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Yoğun Bakımda Takip Edilen COVID-19 Pozitif ve COVID-19 Negatif Hasta Gruplarında Kan Dolaşımı Enfeksiyonları: Vaka Kontrol Çalışması

Yıl 2022, Cilt: 13 Sayı: 2, 182 - 187, 30.06.2022
https://doi.org/10.18663/tjcl.1027448

Öz

Amaç: Kan dolaşımı enfeksiyonları, yoğun bakım ünitelerinde takip edilen hastalarda karşılaştığımız en önemli sorunlardan
biridir. Çalışmamızda yoğun bakım ünitesinde SARS-CoV-2 (COVID-19) pozitifliği veya diğer nedenlerle izlenen hastaların
demografik özellikleri ve bakteriyemi epidemiyolojilerini karşılaştırmalı olarak incelemeyi amaçladık.
Gereç ve Yöntemler: Çalışmaya kan kültürü çalışılan 192 olgu (>18 yaş) dahil edildi. Olgu grubunda 30'u COVID-19 pozitif,
kontrol grubunda 30'u COVID-19 negatif olmak üzere toplam 60 vakanın kan kültürü sonuçları incelendi.
Bulgular: Olgu grubundaki hastaların 13'ü (%43.3) kadın, 17'si (%56.7) erkekti ve grubun yaş ortalaması 63.8±19 (22-88)
idi. Kontrol grubunun 15'i (%50) kadın, 15'i (%50) erkek ve grubun yaş ortalaması 76.1±17.6 (48-92) idi. Cinsiyet (p=0.605),
sepsis dışı komorbid durum (p=0.005), üretilen izolat sayısı (p=0.260), kan kültür seti miktarı (p=0.118), bakteriyemi risk
faktörleri ve ölüm oranları (p=0.612) açısından iki grup arasında istatistiksel olarak anlamlı fark yoktu. Ancak yaş ortalaması
(p=0.000), cilt kontaminasyonu (p=0.028) ve prednizolon tedavisi (p=0.000) açısından farklılıklar vardı.
Sonuç: COVID-19 nedeniyle yoğun bakım ünitelerinde yatan hastalarda kan dolaşımı enfeksiyonu riski, COVID-19 dışı
nedenlerle yatırılan hasta grubundan farklı değildir.

Destekleyen Kurum

yok

Proje Numarası

yok

Kaynakça

  • 1. WHO TEAM. Weekly epidemiological update on COVID-19 - 13 July 2021. https://www.who.int/emergencies/diseases/novelcoronavirus-2019/situation-reports
  • 2. T.C. Sağlık Bakanlığı. COVID-19 Bilgilendirme Platformu (Haziran 2021). https://covid19.saglik.gov.tr
  • 3. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323: 1239–42.
  • 4. Kallel H, Houcke S, Resiere D, et all. Epidemiology and Prognosis of Intensive Care Unit–Acquired Bloodstream Infection. Am. J. Trop. Med. Hyg., 2020; 103: 508–14.
  • 5. Palanisamy N, Vihari N, Meena DS, et all. Clinical profile of bloodstream infections in COVID 19 patients: a retrospective cohort study. Palanisamy et al. BMC Infect Dis 2021; 21: 933.
  • 6. Trubiano JA, Padiglione AA. Nosocomial infections in the intensive care unit. Anaesthesia & Intensive Care Medicine. 2015; 16: 598-602.
  • 7. Spencer RC. Epidemiology of infection in ICU’s. Intensive Care Med 1994; 20: 2-6.
  • 8. Siddiqui S. Mortality profile across our Intensive Care Units: A 5-year database report from a Singapore restructured hospital. Indian J Crit Care Med. 2015; 19: 726-7.
  • 9. Altıay G, Tabakoğlu E, Özdemir L, ve ark. Solunum Yoğun Bakım Hastalarında Mortalite Oranları ve İlişkili Faktörlerin Belirlenmesi. Toraks Dergisi. 2007; 8: 79-84.
  • 10. Erol AT, Aşar S, Sabaz MS, et all. Risk Factors for 28-day Mortality Among COVID-19 Patients in an Intensive Care Unit of a Tertiary Care Center in Istanbul. Med J Bakirkoy 2021; 17: 100-7.
  • 11. Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA. 2020; 323: 1775-6.
  • 12. CDC COVID-19 Response Team, CDC COVID-19 Response Team. Bialek S, Boundy E, Bowen V, vd. Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) - United States, February 12-March 16, 2020. MMWR Morb Mortal Wkly Rep. 2020; 69: 343-6.
  • 13. Baud D, Qi X, Nielsen-Saines K, et al. Real estimates of mortality following COVID-19 infection. Lancet Infect Dis. 2020; 20: 773.
  • 14. Ursavaş A, Ege E, Yüksel EG, et all. Solunumsal Yoğun Bakım Ünitesinde Mortaliteyi Etkileyen Faktörlerin Değerlendirilmesi. Yoğun Bakım Dergisi 2006; 6: 43-8.
  • 15. Çakır E, Kocabeyoğlu GM, Gürbüz Ö, et all. Yoğun Bakım Ünitesinde Mortalite Sıklığı Ve Risk Faktörlerinin Değerlendirilmesi. Ankara Eğt. Arş. Hast. Derg., 2020; 53: 20-4.
  • 16. Arısoy A, Demirkıran H, Günbatar H, et al. Yoğun Bakımımızda Ölen 38 Hastanın Mortalite Nedenleri. Van Tıp Dergisi: 2013; 20: 217-21.
  • 17. Bıçak İ, Varışlı AN, Peker SA. Kan Kültüründen İzole Edilen Etkenlerin Dağılımı ve Antibiyotik Duyarlılıkları: Dört Yıllık Verilerimiz. Cerrahi Ameliyathane Sterilizasyon Enfeksiyon Kontrol Hemşireliği Dergisi 2020; 1: 8-19.
  • 18. Hughes S, Troise O, Donaldson H, et al. Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting. Clin Microbiol Infect 2020; 26: 1395-9.
  • 19. Doğan A, Öztürk Çerik H, Gürgen A, Özturan A. The Effect of Sociodemographic Structure of the Society on the Level of Knowledge, Anxiety and Expectations about the COVID-19 Pandemic. J Immunol Clin Microbiol. 2021; 6: 139-47.
  • 20. Haedo MF, Melendı SE, Maurı ML, et all. Usefulness of Blood Cultures ın COVID-19 Pneumonıa. MEDICINA (Buenos Aires) 2020; 80: 44-7.
  • 21. Altunisik Toplu S, Altunisik N, Turkmen D, Ersoy Y. Relationship between hand hygiene and cutaneous findings during COVID-19 pandemic. J Cosmet Dermatol. 2020; 19 :2468-73.

Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study

Yıl 2022, Cilt: 13 Sayı: 2, 182 - 187, 30.06.2022
https://doi.org/10.18663/tjcl.1027448

Öz

Aim: Bloodstream infections are one of the most important problems we encounter in patients followed up in intensive
care units. In our study, we aimed to comparatively examine the demographic characteristics and bacteremia epidemiology
of patients who were followed up for SARS-CoV-2 (COVID-19) positivity or other reasons in the intensive care units.
Material and Methods: 192 cases (>18 age) whose blood cultures were studied were included in the study. The blood
culture results of a total of 60 cases, 30 of which were positive for COVID-19 in the study group and 30 were negative for
COVID-19 in the control group, were examined.
Results: Thirteen (43.3%) of the patients in the case group were female, 17 (56.7%) were male, and the mean age of the
group was 63.8±19 (22-88). In the control group, 15 (50%) were female, 15 (50%) were male, and the mean age of the
group was 76.1±17.6 (48-92). There was no statistically significant difference between the two groups in terms of sex
(p=0.605), comorbid conditions (excluding sepsis (p=0.005)), the number of isolates produced (p=0.260), the amount
of blood culture set (p=0.118), bacteremia risk factors and mortality rates (p=0.612). However, there were differences in
mean age (p=0.000), skin contamination (p=0.028) and prednisolone treatment (p=0.000).
Conclusion: The risk of bloodstream infection in patients hospitalized in the intensive care units due to COVID-19 is not
different from the group of patients hospitalized for non-COVID-19 reasons.

Proje Numarası

yok

Kaynakça

  • 1. WHO TEAM. Weekly epidemiological update on COVID-19 - 13 July 2021. https://www.who.int/emergencies/diseases/novelcoronavirus-2019/situation-reports
  • 2. T.C. Sağlık Bakanlığı. COVID-19 Bilgilendirme Platformu (Haziran 2021). https://covid19.saglik.gov.tr
  • 3. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323: 1239–42.
  • 4. Kallel H, Houcke S, Resiere D, et all. Epidemiology and Prognosis of Intensive Care Unit–Acquired Bloodstream Infection. Am. J. Trop. Med. Hyg., 2020; 103: 508–14.
  • 5. Palanisamy N, Vihari N, Meena DS, et all. Clinical profile of bloodstream infections in COVID 19 patients: a retrospective cohort study. Palanisamy et al. BMC Infect Dis 2021; 21: 933.
  • 6. Trubiano JA, Padiglione AA. Nosocomial infections in the intensive care unit. Anaesthesia & Intensive Care Medicine. 2015; 16: 598-602.
  • 7. Spencer RC. Epidemiology of infection in ICU’s. Intensive Care Med 1994; 20: 2-6.
  • 8. Siddiqui S. Mortality profile across our Intensive Care Units: A 5-year database report from a Singapore restructured hospital. Indian J Crit Care Med. 2015; 19: 726-7.
  • 9. Altıay G, Tabakoğlu E, Özdemir L, ve ark. Solunum Yoğun Bakım Hastalarında Mortalite Oranları ve İlişkili Faktörlerin Belirlenmesi. Toraks Dergisi. 2007; 8: 79-84.
  • 10. Erol AT, Aşar S, Sabaz MS, et all. Risk Factors for 28-day Mortality Among COVID-19 Patients in an Intensive Care Unit of a Tertiary Care Center in Istanbul. Med J Bakirkoy 2021; 17: 100-7.
  • 11. Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA. 2020; 323: 1775-6.
  • 12. CDC COVID-19 Response Team, CDC COVID-19 Response Team. Bialek S, Boundy E, Bowen V, vd. Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) - United States, February 12-March 16, 2020. MMWR Morb Mortal Wkly Rep. 2020; 69: 343-6.
  • 13. Baud D, Qi X, Nielsen-Saines K, et al. Real estimates of mortality following COVID-19 infection. Lancet Infect Dis. 2020; 20: 773.
  • 14. Ursavaş A, Ege E, Yüksel EG, et all. Solunumsal Yoğun Bakım Ünitesinde Mortaliteyi Etkileyen Faktörlerin Değerlendirilmesi. Yoğun Bakım Dergisi 2006; 6: 43-8.
  • 15. Çakır E, Kocabeyoğlu GM, Gürbüz Ö, et all. Yoğun Bakım Ünitesinde Mortalite Sıklığı Ve Risk Faktörlerinin Değerlendirilmesi. Ankara Eğt. Arş. Hast. Derg., 2020; 53: 20-4.
  • 16. Arısoy A, Demirkıran H, Günbatar H, et al. Yoğun Bakımımızda Ölen 38 Hastanın Mortalite Nedenleri. Van Tıp Dergisi: 2013; 20: 217-21.
  • 17. Bıçak İ, Varışlı AN, Peker SA. Kan Kültüründen İzole Edilen Etkenlerin Dağılımı ve Antibiyotik Duyarlılıkları: Dört Yıllık Verilerimiz. Cerrahi Ameliyathane Sterilizasyon Enfeksiyon Kontrol Hemşireliği Dergisi 2020; 1: 8-19.
  • 18. Hughes S, Troise O, Donaldson H, et al. Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting. Clin Microbiol Infect 2020; 26: 1395-9.
  • 19. Doğan A, Öztürk Çerik H, Gürgen A, Özturan A. The Effect of Sociodemographic Structure of the Society on the Level of Knowledge, Anxiety and Expectations about the COVID-19 Pandemic. J Immunol Clin Microbiol. 2021; 6: 139-47.
  • 20. Haedo MF, Melendı SE, Maurı ML, et all. Usefulness of Blood Cultures ın COVID-19 Pneumonıa. MEDICINA (Buenos Aires) 2020; 80: 44-7.
  • 21. Altunisik Toplu S, Altunisik N, Turkmen D, Ersoy Y. Relationship between hand hygiene and cutaneous findings during COVID-19 pandemic. J Cosmet Dermatol. 2020; 19 :2468-73.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Özgün Makale
Yazarlar

Ahmet Doğan 0000-0001-5110-4027

Yakup Gezer 0000-0002-1582-7313

Hacer Özlem Kalaycı

Proje Numarası yok
Yayımlanma Tarihi 30 Haziran 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 13 Sayı: 2

Kaynak Göster

APA Doğan, A., Gezer, Y., & Kalaycı, H. Ö. (2022). Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study. Turkish Journal of Clinics and Laboratory, 13(2), 182-187. https://doi.org/10.18663/tjcl.1027448
AMA Doğan A, Gezer Y, Kalaycı HÖ. Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study. TJCL. Haziran 2022;13(2):182-187. doi:10.18663/tjcl.1027448
Chicago Doğan, Ahmet, Yakup Gezer, ve Hacer Özlem Kalaycı. “Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study”. Turkish Journal of Clinics and Laboratory 13, sy. 2 (Haziran 2022): 182-87. https://doi.org/10.18663/tjcl.1027448.
EndNote Doğan A, Gezer Y, Kalaycı HÖ (01 Haziran 2022) Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study. Turkish Journal of Clinics and Laboratory 13 2 182–187.
IEEE A. Doğan, Y. Gezer, ve H. Ö. Kalaycı, “Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study”, TJCL, c. 13, sy. 2, ss. 182–187, 2022, doi: 10.18663/tjcl.1027448.
ISNAD Doğan, Ahmet vd. “Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study”. Turkish Journal of Clinics and Laboratory 13/2 (Haziran 2022), 182-187. https://doi.org/10.18663/tjcl.1027448.
JAMA Doğan A, Gezer Y, Kalaycı HÖ. Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study. TJCL. 2022;13:182–187.
MLA Doğan, Ahmet vd. “Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study”. Turkish Journal of Clinics and Laboratory, c. 13, sy. 2, 2022, ss. 182-7, doi:10.18663/tjcl.1027448.
Vancouver Doğan A, Gezer Y, Kalaycı HÖ. Bloodstream Infections in COVID-19 Positive and COVID-19 Negative Patient Groups Followed Up in the Intensive Care Unit: Case-Control Study. TJCL. 2022;13(2):182-7.


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