018;32(1):25-30.
  • 31. Kangül H, Atmaca S, Uzuner N, Çelik M. Dicle Üniversitesi Tıp Fakültesi Hastanesi’nde yatan hastalardan 2018, 2019 ve 2020 yıllarında izole edilen metisiline dirençli Staphylococcus aureus suşlarının çeşitli antibiyotiklere karşı direnç oranları. ANKEM Derg. 2021;35(2):38-44
  • 32. Şanlı K. Hastane kökenli ve toplum kaynaklı Staphylococcus aureus suşlarının çeşitli antimikrobiyallere duyarlılıkları. İKSSTD 2020;12(2):188-93.
  • 33. Coşkun MV, Alper Y, Uyanık MH, Yazgı H. Sensitivity of methicillin-resistant Staphylococcus aureus strains to fusidic acid and other non-β-lactam antibiotics. Klimik Derg. 2019; 32(1): 52-6. Turkish.

Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections

Yıl 2023, Cilt: 13 Sayı: 3, 265 - 270, 30.12.2023

Sevda Soydan Nurşad Çifçi Feray Ferda Şenol

Öz

Aim: We aimed to detect the frequency of methicillin-resistant Staphylococcus aureus (MRSA) strains that were isolated from wound infections in our hospital, and then we want to evaluate the in vitro fusidic acid (FA) susceptibility rates of them to determine the place of FA in empirical treatment.
Material and Method: A total of 110 S. aureus strains, which were isolated from wound culture samples from various services and outpatients, were included in the study. The bacteria were identified and antibiogram using our microbiology laboratory’s classical methods and VITEK 2 (Biomerieux, France) system. Methicillin sensitivity was evaluated according to Clinical and Laboratory Standards Institute (CLSI) criteria, and Fusidic acid sensitivity was assessed according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) criteria. The data were recorded in the IBM Statistical Package for Social Sciences (SPSS) program version 17, statistical analyses were performed, and P <0.05 was considered significant.
Results: 51 (46.4%) of S. aureus were isolated from service patients, and 59 (53.6%) were separated from outpatient clinics. The total methicillin resistance of 110 S. aureus strains was 20.9%. Methicillin resistance in outpatient clinics and services was 17.4% and 23.72%, respectively; their difference was not statistically significant (P >0.05). Sensitivity rates of FA in the outpatient clinics and services were found to be 90.2% and 94.9%, respectively, and the difference was not statistically significant (P >0.05). Methicillin-resistant Staphylococcus aureus was primarily isolated from pediatrics, orthopedics, general surgery, and otorhinolaryngology. In these units, FA sensitivities were 93.7%, 96.1%, 100%, and 100%, respectively.
Conclusion: FA should be considered an effective and safe empirical treatment option in treating soft tissue and wound infections caused by community and hospital-acquired MRSA.

Anahtar Kelimeler

fusidic acid wound infections methicillin-resistant Staphylococcus aureu

Kaynakça

  • 1. Ray GT, Suaya JA, Baxter R. Incidence, microbiology, and patient characteristics of skin and soft-tissue infections in a U.S. population: a retrospective population-based study. BMC Infect Dis. 2013;13:252.
  • 2. Erdemoglu A, Ozsoy MF, Emekdas G, Oncul O, Pahsa A. The resistance of Staphylococci isolated from urine to fu- sidic acid and other antimicrobials. Türk Mikrobiol Cem Derg. 2000;30:6-12.
  • 3. Akcay SS, Oguzoglu N, Inan AS, Kucukercan M, Cobanoglu F. Fucidic acid and mupirocin sensitivity of methicillin-resistant Staphylococcus aureus isolated from skin and soft tissue in- fections. Klimik Derg. 2005;18:117-120.
  • 4. Howe RA, Wootton M, Walsh TR, Bennett PM, Macgowan AP. Heterogeneous resistance to vancomycin in Staphylococcus aureus. J Antimicrob Chemother. 2000;45(1):130-132.
  • 5. Bonamonte D, Belloni Fortina A, Neri L, Patrizi A. Fusidic acid in skin infections and infected atopic eczema. G Ital Dermatol Venereol. 2014;149(4):453-459.
  • 6. Shanson DC. Clinical relevance of resistance to fusidic acid. J Antimicrob Chemother. 1990; 25: 15-21.
  • 7. Clinical and laboratory standards institute. performance standards for antimicrobial susceptibility testing; 20th Informational Supplement, M100-S20. Wayne, PA: CLSI; 2010.p.60-74.
  • 8. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 5.0, 2015.
  • 9. Evirgen Ö. Empirical treatment of skin and soft tissue infections. Yoğun Bakım Dergisi. 2012; 3: 120-127.
  • 10. Demir B, Denk A, Karlıdağ EG, Uçak H. Antibiotic susceptibility of microorganisms isolated from the bacterial skin infections and evaluation of empirical antibiotic therapy. F Ü Sağ Bil Tıp Dergisi. 2014; 1: 05 -10.
  • 11. Ippolito G, Leone S, Lauria FN, Nicastri E, Wenzel RP. Methicillin-resistant Staphylococcus aureus: the superbug. Int J Infect Dis. 2010;14 Suppl 4:S7-S11.
  • 12. Liu Y, Zhang J, Ji Y. PCR-based approaches for the detection of clinical methicillin-resistant Staphylococcus aureus. The Open Micr Journ. 2016; 10: 45-56.
  • 13. Belbase A, Pant ND, Nepal K, Neupane B, Baidhya R, Baidya R, et al. Antibiotic resistance and biofilm production among the strains of Staphylococcus aureus isolated from pus/wound swab samples in a tertiary care hospital in Nepal. Ann Clin Microbiol Antimicrob. 2017 Mar 23;16(1):15. doi: 10.1186/s12941-017-0194-0. Erratum in: Ann Clin Microbiol Antimicrob. 2017 Apr 13;16(1):30.
  • 14. Yazgı H, Ertek M, Aktaş O. İnvestigation of fusidic acid susceptibility of staphylococcus strains isolated from various clinical specimens.Turk Mikrobiyol Cem Derg. 2003; 33: 12-15.
  • 15. Yurtsever SG, Kurultay N, Çeken N, Yurtsever Ş, Afşar İ, Şener A. et al. Evaluation of the microorganisms isolated from wound specimens and their antibiotic susceptibility. Ankem Derg.2009;1:34-8.
  • 16. Liu Y, Geng W, Yang Y, Wang C, Zheng Y, Shang Y. et al. Susceptibility to and resistance determinants of fusidic acid in Staphylococcus aureus isolated from Chinese children with skin and soft tissue infections. FEMS İmmunology&Medical Microbiology. 2012;2: 212-218.
  • 17. Buzaid N, Elzouki AN, Taher I, Ghenghesh KS. Methicillin resistant Staphylococcus aureus (MRSA) in a tertiary surgical and trauma hospital in Benghazi, Libya. J Infect Dev Ctries, 2011;13;5(10): 723-6.
  • 18. Gosbell IB. Methicillin-resistant Staphylococcus aureus. Am J Clin Dermatol. 2004; 4:239-59.
  • 19. Renniea RP, Jonesb RN, Mutnickb AH. Occurrence and antimicrobial susceptibility patterns of pathogens isolated from skin and soft tissue infections: report from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 2000). Diagnostic Microbiology and Infectious Disease. 2003; 45: 287-293.
  • 20. Doğan M, Feyzioğlu B, Baykan M. The change of antibiotic resistance in S. aureus strains within ten year periods. Abant Medical Journal. 2014;3: 237-241.
  • 21. DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010;375(9725):1557-1568.
  • 22. Wang HK, Huang CY, Huang YC. Clinical features and molecular characteristics of childhood community-associated methicillin-resistant Staphylococcus aureus infection in a medical center in northern Taiwan, 2012. BMC Infect Dis. 2017;17(1):470.
  • 23. Khawcharoenporn T, Alan T. Oral antibiotic treatment for methicillin-resistant Staphylococcus aureus skin and soft tissue infections: review of the literature, Hawaii Med J.2006 ;65(10):290-3.
  • 24. İskender S, Yılmaz G, Aydın K, Sucu N, Aktoz Boz G, Çaylan R. et al. İnvestigation of susceptibility of methicillin resistant Staphylococcus aureus strains to fusidic acid and trimetophrim-sulfamethoxazole with disc diffusion method. Flora derg. 2007;12(3):153-156.
  • 25. Geisel R, Schmitz FJ, Fluit AC, Labischinski H. Emergence, mechanism, and clinical implications of reduced glycopeptide susceptibility in Staphylococcus aureus. Eur J Clin Microbiol Infect Dis. 2001;20(10):685-697.
  • 26. Yaman G, Çıkman A, Berktaş M, Paelak M, Güdücüoğlu H, Karahocagil MK. MLSB,fusidic acid and various antibiotic resistance rates of nosocomial Staphylococcus aureus isolates. Ankem Derg. 2010;24(3):130-135.
  • 27. Altun B, Kocagöz S, Hasçelik G, Uzun Ö, Akova M, Ünal S. Susceptibilities to fusidic acid and frequently used antibiotics of staphylococcus strains isolated in various hospitals. Turk Mikrobiyol Cem Derg. 2003; 33: 8-11.
  • 28. Doğan SŞ, Paköz NİE, Aral M.The distribution and antibiotic susceptibility of the microorganisma isolated from wound specimens. Türk Mikrobiyol Cem Derg. 2010; 40 (4): 243 – 249.
  • 29. Nishijima S, Kurokawa I. Antimicrobial resistance of Staphylococcus aureus isolated from skin infections. Int J Antimicrob Agents 2002; 19: 241-3.
  • 30. Atmaca S, Özekinci T, Yakut S, Akpolat N, Gül K. Üç farklı zaman aralığında (2001, 2011, 2017) hastanemizde izole edilen Staphylococcus aureus suşlarının fusidik aside karşı direnç durumları. ANKEM Derg. 2018;32(1):25-30.
  • 31. Kangül H, Atmaca S, Uzuner N, Çelik M. Dicle Üniversitesi Tıp Fakültesi Hastanesi’nde yatan hastalardan 2018, 2019 ve 2020 yıllarında izole edilen metisiline dirençli Staphylococcus aureus suşlarının çeşitli antibiyotiklere karşı direnç oranları. ANKEM Derg. 2021;35(2):38-44
  • 32. Şanlı K. Hastane kökenli ve toplum kaynaklı Staphylococcus aureus suşlarının çeşitli antimikrobiyallere duyarlılıkları. İKSSTD 2020;12(2):188-93.
  • 33. Coşkun MV, Alper Y, Uyanık MH, Yazgı H. Sensitivity of methicillin-resistant Staphylococcus aureus strains to fusidic acid and other non-β-lactam antibiotics. Klimik Derg. 2019; 32(1): 52-6. Turkish.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Mikrobiyoloji
Bölüm Araştırma Makalesi
Yazarlar

Sevda Soydan Bu kişi benim

Nurşad Çifçi Bu kişi benim

Feray Ferda Şenol

Yayımlanma Tarihi 30 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 13 Sayı: 3

Kaynak Göster

APA Soydan, S., Çifçi, N., & Şenol, F. F. (2023). Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections. Kafkas Journal of Medical Sciences, 13(3), 265-270.
AMA Soydan S, Çifçi N, Şenol FF. Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections. Kafkas Journal of Medical Sciences. Aralık 2023;13(3):265-270.
Chicago Soydan, Sevda, Nurşad Çifçi, ve Feray Ferda Şenol. “Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus Aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections”. Kafkas Journal of Medical Sciences 13, sy. 3 (Aralık 2023): 265-70.
EndNote Soydan S, Çifçi N, Şenol FF (01 Aralık 2023) Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections. Kafkas Journal of Medical Sciences 13 3 265–270.
IEEE S. Soydan, N. Çifçi, ve F. F. Şenol, “Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections”, Kafkas Journal of Medical Sciences, c. 13, sy. 3, ss. 265–270, 2023.
ISNAD Soydan, Sevda vd. “Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus Aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections”. Kafkas Journal of Medical Sciences 13/3 (Aralık 2023), 265-270.
JAMA Soydan S, Çifçi N, Şenol FF. Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections. Kafkas Journal of Medical Sciences. 2023;13:265–270.
MLA Soydan, Sevda vd. “Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus Aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections”. Kafkas Journal of Medical Sciences, c. 13, sy. 3, 2023, ss. 265-70.
Vancouver Soydan S, Çifçi N, Şenol FF. Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections. Kafkas Journal of Medical Sciences. 2023;13(3):265-70.
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