Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media

Dursun Mehmet Mehel; Nesrettin Fatih Turgut; Sevil Alkan Çeviker; Doğukan Özdemir; Abdulkadir Özgür

Araştırma Makalesi

Yıl 2022, Cilt: 39 Sayı: 2, 365 - 368, 18.03.2022

Dursun Mehmet Mehel Nesrettin Fatih Turgut Sevil Alkan Çeviker Doğukan Özdemir Abdulkadir Özgür

Öz

Kaynakça

1. Hui CP, Canadian Paediatric Society ID, İmmunization C. Acute otitis externa. Paediatric Child Health. 2013;18(2):96-101.
2. Osguthorpe JD, Nielsen DR. Otitis externa: Reviewand clinical update. Am Fam Physician. 2006;74(9):1510-6.
3. Neher A, Nagl M, Scholtz AW. Otitis externa: etiology, diagnostic and therapy. Hno 2008;56(10):1067–79.
4. Kaushik V, Malik T, Saeed SR. İnterventions for acute otitis externa. Cochrane Database Syst Rev. 2010;20(1):CD004740.
5. Mosges R, Nematian-Samani M, Eichel A. Treatmant of acute otitis externa with ciprofloxacin otic %0.2 antibiotic ear solution. Ther Clin Risk manag. 2011;7:325-36.
6. Scholz H, Schwabe U. (Hrsg.). Taschenbuch der arzneibehandlung – angewandte pharmakologie. Berlin Heidelberg: Springer Verlag; 2005.
7. Edwin B, Prasanna V, Kannan I, Katiyar VH, Dhanapal E. Incidence of bacterial colonization in the oropharynx of patients with ear, nose and throat infections.İnternational Journal of Medical Science and Public Health.2014;3(8)931-4.
8. Centers for Disease Control and Prevention (CDC). Estimated burden of acute otitis externa–United States, 2003-2007. MMWR Morb Mortal Wkly Rep. 2011;60:605–9.
9. Rosenfeld RM, Singer M, Wasserman JM, Stinnett SS. Systematic review of topical antimicrobial therapy for acute otitis externa. Otolaryngol Head Neck Surg. 2006 134;(4):24–48.
10. Martinez-Devesa P, Willis CM, Capper JWR. External auditory canal pH in chronic otitis externa. Clin Otolaryngol Allied Sci. 2003;28:320-4.
11. Lee H, Kim J, Nguyen V. Ear infections: otitis externa and otitis media, Prim Care Clin Office Pract. 2013;40(3):671-86.
12. Villedieu A, Papesh E, Weinberg E, Teare L, Radhakrishnan J, Elamin WF. Seasonal variation of Pseudomonas aeruginosa in culture positive otitis externa in South East England.Epidemiol İnfect. 2018;146(14):1811-2.
13. Rosenfeld RM, Schwartz SR, Cannon CR. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150:S1–S24.
14. Ahmad N, Etheridge C, Farrigton M, Bauley DM. Prospective study of the microbiological flora of hearing aid moulds and the efficacy of current cleaning techniques. J Laryngol Otol. 2007;121(2):110-3.
15. Heward E, Cullen M, Hobson J. Microbiology and antimicrobial susceptibility of otitis externa: a changing pattern of antimicrobial resistance. J Laryngology Otology 2018;132(4)314-17.
16. Pino Rivero V, Pantoja Hernandez CG, Gonzalez Palomino G, Santos ME, Pardo Romero G, Blasco Huelva A. Pseudomonans and acute external otitis. Results of amicrobial study in patient without previous antibiotic treatment. An Otorinolaringol İbero Am. 2007;34(1)45-51.
17. Borsa BA, Kaplan HH, Aldağ ME, Dengiz Y, Hanay A, Tandoğan B. Otitis eksterna ve otitis media hastalarında etken mikroorganizmaların ve antibiyotik duyarlılıklarının belirlenmesi. ANKEM Derg. 2016;30(2):48-52.
18. Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeutic Advances in Drug Safety. 2014;5(6)229-41.
19. Bath AP, Walsh RM, Bance ML, Rutka JA. Ototoxicity of topical gentamicin preparations. Laryngoscope 1999;109:1088-93.
20. Dohar JE, Alper CM, Rose EA, Doyle WJ, Casselbrant ML, Kenna MA, et al. Treatment of chronic suppurative otitis media with topical ciprofloxacin. Ann Otol Rhinol Laryngol 1998;107: 865-71.
21. Berenholz L, Katzenell U, Harell M. Evolving resistant pseudomonas to ciprofloxacin in malignant otitis externa. Laryngoscope 2002;112(9)1619-22.
22. Duarte MJ, Kozin ED, Bispo PJM, Mitchell AH, Gilmore MS, Remenschneider AK. Methicillin-resistant Staphylococcus aureus in acute otitis externa. World J Otorhinolaryngol Head Neck Surg. 2017;23(4):246-52.
23. Pane G, Cacciola G, Giacco E, Mariottini GL, Coppo E. Assessment of the Antimicrobial Activity of Algae Extracts on Bacteria Responsible of External Otitis Mar Drugs . 2015;13(10): 6440–52.
24. A Abou-Elnasr, AA. EL- Madbouly. İmpact of pathogen identification on the morbidity and treatment strategy in patients with malignant otitis externa. AAMJ 2015;13(3):suppl2.

Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media

Yıl 2022, Cilt: 39 Sayı: 2, 365 - 368, 18.03.2022

Dursun Mehmet Mehel Nesrettin Fatih Turgut Sevil Alkan Çeviker Doğukan Özdemir Abdulkadir Özgür

Öz

Acute otitis externa is an infection of the outer ear canal that can occur at any age and is diagnosed by symptoms and examination findings. The aims of our study were to understand the seasonal frequency of acute otitis externa and to determine the susceptibility of causative bacteria to ciprofloxacin. Discharge samples were collected from the external ear canals of 76 patients diagnosed with acute otitis externa. The samples were evaluated and culture-antibiogram results were compiled. Routine microbiological methods were used for the reproduction of clinical material as bacterial and fungal cultures. The 76 enrolled patients were 18–80 years old (mean 41.6 years). Acute otitis externa occurred most frequently during summer, especially in July. Culture results revealed Pseudomonas aeruginosa growth in 30 cases (39.4%), Staphylococcus aureus in 18 cases (23.6%), and Serratia spp. in 5 cases (6.5%), while fungal growth was observed in 10 cases (13.1%). The antibiogram analyses determined ciprofloxacin resistance in P. aeruginosa in 13 patients (43.3%) and in S. aureus in 6 patients (33.3%). Acute otitis externa should be treated with antibiotics in accordance with culture antibiogram results, while keeping in mind that bacterial causes could be ciprofloxacin resistant.

Anahtar Kelimeler

Acute otitis externa, season, culture antibiogram, ciprofloxacin effectiveness

Kaynakça

1. Hui CP, Canadian Paediatric Society ID, İmmunization C. Acute otitis externa. Paediatric Child Health. 2013;18(2):96-101.
2. Osguthorpe JD, Nielsen DR. Otitis externa: Reviewand clinical update. Am Fam Physician. 2006;74(9):1510-6.
3. Neher A, Nagl M, Scholtz AW. Otitis externa: etiology, diagnostic and therapy. Hno 2008;56(10):1067–79.
4. Kaushik V, Malik T, Saeed SR. İnterventions for acute otitis externa. Cochrane Database Syst Rev. 2010;20(1):CD004740.
5. Mosges R, Nematian-Samani M, Eichel A. Treatmant of acute otitis externa with ciprofloxacin otic %0.2 antibiotic ear solution. Ther Clin Risk manag. 2011;7:325-36.
6. Scholz H, Schwabe U. (Hrsg.). Taschenbuch der arzneibehandlung – angewandte pharmakologie. Berlin Heidelberg: Springer Verlag; 2005.
7. Edwin B, Prasanna V, Kannan I, Katiyar VH, Dhanapal E. Incidence of bacterial colonization in the oropharynx of patients with ear, nose and throat infections.İnternational Journal of Medical Science and Public Health.2014;3(8)931-4.
8. Centers for Disease Control and Prevention (CDC). Estimated burden of acute otitis externa–United States, 2003-2007. MMWR Morb Mortal Wkly Rep. 2011;60:605–9.
9. Rosenfeld RM, Singer M, Wasserman JM, Stinnett SS. Systematic review of topical antimicrobial therapy for acute otitis externa. Otolaryngol Head Neck Surg. 2006 134;(4):24–48.
10. Martinez-Devesa P, Willis CM, Capper JWR. External auditory canal pH in chronic otitis externa. Clin Otolaryngol Allied Sci. 2003;28:320-4.
11. Lee H, Kim J, Nguyen V. Ear infections: otitis externa and otitis media, Prim Care Clin Office Pract. 2013;40(3):671-86.
12. Villedieu A, Papesh E, Weinberg E, Teare L, Radhakrishnan J, Elamin WF. Seasonal variation of Pseudomonas aeruginosa in culture positive otitis externa in South East England.Epidemiol İnfect. 2018;146(14):1811-2.
13. Rosenfeld RM, Schwartz SR, Cannon CR. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150:S1–S24.
14. Ahmad N, Etheridge C, Farrigton M, Bauley DM. Prospective study of the microbiological flora of hearing aid moulds and the efficacy of current cleaning techniques. J Laryngol Otol. 2007;121(2):110-3.
15. Heward E, Cullen M, Hobson J. Microbiology and antimicrobial susceptibility of otitis externa: a changing pattern of antimicrobial resistance. J Laryngology Otology 2018;132(4)314-17.
16. Pino Rivero V, Pantoja Hernandez CG, Gonzalez Palomino G, Santos ME, Pardo Romero G, Blasco Huelva A. Pseudomonans and acute external otitis. Results of amicrobial study in patient without previous antibiotic treatment. An Otorinolaringol İbero Am. 2007;34(1)45-51.
17. Borsa BA, Kaplan HH, Aldağ ME, Dengiz Y, Hanay A, Tandoğan B. Otitis eksterna ve otitis media hastalarında etken mikroorganizmaların ve antibiyotik duyarlılıklarının belirlenmesi. ANKEM Derg. 2016;30(2):48-52.
18. Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeutic Advances in Drug Safety. 2014;5(6)229-41.
19. Bath AP, Walsh RM, Bance ML, Rutka JA. Ototoxicity of topical gentamicin preparations. Laryngoscope 1999;109:1088-93.
20. Dohar JE, Alper CM, Rose EA, Doyle WJ, Casselbrant ML, Kenna MA, et al. Treatment of chronic suppurative otitis media with topical ciprofloxacin. Ann Otol Rhinol Laryngol 1998;107: 865-71.
21. Berenholz L, Katzenell U, Harell M. Evolving resistant pseudomonas to ciprofloxacin in malignant otitis externa. Laryngoscope 2002;112(9)1619-22.
22. Duarte MJ, Kozin ED, Bispo PJM, Mitchell AH, Gilmore MS, Remenschneider AK. Methicillin-resistant Staphylococcus aureus in acute otitis externa. World J Otorhinolaryngol Head Neck Surg. 2017;23(4):246-52.
23. Pane G, Cacciola G, Giacco E, Mariottini GL, Coppo E. Assessment of the Antimicrobial Activity of Algae Extracts on Bacteria Responsible of External Otitis Mar Drugs . 2015;13(10): 6440–52.
24. A Abou-Elnasr, AA. EL- Madbouly. İmpact of pathogen identification on the morbidity and treatment strategy in patients with malignant otitis externa. AAMJ 2015;13(3):suppl2.

Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Sağlık Kurumları Yönetimi
Bölüm	Clinical Research
Yazarlar	Dursun Mehmet Mehel 0000-0002-5613-3393 Nesrettin Fatih Turgut 0000-0001-6265-0058 Sevil Alkan Çeviker 0000-0003-1944-2477 Doğukan Özdemir 0000-0003-2008-163X Abdulkadir Özgür 0000-0002-6155-5988
Erken Görünüm Tarihi	18 Mart 2022
Yayımlanma Tarihi	18 Mart 2022
Gönderilme Tarihi	3 Ağustos 2021
Kabul Tarihi	15 Ekim 2021
Yayımlandığı Sayı	Yıl 2022 Cilt: 39 Sayı: 2

Kaynak Göster

APA	Mehel, D. M., Turgut, N. F., Alkan Çeviker, S., Özdemir, D., vd. (2022). Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. Journal of Experimental and Clinical Medicine, 39(2), 365-368.
AMA	Mehel DM, Turgut NF, Alkan Çeviker S, Özdemir D, Özgür A. Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. J. Exp. Clin. Med. Mart 2022;39(2):365-368.
Chicago	Mehel, Dursun Mehmet, Nesrettin Fatih Turgut, Sevil Alkan Çeviker, Doğukan Özdemir, ve Abdulkadir Özgür. “Effectiveness of Ciprofloxacin in the Treatment of Acute Otitis Media”. Journal of Experimental and Clinical Medicine 39, sy. 2 (Mart 2022): 365-68.
EndNote	Mehel DM, Turgut NF, Alkan Çeviker S, Özdemir D, Özgür A (01 Mart 2022) Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. Journal of Experimental and Clinical Medicine 39 2 365–368.
IEEE	D. M. Mehel, N. F. Turgut, S. Alkan Çeviker, D. Özdemir, ve A. Özgür, “Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media”, J. Exp. Clin. Med., c. 39, sy. 2, ss. 365–368, 2022.
ISNAD	Mehel, Dursun Mehmet vd. “Effectiveness of Ciprofloxacin in the Treatment of Acute Otitis Media”. Journal of Experimental and Clinical Medicine 39/2 (Mart 2022), 365-368.
JAMA	Mehel DM, Turgut NF, Alkan Çeviker S, Özdemir D, Özgür A. Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. J. Exp. Clin. Med. 2022;39:365–368.
MLA	Mehel, Dursun Mehmet vd. “Effectiveness of Ciprofloxacin in the Treatment of Acute Otitis Media”. Journal of Experimental and Clinical Medicine, c. 39, sy. 2, 2022, ss. 365-8.
Vancouver	Mehel DM, Turgut NF, Alkan Çeviker S, Özdemir D, Özgür A. Effectiveness of ciprofloxacin in the treatment of Acute Otitis Media. J. Exp. Clin. Med. 2022;39(2):365-8.

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