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Effects of Ketogenic Nutrition on PCOS

Year 2021, , 93 - 102, 30.08.2021

Gülşen Delikanlı Akbay

https://doi.org/10.51754/cusbed.841267

Abstract

Polycystic ovary syndrome is a health problem that is one of the important causes of infertility, hirsutism and anovulation in premenopausal women with unknown etiology. This problem can cause many disorders such as insulin resistance, Type II Diabetes, Gestational Diabetes, heart disease, sleep apnea and stroke in women of childbearing age. The Ketogenic Diet is a type of diet that is high in fat and low in carbohydrate, and contains sufficient protein and energy. Ketogenic Diet is currently used in the treatment of diseases such as obesity, epilepsy and cancer. The purpose of this review is to examine the effect of Ketogenic Nutrition on Polycystic Ovary Syndrome. Large-scale and long-term human studies are needed to get accurate results.

Keywords

Diet Ketogenic ovary polycystic

References

  • Referans1 Aksoy M (2007) Keton Cisimcikleri. In: Beslenme Biyokimyası Hatipoğlu Yayıncılık, Ankara, pp 158–9.
  • Referans2 Alharbi A, Al-Sowayan NS (2020). The Effect of Ketogenic-Diet on Health. Food Nutr Sci;11(04):301–13.
  • Referans3 Alwahab UA, Pantalone KM, Burguera B (2018). A Ketogenic Diet May Restore Fertility in Women With Polycystic Ovary Syndrome: a Case Series. AACE Clin Case Reports;4(5):e427–31.
  • Referans4 Arslan AK (2020). Polikistik Over Sendromu. Fırat Med J; 25(2):62-8.
  • Referans5 Azziz R (2007). The Polycystic Ovary Syndrome: Current Concepts On Pathogenesis and Clinical Care. 5th editio. Springer Science & Business Media.
  • Referans6 Badawy A, Elnashar A (2011). Treatment options for polycystic ovary syndrome. Int J Womens Health;3(1):25–35.
  • Referans7 Baranano KW, Hartman AL (2008). The ketogenic diet:uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol;10(6):410–9.
  • Referans8 Bough KJ, Rho JM (2007). Anticolvulsant mechanisms of the ketogenic diet. Epilepsia;48(1):43–58.
  • Referans9 Broom GM, Shaw IC, Rucklidge JJ (2019). The ketogenic diet as a potential treatment and prevention strategy for Alzheimer’s disease. Nutrition;(60):118–21
  • Referans10 Diabetes Prevention Program Research (2002). Reduction in the incidence of type 2 diabetes with life style intervention or metformin. N Engl J Med;346(6):393–403.
  • Referans11 Ding J, Xu X, Wu X, Huang Z, Kong G, Liu J et al (2019). Bone loss and biomechanical reduction of appendicular and axial bones under ketogenic diet in rats. Exp Ther Med;2503–10.
  • Referans12 Duchowny MS (2005). Food for Thought: The Ketogenic Diet and Adverse Effects in Children. Epilepsy Curr;5(4):152–4.
  • Referans13 Fan Y, Meng HM, Hu GR, Li FL (2018). Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms. Appl Microbiol Biotechnol;102(7):3027–35.
  • Referans14 Farschi H, Rane A, Love A, Kennedy RL (2007). Diet and nutrition in polycystic ovary syndrome (PCOS): Pointers for nutritional management. J Obs Gynaecol;27(8):762–73.
  • Referans15 Freeman JM, Vining EPG (1999). Seizures decrease rapidly after fasting: preliminary studies of the ketogenic diet. Arch pediatr Adol med;(153):946–9.
  • Referans16 Furth SL, Casey JC, Pyzic PL et al (2000). Risk factors for urolithiasis in children on the ketogenic diet. Ped Nephrol;(15):125–8.
  • Referans17 Gambineri A, Patton L, Vaccina A, Cacciari M, Cavazza C, Pagotta U (2006). Treatment with flutamide, metformin and their combination added to a hypocaloric diet in ower-weight obese women with PCOS: a randomised, 12- month, placebo-controlled study. J Clin Endocrinol Metab;(91):3970–80.
  • Referans18 Gower A (2009). Favourable metabolic effects of a eucaloric lower-carbohydrate diet in women with PCOS;6(4):247–53.
  • Referans19 Harvey, FD (2017) In: Lippincott’s Illustrated Wilkins, Reviews: Biochemistry. 7th Ed. Lippincott William and Philadelphia, USA.
  • Referans20 Innosa D, Ianni A, Palazzo F, Martino F, Bennato F, Grotta L et al (2019). High temperature and heating effect on the oxidative stability of dietary cholesterol in different real food systems arising from eggs. Eur Food Res Technol;245(7):1533–8.
  • Referans21 Jagadish S, Payne ET, Wong-Kisiel L, Nickels KC, Eckert S (2019). The Ketogenic and Modified Atkins Diet Therapy for Children With Refractory Epilepsy of Genetic Etiology. Pediatr Neurol;(94):32–7.
  • Referans22 Jin Q, Kun L, Peifang W, Chao W, Jingjing L, Xin T et al (2018) . Unraveling adsorption behavior and mechanism of perfluorooctane sulfonate (PFOS) on aging aquatic sediments contaminated with engineered nano-TiO2. Environ Sci Pollut Res;25:17878–17889.
  • Referans23 Kossoff EH, Freeman JM, Turner Z (2011). Ketgenic Diets: Treatment for Epilepsy and Other Disorders. Fifth edit. New York: Demos Health.
  • Referans24 Kwiterovich PO, Vining EP, Freeman JM (2003). Lipid Research Atherosclerosis Division, Department of Neurology, Johns Hopkins Medical Institutions, USA.
  • Referans25 Kwiterovich PO, Vining EPG, Pyzic P et al (2003). Effect of a high- Fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children. JAMA;(290):912–20
  • Referans26 Liu LT (2012). Hypothalamic Hormones and Metabolism. Epilepsy Res;100(3):245–51.
  • Referans27 Ma S, Suzuki K (2019). Keto-Adaptation and Endurance Exercise Capacity, Fatigue Recovery, and Exercise-Induced Muscle and Organ Damage Prevention: A Narrative Review. Sport;13(7):2.
  • Referans28 Masood W, Annamaraju P, Uppaluri KR (2020) Ketogenic Diet. In: StatPearls. StatPearls Publishing.
  • Referans29 Marsh K, Brand M. (2005). The optimal diet for women with polycystic ovary syndrome? Br J Nutr;94(2):154–65.
  • Referans30 Mavropoulos JC, Yancy WS, Hepburn J, Westman EC (2005). The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: A pilot study. Nutr Metab;2:1–5.
  • Referans31 Mohorko N, Černelič-Bizjak M, Poklar-Vatovec T, Grom G, Kenig S, Petelin AJ et al (2019). Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults. Nutr Res;(62):64–77.
  • Referans32 Moran LJ, Brinkworth GD, Norman RJ (2008). Dietary theraphy in polycystic ovary syndrome. Semin Reprod Med;26(1):85–92.
  • Referans33 Motta AB (2012). The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des;18(17):2482–91
  • Referans34 Murphy P, Likhodii SS, Hatamian M, Burnham WM (2005). Effect of the ketogenic diet on the activity level of wistar rats. Pediatr Res;57(3):353–7.
  • Referans35 Neal EG, Cross JH (2010). Efficacy of dietary treatments for epilepsy. J Hum Nutr Diet;23(2):113–9.
  • Referans36 Oh R, Gilani B, Uppaluri KR. (2020). Low Carbohydrate Diet. Treasure Isl.
  • Referans37 Okhan Akın (2014) Keton Cisimleri. https://slideplayer.biz.tr/slide/1878498/ . Accessed 10.10.2020
  • Referans38 Pabuççu R (2001). Polikistik Ovaryan Sendrom Hiperandrojenizm ve Hirsutizm. 1. baskı. istanbul: Atlas yayıncılık.
  • Referans39 Palomba S, Falbo A, Chiossi G, Muscogiuri G, Fornaciari E, Orio F et al (2014). Lipid profile in nonobese pregnant women with polycystic ovary syndrome: A prospective controlled clinical study. Steroids;88:36–43.
  • Referans40 Palomba S ,Giallauria F, Falbo A, Russo T, Oppedisano R, Tolino A et al (2006). Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: a 24-week pilot study. Human Reproduction;21:80-9.
  • Referans41 Paoli A, Mancin L, Giacona MC, Bianco A, Caprio M (2020). Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J Transl Med;18(1):1–11.
  • Referans42 Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D et al (2017). A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab;26(3):539-546.
  • Referans43 Sim KA, Dezarnaulds GM, Denyer GS, Skilton IC (2014). Weight loss improves reproductive outcomes in obese women undergoing fertility treatment: a randomized controlled trial. Clin Obes.;4(2):61–8.
  • Referans44 Şahin H (2010). Polikistik Over Sendromunda Beslenme Yaklaşımı. In: 7 Uluslararası Beslenme ve Diyetetik Kongresi Bildiri Kitabı. İstanbul,pp. 244–6.
  • Referans45 Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH (2006). Combined lifestyle modification and metformin in obese patients with PCOS. A randomised, placebo-controlled, double-blind multicentre study. Hum Reprod;(21):80–9.
  • Referans46 Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD (2008). The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab;93(9):3370–80.
  • Referans47 Tunca M (1996). Uzun süren açlıklarda karsılasılan sorunlar ve tedavileri STED;(5). Wilder RM (1921). The Effects of Ketonemia on the course of Epilepsy. Mayo Clin Proc;(2):207–8.
  • Referans48 Yildiz BO, Bozdağ G, Yapici Z, Esinler I, Yarali H (2012). Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum Reprod;27(10):3067–73.

PKOS' ta Ketojenik Beslenmenin Etkileri

Year 2021, , 93 - 102, 30.08.2021

Gülşen Delikanlı Akbay

https://doi.org/10.51754/cusbed.841267

Abstract

Polikistik over sendromu etiyolojisi bilinmeyen, premenopozal kadınlarda infertilite, hirsutizm ve anovülasyonun önemli nedenlerinden biri olan sağlık sorunudur. Bu sorun doğurganlık çağındaki kadınlarda insülin direnci, Tip II Diyabet, Gestasyonel Diyabet, kalp hastalığı, yüksek kan basıncı, uyku apnesi ve inme gibi birçok bozukluğa neden olabilmektedir. Ketojenik Diyet yağ oranı yüksek, karbonhidrat oranı düşük olan ve yeterli protein ile enerji içeren bir beslenme türüdür. Ketojenik Diyet günümüzde obezite, epilepsi, kanser gibi hastalıkların tedavisinde kullanılmaktadır. Bu derlemenin amacı Polikistik over sendromunda Ketojenik Beslenmenin etkisini incelemektir. Doğru sonuç alabilmek için geniş çaplı ve uzun süreli insan çalışmalarına ihtiyaç duyulmaktadır.

Keywords

Diyet ketojenik over polikistik

References

  • Referans1 Aksoy M (2007) Keton Cisimcikleri. In: Beslenme Biyokimyası Hatipoğlu Yayıncılık, Ankara, pp 158–9.
  • Referans2 Alharbi A, Al-Sowayan NS (2020). The Effect of Ketogenic-Diet on Health. Food Nutr Sci;11(04):301–13.
  • Referans3 Alwahab UA, Pantalone KM, Burguera B (2018). A Ketogenic Diet May Restore Fertility in Women With Polycystic Ovary Syndrome: a Case Series. AACE Clin Case Reports;4(5):e427–31.
  • Referans4 Arslan AK (2020). Polikistik Over Sendromu. Fırat Med J; 25(2):62-8.
  • Referans5 Azziz R (2007). The Polycystic Ovary Syndrome: Current Concepts On Pathogenesis and Clinical Care. 5th editio. Springer Science & Business Media.
  • Referans6 Badawy A, Elnashar A (2011). Treatment options for polycystic ovary syndrome. Int J Womens Health;3(1):25–35.
  • Referans7 Baranano KW, Hartman AL (2008). The ketogenic diet:uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol;10(6):410–9.
  • Referans8 Bough KJ, Rho JM (2007). Anticolvulsant mechanisms of the ketogenic diet. Epilepsia;48(1):43–58.
  • Referans9 Broom GM, Shaw IC, Rucklidge JJ (2019). The ketogenic diet as a potential treatment and prevention strategy for Alzheimer’s disease. Nutrition;(60):118–21
  • Referans10 Diabetes Prevention Program Research (2002). Reduction in the incidence of type 2 diabetes with life style intervention or metformin. N Engl J Med;346(6):393–403.
  • Referans11 Ding J, Xu X, Wu X, Huang Z, Kong G, Liu J et al (2019). Bone loss and biomechanical reduction of appendicular and axial bones under ketogenic diet in rats. Exp Ther Med;2503–10.
  • Referans12 Duchowny MS (2005). Food for Thought: The Ketogenic Diet and Adverse Effects in Children. Epilepsy Curr;5(4):152–4.
  • Referans13 Fan Y, Meng HM, Hu GR, Li FL (2018). Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms. Appl Microbiol Biotechnol;102(7):3027–35.
  • Referans14 Farschi H, Rane A, Love A, Kennedy RL (2007). Diet and nutrition in polycystic ovary syndrome (PCOS): Pointers for nutritional management. J Obs Gynaecol;27(8):762–73.
  • Referans15 Freeman JM, Vining EPG (1999). Seizures decrease rapidly after fasting: preliminary studies of the ketogenic diet. Arch pediatr Adol med;(153):946–9.
  • Referans16 Furth SL, Casey JC, Pyzic PL et al (2000). Risk factors for urolithiasis in children on the ketogenic diet. Ped Nephrol;(15):125–8.
  • Referans17 Gambineri A, Patton L, Vaccina A, Cacciari M, Cavazza C, Pagotta U (2006). Treatment with flutamide, metformin and their combination added to a hypocaloric diet in ower-weight obese women with PCOS: a randomised, 12- month, placebo-controlled study. J Clin Endocrinol Metab;(91):3970–80.
  • Referans18 Gower A (2009). Favourable metabolic effects of a eucaloric lower-carbohydrate diet in women with PCOS;6(4):247–53.
  • Referans19 Harvey, FD (2017) In: Lippincott’s Illustrated Wilkins, Reviews: Biochemistry. 7th Ed. Lippincott William and Philadelphia, USA.
  • Referans20 Innosa D, Ianni A, Palazzo F, Martino F, Bennato F, Grotta L et al (2019). High temperature and heating effect on the oxidative stability of dietary cholesterol in different real food systems arising from eggs. Eur Food Res Technol;245(7):1533–8.
  • Referans21 Jagadish S, Payne ET, Wong-Kisiel L, Nickels KC, Eckert S (2019). The Ketogenic and Modified Atkins Diet Therapy for Children With Refractory Epilepsy of Genetic Etiology. Pediatr Neurol;(94):32–7.
  • Referans22 Jin Q, Kun L, Peifang W, Chao W, Jingjing L, Xin T et al (2018) . Unraveling adsorption behavior and mechanism of perfluorooctane sulfonate (PFOS) on aging aquatic sediments contaminated with engineered nano-TiO2. Environ Sci Pollut Res;25:17878–17889.
  • Referans23 Kossoff EH, Freeman JM, Turner Z (2011). Ketgenic Diets: Treatment for Epilepsy and Other Disorders. Fifth edit. New York: Demos Health.
  • Referans24 Kwiterovich PO, Vining EP, Freeman JM (2003). Lipid Research Atherosclerosis Division, Department of Neurology, Johns Hopkins Medical Institutions, USA.
  • Referans25 Kwiterovich PO, Vining EPG, Pyzic P et al (2003). Effect of a high- Fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children. JAMA;(290):912–20
  • Referans26 Liu LT (2012). Hypothalamic Hormones and Metabolism. Epilepsy Res;100(3):245–51.
  • Referans27 Ma S, Suzuki K (2019). Keto-Adaptation and Endurance Exercise Capacity, Fatigue Recovery, and Exercise-Induced Muscle and Organ Damage Prevention: A Narrative Review. Sport;13(7):2.
  • Referans28 Masood W, Annamaraju P, Uppaluri KR (2020) Ketogenic Diet. In: StatPearls. StatPearls Publishing.
  • Referans29 Marsh K, Brand M. (2005). The optimal diet for women with polycystic ovary syndrome? Br J Nutr;94(2):154–65.
  • Referans30 Mavropoulos JC, Yancy WS, Hepburn J, Westman EC (2005). The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: A pilot study. Nutr Metab;2:1–5.
  • Referans31 Mohorko N, Černelič-Bizjak M, Poklar-Vatovec T, Grom G, Kenig S, Petelin AJ et al (2019). Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults. Nutr Res;(62):64–77.
  • Referans32 Moran LJ, Brinkworth GD, Norman RJ (2008). Dietary theraphy in polycystic ovary syndrome. Semin Reprod Med;26(1):85–92.
  • Referans33 Motta AB (2012). The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des;18(17):2482–91
  • Referans34 Murphy P, Likhodii SS, Hatamian M, Burnham WM (2005). Effect of the ketogenic diet on the activity level of wistar rats. Pediatr Res;57(3):353–7.
  • Referans35 Neal EG, Cross JH (2010). Efficacy of dietary treatments for epilepsy. J Hum Nutr Diet;23(2):113–9.
  • Referans36 Oh R, Gilani B, Uppaluri KR. (2020). Low Carbohydrate Diet. Treasure Isl.
  • Referans37 Okhan Akın (2014) Keton Cisimleri. https://slideplayer.biz.tr/slide/1878498/ . Accessed 10.10.2020
  • Referans38 Pabuççu R (2001). Polikistik Ovaryan Sendrom Hiperandrojenizm ve Hirsutizm. 1. baskı. istanbul: Atlas yayıncılık.
  • Referans39 Palomba S, Falbo A, Chiossi G, Muscogiuri G, Fornaciari E, Orio F et al (2014). Lipid profile in nonobese pregnant women with polycystic ovary syndrome: A prospective controlled clinical study. Steroids;88:36–43.
  • Referans40 Palomba S ,Giallauria F, Falbo A, Russo T, Oppedisano R, Tolino A et al (2006). Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: a 24-week pilot study. Human Reproduction;21:80-9.
  • Referans41 Paoli A, Mancin L, Giacona MC, Bianco A, Caprio M (2020). Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J Transl Med;18(1):1–11.
  • Referans42 Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D et al (2017). A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab;26(3):539-546.
  • Referans43 Sim KA, Dezarnaulds GM, Denyer GS, Skilton IC (2014). Weight loss improves reproductive outcomes in obese women undergoing fertility treatment: a randomized controlled trial. Clin Obes.;4(2):61–8.
  • Referans44 Şahin H (2010). Polikistik Over Sendromunda Beslenme Yaklaşımı. In: 7 Uluslararası Beslenme ve Diyetetik Kongresi Bildiri Kitabı. İstanbul,pp. 244–6.
  • Referans45 Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH (2006). Combined lifestyle modification and metformin in obese patients with PCOS. A randomised, placebo-controlled, double-blind multicentre study. Hum Reprod;(21):80–9.
  • Referans46 Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD (2008). The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab;93(9):3370–80.
  • Referans47 Tunca M (1996). Uzun süren açlıklarda karsılasılan sorunlar ve tedavileri STED;(5). Wilder RM (1921). The Effects of Ketonemia on the course of Epilepsy. Mayo Clin Proc;(2):207–8.
  • Referans48 Yildiz BO, Bozdağ G, Yapici Z, Esinler I, Yarali H (2012). Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum Reprod;27(10):3067–73.
There are 48 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review
Authors

Gülşen Delikanlı Akbay 0000-0003-1366-4685

Publication Date August 30, 2021
Published in Issue Year 2021

Cite

APA Delikanlı Akbay, G. (2021). PKOS’ ta Ketojenik Beslenmenin Etkileri. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 6(2), 93-102. https://doi.org/10.51754/cusbed.841267

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