Araştırma Makalesi
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PREİNVAZİV SERVİKAL LEZYONLAR ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU ve KLİNİK ÖNEMİ

Yıl 2018, Cilt: 21 Sayı: 1, 18 - 23, 06.12.2019

Öz

Amaç:

Preinvaziv servikal lezyon ve serviks
kanserinde  p16INK4a  ekspresyonunun klinik önemini saptamak.

Materyal
Method:

Başkent Üniversitesi Kadın Hastalıkları ve Doğum Ana
Bilim Dalı Jinekolojik Onkoloji Bölümü’nde Şubat 2007 ile Eylül 2009 tarihleri
arasında LEEP yapılan  histopatolojik
inceleme sonucu LSIL olan 48 vaka ile, 46 
HSIL olarak raporlanmış toplam 94 hasta ve kontrol grubu olarak da 30
squamoz hücreli servikal kanser olgusu retrospektif  p16 ile immunohistokimyasal olarak boyanma
paterninin lezyon derecesi ile ilişkisi  değerlendirilmiştir.

Sonuç:











p16INK4a pozitifliği, lezyonun derecesi
ve HPV DNA pozitifliği ile anlamlı olarak artmaktadır ve lezyonun ciddiyetini
göstermektedir.

Kaynakça

  • 1- Rock JA, Jones HW, Te Linde RW. Te Linde's operative gynecology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008.
  • 2- Focchi GR, Silva ID, Nogueira-de-Souza NC, Dobo C, Oshima CT, Stavale JN. Immunohistochemical expression of p16(INK4A) in normal uterine cervix, nonneoplastic epithelial lesions, and low-grade squamous intraepithelial lesions. J Low Genit Tract Dis. 2007 Apr;11(2):98-104.
  • 3.- Godoy AE, Mandelli J, Oliveira FH, Calegari S, Moura LB, Serafini EP. p16INK4 expression in precursor lesions of squamous cell cervical cancer related to the presence of HPV-DNA. Braz J Med Biol Res. 2008 Jul;41(7):583-8
  • 4- Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 2001 Apr 15;92(2):276-84.
  • 5- Wang SS, Trunk M, Schiffman M, Herrero R, Sherman ME, Burk RD, et al. Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev. 2004 Aug;13(8):1355-60.
  • 6- Lukaszuk K, Liss J, Gulczynski J, Nowaczyk M, Nakonieczny M, Piatkowski M, et al. Predictive value of HPV DNA in lymph nodes in surgically treated cervical carcinoma patients--a prospective study. Gynecol Oncol. 2007 Mar;104(3):721-6.
  • 7- Guimaraes MC, Goncalves MA, Soares CP, Bettini JS, Duarte RA, Soares EG. Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions. J Histochem Cytochem. 2005 Apr;53(4):509-16
  • 8- Ozgul N, Cil AP, Bozdayi G, Usubutun A, Bulbul D, Rota S, et al. Staining characteristics of p16INK4a: is there a correlation with lesion grade or high-risk human papilloma virus positivity? J Obstet Gynaecol Res. 2008 Oct;34(5):865-71
  • 9- Yildiz IZ, Usubutun A, Firat P, Ayhan A, Kucukali T. Efficiency of immunohistochemical p16 expression and HPV typing in cervical squamous intraepithelial lesion grading and review of the p16 literature. Pathol Res Pract. 2007;203(6):445-9.
  • 10- Omori M, Hashi A, Nakazawa K, Yuminamochi T, Yamane T, Hirata S, et al. Estimation of prognoses for cervical intraepithelial neoplasia 2 by p16INK4a immunoexpression and high-risk HPV in situ hybridization signal types. Am J Clin Pathol. 2007 Aug;128(2):208-17.
  • 11 Nam EJ, Kim JW, Kim SW, Kim YT, Kim JH, Yoon BS, et al. The expressions of the Rb pathway in cervical intraepithelial neoplasia; predictive and prognostic significance. Gynecol Oncol. 2007 Jan;104(1):207-11
  • 12. Iaconis L, Hyjek E, Ellenson LH, Pirog EC. p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection. Arch Pathol Lab Med. 2007 Sep;131(9):1343-9.
  • 13. Hariri J, Oster A. The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix. Int J Gynecol Pathol. 2007 Jul;26(3):223-8.
  • 14- Eleuterio Junior J, Giraldo PC, Cavalcante DI, Goncalves AK, Eleuterio RM. [Association between high risk HPV viral load, p16ink4a expression and intra-epithelial cervical lesions]. Rev Assoc Med Bras. 2007 Nov-Dec;53(6):530-4.
  • 15- Bahnassy AA, Zekri AR, Saleh M, Lotayef M, Moneir M, Shawki O. The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma. BMC Clin Pathol. 2007;7:4.
  • 16- Queiroz C, Silva TC, Alves VA, Villa LL, Costa MC, Travassos AG, et al. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathol Res Pract. 2006;202(2):77-83.
  • 17- Lambert AP, Anschau F, Schmitt VM. p16INK4A expression in cervical premalignant and malignant lesions. Exp Mol Pathol. 2006 Apr;80(2):192-6.
  • 18- Ishikawa M, Fujii T, Saito M, Nindl I, Ono A, Kubushiro K, et al. Overexpression of p16 INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia. Int J Gynecol Cancer. 2006 Jan-Feb;16(1):347-53.
  • 19- Ekalaksananan T, Pientong C, Sriamporn S, Kongyingyoes B, Pengsa P, Kleebkaow P, et al. Usefulness of combining testing for p16 protein and human papillomavirus (HPV) in cervical carcinoma screening. Gynecol Oncol. 2006 Oct;103(1):62-6.
  • 20- Bulten J, van der Avoort IA, Melchers WJ, Massuger LF, Grefte JM, Hanselaar AG, et al. p14ARF and p16INK4A, two products of the same gene, are differently expressed in cervical intraepithelial neoplasia. Gynecol Oncol. 2006 Jun;101(3):487-94.
  • 21- Benevolo M, Mottolese M, Marandino F, Vocaturo G, Sindico R, Piperno G, et al. Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions. Mod Pathol. 2006 Mar;19(3):384-91.
  • 22- Andersson S, Wangsa D, Flores-Staino C, Safari H, Mints M, Hjerpe A, et al. Expression of p16(INK4a) in relation to histopathology and viral load of 'high-risk' HPV types in cervical neoplastic lesions. Eur J Cancer. 2006 Nov;42(16):2815-20.
  • 23- Qiao X, Bhuiya TA, Spitzer M. Differentiating high-grade cervical intraepithelial lesion from atrophy in postmenopausal women using Ki-67, cyclin E, and p16 immunohistochemical analysis. J Low Genit Tract Dis. 2005 Apr;9(2):100-7.
  • 24- Nieh S, Chen SF, Chu TY, Lai HC, Lin YS, Fu E, et al. Is p16(INK4A) expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies. Gynecol Oncol. 2005 Apr;97(1):35-40.
  • 25- Lorenzato M, Caudroy S, Bronner C, Evrard G, Simon M, Durlach A, et al. Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions? Hum Pathol. 2005 Oct;36(10):1101-7.
  • 26- Lin Z, Gao M, Zhang X, Kim YS, Lee ES, Kim HK, et al. The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions. J Cancer Res Clin Oncol. 2005 Jun;131(6):364-70.
  • 27- Kim HJ, Kim MH, Song MH, Song DE, Yu E. [Immunohistochemical study of p53 mutation and p16, p14 alterations encoded by INK4a-ARF in mucin-hypersecreting bile duct tumor]. Korean J Gastroenterol. 2005 Mar;45(3):189-94.
  • 28- Kalof AN, Evans MF, Simmons-Arnold L, Beatty BG, Cooper K. p16INK4A immunoexpression and HPV in situ hybridization signal patterns: potential markers of high-grade cervical intraepithelial neoplasia. Am J Surg Pathol. 2005 May;29(5):674-9.
  • 29- Yuan JR, Li Y, Hu SJ, Li P. [Methylation and aberrant expression of the p16 gene in cervical carcinoma]. Yi Chuan. 2005 Jan;27(1):39-43.
  • 30- Dray M, Russell P, Dalrymple C, Wallman N, Angus G, Leong A, et al. p16(INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical biopsies. Pathology. 2005 Apr;37(2):112-24.
  • 31- Carozzi F, Confortini M, Dalla Palma P, Del Mistro A, Gillio-Tos A, De Marco L, et al. Use of p16-INK4A overexpression to increase the specificity of human papillomavirus testing: a nested substudy of the NTCC randomised controlled trial. Lancet Oncol. 2008 Oct;9(10):937-45.
  • 32- Tsoumpou I, Arbyn M, Kyrgiou M, Wentzensen N, Koliopoulos G, Martin-Hirsch P, et al. p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat Rev. 2009 May;35(3):210-20.
  • 33- Negri G, Vittadello F, Romano F, Kasal A, Rivasi F, Girlando S, et al. p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri. Virchows Arch. 2004 Dec;445(6):616-20.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Cerrahi
Bölüm Araştırma Makalesi
Yazarlar

Gonca Çoban 0000-0002-3285-5519

Halis Özdemir 0000-0002-9194-8504

Özlem Özen Bu kişi benim 0000-0002-9082-1317

Asuman Nihan Haberal Bu kişi benim 0000-0001-9852-9911

Polat Dursun 0000-0001-5139-364X

Ali Ayhan Bu kişi benim

Yayımlanma Tarihi 6 Aralık 2019
Gönderilme Tarihi 7 Şubat 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 21 Sayı: 1

Kaynak Göster

APA Çoban, G., Özdemir, H., Özen, Ö., Haberal, A. N., vd. (2019). PREİNVAZİV SERVİKAL LEZYONLAR ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU ve KLİNİK ÖNEMİ. Türk Jinekolojik Onkoloji Dergisi, 21(1), 18-23.
AMA Çoban G, Özdemir H, Özen Ö, Haberal AN, Dursun P, Ayhan A. PREİNVAZİV SERVİKAL LEZYONLAR ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU ve KLİNİK ÖNEMİ. TRSGO Dergisi. Aralık 2019;21(1):18-23.
Chicago Çoban, Gonca, Halis Özdemir, Özlem Özen, Asuman Nihan Haberal, Polat Dursun, ve Ali Ayhan. “PREİNVAZİV SERVİKAL LEZYONLAR Ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU Ve KLİNİK ÖNEMİ”. Türk Jinekolojik Onkoloji Dergisi 21, sy. 1 (Aralık 2019): 18-23.
EndNote Çoban G, Özdemir H, Özen Ö, Haberal AN, Dursun P, Ayhan A (01 Aralık 2019) PREİNVAZİV SERVİKAL LEZYONLAR ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU ve KLİNİK ÖNEMİ. Türk Jinekolojik Onkoloji Dergisi 21 1 18–23.
IEEE G. Çoban, H. Özdemir, Ö. Özen, A. N. Haberal, P. Dursun, ve A. Ayhan, “PREİNVAZİV SERVİKAL LEZYONLAR ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU ve KLİNİK ÖNEMİ”, TRSGO Dergisi, c. 21, sy. 1, ss. 18–23, 2019.
ISNAD Çoban, Gonca vd. “PREİNVAZİV SERVİKAL LEZYONLAR Ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU Ve KLİNİK ÖNEMİ”. Türk Jinekolojik Onkoloji Dergisi 21/1 (Aralık 2019), 18-23.
JAMA Çoban G, Özdemir H, Özen Ö, Haberal AN, Dursun P, Ayhan A. PREİNVAZİV SERVİKAL LEZYONLAR ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU ve KLİNİK ÖNEMİ. TRSGO Dergisi. 2019;21:18–23.
MLA Çoban, Gonca vd. “PREİNVAZİV SERVİKAL LEZYONLAR Ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU Ve KLİNİK ÖNEMİ”. Türk Jinekolojik Onkoloji Dergisi, c. 21, sy. 1, 2019, ss. 18-23.
Vancouver Çoban G, Özdemir H, Özen Ö, Haberal AN, Dursun P, Ayhan A. PREİNVAZİV SERVİKAL LEZYONLAR ve İNVAZİV SKUAMOZ HÜCRELİ KANSERDE p16INK4a’NIN EKSPRESYONU ve KLİNİK ÖNEMİ. TRSGO Dergisi. 2019;21(1):18-23.