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Alzheimer Hastalığında B12 Vitamini Eksikliği

Yıl 2019, Cilt: 4 Sayı: 3, - , 31.12.2019

Gülşen Delikanlı Akbay

Öz

Alzheimer Hastalığı dünya genelinde yaygın
olarak görülen ve büyük toplulukları tehdit eden önemli bir sağlık sorunudur.
Hastalığın kesin tedavisi için bir yöntem olmayıp, oluşumunu engellemek veya
geciktirmek ve semptomlarını azaltmak için çalışmalar yürütülmektedir. Yaşlanma
sürecinde ve suda çözünen bir vitamin olan B12 vitamininin yetersizliğinde,
Alzheimer Hastalığı dahil birçok dejeneratif sorunlar ve demans
oluşabilmektedir. Hastalıktan korunmak için yeterli miktarda B12 vitamini
alınmalıdır. Bu derlemede B12 vitamini yetersizliğinin Alzheimer
Hastalığı ile ilişkisi incelenmiştir

Anahtar Kelimeler

Alzheimer Hastalığı B12 Vitamini demans

Kaynakça

  • Referans1. Paul SA, Lon SS, Mary S, Ramon DA, Christopher H van Dyck, Myron FW, et al. (2008). High Dose B vitamin supplementation and cognitive decline in Alzheimer’s Disease: A randomized controlled trial. JAMA; 300(15):1774-1783.
  • Referans2. Ane OA, Pilar A, Ana E, Elena U, Pablo ML. (2014). Diet, cognition and Alzheimer’s Disease: food for thought. Eur J Nutr; 53:1-23.
  • Referans3. Mohajeri MH, Troesch B, Weber P. Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer’s type dementia. (2015). Nutrition; 31(2):261-75.
  • Referans4. Wikipedia. Alzheimer’s disease. https://www.google.com/search?q=wikipedia+alzheimer%27s+disease&oq=wikipedia+alzheimer&aqs=chrome.1.69i57j0l5.8871j0j4&sourceid=chrome&ie=UTF-8. Erişim tarihi: 19/11/2014.
  • Referans5. Wimo A, Prince M. (2010). World Alzheimer report 2010: the global economic impact of dementia. ADI
  • Referans6. Marcel GMOR, Frans RV, John WCS, Femke HB, Paul LJD, Mirian L, et al. (2014). Differences in nutritional status between very mild Alzheimer’s Disease patients and healthy controls. Journal of Alzheimer’s Disease; 41(1):261–271.
  • Referans7. Vellas B, Elemans S, Lushsinger J, Kamphuis P, Yaffe K, Sijben J, et al. (2014). Plasma nutrient status of patients with Alzheimer’s disease: Systematic review and meta-analysis. Alzheimer’s & Dementia;10: 485–502.
  • Referans8. Gu Y, Jeri WN, Yaakov S, Jose AL, Nikolaos S. (2010). Food combination and Alzheimer Disease risk: a protective diet. Arch Neurol;67(6): 699–706.
  • Referans9. Wolffenbuttel Bruce HR, Wouters Hanneke JCM, Heiner-Fokkema M Rebecca, van der Klauw Melanie M. (2019). The mant faces of cobalamin (vitamin B12) deficiency. Mayo Clin Proc Innov Qual Outcomes; 3(2):200-214.
  • Referans10. Agnoletti D, Yi Z, Galan P, Serge H, Safar ME, Blacher J. (2011). Fortification of vitamin B12 to flour and the metabolic response. Academic Press; s. 437-449.
  • Referans11. Prodan CI, Cowan LD, Stoner JA, Ross ED. (2009). Cumulative incidence of vitamin B12 deficiency in patients with Alzheimer disease. Journal of the Neurological Sciences; 284: 144–148.
  • Referans12. Grarup N, Sulem P, Camillia HS, Gudmar T, Tarunveer SA, Helgi B, et al. (2013). Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. PLOS Genetics; 9(6):1-3.
  • Referans13. Mangialasche F, Kalpouzos G, Solomon A, Erika JL, Lars B, Laura F, et al. (2014). Vitamin B12 and folate in relation to the rate of brain atrophy in subjects at risk of dementia: a longitudinal population based study. Alzheimer’s & Demantia; 10(4):185.
  • Referans14. Quadri P, Fragiacomo C, Pezzati R, Zanda E, Forloni G, Tettamanti M. (2004). Homocysteine, folate, and vitamin B12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr; 80:114–122.
  • Referans15. Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N. (2005). Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr; 82:636–643.
  • Referans16. Wang H, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. (2001). Vitamin B12 and folate in relation to the development of Alzheimer’s disease. Neurology; 56:1188–1194
  • Referans17. Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, et al. (2010). Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE; 5(9):e12244.
  • Referans18. Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB. (2010). A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging; 14:224–230.
  • Referans19. Esmee LD, Anna S, Carla D, Olga WS, Anna B, Lisette CPGM de Groot, et al. (2013). Vitamin B12 intake and status and cognitive function in elderly people. Epidemiol Rev; 35:2–21.
  • Referans20. Scheltens P, Twisk WR, Blesa R, Scarpini E, von Arnim CA, Bongers A, et al. (2012). Efficacy of souvenaid in Mild Alzheimer’s disease: results from a randomized, controlled trial. J Alz Dis; 31:225–236.
  • Referans21. Eileen M, Julie P, Alastair M, Kerie S, Ross C, Nicole J, et al. (2014). The prevalence of vitamin B12 deficiency in a random sample from the Australian population. J Invest Biochem; 3(3):95-100.
  • Referans22. Mi W, Cansev M, Kamphuis PJ, Wjick van M, Sijben JW. (2013). Nutritional approaches in the risk reduction and management of Alzheimer’s disease. Nutrition; 29:1080–1089.
  • Referans23. Siuda J, Gorzkowska A, Patalong-Ogiewa M, Krzystanek E, Czech E, Wiechuła B, Garczorz W, et al. (2009). From mild cognitive impairment to Alzheimer's disease - influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up. Neurol Neurochir Pol.; 43(4):321-9.
  • Referans24. Köseoğlu E, Karaman Y. (2007). Relations between homocysteine, folate and vitamin B12 in vascular dementia and in Alzheimer disease. Clinical Biochemistry; 40: 859–863.
  • Referans25. Aisen PS, Schineider LS, Sano M, Weiner MF, Bottiglieri T, Jin S, et al. (2008). High-dose B vitamin supplementation and cognitive decline in Alzheimer Disease. JAMA; 300(15): 1774-83.
  • Referans26. Bozoğlu E, Işık AT. (2010). When do elderly patients with Alzheimer’s disease need the vitamin B12 supplementation? Alzheimer's & Dementia; 6(4):571.
  • Referans27. Barnard ND, Bush AI, Ceccarelli A, Cooper J, Erickson KI, Fraser G, et al. (2014). Dietary and lifestyle guidelines for the prevention of Alzheimer’s disease. Neurobiology of Aging; 35: 74-78.
  • Referans28. Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R. (2005). Reduced risk of Alzheimer’s disease with high folate intake:the Baltimore longitudinal study of aging. Alzheimer’s Dement; 1 (1):11-8.
  • Referans29. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggrawal NT, et al. (2005). Relation of the tocopherol forms to incident Alzheimer’s disease and to cognitive change. Am J Clin Nutr; 81(2):508-14.
  • Referans30. Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A. (2005). High homocysteine and low B vitamins predict cognitive decline in aging men: the veterans affairs Normative aging Study. Am J Clin Nutr; 82(3):627-35.
  • Referans31. Douaud G, Refsum H, De Jagger CA, Jacoby R, Nichols TE, Smith AD, Smith SM, et al. (2003). Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci USA; 110 (23):9523-8.

Yıl 2019, Cilt: 4 Sayı: 3, - , 31.12.2019

Gülşen Delikanlı Akbay

Öz

Kaynakça

  • Referans1. Paul SA, Lon SS, Mary S, Ramon DA, Christopher H van Dyck, Myron FW, et al. (2008). High Dose B vitamin supplementation and cognitive decline in Alzheimer’s Disease: A randomized controlled trial. JAMA; 300(15):1774-1783.
  • Referans2. Ane OA, Pilar A, Ana E, Elena U, Pablo ML. (2014). Diet, cognition and Alzheimer’s Disease: food for thought. Eur J Nutr; 53:1-23.
  • Referans3. Mohajeri MH, Troesch B, Weber P. Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer’s type dementia. (2015). Nutrition; 31(2):261-75.
  • Referans4. Wikipedia. Alzheimer’s disease. https://www.google.com/search?q=wikipedia+alzheimer%27s+disease&oq=wikipedia+alzheimer&aqs=chrome.1.69i57j0l5.8871j0j4&sourceid=chrome&ie=UTF-8. Erişim tarihi: 19/11/2014.
  • Referans5. Wimo A, Prince M. (2010). World Alzheimer report 2010: the global economic impact of dementia. ADI
  • Referans6. Marcel GMOR, Frans RV, John WCS, Femke HB, Paul LJD, Mirian L, et al. (2014). Differences in nutritional status between very mild Alzheimer’s Disease patients and healthy controls. Journal of Alzheimer’s Disease; 41(1):261–271.
  • Referans7. Vellas B, Elemans S, Lushsinger J, Kamphuis P, Yaffe K, Sijben J, et al. (2014). Plasma nutrient status of patients with Alzheimer’s disease: Systematic review and meta-analysis. Alzheimer’s & Dementia;10: 485–502.
  • Referans8. Gu Y, Jeri WN, Yaakov S, Jose AL, Nikolaos S. (2010). Food combination and Alzheimer Disease risk: a protective diet. Arch Neurol;67(6): 699–706.
  • Referans9. Wolffenbuttel Bruce HR, Wouters Hanneke JCM, Heiner-Fokkema M Rebecca, van der Klauw Melanie M. (2019). The mant faces of cobalamin (vitamin B12) deficiency. Mayo Clin Proc Innov Qual Outcomes; 3(2):200-214.
  • Referans10. Agnoletti D, Yi Z, Galan P, Serge H, Safar ME, Blacher J. (2011). Fortification of vitamin B12 to flour and the metabolic response. Academic Press; s. 437-449.
  • Referans11. Prodan CI, Cowan LD, Stoner JA, Ross ED. (2009). Cumulative incidence of vitamin B12 deficiency in patients with Alzheimer disease. Journal of the Neurological Sciences; 284: 144–148.
  • Referans12. Grarup N, Sulem P, Camillia HS, Gudmar T, Tarunveer SA, Helgi B, et al. (2013). Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. PLOS Genetics; 9(6):1-3.
  • Referans13. Mangialasche F, Kalpouzos G, Solomon A, Erika JL, Lars B, Laura F, et al. (2014). Vitamin B12 and folate in relation to the rate of brain atrophy in subjects at risk of dementia: a longitudinal population based study. Alzheimer’s & Demantia; 10(4):185.
  • Referans14. Quadri P, Fragiacomo C, Pezzati R, Zanda E, Forloni G, Tettamanti M. (2004). Homocysteine, folate, and vitamin B12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr; 80:114–122.
  • Referans15. Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N. (2005). Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr; 82:636–643.
  • Referans16. Wang H, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. (2001). Vitamin B12 and folate in relation to the development of Alzheimer’s disease. Neurology; 56:1188–1194
  • Referans17. Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, et al. (2010). Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE; 5(9):e12244.
  • Referans18. Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB. (2010). A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging; 14:224–230.
  • Referans19. Esmee LD, Anna S, Carla D, Olga WS, Anna B, Lisette CPGM de Groot, et al. (2013). Vitamin B12 intake and status and cognitive function in elderly people. Epidemiol Rev; 35:2–21.
  • Referans20. Scheltens P, Twisk WR, Blesa R, Scarpini E, von Arnim CA, Bongers A, et al. (2012). Efficacy of souvenaid in Mild Alzheimer’s disease: results from a randomized, controlled trial. J Alz Dis; 31:225–236.
  • Referans21. Eileen M, Julie P, Alastair M, Kerie S, Ross C, Nicole J, et al. (2014). The prevalence of vitamin B12 deficiency in a random sample from the Australian population. J Invest Biochem; 3(3):95-100.
  • Referans22. Mi W, Cansev M, Kamphuis PJ, Wjick van M, Sijben JW. (2013). Nutritional approaches in the risk reduction and management of Alzheimer’s disease. Nutrition; 29:1080–1089.
  • Referans23. Siuda J, Gorzkowska A, Patalong-Ogiewa M, Krzystanek E, Czech E, Wiechuła B, Garczorz W, et al. (2009). From mild cognitive impairment to Alzheimer's disease - influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up. Neurol Neurochir Pol.; 43(4):321-9.
  • Referans24. Köseoğlu E, Karaman Y. (2007). Relations between homocysteine, folate and vitamin B12 in vascular dementia and in Alzheimer disease. Clinical Biochemistry; 40: 859–863.
  • Referans25. Aisen PS, Schineider LS, Sano M, Weiner MF, Bottiglieri T, Jin S, et al. (2008). High-dose B vitamin supplementation and cognitive decline in Alzheimer Disease. JAMA; 300(15): 1774-83.
  • Referans26. Bozoğlu E, Işık AT. (2010). When do elderly patients with Alzheimer’s disease need the vitamin B12 supplementation? Alzheimer's & Dementia; 6(4):571.
  • Referans27. Barnard ND, Bush AI, Ceccarelli A, Cooper J, Erickson KI, Fraser G, et al. (2014). Dietary and lifestyle guidelines for the prevention of Alzheimer’s disease. Neurobiology of Aging; 35: 74-78.
  • Referans28. Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R. (2005). Reduced risk of Alzheimer’s disease with high folate intake:the Baltimore longitudinal study of aging. Alzheimer’s Dement; 1 (1):11-8.
  • Referans29. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggrawal NT, et al. (2005). Relation of the tocopherol forms to incident Alzheimer’s disease and to cognitive change. Am J Clin Nutr; 81(2):508-14.
  • Referans30. Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A. (2005). High homocysteine and low B vitamins predict cognitive decline in aging men: the veterans affairs Normative aging Study. Am J Clin Nutr; 82(3):627-35.
  • Referans31. Douaud G, Refsum H, De Jagger CA, Jacoby R, Nichols TE, Smith AD, Smith SM, et al. (2003). Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci USA; 110 (23):9523-8.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derleme
Yazarlar

Gülşen Delikanlı Akbay 0000-0003-1366-4685

Yayımlanma Tarihi 31 Aralık 2019
Yayımlandığı Sayı Yıl 2019Cilt: 4 Sayı: 3

Kaynak Göster

APA Delikanlı Akbay, G. (2019). Alzheimer Hastalığında B12 Vitamini Eksikliği. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 4(3).
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