Research Article
Evaluation of In Vitro Anticancer Effect of Plantago major L. and Plantago lanceolata L. Leaf Extracts from Sivas
Abstract
Recently, there have been
studies on the use of some synthetic and semi-synthetic compounds as
pharmaceuticals instead of herbal medicines, although drugs produced from plant
extracts, are widely used all over the world. In addition, it is known that the
various parts of the plant, passed through processes directly simple as ethno
pharmacological way, widely used for the treatment among the people. Although
the interest is increasing every day, the scientific data about the biological
effects and activities of plant-derived extracts are still insufficient. Among the various known therapeutic effects of Plantago
plants, a few recent
studies have shown that preparations of the crude extracts of Plantago leaves could prevent or regress
the growth of some kind of tumours. In this study, showing the distribution in our country and known to be used for
medicinal purposes in the treatment of various diseases, Plantago major and Plantago
lanceolata extracts’ the cytotoxic effects were investigated using human breast adenocarcinoma cell line
(MCF-7).
References
- Bhakuni DS, Bittner M, Marticorena C. Screening of Chilean Plants for antiancer activity. Lloydia, 1976; 39: 225-243
- Chaibakhsh C, Ahmadi N, Zanjanchi MA. Use of Plantago major L. as a natural coagulant for optimizeddecolorization of dye-containing wastewater. Industrial Crops and Products 2014; 61 : 169–175
- Chiang LC, Chiang W, Chang MY, Ng LT, Lin CC. Antiviral Activity of Plantago major Extracts and Related Compounds In vitro. Antiviral Res. 2002; 55: 53-62.
- Fleurentin J, Mazars G, Pelt JM. Additional information on the cultural background of drugs and medicinal plants of Yemen. Journal of Ethnopharmacology 1983; 8, 335– 344.
- Franca F, Lago EL, Marsden PD. Plants used in the treatment of leishmanial ulcers due to Leishmania (Viannia) braziliensis in an endemic area of Bahia, Brazil. Rev. Soc. Bras. Med. Trop. 1996; 29: 229-232.
- Galvez M, Martin-Cordero C, Lopez-Lazaro M, Cortes F, Ayuso MJ. Cytotoxic effect of Plantago spp. on cancer cell lines. J. Ethnopharmacol. 2003; 88: 125-130.
- Gomez FR, Calderon CL, Scheibel LW, Tamez- Guerra P, Rodriguez-Padilla C, Tamez- Guerra R, Weber RJ. Immunoenhancing properties of Plantago major leaf extract. Phytother. Res. 2000; 14: 617-622.
- Goun EA, Petrichenko VM, Solodnikov SU, Suhinina TV, Kline MA, Cunningham G, Nguyen C, Miles H. Anticancer and antithrombin activity of Russian plants. Journal of Ethnopharmacology, 2002; 81: 337-342.
- Grigorescu E, Stanescu U, Basceanu V, Aur MM. Phytochemical and microbiological control of some plant species used in folk medicine. II. Plantago lanceolata L., Plantago media L., Plantago major L. Rev. Med. Chir. Soc. Med. Nat. 1973; 77: 835-841
- Le Bail JC, Varnat F, Nicolas JC, Habrioux G. Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. Cancer Lett. 1998; 130: 209-216.
- Lithander A. Intracellular Fluid of Waybread (Plantago major) as a Prophylactic for Mammary Cancer in Mice. Tumor Biology, 1992; 13: 138-141.
- Matev M, Angelova I, Koichev A, Leseva M, Stefanov G. Clinical trial of a Plantago major preparation in the treatment of chronic bronchitis. Vitr. Boles, 1982; 21: 133-137.
- Mc Cutcheon AR, Roberts TE, Gibbons E. Antiviral Screening of British Colombian Medicinal Plants. J. Ethnopharmacol.1995; 49: 101-110
- Mohamed, IK, Abdel-Fatah OM, Samiha M, El- Salam A, Mohamed Z. Biochemical studies on Plantago Cyamopsistetragonoloba L. International Journal of Biodiversity and Conservation. 2011; 3(3): 83-91. L. and
- Nazarizadeh A., Mikaili P.,Moloudizargari1 M, Aghajanshakeri1 S, Javaherypour S. Therapeutic Uses and Pharmacological Properties of Plantago major L. and its Active Constituents J. Basic. Appl. Sci. Res. 2013; 3(9)212-221.
- Ozaslan M, Karagoz ID, Kalender ME, Kılıc IH, Sarı I, Karagoz A. In vivo Antitumoral Effect of Plantago major L. Extract on Balb/C Mouse with Ehrlich ascites tumour. Am. J. Chin. Med. 2007; 35(5): 841-851.
- Ozaslan M, Karagoz K, Kiliç IH, Cengiz B, Kalender ME, Güldür ME, Karagoz A, Zümrütdal ME. Effect of Plantago major sap on Ehrlich ascites tumors in mice. Afr. J. Biotechnol., 2009; 8, 6, 955-959.
- Post JFM, Varma RS. Growth inhibitory effects of bioflavonoids and related compounds on human leukemic CEM-C1 and CEM-C7 cells. Cancer Lett. 1992; 67:207-213
- Ryu SY, Choi SU, Lee CO, Lee SH, Ahn JW, Zee OP. Antitumor activity of some phenolic components in plants. Arch. Pharmacol. Res. 1994; 17: 42-44.
- Samuelsen, A.B. The traditional uses, chemical constituents and biologicalactivities of Plantago major L.: a review. J. Ethnopharmacol. 2000; 71, 1–21.
- Yaremenko KV. Adaptogens of the Natural Origin in Prophylactyc Oncology. J. Cancer Res. Clin. Oncol. 1990; 116: 82.
- Corresponding Author: Sevgi Durna DAŞTAN,
- Cumhuriyet University, Faculty of Veterinary,
- Department of Zootechnical and Animal Nutrition, Sivas- TURKEY
- e-mail: sdurna@cumhuriyet.edu.tr,
- Tel: +90(346)219 10 10-2565
Year 2016,
Volume: 1 Issue: 1, 7 - 14, 28.07.2016
Abstract
References
- Bhakuni DS, Bittner M, Marticorena C. Screening of Chilean Plants for antiancer activity. Lloydia, 1976; 39: 225-243
- Chaibakhsh C, Ahmadi N, Zanjanchi MA. Use of Plantago major L. as a natural coagulant for optimizeddecolorization of dye-containing wastewater. Industrial Crops and Products 2014; 61 : 169–175
- Chiang LC, Chiang W, Chang MY, Ng LT, Lin CC. Antiviral Activity of Plantago major Extracts and Related Compounds In vitro. Antiviral Res. 2002; 55: 53-62.
- Fleurentin J, Mazars G, Pelt JM. Additional information on the cultural background of drugs and medicinal plants of Yemen. Journal of Ethnopharmacology 1983; 8, 335– 344.
- Franca F, Lago EL, Marsden PD. Plants used in the treatment of leishmanial ulcers due to Leishmania (Viannia) braziliensis in an endemic area of Bahia, Brazil. Rev. Soc. Bras. Med. Trop. 1996; 29: 229-232.
- Galvez M, Martin-Cordero C, Lopez-Lazaro M, Cortes F, Ayuso MJ. Cytotoxic effect of Plantago spp. on cancer cell lines. J. Ethnopharmacol. 2003; 88: 125-130.
- Gomez FR, Calderon CL, Scheibel LW, Tamez- Guerra P, Rodriguez-Padilla C, Tamez- Guerra R, Weber RJ. Immunoenhancing properties of Plantago major leaf extract. Phytother. Res. 2000; 14: 617-622.
- Goun EA, Petrichenko VM, Solodnikov SU, Suhinina TV, Kline MA, Cunningham G, Nguyen C, Miles H. Anticancer and antithrombin activity of Russian plants. Journal of Ethnopharmacology, 2002; 81: 337-342.
- Grigorescu E, Stanescu U, Basceanu V, Aur MM. Phytochemical and microbiological control of some plant species used in folk medicine. II. Plantago lanceolata L., Plantago media L., Plantago major L. Rev. Med. Chir. Soc. Med. Nat. 1973; 77: 835-841
- Le Bail JC, Varnat F, Nicolas JC, Habrioux G. Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. Cancer Lett. 1998; 130: 209-216.
- Lithander A. Intracellular Fluid of Waybread (Plantago major) as a Prophylactic for Mammary Cancer in Mice. Tumor Biology, 1992; 13: 138-141.
- Matev M, Angelova I, Koichev A, Leseva M, Stefanov G. Clinical trial of a Plantago major preparation in the treatment of chronic bronchitis. Vitr. Boles, 1982; 21: 133-137.
- Mc Cutcheon AR, Roberts TE, Gibbons E. Antiviral Screening of British Colombian Medicinal Plants. J. Ethnopharmacol.1995; 49: 101-110
- Mohamed, IK, Abdel-Fatah OM, Samiha M, El- Salam A, Mohamed Z. Biochemical studies on Plantago Cyamopsistetragonoloba L. International Journal of Biodiversity and Conservation. 2011; 3(3): 83-91. L. and
- Nazarizadeh A., Mikaili P.,Moloudizargari1 M, Aghajanshakeri1 S, Javaherypour S. Therapeutic Uses and Pharmacological Properties of Plantago major L. and its Active Constituents J. Basic. Appl. Sci. Res. 2013; 3(9)212-221.
- Ozaslan M, Karagoz ID, Kalender ME, Kılıc IH, Sarı I, Karagoz A. In vivo Antitumoral Effect of Plantago major L. Extract on Balb/C Mouse with Ehrlich ascites tumour. Am. J. Chin. Med. 2007; 35(5): 841-851.
- Ozaslan M, Karagoz K, Kiliç IH, Cengiz B, Kalender ME, Güldür ME, Karagoz A, Zümrütdal ME. Effect of Plantago major sap on Ehrlich ascites tumors in mice. Afr. J. Biotechnol., 2009; 8, 6, 955-959.
- Post JFM, Varma RS. Growth inhibitory effects of bioflavonoids and related compounds on human leukemic CEM-C1 and CEM-C7 cells. Cancer Lett. 1992; 67:207-213
- Ryu SY, Choi SU, Lee CO, Lee SH, Ahn JW, Zee OP. Antitumor activity of some phenolic components in plants. Arch. Pharmacol. Res. 1994; 17: 42-44.
- Samuelsen, A.B. The traditional uses, chemical constituents and biologicalactivities of Plantago major L.: a review. J. Ethnopharmacol. 2000; 71, 1–21.
- Yaremenko KV. Adaptogens of the Natural Origin in Prophylactyc Oncology. J. Cancer Res. Clin. Oncol. 1990; 116: 82.
- Corresponding Author: Sevgi Durna DAŞTAN,
- Cumhuriyet University, Faculty of Veterinary,
- Department of Zootechnical and Animal Nutrition, Sivas- TURKEY
- e-mail: sdurna@cumhuriyet.edu.tr,
- Tel: +90(346)219 10 10-2565
There are 26 citations in total.
Details
| Subjects | Clinical Sciences |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | July 28, 2016 |
| Published in Issue | Year 2016Volume: 1 Issue: 1 |
