Derleme
Yıl 2023,
Cilt: 3 Sayı: 1, 106 - 116, 31.01.2023
Öz
Amaç: Bu derleme otizm spektrum bozukluğunda oksitosinin etkinliğini incelemektedir.
Gereç ve Yöntem: Bu derleme çalışmasında ulusal ve uluslararası veri tabanlarındaki araştırmalardan yararlanılmıştır.
Tartışma: Otizm spektrum bozukluğu, yaşamın erken dönemlerinde başlayan, sosyal iletişimde ve tekrarlayan davranışlarda belirli bir bozulma, yüksek düzeyde sınırlı ilgi alanları ve/veya duyusal davranışların belirli bir kombinasyonuna sahip bireyleri tanımlamak için kullanılan nörogelişimsel bir hastalıktır. Oksitosin, sosyal uyaranların belirginliğini artırma özelliği olan ve organizmanın bu uyaranlara daha iyi katılabilmesi ve yanıt verebilmesi için nöral süreçlerin ince ayarını yapan hipotalamustan sentezlenen bir hormondur. Gelen duyusal sinyalleri işleyen beyin bölgelerindeki sosyal bilgilerin sinyal-gürültü oranını artırma ve akışı kolaylaştırma potansiyeline sahiptir. Bu bilgilerin duyuşsal ve bilişsel süreçlerle ilgili alanlara aktarılması, öğrenmeyi ve hafızayı ödüllendirir. Sosyal belirginliğin davranışsal etkilerinin artması, büyük ölçüde bağlam ve organizmanın aldığı sosyal bilginin türüne bağlıdır. Oksitosinin insan sosyal davranışını ve bilişini modüle edebilmesi, otizm spektrum bozukluğunun sosyal çekirdek semptomları için potansiyel bir terapötik kaynak olabileceğine dair görüşleri gündeme getirmiştir. Uygulama yolunun optimizasyonu, dozları, tedavi süresi, uygulama aralığı ve tedaviye başlama zamanlamasını gibi problemler oksitosinin etkinliği konusunda bazı soru işaretlerini oluşturmaktadır.
Sonuç: Nörobiyolojik tedavi mekanizmalarını araştırmak ve otizm spektrum bozukluğunun temel semptomlarındaki boylamsal değişiklikleri doğru ve nesnel olarak değerlendirmek için konu ile ilgili ek araştırmalar yapılması önerilmektedir.
Anahtar Kelimeler
Kaynakça
- 1. Hodges H, Fealko C, Soares N. Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation. Translational pediatrics. 2020;9(Suppl 1):S55.
- 2. John S, Jaeggi AV. Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies. Autism. 2021;25(8):2152-61.
- 3. Gordon I, Vander Wyk BC, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, et al. Oxytocin enhances brain function in children with autism. Proc Natl Acad Sci U S A. 2013;110(52):20953-8.
- 4. Martins DA, Mazibuko N, Zelaya F, Vasilakopoulou S, Loveridge J, Oates A, et al. Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans. Nat Commun. 2020;11(1):1160.
- 5. Lee H-J, Macbeth AH, Pagani JH, Young 3rd WS. Oxytocin: the great facilitator of life. Progress in neurobiology. 2009;88(2):127-51.
- 6. Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR, et al. Is oxytocin “nature’s medicine”? Pharmacological reviews. 2020;72(4):829-61.
- 7. Chatterjee O, Patil K, Sahu A, Gopalakrishnan L, Mol P, Advani J, et al. An overview of the oxytocin-oxytocin receptor signaling network. Journal of cell communication and signaling. 2016;10(4):355-60.
- 8. Ebstein RP, Knafo A, Mankuta D, Chew SH, San Lai P. The contributions of oxytocin and vasopressin pathway genes to human behavior. Hormones and behavior. 2012;61(3):359-79.
- 9. Baptista T, de Azeredo LA, Zaparte A, Viola TW, Coral SC, Nagai MA, et al. Oxytocin Receptor Exon III Methylation in the Umbilical Cord Blood of Newborns With Prenatal Exposure to Crack Cocaine. Frontiers in Cell and Developmental Biology. 2021;9:1424.
- 10. Quintana DS, Rokicki J, van der Meer D, Alnæs D, Kaufmann T, Córdova-Palomera A, et al. Oxytocin pathway gene networks in the human brain. Nature communications. 2019;10(1):1-12.
- 11. Grinevich V, Knobloch-Bollmann HS, Eliava M, Busnelli M, Chini B. Assembling the puzzle: pathways of oxytocin signaling in the brain. Biological psychiatry. 2016;79(3):155-64.
- 12. Freeman SM, Inoue K, Smith AL, Goodman MM, Young LJ. The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta). Psychoneuroendocrinology. 2014;45:128-41.
- 13. Wilczyński KM, Siwiec A, Janas-Kozik M. Systematic review of literature on single-nucleotide polymorphisms within the oxytocin and vasopressin receptor genes in the development of social cognition dysfunctions in individuals suffering from autism spectrum disorder. Frontiers in Psychiatry. 2019;10:380.
- 14. Devost D, Wrzal P, Zingg HH. Oxytocin receptor signalling. Progress in brain research. 2008;170:167-76.
- 15. Rokicki J, Kaufmann T, De Lange A-MG, van der Meer D, Bahrami S, Sartorius AM, et al. Oxytocin receptor expression patterns in the human brain across development. Neuropsychopharmacology. 2022:1-11.
- 16. Neumann ID, Slattery DA. Oxytocin in general anxiety and social fear: a translational approach. Biological psychiatry. 2016;79(3):213-21.
- 17. Haas BW, Filkowski MM, Cochran RN, Denison L, Ishak A, Nishitani S, et al. Epigenetic modification of OXT and human sociability. Proceedings of the National Academy of Sciences. 2016;113(27):E3816-E23.
- 18. Gutkowska J, Jankowski M. Oxytocin revisited: its role in cardiovascular regulation. Journal of neuroendocrinology. 2012;24(4):599-608.
- 19. Japundžić-Žigon N, Lozić M, Šarenac O, Murphy D. Vasopressin & oxytocin in control of the cardiovascular system: an updated review. Current Neuropharmacology. 2020;18(1):14-33.
- 20. Benameur T, Panaro MA, Porro C. The antiaging role of oxytocin. Neural regeneration research. 2021;16(12):2413.
- 21. Zheng H, Lim JY, Kim Y, Jung ST, Hwang SW. The role of oxytocin, vasopressin, and their receptors at nociceptors in peripheral pain modulation. Frontiers in Neuroendocrinology. 2021;63:100942.
- 22. Kerem L, Lawson EA. Oxytocin, eating behavior, and metabolism in humans. Handbook of Clinical Neurology. 2021;180:89-103.
- 23. Uvnäs-Moberg K, Ekström-Bergström A, Berg M, Buckley S, Pajalic Z, Hadjigeorgiou E, et al. Maternal plasma levels of oxytocin during physiological childbirth–a systematic review with implications for uterine contractions and central actions of oxytocin. BMC pregnancy and childbirth. 2019;19(1):1-17.
- 24. Szczepanska-Sadowska E, Wsol A, Cudnoch-Jedrzejewska A, Żera T. Complementary role of oxytocin and vasopressin in cardiovascular regulation. International journal of molecular sciences. 2021;22(21):11465.
- 25. Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci U S A. 2010;107(9):4389-94.
- 26. Chita-Tegmark M. Social attention in ASD: A review and meta-analysis of eye-tracking studies. Res Dev Disabil. 2016;48:79-93.
- 27. Anagnostou E, Soorya L, Chaplin W, Bartz J, Halpern D, Wasserman S, et al. Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial. Mol Autism. 2012;3(1):16.
- 28. Le J, Kou J, Zhao W, Fu M, Zhang Y, Becker B, et al. Oxytocin biases eye-gaze to dynamic and static social images and the eyes of fearful faces: associations with trait autism. Transl Psychiatry. 2020;10(1):142.
- 29. Le J, Zhao W, Kou J, Fu M, Zhang Y, Becker B, et al. Oxytocin facilitates socially directed attention. Psychophysiology. 2021;58(9):e13852.
- 30. Bernaerts S, Boets B, Bosmans G, Steyaert J, Alaerts K. Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up. Mol Autism. 2020;11(1):6.
- 31. Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, et al. Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial. Mol Psychiatry. 2020;25(8):1849-58.
- 32. Dadds MR, MacDonald E, Cauchi A, Williams K, Levy F, Brennan J. Nasal oxytocin for social deficits in childhood autism: a randomized controlled trial. J Autism Dev Disord. 2014;44(3):521-31.
- 33. Sikich L, Kolevzon A, King BH, McDougle CJ, Sanders KB, Kim SJ, et al. Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder. N Engl J Med. 2021;385(16):1462-73.
- 34. Wei H, Zhu Y, Wang T, Zhang X, Zhang K, Zhang Z. Genetic risk factors for autism-spectrum disorders: A systematic review based on systematic reviews and meta-analysis. Journal of Neural Transmission. 2021;128(6):717-34.
- 35. Kucharska K, Kot E, Biernacka K, Zimowski J, Rogoza R, Rybakowski F, et al. Interaction between polymorphisms of the oxytocinergic system genes and emotion perception in inpatients with anorexia nervosa. European Eating Disorders Review. 2019;27(5):481-94.
- 36. Rutigliano G, Rocchetti M, Paloyelis Y, Gilleen J, Sardella A, Cappucciati M, et al. Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis. Psychiatry Research. 2016;241:207-20.
- 37. Wang T, Zhao T, Liu L, Teng H, Fan T, Li Y, et al. Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder. EBioMedicine. 2022;81:104091.
- 38. Maejima Y, Yokota S, Nishimori K, Shimomura K. The anorexigenic neural pathways of oxytocin and their clinical implication. Neuroendocrinology. 2018;107:91-104.
- 39. Grieb ZA, Cross EA, Albers HE. Alpha-melanocyte-stimulating hormone (αMSH) modulates the rewarding properties of social interactions in an oxytocin receptor-dependent manner in Syrian hamsters (Mesocricetus Auratus). Physiology & Behavior. 2022;252:113828.
- 40. Zhang R, Xu X-J, Zhang H-F, Han S-P, Han J-S. The role of the oxytocin/arginine vasopressin system in animal models of autism spectrum disorder. Translational Anatomy and Cell Biology of Autism Spectrum Disorder. 2017:135-58.
- 41. Xu XJ, Shou XJ, Li J, Jia MX, Zhang JS, Guo Y, et al. Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone. PLoS One. 2013;8(9):e74849.
- 42. Chien LN, Lin HC, Shao YH, Chiou ST, Chiou HY. Risk of autism associated with general anesthesia during cesarean delivery: a population-based birth-cohort analysis. J Autism Dev Disord. 2015;45(4):932-42.
- 43. Ghozy S, Tran L, Naveed S, Quynh TTH, Helmy Zayan A, Waqas A, et al. Association of breastfeeding status with risk of autism spectrum disorder: A systematic review, dose-response analysis and meta-analysis. Asian J Psychiatr. 2020;48:101916.
- 44. Shafai T, Mustafa M, Hild T, Mulari J, Curtis A. The association of early weaning and formula feeding with autism spectrum disorders. Breastfeed Med. 2014;9(5):275-6.
- 45. LoParo D, Waldman ID. The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis. Mol Psychiatry. 2015;20(5):640-6.
- 46. Ramo-Fernández L, Gumpp AM, Boeck C, Krause S, Bach AM, Waller C, et al. Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother-newborn dyads. Transl Psychiatry. 2021;11(1):449.
- 47. Le J, Zhang L, Zhao W, Zhu S, Lan C, Kou J, et al. Infrequent Intranasal Oxytocin Followed by Positive Social Interaction Improves Symptoms in Autistic Children: A Pilot Randomized Clinical Trial. Psychother Psychosom. 2022:1-13.
Toplam 47 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Derlemeler |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Ocak 2023 |
| Gönderilme Tarihi | 1 Ağustos 2022 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 3 Sayı: 1 |
