2, 4-Dihidro-1,2,4-Triazol Aminometil Türevlerinin İn Vitro Antioksidan ve Antimikrobiyal Aktivitelerinin Değerlendirilmesi
Abstract
Günümüzde ilaç olarak kullanılan çoğu bileşiğin ana yapısında özellikle triazol, tiyadiazol ve oksadiazol gibi beş üyeli heterosiklik halka yapısı bulunmaktadır. Triazol bileşiklerinin büyük bir kısmının kullanımı, toksisite riski, uygulama zorluğu, yüksek oranda ilaç direncinin ortaya çıkması gibi sebeplerle ve istenmeyen yan etkilerin gözlenmesi, aktivitesindeki yetersizlik ve farmakokinetik eksiklikleri nedenleriyle sınırlı kalmıştır. Beş üyeli halka içeren bu bileşiklerin sağlık sektöründe, farmasötik kimyada, başta antikanser aktivite olmak üzere antifungal, anti-HIV, antitümör, antibakteriyal, antiviral, antidepresan, iltihap önleyici (antiinflamatuvar), tüberküloza karşı etkili (antitüberküloz), ağrı kesici (analjezik), idrar söktürücü (diüretik) gibi çok kapsamlı aktif biyolojik spektrumları bulunmaktadır. Bu çalışma ile farklı triazol bileşiklerinin (M1-M10) bazı biyolojik aktiviteleri araştırılarak triazoller konusunda yapılmış çalışmalara katkı sağlanması ve ilaç olabilme potansiyellerinin ortaya konulması planlanmıştır. Bu amaçla farklı triazol türevlerinin in vitro antioksidan aktiviteleri indirgeme-yükseltgeme potansiyelleri ile antimikrobiyal aktiviteleri araştırılmıştır. Bu çalışma kapsamında kullandığımız test bileşiklerinin bazılarının yüksek biyolojik aktivite özellikleriyle daha sonraki yapılacak çalışmalarda yol gösterici olacağını, başta ilaç sektörü olmak üzere yeni biyoyararlı malzemelerin üretimi konularında katkı sağlayacağına inanmaktayız. Ayrıca bu konunun literatüre kazandırılması ile de bu disiplinde çalışan bilim insanlarına yeni fikirler vereceğini düşünmekteyiz.
References
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Evaluation of In Vitro Antioxidant and Antimicrobial Activities of 2, 4-Dihydro-1,2,4- Triazole Aminomethyl Derivatives
Abstract
The main structure of most compounds used today as drugs is in particular the five-membered heterocyclic ring structure such as triazole, thiadiazole and oxadiazole. The use of a large proportion of triazole compounds has been limited by reasons of toxicity, difficulty in application, observation of occasional and undesirable side effects such as high drug resistance, inadequacy of activity and pharmacokinetic deficiencies. These compounds containing five members of the ring can be used in the healthcare sector in pharmaceutical chemistry, especially antifungal, anti-HIV, antitumoral, antibacterial, antiviral, antiinflammatory, analgesic, and diuretics. In this study, it was planned to investigate some biological activities of different triazole compounds (M1-M10) and to contribute the triazoles to studies and to determine the drug potentials. For this purpose, the antioxidant activities of different triazole derivatives were investigated by their reduction-oxidation potentials and antimicrobial activities. We believe that some of the test compounds we use in this study will contribute to the future work with high biological activity properties and will contribute to the production of new bioactive materials, especially in the pharmaceutical sector. We also think that this will give new ideas to the scientists who work in this discipline with the introduction of the literature.
References
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Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Article |
| Authors | |
| Publication Date | August 1, 2018 |
| Published in Issue | Year 2018Volume: 3 Issue: 1 |
