Research Article
Year 2017,
Volume: 2 Issue: 1, 18 - 25, 01.08.2017
Abstract
Bu çalışmada, fazla
miktarda çinko içeren diyetle beslenen ratların dalak dokusunda bazı
elementlerin (Zn, Cu, Mn, Mg, Ca, Fe, K) düzeyleri ve antioksidan etkileri ile
çinkonun yetersizliği ve fazlalığında meydana gelen değişiklikler
araştırılmıştır. Araştırmada hayvan materyali olarak rat kullanılmıştır.
Ratlar, her grupta 10 adet olacak şekilde 2 ayrı gruba ayrılmıştır. Kontrol
grubundaki ratlar ad libitum
beslenmeye tabi tutulmuş olup içme suyu olarak deiyonize su verilmiştir. Deneme
gurubuna ise 4 hafta süreyle çinko sülfat içme sularına 227mg/l oranında
karıştırılarak verilmiştir. Kan ve doku örnekleri alındıktan sonra yapılan
analizler sonucunda kontrol grubu ve deney grubunun çinko düzeyleri 0.30±0.12,
0.28±0.16 mg/dl; bakır düzeyi 0.03±0.03, 0.03±0.002 mg/dl; manganez düzeyi 0.32±0.003,
0.025±0.004 mg/dl; Magnezyum düzeyleri 2.39±0.13, 2.42±0.43 mg/dl; Kalsiyum
düzeyi 1.83±0.50, 1.78±0.75 mg/dl; demir düzeyi 11.01±0.55, 9.67±0.62 mg/dl ve
potasyum düzeyleri 20.44±0.16, 19.26±0.28 mg/dl olarak sırasıyla bulundu. Sonuç
olarak, rat içme suyuna 227mg/l çinko ilavesinin rat dalak dokusu üzerine
herhangi bir olumsuz etkisinin olmadığı belirlenmiştir. Potasyum fazlalığında
Zn takviyesi faydalı olabilir.
Keywords
References
- 1. Alarcon OM. Serum level of Zn, Cu and Fe in healty schoolchildren residing in Merida, Venezuella. Ach Latinoam Nutr, 47, 118-122,1997.
- 2. Alcock NW. Trace Elements. In: Kaplan LA, Pesce A, eds. Clinical Chemistry,1996.
- 3. Anonim. What is Zinc? www.drliza.com/healty/zinc.htm,2006.
- 4. Barceloux D.G. Zinc, Clin Toxicol, 37,279-292,1999.
- 5. Belgemen T, Akar N. Çinkonun yasamsal fonksiyonları ve çinkonun Metabolizması ile iliskili genler. AÜ Tıp Fak Mecmuası, 57 (3), 161–166,2004.
- 6. Berger LL. Trace minerals: keys to immunity. Animal Sciences Univ İllinois,1996.
- 7. Cogan MG. Fluid and Electrolytes, Prentice-Hall Internetional Inc. San Fransisco, 179-193,1991.
- 8. Cox, D.H., Harris, D.L. Effect of Excess Dietary Zinc on Iron and Copper in the Rat. J Nutr, 70-60, 515-520,2011.
- 9. Dube L Granry J.C. The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review. Can J Anaesth, 50 (10), 732-46,2003.
- 10. Eaton S.B. and Eaton S.B. Consumption of Trace Elements and Minerals by Pragricultural Humans Chepter 1. in: Clinical Nutrition of the Essential Trace Elements and Minerals Ed: Bogden J.D. Klevay L.M. Humana Press, Totowa, New Jersey,2000.
- 11. Ergün A, Şehu A. Dengesiz beslenmenin immün sistem üzerine etkileri. Tavukçuluk araştırma Derg, 1 (1), 45-50,1999.
- 12. Goel A, Dani V, Dhawan DK. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity, Chemico-Biological Interactions, 156, 131–140,2005.
- 13. Güngör K. “ The Important of Vitamin and Minerals in Density ” Diş Hek Faki Derg, 20 (3), 51-56,2003.
- 14. Hadrzynski C. Diabetes and trace elements. J Trace El em Exp Med, 12, 367-374,1999.
- 15. Halsted JA, Smith JC, Irwin MI. A. Conspectus of Research on Zinc Requirements of man. J.Nutr. 104 (3), 345 -378,1997.
- 16. Jeanne I. R, Karena A, Wolnik T, Cynthiam G, Azevelynm C, James T. P, Az M.R, Spivey F. A, Frickeaz L. Trace Element Studies in Weanling Rats: Maternal Diets and Baseline Tissue Mineral Values. J.Nutr, 114, 1946-1954,1984.
- 17. Kapaki E, Sagtidsa J, Papageorgiou C. Zinc, copper and magnesium concentration in serum and CSF of patients with neurological disorders, Acta Neurol Scand, 79, 373-378,1989.
- 18. Mary A, O'Neil-Cutting, Bomford A, Munro H. N. Effect of Excess Dietary Zinc on Tissue Storage of Iron in Rats. J Clin Nutr, 111, 1969-1979,2011.
- 19. Milne DB. Trace Elements. In: Burtis CA, Ashwood ER, Eds. Tietz Textbook of Clinical Chemistry, London: WB Saunders; pp 1317–1350,1994.
- 20. Morton S, Roberts DJ. University of Bristol Unicam AAS Methods, Manual Issue 2 (05/93),1993.
- 21. Ozawa Y, Imafuku Y, Nishi S, Yoshida H. Potassium Flux of Erythrocytes in Chronic Hemodialysis Patients. C Chimica A, 350 (1-2), 189-193,2004.
- 22. Rotsan EF, DeBuys HV, Madey DL. Evidence supporting zinc as an important antioxidant for skin, Int J Dermatol, 4, 606–611,2002.
- 23. Underwood EJ. Copper. (In) Trace Elements in Human and Animal Nutrition 4th Edition, 57–100, Academic Press, New York,1977.
- 24. Vayenas DV, Repanti M, Vassilopoulos A. Influence of iron overload on manganese, zinc, and copper concentration in rat tissues in vivo: Study of liver, splen, and brain. J Clin Lab Res, 28, 183-186,1998.
- 25. World Health Organization. Trace elements in human nutrition and health. World Health Organization Geneva, 72–75, 123–130, 155–158, 163–166,1996.
- 26. Yorbık Ö. Otistik bozukluğu olan çocuklarda antioksidan enzimler ve bunlarla ilgili eser elementlerin araştırılması, Gülhane Askeri Tıp Akademisi ve Askeri Tıp Fakültesi Çocuk Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı Uzmanlık Tezi, s:114-115,1999.
- 27. Young A.B, Ott L.G, Beard D, Dempsey R.J, Tibbs P.A, McClain C.J. The acute-phase responseof the brain-injured patient, J Neurosurg, 69, 375-380,1988.
Year 2017,
Volume: 2 Issue: 1, 18 - 25, 01.08.2017
Abstract
References
- 1. Alarcon OM. Serum level of Zn, Cu and Fe in healty schoolchildren residing in Merida, Venezuella. Ach Latinoam Nutr, 47, 118-122,1997.
- 2. Alcock NW. Trace Elements. In: Kaplan LA, Pesce A, eds. Clinical Chemistry,1996.
- 3. Anonim. What is Zinc? www.drliza.com/healty/zinc.htm,2006.
- 4. Barceloux D.G. Zinc, Clin Toxicol, 37,279-292,1999.
- 5. Belgemen T, Akar N. Çinkonun yasamsal fonksiyonları ve çinkonun Metabolizması ile iliskili genler. AÜ Tıp Fak Mecmuası, 57 (3), 161–166,2004.
- 6. Berger LL. Trace minerals: keys to immunity. Animal Sciences Univ İllinois,1996.
- 7. Cogan MG. Fluid and Electrolytes, Prentice-Hall Internetional Inc. San Fransisco, 179-193,1991.
- 8. Cox, D.H., Harris, D.L. Effect of Excess Dietary Zinc on Iron and Copper in the Rat. J Nutr, 70-60, 515-520,2011.
- 9. Dube L Granry J.C. The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review. Can J Anaesth, 50 (10), 732-46,2003.
- 10. Eaton S.B. and Eaton S.B. Consumption of Trace Elements and Minerals by Pragricultural Humans Chepter 1. in: Clinical Nutrition of the Essential Trace Elements and Minerals Ed: Bogden J.D. Klevay L.M. Humana Press, Totowa, New Jersey,2000.
- 11. Ergün A, Şehu A. Dengesiz beslenmenin immün sistem üzerine etkileri. Tavukçuluk araştırma Derg, 1 (1), 45-50,1999.
- 12. Goel A, Dani V, Dhawan DK. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity, Chemico-Biological Interactions, 156, 131–140,2005.
- 13. Güngör K. “ The Important of Vitamin and Minerals in Density ” Diş Hek Faki Derg, 20 (3), 51-56,2003.
- 14. Hadrzynski C. Diabetes and trace elements. J Trace El em Exp Med, 12, 367-374,1999.
- 15. Halsted JA, Smith JC, Irwin MI. A. Conspectus of Research on Zinc Requirements of man. J.Nutr. 104 (3), 345 -378,1997.
- 16. Jeanne I. R, Karena A, Wolnik T, Cynthiam G, Azevelynm C, James T. P, Az M.R, Spivey F. A, Frickeaz L. Trace Element Studies in Weanling Rats: Maternal Diets and Baseline Tissue Mineral Values. J.Nutr, 114, 1946-1954,1984.
- 17. Kapaki E, Sagtidsa J, Papageorgiou C. Zinc, copper and magnesium concentration in serum and CSF of patients with neurological disorders, Acta Neurol Scand, 79, 373-378,1989.
- 18. Mary A, O'Neil-Cutting, Bomford A, Munro H. N. Effect of Excess Dietary Zinc on Tissue Storage of Iron in Rats. J Clin Nutr, 111, 1969-1979,2011.
- 19. Milne DB. Trace Elements. In: Burtis CA, Ashwood ER, Eds. Tietz Textbook of Clinical Chemistry, London: WB Saunders; pp 1317–1350,1994.
- 20. Morton S, Roberts DJ. University of Bristol Unicam AAS Methods, Manual Issue 2 (05/93),1993.
- 21. Ozawa Y, Imafuku Y, Nishi S, Yoshida H. Potassium Flux of Erythrocytes in Chronic Hemodialysis Patients. C Chimica A, 350 (1-2), 189-193,2004.
- 22. Rotsan EF, DeBuys HV, Madey DL. Evidence supporting zinc as an important antioxidant for skin, Int J Dermatol, 4, 606–611,2002.
- 23. Underwood EJ. Copper. (In) Trace Elements in Human and Animal Nutrition 4th Edition, 57–100, Academic Press, New York,1977.
- 24. Vayenas DV, Repanti M, Vassilopoulos A. Influence of iron overload on manganese, zinc, and copper concentration in rat tissues in vivo: Study of liver, splen, and brain. J Clin Lab Res, 28, 183-186,1998.
- 25. World Health Organization. Trace elements in human nutrition and health. World Health Organization Geneva, 72–75, 123–130, 155–158, 163–166,1996.
- 26. Yorbık Ö. Otistik bozukluğu olan çocuklarda antioksidan enzimler ve bunlarla ilgili eser elementlerin araştırılması, Gülhane Askeri Tıp Akademisi ve Askeri Tıp Fakültesi Çocuk Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı Uzmanlık Tezi, s:114-115,1999.
- 27. Young A.B, Ott L.G, Beard D, Dempsey R.J, Tibbs P.A, McClain C.J. The acute-phase responseof the brain-injured patient, J Neurosurg, 69, 375-380,1988.
There are 27 citations in total.
Details
| Journal Section | Research Article |
|---|---|
| Authors | |
| Publication Date | August 1, 2017 |
| Published in Issue | Year 2017Volume: 2 Issue: 1 |
