Research Article
Year 2022,
, 226 - 229, 30.12.2022
Abstract
In this study, tetracycline group antibiotic residue was investigated in plain and flavored UHT milk of different brands. A total of 90 UHT milk samples (62 plain and 28 flavored) were analyzed by ELISA method. Tetracycline residues were detected in all samples as a result of the analysis. The mean level of tetracycline was determined as 6.98±0.38 ppb in plain milk and 6.53±0.48 ppb in flavored milk. Residue levels in analyzed UHT milk were found to comply with the legal limits announced by the European Union (EU) commission and Turkish Food Codex Communiqué.
Keywords
References
- Agadellis, E., Tartaglia, A., Locatelli, M., Kabir, A., Furton, K. G., Samanidou, V. (2020). Mixed-mode fabric phase sorptive extraction of multiple tetracycline residues from milk samples prior to high performance liquid chromatography-ultraviolet analysis. Microchemical Journal, 159, 105437.
- Alves, D. R. (2001). The role of UHT milk in the growth of the Brazilian milk market. Australian Journal of Dairy Technology, 56(2), 116.
- Buczkowska, M., Górski, M., Garbicz, J., Grajek, M., Buczkowski, K., Garbowska, D., Duda, S. (2021). Penicillin and tetracycline residues in selected fresh and UHT milk with different fat contents. International Food Research Journal, 28(4).
- Du, B., Wen, F., Zhang, Y., Zheng, N., Li, S., Li, F., Wang, J. (2019). Presence of tetracyclines, quinolones, lincomycin and streptomycin in milk. Food Control, 100, 171-175.
- European Commission (EU) (2010). Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Official Journal European Union, 15: 1-72.
- Fritz, J. W., Zuo, Y. (2007). Simultaneous determination of tetracycline, oxytetracycline, and 4-epitetracycline in milk by high-performance liquid chromatography. Food Chemistry, 105(3), 1297-1301.
- Hussien, S., Ahlam, A., Nesma, E. (2020). Oxytetracycline and β- lactam residues in raw milk of different species marketed in Alexandria city, Egypt. Alexandria Journal of Veterinary Sciences, 65(1):60-65.
- Geçer, B. Y., Akgün, S. T. D. (2006). Pastörize ve UHT sütlerde antibiyotik kalıntılarının HPLC yöntemi ile belirlenmesi (Doctoral dissertation, Ankara Üniversitesi Sağlık Bilimleri Enstitüsü Besin Hijyeni ve Teknolojisi Anabilim Dalı).
- Han, R. W., Zheng, N., Wang, J. Q., Zhen, Y. P., Lı, S. L., Yu, Q. L. (2013). Survey of tetracyclines, sulfonamides, sulfamethazine, and quinolones in UHT milk in China market. Journal of Integrative Agriculture, 12(7), 1300-1305.
- Kabrite, S., Bou-Mitri, C., Fares, J. E. H., Hassan, H. F., Boumosleh, J. M. (2019). Identification and dietary exposure assessment of tetracycline and penicillin residues in fluid milk, yogurt, and labneh: A cross-sectional study in Lebanon. Veterinary world, 12(4), 527.
- Kaya SE, Filazi A. 2010. Determination of antibiotic residues in milk samples. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16:31-35.
- Kaya, S., Pirinçci, İ., Bilgili, A. (2000). Veteriner Uygulamalı Farmakoloji. Ankara: Medisan Yayınevi. ISBN: 975-7774-39-1 Cilt2 sayfa 343-351.
- Larocque, L., & Neville, G. A. (1985). Quantitative evaluation of a bovine antibiotic infusion product by milk residue depletion studies. Journal of food protection, 48(7), 611-615.
- Novaes, S. F. D., Schreiner, L. L., Silva, I. P., Franco, R. M. (2017). Residues of veterinary drugs in milk in Brazil. Ciência Rural, 47.
- Rassouli, A., Abdolmaleki, Z., Bokaee, S., Kamkar, A., Shams, G. (2010). A cross sectional study on Oxytetracycline and Tetracycline residues in pasteurized milk supplied in Tehran by an HPLC method. Int J Vet Res, 4(1), 1-3.
- Saraç, Y. (2015). İstanbul’da satışa sunulan içme sütlerinde antibiyotik kalıntı düzeylerinin araştırılması. Yüksek Lisans Tezi. İstanbul Aydın Üniversitesi Fen Bilimleri Enstitüsü, İstanbul.
- Scott, D. L. (2008). UHT processing and aseptic filling of dairy foods.
- SPSS 2014. IBM SPSS Statistics for Windows, version 22.00. SPSS Inc., Chicago, IL.
- Türk Gıda Kodeksi (TGK). 2017. Hayvansal Gıdalarda Bulunabilecek Farmakolojik Aktif Maddelerin Sınıflandırılması ve Maksimum Kalıntı Limitleri Yönetmeliği. Resmi Gazete, 7 Mart 2017, Sayı. 30000, Başbakanlık Basımevi, Ankara.
- Türk Gıda Kodeksi (TGK). 2019. Türk Gıda Kodeksi İçme Sütleri Tebliği (Tebliğ No: 2019/12) Resmi Gazete, 27 Şubat 2019, Sayı. 30699, Başbakanlık Basımevi, Ankara.
- Unusan, N. (2009). Occurrence of chloramphenicol, streptomycin and tetracycline residues in ultra-heat-treatment milk marketed in Turkey. International journal of food sciences and nutrition, 60(5), 359-364.
- Yarsan, E. (2013). Veteriner hekimlikte antibiyotikler (pratik bilgiler rehberi). Güneş Tıp Kitabevi.
- Zahreddine, Z., Jaber, A., Haidar, S. A., Hosri, C., Ibrahim, G. (2021). HPLC-DAD multi-residue method for determination of florfenicol, penicillin and tetracycline residues in raw cow milk. Journal of Clinical and Laboratory Research, 2(3), 2768-0487
- Zhang, Y. D., Zheng, N., Han, R. W., Zheng, B. Q., Yu, Z. N., Li, S. L., Wang, J. Q. (2014). Occurrence of tetracyclines, sulfonamides, sulfamethazine and quinolones in pasteurized milk and UHT milk in China's market. Food control, 36(1), 238-242.
Year 2022,
, 226 - 229, 30.12.2022
Abstract
Bu çalışmada, farklı markalara ait sade ve aromalı UHT sütlerde tetrasiklin grubu antibiyotik kalıntısı araştırıldı. Toplam 90 adet UHT süt örneği (62 sade, 28 aromalı) ELISA yöntemi ile analiz edildi. Analiz sonuçlarına tüm örneklerde tetrasiklin kalıntısı tespit edildi. Tetrasiklin ortalama düzeyi sade sütlerde 6,98±0,38 ppb, aromalı sütlerde 6,53±0,48 ppb olarak belirlendi. Analizi yapılan UHT sütlerdeki kalıntı seviyeleri Avrupa Birliği (AB) komisyonu ve Türk Gıda Kodeksi Tebliği tarafından açıklanan yasal limitlere uygun bulundu.
Keywords
References
- Agadellis, E., Tartaglia, A., Locatelli, M., Kabir, A., Furton, K. G., Samanidou, V. (2020). Mixed-mode fabric phase sorptive extraction of multiple tetracycline residues from milk samples prior to high performance liquid chromatography-ultraviolet analysis. Microchemical Journal, 159, 105437.
- Alves, D. R. (2001). The role of UHT milk in the growth of the Brazilian milk market. Australian Journal of Dairy Technology, 56(2), 116.
- Buczkowska, M., Górski, M., Garbicz, J., Grajek, M., Buczkowski, K., Garbowska, D., Duda, S. (2021). Penicillin and tetracycline residues in selected fresh and UHT milk with different fat contents. International Food Research Journal, 28(4).
- Du, B., Wen, F., Zhang, Y., Zheng, N., Li, S., Li, F., Wang, J. (2019). Presence of tetracyclines, quinolones, lincomycin and streptomycin in milk. Food Control, 100, 171-175.
- European Commission (EU) (2010). Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Official Journal European Union, 15: 1-72.
- Fritz, J. W., Zuo, Y. (2007). Simultaneous determination of tetracycline, oxytetracycline, and 4-epitetracycline in milk by high-performance liquid chromatography. Food Chemistry, 105(3), 1297-1301.
- Hussien, S., Ahlam, A., Nesma, E. (2020). Oxytetracycline and β- lactam residues in raw milk of different species marketed in Alexandria city, Egypt. Alexandria Journal of Veterinary Sciences, 65(1):60-65.
- Geçer, B. Y., Akgün, S. T. D. (2006). Pastörize ve UHT sütlerde antibiyotik kalıntılarının HPLC yöntemi ile belirlenmesi (Doctoral dissertation, Ankara Üniversitesi Sağlık Bilimleri Enstitüsü Besin Hijyeni ve Teknolojisi Anabilim Dalı).
- Han, R. W., Zheng, N., Wang, J. Q., Zhen, Y. P., Lı, S. L., Yu, Q. L. (2013). Survey of tetracyclines, sulfonamides, sulfamethazine, and quinolones in UHT milk in China market. Journal of Integrative Agriculture, 12(7), 1300-1305.
- Kabrite, S., Bou-Mitri, C., Fares, J. E. H., Hassan, H. F., Boumosleh, J. M. (2019). Identification and dietary exposure assessment of tetracycline and penicillin residues in fluid milk, yogurt, and labneh: A cross-sectional study in Lebanon. Veterinary world, 12(4), 527.
- Kaya SE, Filazi A. 2010. Determination of antibiotic residues in milk samples. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16:31-35.
- Kaya, S., Pirinçci, İ., Bilgili, A. (2000). Veteriner Uygulamalı Farmakoloji. Ankara: Medisan Yayınevi. ISBN: 975-7774-39-1 Cilt2 sayfa 343-351.
- Larocque, L., & Neville, G. A. (1985). Quantitative evaluation of a bovine antibiotic infusion product by milk residue depletion studies. Journal of food protection, 48(7), 611-615.
- Novaes, S. F. D., Schreiner, L. L., Silva, I. P., Franco, R. M. (2017). Residues of veterinary drugs in milk in Brazil. Ciência Rural, 47.
- Rassouli, A., Abdolmaleki, Z., Bokaee, S., Kamkar, A., Shams, G. (2010). A cross sectional study on Oxytetracycline and Tetracycline residues in pasteurized milk supplied in Tehran by an HPLC method. Int J Vet Res, 4(1), 1-3.
- Saraç, Y. (2015). İstanbul’da satışa sunulan içme sütlerinde antibiyotik kalıntı düzeylerinin araştırılması. Yüksek Lisans Tezi. İstanbul Aydın Üniversitesi Fen Bilimleri Enstitüsü, İstanbul.
- Scott, D. L. (2008). UHT processing and aseptic filling of dairy foods.
- SPSS 2014. IBM SPSS Statistics for Windows, version 22.00. SPSS Inc., Chicago, IL.
- Türk Gıda Kodeksi (TGK). 2017. Hayvansal Gıdalarda Bulunabilecek Farmakolojik Aktif Maddelerin Sınıflandırılması ve Maksimum Kalıntı Limitleri Yönetmeliği. Resmi Gazete, 7 Mart 2017, Sayı. 30000, Başbakanlık Basımevi, Ankara.
- Türk Gıda Kodeksi (TGK). 2019. Türk Gıda Kodeksi İçme Sütleri Tebliği (Tebliğ No: 2019/12) Resmi Gazete, 27 Şubat 2019, Sayı. 30699, Başbakanlık Basımevi, Ankara.
- Unusan, N. (2009). Occurrence of chloramphenicol, streptomycin and tetracycline residues in ultra-heat-treatment milk marketed in Turkey. International journal of food sciences and nutrition, 60(5), 359-364.
- Yarsan, E. (2013). Veteriner hekimlikte antibiyotikler (pratik bilgiler rehberi). Güneş Tıp Kitabevi.
- Zahreddine, Z., Jaber, A., Haidar, S. A., Hosri, C., Ibrahim, G. (2021). HPLC-DAD multi-residue method for determination of florfenicol, penicillin and tetracycline residues in raw cow milk. Journal of Clinical and Laboratory Research, 2(3), 2768-0487
- Zhang, Y. D., Zheng, N., Han, R. W., Zheng, B. Q., Yu, Z. N., Li, S. L., Wang, J. Q. (2014). Occurrence of tetracyclines, sulfonamides, sulfamethazine and quinolones in pasteurized milk and UHT milk in China's market. Food control, 36(1), 238-242.
There are 24 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 30, 2022 |
| Published in Issue | Year 2022 |
