Research Article
Siyatik sinir yaralanması oluşturulan ratlarda Andız (Juniperus sp) kökü ekstraktının ve B12 vitamininin sinir iyileşmesi üzerine etkisinin karşılaştırılması
Abstract
Periferik sinirlerin kendi kendini onarma kapasitesi sınırlıdır ve ciddi şekilde hasar görmüş veya önemli kusurları olanların onarımı zordur. Bu nedenle periferik sinir rejenerasyonu ile ilgili klinik öncesi çalışmalar için en sık kullanılan deneysel model, siyatik sinir yaralanması modelidir. Ratlarda siyatik sinir yaralanması, periferik sinir rejenerasyonu ile ilgili çalışmalarda en çok kullanılan modeldir.
Materyal Metot: Bu çalışmada 32 rata siyatik sinir yaralanması sonrası B12 vitamini ve Andız kökü ekstraktı uygulamaları yapılmıştır. Uygulamalar sonrasında ratlar 21. günde sakrifiye edilerek siyatik sinir doku örnekleri alınmıştır. Alınan örnekler histopatolojik ve immunofloresan yöntemlerle incelenmiştir.
Bulgular: İncelenme B12 ve Andız kökü ekstraktının ayrı ayrı uygulandığı ratlarda histopatolojik olarak sınırlı düzeyde ve benzer şekilde fayda sağladığı, birlikte uygulanan grubun ise tüm gruplara göre daha etkili pozitif yönde etki sağladığı görülmüştür. Ayrıca immunofloresan yöntemle S100 ve GFAP ekspresyonunda da ayrı ayrı uygulamaların benzer şekilde fayda sağladığı görülürken, birlikte uygulama yapılan grupta ise diğer tüm gruplara kıyasla daha iyi katkı sağladığı görülmüştür.
Sonuç: Sonuç olarak ratlarda uygulanan siyatik sinir yaralanması modelinde iyileşme düzeylerinin belirlenmesi için ayrı ayrı uygulanan Andız kökü ekstraktı ve B12 vitaminin kontrol grubuna göre sınırlı düzeyde ve benzer şekilde etki oluşturduğu, birlikte uygulandığında ise sinerjik etki göstererek diğer tüm gruplara göre sinir iyileşmesine daha etkili bir şekilde katkı sağladığı belirlenmiştir.
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Thanks
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References
- Abushukur, Y., Knackstedt, R. (2022). The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature. Cureus, 14(5).
- Albay, C., Adanir, O., Kahraman Akkalp, A., Dogan, V.B., Gulec, M.A., Beytemur, O. (2020). Cyanocobalamin and cholecalciferol synergistically improve functional and histopathological nerve healing in experimental rat model. Clin Neurosci, 73.
- Albay, C., Akkalp, A.K. (2021). Alpha-Tocopherol and Cyanocobalamin Combination Accelerates Peripheral Nerve Healing: An Experimental Animal Study. Turk Neurosurg, 31(2):247-253.
- Al-Owamri, F.S.N., Al Sibay, L.S.A., Reddy, S.H., Hussain, S.A., Gangireddygari, V.S.R. (2023). Phytochemical, Antioxidant, hair growth and wound healing property of Juniperus excelsa, Olea oleaster and Olea europaea. J King Saud Univ Sci, 35(2):102446.
- Altun, I., Kurutaş, E.B. (2016). Vitamin B complex and vitamin B12 levels after peripheral nerve injury. Neural Regen Res, 11(5):842-845.
- Aman, M., Zimmermann, K.S., Boecker, A.H., Thielen, M., Falkner, F., Daeschler, S., et al. (2023). Peripheral nerve injuries in children—prevalence, mechanisms and concomitant injuries: a major trauma center’s experience. Eur J Med Res, 28(1): 1-7.
- Arikan, M., Togral, G., Hastürk, A.E., Horasanli, B., Helvacioglu, F., Dagdeviren, A., et al. (2016). Histomorphometric and ultrastructural evaluation of long-term alpha lipoic acid and vitamin B12 use after experimental sciatic nerve injury in rats. Turk Neurosurg, 26(6):944-952.
- Avcı, E. (2020). Determination of Antimicrobial Properties of Andiz (Juniperus Sp) Root Extract and Its Effects on Wound Development in Rainbow Treats (Oncorhynchus Mykiss). MSc. Thesis, Department of Fisheries Engineering, Institute of Science and Technology, Van Yüzüncü Yıl University, Van, Türkiye.
- Bai, J., Liu, F., Wu, L.F., Wang, Y.F., Li, X.Q. (2018). Attenuation of TRPV1 by AMG-517 after nerve injury promotes peripheral axonal regeneration in rats. Mol Pain, 14: 1744806918777614.
- Bretová, K., Svobodová, V., Dubový, P. (2023). Astrocyte reactivity in the glia limitans superficialis of the rat medial prefrontal cortex following sciatic nerve injury. Histochem Cell Biol, 159(2):185-198.
- Buhşem, Ö. (2021) Investigation of the Effects of the 5-Fluorouracil Applied After Rat Sciatic Nerve Repair on the Epineural and Extraneural Scar Tissue Formation and Nerve Regeneration. International Anatolia Academic Online Journal Health Sciences, 7(1);81-100.
- Chen, Y., Pan, Z., Meng, F., Yu, X., Xu, Q., Huang, L., et al. (2022). Magnetic resonance imaging assessment of the therapeutic effect of combined electroacupuncture and stem cells in acute peripheral nerve injury. Front Cell Neurosci, 16:1065557.
- Çağlaroğlu. Y. (2021). Investigation of the Role of Asiatic Acid in Experimentally Created Peripheral Nerve Injuries in Rats. Master Thesis, Atatürk University Faculty of Medicine, Department of Neurosurgery, Erzurum, Türkiye.
- Duan, G., Li, C., Yan, X., Yang, S., Wang, S., Sun, X., et al. (2023). Construction of a mineralized collagen nerve conduit for peripheral nerve injury repair. Regen Biomater, 10.
- Dubový, P., Klusáková, I., Hradilová-Svíženská, I., Joukal, M., Boadas-Vaello, P. (2018). Activation of astrocytes and microglial cells and CCL2/CCR2 upregulation in the dorsolateral and ventrolateral nuclei of periaqueductal gray and rostral ventromedial medulla following different types of sciatic nerve injury. Front Cell Neurosci, 30:12;40.
- Goswami, D., Anuradha, U., Angati, A., Kumari, N., & Singh, R. K. (2023). Pharmacological and pathological relevance of S100 proteins in neurological disorders. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders).
- Güven N, Özkan S, Türközü T, Koç S, Keleş ÖF, Yener Z, Karasu A. (2022). The effect of Theranekron on femur fracture healing in an experimental rat model. Jt Dis Relat Surg, 33(2):374-384.
- Horasanli, B., Hasturk, A.E., Arikan, M., Togral, G., Helvacioglu, F., Mut, S., et al. (2017). Comparative evaluation of the electrophysiological, functional and ultrastructural effects of alpha lipoic acid and cyanocobalamin administration in a rat model of sciatic nerve injury. J Back Musculoskelet Rehabil, 30(5):967-974.
- İshakoğlu, Ö.K. (2019). Effects of Caparine in Experimental Sciatic Nerve Damage-induced Rats. PhD Thesis, Hatay Mustafa Kemal University, Institute of Health Sciences, Department of Physiology (Medicine). Hatay, Türkiye.
- Kapdan, E., Sezgin, M., Kahya, M. (2019). The use of Juniper (Juniperus L.) species in the treatment of diseases among people and in Modern Medicine. Conference: Internatıonal Eurasian Conference on Biologıcal and Chemical Science. June, 2019. Ankara/ Türkiye.
- Kastamoni, M. (2019). Combined effect of fat graft and platelet-rich fibrin on perineural adhesion and scar formation in a rat model. Master Thesis, Bursa Uludağ University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery. Bursa, Türkiye.
- Li, R., Wu, J., Lin, Z., Nangle, M.R., Li, Y., Cai, P., et al. (2017). Single injection of a novel nerve growth factor coacervate improves structural and functional regeneration after sciatic nerve injury in adult rats. Exp Neurol, 288:1-10.
- Liu, G.B., Cheng, Y.X., Feng, Y.K., Pang, C.J., Li, Q., Wang, Y., et al. (2011). Adipose-derived stem cells promote peripheral nerve repair. Arch Med Sci, 7(4):592-596.
- Lopez, J.F., Sarkanen, J.R., Huttala, O. (2018). Adipose tissue extract shows potential for wound healing: in vitro proliferation and migration of cell types contributing to wound healing in the presence of adipose tissue preparation and platelet rich plasma. Cytotechnology, 70(4):1193-1204.
- Luo, X., Li, B., Zhang, D., Chen, H., Zhou, X., Yao, C., et al. (2022). A new insight on peripheral nerve repair: the technique of internal nerve splinting. J Neurosurg, 1:1-12.
- Lv, T., Mo, Y., Yu, T., Shao, S., Lu, M., Luo, Y., et al. (2020). Using RNA-Seq to Explore the Repair Mechanism of the Three Methods and Three-Acupoint Technique on DRGs in Sciatic Nerve Injured Rats. Pain Res Manag, 1-12.
- Metineren, H., Dülgeroğlu, T.C., Metineren, M.H. (2017). Histopathological effects of Platelet rich fibrin on peripheral nerve healing. Dicle Medical Journal, 44(3): 243-250.
- Middeldorp, J., Hol, E.M. (2011). GFAP in health and disease. Prog Neurobiol, 93(3): 421-443.
- Otani, N., Nawashiro, H., Fukui, S., Ooigawa, H., Ohsumi, A., Toyooka, T., et al. (2006). Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice. J Clin Neurosci, 13, 934-938.
- Ozay, R., Keskin, E., Balkan, M.S., Aktas, A., Akturk, U.D., Esener, O.B.B., et al. (2023). Effects of Topically Applied Contractubex® on Epidural Fibrosis and Axonal Regeneration in Injured Rat Sciatic Nerve. Turk Neurosurg, 33(3):437-446.
- Ozgenel, G.Y., Filiz, G. (2004). Combined application of human amniotic membrane wrapping and hyaluronic acid injection in epineurectomized rat sciatic nerve. J Reconstr Microsurg, 20:153-7.
- Özkan, M.Ç., Tuncel, B., Ozgenel, G.Y. (2018). The effect of topical 5-fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve. Marmara Med J, 31:1-10.
- Rustamov, N. (2020). A New Method in Nerve Defect Reconstruction: Silk Road Technique. Kocaeli University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Master thesis, Kocaeli.
- Salman, E., Salman, R.B., Tufan, A. (2020). S100 Proteins as an Important Regulator Of Inflammation. Ankara Eğt Arş Hast Derg, 53(1): 41-45.
- Seo, M., Lim, D., Kim, S., Kim, T., Kwon, B.S., Nam, K. (2021). Effect of Botulinum Toxin Injection and Extracorporeal Shock Wave Therapy on Nerve Regeneration in Rats with Experimentally Induced Sciatic Nerve Injury. Toxins, 13(12):879.
- Shin, Y.H., Yun, H.W., Park, S.Y., Choi, S.J., Park, I.S., Min, B.H., et al. (2020). Effect of glutaraldehyde‐crosslinked cartilage acellular matrix film on antiadhesion and nerve regeneration in a rat sciatic nerve injury model. J Tissue Eng Regen Med, 15:1023–1036.
- Steiner, J., Bogerts, B., Schroeter, M.L., Bernstein, H.G. (2011). S100B protein in neurodegenerative disorders. CCLM, 49(3): 409-424.
- Tumen, I., Süntar, I., Keleş, H., Küpeli Akkol, E. (2012). A therapeutic approach for wound healing by using essential oils of Cupressus and Juniperus species growing in Turkey. eCAM, 1-7.
- Yang, J., Hsu, C.C., Cao, T.T., Ye, H., Chen, J., Li, Y.Q. (2023). A hyaluronic acid granular hydrogel nerve guidance conduit promotes regeneration and functional recovery of injured sciatic nerves in rats. Neural Regen Res, 18(3):657-663.
- Yardım, A., Kandemir, F.M., Çomaklı, S., Özdemir, S., Caglayan, C., Kucukler, S., et al. (2021). Protective effects of curcumin against paclitaxel-induced spinal cord and sciatic nerve injuries in rats. Neurochem Res, 46:379-395.
- Yu J, Lin Y, Wang G, Song J, Hayat U, Liu C, et al. (2022). Zein-induced immune response and modulation by size, pore structure and drug-loading: application for sciatic nerve regeneration. Acta Biomater, 140:289-301.
- Zhang, Z., Zhang, M., Sun, Y., Li, M., Chang, C., Liu, W., et al. (2023). Effects of adipose derived stem cells pretreated with resveratrol on sciatic nerve regeneration in rats. Sci Rep, 13(1):5812.
Comparison Of The Effects Of Andız (Juniperus sp) Root Extract And Vitamin B12 On Nerve Healing in Rats With Sciatic Nerve Injury
Abstract
The self-repair capacity of peripheral nerves is limited, and the repair of severely damaged or significantly flawed nerves is challenging. For preclinical investigations on peripheral nerve regeneration, the sciatic nerve injury model is the most often used experimental model. In rats, sciatic nerve injury is the most frequently used model in studies related to peripheral nerve regeneration.
Material and Methods: In this study, 32 rats were subjected to sciatic nerve injury, and applications of B12 vitamin and Andız root extract were performed. After the applications, the rats were sacrificed on the 21st day, and samples of the sciatic nerve tissue were taken. The collected samples were examined using histopathological and immunofluorescence methods.
Results: The examination revealed that B12 vitamin and Andız root extract, when applied separately to the rats, provided limited and similar benefits histopathologically, while the group that received combined treatment showed more effective positive effects compared to all other groups. Additionally, when assessing S100 and GFAP expression through immunofluorescence, it was observed that individual applications provided similar benefits, while the group that received combined treatment contributed more effectively compared to all other groups.
Conclusion: In conclusion, in the rat model of sciatic nerve injury, it was determined that Andız root extract and B12 vitamin, when applied separately, had limited and similar effects compared to the control group in determining the levels of recovery. However, when applied together, they exhibited a synergistic effect, providing a greater contribution to nerve regeneration compared to all other groups.
Project Number
Yok
References
- Abushukur, Y., Knackstedt, R. (2022). The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature. Cureus, 14(5).
- Albay, C., Adanir, O., Kahraman Akkalp, A., Dogan, V.B., Gulec, M.A., Beytemur, O. (2020). Cyanocobalamin and cholecalciferol synergistically improve functional and histopathological nerve healing in experimental rat model. Clin Neurosci, 73.
- Albay, C., Akkalp, A.K. (2021). Alpha-Tocopherol and Cyanocobalamin Combination Accelerates Peripheral Nerve Healing: An Experimental Animal Study. Turk Neurosurg, 31(2):247-253.
- Al-Owamri, F.S.N., Al Sibay, L.S.A., Reddy, S.H., Hussain, S.A., Gangireddygari, V.S.R. (2023). Phytochemical, Antioxidant, hair growth and wound healing property of Juniperus excelsa, Olea oleaster and Olea europaea. J King Saud Univ Sci, 35(2):102446.
- Altun, I., Kurutaş, E.B. (2016). Vitamin B complex and vitamin B12 levels after peripheral nerve injury. Neural Regen Res, 11(5):842-845.
- Aman, M., Zimmermann, K.S., Boecker, A.H., Thielen, M., Falkner, F., Daeschler, S., et al. (2023). Peripheral nerve injuries in children—prevalence, mechanisms and concomitant injuries: a major trauma center’s experience. Eur J Med Res, 28(1): 1-7.
- Arikan, M., Togral, G., Hastürk, A.E., Horasanli, B., Helvacioglu, F., Dagdeviren, A., et al. (2016). Histomorphometric and ultrastructural evaluation of long-term alpha lipoic acid and vitamin B12 use after experimental sciatic nerve injury in rats. Turk Neurosurg, 26(6):944-952.
- Avcı, E. (2020). Determination of Antimicrobial Properties of Andiz (Juniperus Sp) Root Extract and Its Effects on Wound Development in Rainbow Treats (Oncorhynchus Mykiss). MSc. Thesis, Department of Fisheries Engineering, Institute of Science and Technology, Van Yüzüncü Yıl University, Van, Türkiye.
- Bai, J., Liu, F., Wu, L.F., Wang, Y.F., Li, X.Q. (2018). Attenuation of TRPV1 by AMG-517 after nerve injury promotes peripheral axonal regeneration in rats. Mol Pain, 14: 1744806918777614.
- Bretová, K., Svobodová, V., Dubový, P. (2023). Astrocyte reactivity in the glia limitans superficialis of the rat medial prefrontal cortex following sciatic nerve injury. Histochem Cell Biol, 159(2):185-198.
- Buhşem, Ö. (2021) Investigation of the Effects of the 5-Fluorouracil Applied After Rat Sciatic Nerve Repair on the Epineural and Extraneural Scar Tissue Formation and Nerve Regeneration. International Anatolia Academic Online Journal Health Sciences, 7(1);81-100.
- Chen, Y., Pan, Z., Meng, F., Yu, X., Xu, Q., Huang, L., et al. (2022). Magnetic resonance imaging assessment of the therapeutic effect of combined electroacupuncture and stem cells in acute peripheral nerve injury. Front Cell Neurosci, 16:1065557.
- Çağlaroğlu. Y. (2021). Investigation of the Role of Asiatic Acid in Experimentally Created Peripheral Nerve Injuries in Rats. Master Thesis, Atatürk University Faculty of Medicine, Department of Neurosurgery, Erzurum, Türkiye.
- Duan, G., Li, C., Yan, X., Yang, S., Wang, S., Sun, X., et al. (2023). Construction of a mineralized collagen nerve conduit for peripheral nerve injury repair. Regen Biomater, 10.
- Dubový, P., Klusáková, I., Hradilová-Svíženská, I., Joukal, M., Boadas-Vaello, P. (2018). Activation of astrocytes and microglial cells and CCL2/CCR2 upregulation in the dorsolateral and ventrolateral nuclei of periaqueductal gray and rostral ventromedial medulla following different types of sciatic nerve injury. Front Cell Neurosci, 30:12;40.
- Goswami, D., Anuradha, U., Angati, A., Kumari, N., & Singh, R. K. (2023). Pharmacological and pathological relevance of S100 proteins in neurological disorders. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders).
- Güven N, Özkan S, Türközü T, Koç S, Keleş ÖF, Yener Z, Karasu A. (2022). The effect of Theranekron on femur fracture healing in an experimental rat model. Jt Dis Relat Surg, 33(2):374-384.
- Horasanli, B., Hasturk, A.E., Arikan, M., Togral, G., Helvacioglu, F., Mut, S., et al. (2017). Comparative evaluation of the electrophysiological, functional and ultrastructural effects of alpha lipoic acid and cyanocobalamin administration in a rat model of sciatic nerve injury. J Back Musculoskelet Rehabil, 30(5):967-974.
- İshakoğlu, Ö.K. (2019). Effects of Caparine in Experimental Sciatic Nerve Damage-induced Rats. PhD Thesis, Hatay Mustafa Kemal University, Institute of Health Sciences, Department of Physiology (Medicine). Hatay, Türkiye.
- Kapdan, E., Sezgin, M., Kahya, M. (2019). The use of Juniper (Juniperus L.) species in the treatment of diseases among people and in Modern Medicine. Conference: Internatıonal Eurasian Conference on Biologıcal and Chemical Science. June, 2019. Ankara/ Türkiye.
- Kastamoni, M. (2019). Combined effect of fat graft and platelet-rich fibrin on perineural adhesion and scar formation in a rat model. Master Thesis, Bursa Uludağ University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery. Bursa, Türkiye.
- Li, R., Wu, J., Lin, Z., Nangle, M.R., Li, Y., Cai, P., et al. (2017). Single injection of a novel nerve growth factor coacervate improves structural and functional regeneration after sciatic nerve injury in adult rats. Exp Neurol, 288:1-10.
- Liu, G.B., Cheng, Y.X., Feng, Y.K., Pang, C.J., Li, Q., Wang, Y., et al. (2011). Adipose-derived stem cells promote peripheral nerve repair. Arch Med Sci, 7(4):592-596.
- Lopez, J.F., Sarkanen, J.R., Huttala, O. (2018). Adipose tissue extract shows potential for wound healing: in vitro proliferation and migration of cell types contributing to wound healing in the presence of adipose tissue preparation and platelet rich plasma. Cytotechnology, 70(4):1193-1204.
- Luo, X., Li, B., Zhang, D., Chen, H., Zhou, X., Yao, C., et al. (2022). A new insight on peripheral nerve repair: the technique of internal nerve splinting. J Neurosurg, 1:1-12.
- Lv, T., Mo, Y., Yu, T., Shao, S., Lu, M., Luo, Y., et al. (2020). Using RNA-Seq to Explore the Repair Mechanism of the Three Methods and Three-Acupoint Technique on DRGs in Sciatic Nerve Injured Rats. Pain Res Manag, 1-12.
- Metineren, H., Dülgeroğlu, T.C., Metineren, M.H. (2017). Histopathological effects of Platelet rich fibrin on peripheral nerve healing. Dicle Medical Journal, 44(3): 243-250.
- Middeldorp, J., Hol, E.M. (2011). GFAP in health and disease. Prog Neurobiol, 93(3): 421-443.
- Otani, N., Nawashiro, H., Fukui, S., Ooigawa, H., Ohsumi, A., Toyooka, T., et al. (2006). Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice. J Clin Neurosci, 13, 934-938.
- Ozay, R., Keskin, E., Balkan, M.S., Aktas, A., Akturk, U.D., Esener, O.B.B., et al. (2023). Effects of Topically Applied Contractubex® on Epidural Fibrosis and Axonal Regeneration in Injured Rat Sciatic Nerve. Turk Neurosurg, 33(3):437-446.
- Ozgenel, G.Y., Filiz, G. (2004). Combined application of human amniotic membrane wrapping and hyaluronic acid injection in epineurectomized rat sciatic nerve. J Reconstr Microsurg, 20:153-7.
- Özkan, M.Ç., Tuncel, B., Ozgenel, G.Y. (2018). The effect of topical 5-fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve. Marmara Med J, 31:1-10.
- Rustamov, N. (2020). A New Method in Nerve Defect Reconstruction: Silk Road Technique. Kocaeli University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Master thesis, Kocaeli.
- Salman, E., Salman, R.B., Tufan, A. (2020). S100 Proteins as an Important Regulator Of Inflammation. Ankara Eğt Arş Hast Derg, 53(1): 41-45.
- Seo, M., Lim, D., Kim, S., Kim, T., Kwon, B.S., Nam, K. (2021). Effect of Botulinum Toxin Injection and Extracorporeal Shock Wave Therapy on Nerve Regeneration in Rats with Experimentally Induced Sciatic Nerve Injury. Toxins, 13(12):879.
- Shin, Y.H., Yun, H.W., Park, S.Y., Choi, S.J., Park, I.S., Min, B.H., et al. (2020). Effect of glutaraldehyde‐crosslinked cartilage acellular matrix film on antiadhesion and nerve regeneration in a rat sciatic nerve injury model. J Tissue Eng Regen Med, 15:1023–1036.
- Steiner, J., Bogerts, B., Schroeter, M.L., Bernstein, H.G. (2011). S100B protein in neurodegenerative disorders. CCLM, 49(3): 409-424.
- Tumen, I., Süntar, I., Keleş, H., Küpeli Akkol, E. (2012). A therapeutic approach for wound healing by using essential oils of Cupressus and Juniperus species growing in Turkey. eCAM, 1-7.
- Yang, J., Hsu, C.C., Cao, T.T., Ye, H., Chen, J., Li, Y.Q. (2023). A hyaluronic acid granular hydrogel nerve guidance conduit promotes regeneration and functional recovery of injured sciatic nerves in rats. Neural Regen Res, 18(3):657-663.
- Yardım, A., Kandemir, F.M., Çomaklı, S., Özdemir, S., Caglayan, C., Kucukler, S., et al. (2021). Protective effects of curcumin against paclitaxel-induced spinal cord and sciatic nerve injuries in rats. Neurochem Res, 46:379-395.
- Yu J, Lin Y, Wang G, Song J, Hayat U, Liu C, et al. (2022). Zein-induced immune response and modulation by size, pore structure and drug-loading: application for sciatic nerve regeneration. Acta Biomater, 140:289-301.
- Zhang, Z., Zhang, M., Sun, Y., Li, M., Chang, C., Liu, W., et al. (2023). Effects of adipose derived stem cells pretreated with resveratrol on sciatic nerve regeneration in rats. Sci Rep, 13(1):5812.
There are 42 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Surgery |
| Journal Section | Research Article |
| Authors | |
| Project Number | Yok |
| Publication Date | August 31, 2023 |
| Published in Issue | Year 2023Volume: 8 Issue: 2 |
