Topikal Takrolimusun Veteriner Dermatolojide Kullanımı

Ezgi Kaya

Review

Use of Topical Tacrolimus in Veterinary Dermatology

Year 2020, Volume: 5 Issue: 1, 30 - 37, 30.04.2020

Ezgi Kaya

Abstract

Tacrolimus (FK506) is a calcineurin inhibitor, macrolide group, immunosuppressive agent, commonly used to prevent tissue rejection after organ transplants. In recent studies, the use of topical tacrolimus has been shown to be effective in the treatment of atopic dermatitis, idiopathic dermatitis of cats, proliferative and necrotizing otitis externa, eosinophilic granuloma complex, lupus erythematosus and pemphigus erythematosus. This review aims to review the pharmacological properties of tacrolimus and its use in veterinary dermatology.

Keywords

Tacrolimus (FK506), veterinary, dermatology

References

1. Noli C, Foster AP, Rosenkrantz W. (2014). Veterinary Allergy. Wiley Blackwell; West Sussex, UK. p.97-8.
2. Thacker EL. (2010). Immunomodulators, immunostimulants, and immunotherapies in small animal veterinary medicine, Vet Clin North Am Small Anim Pract; 40(3): 473-83.
3. Wallemacq PE, Reding R. (1993). FK(506)Tacrolimus,a novel immunosuppressant in organ transplantation:clinical,biomedical,and analytical aspects. Clin Chem; 39(11), 2219-28.
4. Misseghers BS, Binnington AG, Mathews KA. (2000). Clinical observations of the treatment of canine perianal fistulas with topical tacrolimus in 10 dogs. Can Vet J; 41(8), 623.
5. Moore CP. (2004). Ocular therapeutics. Vet Clin North Am Small Anim Pract. 34:XI.
6. Koch SN, Torres SMF, Plumb DC. (2012). Topical Agents. In: Canine and Feline Dermatology Drug Handbook, First Edition. Blackwell Publishing Ltd. 322-23.
7. Reitamo S, Rissanen J, Remitz A, Granlund H, Erkko P, Elg P et al. (1998) Tacrolimus ointment does not affect collagen synthesis; results of a single-center randomized trial. J Invest Dermatol; 111: 396-98.
8. Çiftçi HŞ, Ayna TY, Çalışkan Y, Güney İ, Gürtekin M. (2011). Farmakogenetik ve kalsinörin inhibitörleri. Turkiye Klinikleri Journal of Nephrology; 6.2: 62-68.
9. Jovanović M, Golušin Z. (2016). Nonsteroidal Topical Immunomodulators in Allergology and Dermatology. Biomed Res Int; 1-11.
10. Marsella R, Nıcklın CF , Saglıo S, Lopez J. (2004). Investigation on the clinical efficacy and safety of 0.1% tacrolimus ointment (Protopic®) in canine atopic dermatitis: a randomized, double‐blinded, placebo‐controlled, cross‐over study . Vet Dermatol; 15(5), 294-303.
11. Bensignor E, Olivry T. (2005). Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded randomized controlled trial. Vet Dermatol; 16(1), 52-60.
12. Marsella R, Nıcklın CF. (2002). Investigation on the use of 0.3% tacrolimus lotion for canine atopic dermatitis: a pilot study. Vet Dermatol; 13(4):203-10.
13. Bhang D,Choi U,Jung Y,Kim M,Choi E,Seo K et al (2008). Topical 0.03% Tacrolimus for Treatment of Pemphigus Erythematosus in a Korea Jindo Dog. J Vet Med Sci; 70(4): 415–17.
14. Griffies JD, Mendelsohn CL, Rosenkrantz WS, Muse R, Boord MJ, Griffin CE. (2004). Topical 0.1% Tacrolimus for the Treatment of Discoid Lupus Erythematosus and Pemphigus Erythematosus in Dogs. J Am Anim Hosp Assoc; 40(1) 29-41.
15. Chung T,Ryu M,Kim D,Yoon H,Hwang C. (2009). Topical tacrolimus (FK506) for the treatment of feline idiopathic facial dermatitis. Aust Vet J; 87:417–20.
16. Moon M,Suh G,Kwon Y,Kim H. (2017)., Effective treatment of eosinophilic granuloma in a cat using tacrolimus with prednisolone. J Biomed Transl; 18(3):118-20.
17. Banovic F, Robson D, Linek M, Olivry T. (2017). Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus. Vet Dermatol; 28(5):493-e115
18. Lehner GM, Linek M. (2013). A case of vesicular cutaneous lupus erythematosus in a Border collie successfully treated with topical tacrolimus and nicotinamide-tetracycline. Vet Dermatol ;24(6):639-41
19. Messinger L, Strauss T, Jonas L. (2017). A Randomized, Double-Blinded Placebo Controlled Crossover Study Evaluating 0.03% Tacrolimus Ointment Monotherapy in the Treatment of Discoid Lupus Erythematosus in Dogs. SOJ Vet Sci; 3(1): 1-6.
20. Bond R, Curtis CF, Ferguson EA, Mason IS, Rest J. (2000). An idiopathic facial dermatitis of Persian cats. Vet Dermatol; 11:35–42.
21. Paradis M, Scott D. (1990). Hereditary primary seborrhea oleosa in Persian cats. Feline Pract;18(1):17–20. 22. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. (2005). Necrotizing diseases of the epidermis. In: Skin Diseases of the Dog and Cat, 2nd edn. Ames, IA: Blackwell Science Ltd; 79–81.
23. Mauldin EA, Ness TA, Goldschmidt MH. (2007). Proliferative and necrotizing otitis externa in four cats. Vet Dermatol; 18(5), 370-77.
24. Nalesnik MA, Todo S, Murase N, Gryzan S, Lee PH, Makowka L, Starzl TE. (1987). Toxicology of FK-506 in the Lewis rat. Transplant Proc;19(5 Suppl 6):89-92.
25. Yokota K, Takishima T, Sato K, Osakabe T, Nakayama Y, Uchida H Aso K, Masaki Y, Ohbu M, Okudaira M. (1989). Comparative studies of FK506 and cyclosporine in canine orthotopic hepatic allograft survival. Transplant Proc;21(1 Pt 1):1066-68.
26. Todo S, Demetris AJ, Ueda Y, Imventarza O, Okuda K, Casavilla A, Cemaj S, Ghalab A, Mazzaferro V, Rhoe BS, Tonghua Y, Makowka L, and Starzl TE. (1987). Canine kidney transplantation with FK-506 along or in combination with cyclosporine and steroids. Transplant Proc; 19(5 Suppl 6): 57–61.
27. Collier DS, Thiru S, Calne R. (1987). Kidney transplantation in the dog receiving FK-506. Transplant Proc;19(5 Suppl 6):62.
28. Adkins EA, Hendrix DVH, Stuffle L, Ward DA, Skorobohach BJ. (2003). An investigation of the safety and efficacy of topical ophthalmic application of tacrolimus in dogs (Abstract). Annual Meeting of the American College of Veterinary Ophthalmologists; 34: 39.