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Tat Reseptörlerinde Tek Nükleotid Gen Polimorfizmi, Besin Tercihi ve Sağlık Arasındaki İlişki

Year 2020, Volume: 5 Issue: 3, 219 - 234, 30.12.2020

Saniye Sözlü

Abstract

Tat duyusu yiyecek ve içeceklerin lezzetlerinin algılanmasında, besinlerin ve zehirli olabilecek maddelerin ayırt edilmesinde rol oynamaktadır. Bu özelliği ile bireylerin çevreleri hakkında bilgi edinerek davranışlarını uyarlamalarını sağlayan tat algısını etkileyen çevresel ve genetik faktörler bulunmaktadır. Son dönemde tat algısında rol oynadığı düşünülen reseptörlerde bulunan tek nükleotit polimorfizmlerinin (SNP), bireylerin tatlı, tuzlu, ekşi, acı ve umami tatlara ek olarak yağlı tat algısına ve dolayısıyla besin tercihlerine etki edebileceği öne sürülmektedir. Bu derlemenin amacı temel tatlara ek olarak yağlı tat ile ilişkili olduğu bilinen SNP’leri özetlemek, bunların besin tercihlerine ve kronik hastalıklara olası etkilerini açıklamaktır. Yapılan çalışmalar olası ilişkiye ışık tutsa da SNPlerin bireylerin besin alımını ve beslenme davranışlarını ne ölçüde etkilediği ve etki mekanizmaları net olarak anlaşılamamıştır.

Keywords

beslenme tek nükleotid polimorfizmi beslenme davranışı

References

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Year 2020, Volume: 5 Issue: 3, 219 - 234, 30.12.2020

Saniye Sözlü

Abstract

References

  • Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ ve Zuker CS (2000) A novel family of mammalian taste receptors. Cell 100:693-702.
  • Alberts B, Bray D, Lewis J, Raff M, Roberts K & Watson JD (1994) Molecular biology ofthe cell. GarlandPublishing, New York.
  • Anliker JA, Bartoshuk L, Ferris AM & Hooks L D (1991) Children's food preferences and genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). Am J Clin Nutr 54:316-20.
  • Bakke A & Vickers Z (2007) Consumer liking of refined and whole wheat breads. J Food Sci 72:S473-80.
  • Bartel DL, Sullivan SL, Lavoie EG, Sévigny J & Finger TE (2006) Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. J Comp Neurol 497:1-12.
  • Behrens M & Meyerhof W (2011) Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav 105:4-13.
  • Breslin PAS & Huang L (2006) Human taste: peripheral anatomy, taste transduction, and coding. Adv Otorhinolaryngol 63:152-190.
  • Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack Jp, Kim Uk, Drayna D & Meyerhof W (2005) The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 15:322-7.
  • Cao Y, Zhao FL, Kolli T, Hivley R & Herness S (2009) GABA expression in the mammalian taste bud functions as a route of inhibitory cell-to-cell communication. Proc Natl Acad Sci U S A 106:4006-11.
  • Chamoun E, Mutch DM, Allen-Vercoe E, Buchholz AC, Duncan AM, Spriet LL, Haines J, Ma DW & Study GFH (2018a) A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health. Critical reviews in food science and nutrition 58:194-207.
  • Chamoun E, Mutch DM, Allen-Vercoe E, Buchholz AC, Duncan AM, Spriet LL, Haines J & Ma DWL (2018b A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health. Crit Rev Food Sci Nutr 58:194-207.
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  • Cox DN, Hendrie GA & Carty D (2016) Sensitivity, hedonics and preferences for basic tastes and fat amongst adults and children of differing weight status: A comprehensive review. Food Quality and Preference 48:359-367.
  • Des Gachons CP, Beauchamp GK & Breslin PA (2009) The genetics of bitterness and pungency detection and its impact on phytonutrient evaluation. Ann N Y Acad Sci 1170:140-4.
  • Di Salle F, Cantone E, Savarese MF, Aragri A, Prinster A, Nicolai E, Sarnelli G, Lengo M, Buyckx M & Cuomo R (2013) Effect of carbonation on brain processing of sweet stimuli in humans. Gastroenterology 145:537-9.e3.
  • Dias AG, Rousseau D, Duizer L, Cockburn M, Chiu W, Nielsen D & El-Sohemy A (2013) Genetic variation in putative salt taste receptors and salt taste perception in humans. Chem Senses 38:137-45.
  • Dinehart ME, Hayes JE, Bartoshuk LM, Lanier SL & Duffy VB (2006) Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav 87:304-13.
  • Donaldson LF, Bennett L, Baic S & Melichar JK (2009) Taste and weight: is there a link? Am J Clin Nutr 90:800s-803s.
  • Dotson CD, Colbert CL, Garcea M, Smith JC & Spector AC (2012) The consequences of gustatory deafferentation on body mass and feeding patterns in the rat. Am J Physiol Regul Integr Comp Physiol 303:R611-23.
  • Drewnowski A, Henderson SA, Levine A & Hann C (1999) Taste and food preferences as predictors of dietary practices in young women. Public Health Nutr 2:513-9.
  • Drewnowski A, Henderson SA, Shore AB & Barratt-Fornell A (1998) Sensory responses to 6-n-propylthiouracil (PROP) or sucrose solutions and food preferences in young women. Ann N Y Acad Sci 855:797-801.
  • Duffy VB & Bartoshuk LM (2000) Food acceptance and genetic variation in taste. J Am Diet Assoc 100:647-55.
  • Efeyan A, Comb WC & Sabatini DM (2015) Nutrient-sensing mechanisms and pathways. Nature 517:302-10.
  • Ekstrand B, Young JF & Rasmussen MK (2017) Taste receptors in the gut - A new target for health promoting properties in diet. Food Res Int 100:1-8.
  • El-Yassimi A, Hichami A, Besnard P & Khan NA (2008) Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. Journal of biological chemistry 283:12949-12959.
  • Eny KM, Wolever TM, Corey PN & El-Sohemy A (2010) Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations. Am J Clin Nutr 92:1501-10.
  • Fay LB & German JB (2008) Personalizing foods: is genotype necessary? Curr Opin Biotechnol 19:121-8.
  • Fushan AA, Simons CT, Slack JP, Manichaikul A & Drayna D (2009) Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. Curr Biol 19:1288-93.
  • Gayathri Devi A, Henderson SA & Drewnowski A (1997) Sensory acceptance of Japanese green tea and soy products is linked to genetic sensitivity to 6-n-propylthiouracil. Nutr Cancer 29:146-51.
  • Glanz K, Basil M, Maibach E, Goldberg J & Snyder D (1998) Why Americans eat what they do: taste, nutrition, cost, convenience, and weight control concerns as influences on food consumption. J Am Diet Assoc 98:1118-26.
  • Grimm ER & Steinle NI (2011) Genetics of eating behavior: established and emerging concepts. Nutr Rev 69:52-60.
  • Heckmann JG, Heckmann SM, Lang CJ & Hummel T (2003) Neurological aspects of taste disorders. Arch Neurol 60:667-71.
  • Heni M, Müssig K, Machicao F, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU & Staiger H (2011) Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity. Obesity (Silver Spring) 19:1004-9.
  • Huang YA, Pereira E & Roper SD (2011) Acid stimulation (sour taste) elicits GABA and serotonin release from mouse taste cells. PLoS One 6:e25471.
  • Jerzsa-Latta M, Krondl M & Coleman P (1990) Use and perceived attributes of cruciferous vegetables in terms of genetically-mediated taste sensitivity. Appetite 15:127-34.
  • Keast RS & Costanzo A (2015) Is fat the sixth taste primary? Evidence and implications. Flavour 4:5.
  • Keller KL, Liang LC, Sakimura J, May D, Van Belle C, Breen C, Driggin E, Tepper BJ, Lanzano PC & Deng L (2012) Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans. Obesity 20:1066-1073.
  • Keski-Rahkonen A, Bulik CM, Pietiläinen KH, Rose RJ, Kaprio J & Rissanen A (2007) Eating styles, overweight and obesity in young adult twins. Eur J Clin Nutr 61:822-9.
  • Keskitalo K, Tuorila H, Spector TD, Cherkas LF, Knaapila A, Kaprio J, Silventoinen K & Perola M (2008) The Three-Factor Eating Questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations. Am J Clin Nutr 88:263-71.
  • Khan AS, Murtaza B, Hichami A & Khan NA (2019) A cross-talk between fat and bitter taste modalities. Biochimie 159:3-8.
  • Kim UK, Breslin PA, Reed D & Drayna D (2004) Genetics of human taste perception. J Dent Res 83:448-53.
  • Kim UK, Wooding S, Riaz N, Jorde LB & Drayna D (2006) Variation in the human TAS1R taste receptor genes. Chem Senses 31:599-611.
  • Kulkarni GV, Chng T, Eny KM, Nielsen D, Wessman C & El-Sohemy A (2013) Association of GLUT2 and TAS1R2 genotypes with risk for dental caries. Caries Res 47:219-25.
  • Li X, Staszewski L, Xu H, Durick K, Zoller M & Adler E (2002) Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 99:4692-6.
  • Lindemann B (2001) Receptors and transduction in taste. Nature 413:219-25.
  • Liu D, Archer N, Duesing K, Hannan G & Keast R (2016) Mechanism of fat taste perception: Association with diet and obesity. Progress in lipid research 63:41-49.
  • Looy H & Weingarten HP (1992) Facial expressions and genetic sensitivity to 6-n-propylthiouracil predict hedonic response to sweet. Physiol Behav 52:75-82.
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There are 87 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review
Authors

Saniye Sözlü 0000-0003-1791-0003

Publication Date December 30, 2020
Published in Issue Year 2020Volume: 5 Issue: 3

Cite

APA Sözlü, S. (2020). Tat Reseptörlerinde Tek Nükleotid Gen Polimorfizmi, Besin Tercihi ve Sağlık Arasındaki İlişki. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 5(3), 219-234.
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